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Effectiveness of Post-Traumatic Growth Intervention to Promote Positive Post-Traumatic Traits in Chinese Breast Cancer Patients:A Randomized Controlled Trial
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作者 Cuirong Xu Han Yan +7 位作者 Dawei Xu Guanjie Chen Qian Xu Kunpeng Li Yehao Rui Zanmin Song Neeraj Gill Jing Sun 《International Journal of Mental Health Promotion》 2023年第10期1089-1102,共14页
Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomize... Objective:The purpose of this study was to evaluate the effectiveness of post-traumatic growth(PTG)model-based intervention to improve positive psychological traits in Chinese breast cancer patients.Design:A randomized control trial of a psychological group intervention based on PTG model.Methods:The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264.A total of 92 patients with breast cancer were recruited.The participants were randomly assigned to the experimental group(n=46)and the control group(n=46).A six-session psychological group intervention based on PTG model was implemented in the experimental group,and a six-session health education was implemented in the control group.The outcomes weremeasured at baseline(pre-intervention),3 weeks,6 weeks after the intervention.The primary outcome was posttraumatic growth assessed by the Chinese version of the Post-Traumatic Growth Inventory(PTGI);Secondary outcomes included psychological resilience,family resilience,rumination,and self-disclosure.Results:A total of 87 patients with breast cancer completed this study,including 44 patients in the experimental group and 43 patients in the control group.There was no significant difference in baseline data of breast cancer patients between the two groups except for the treatment regimen(p>0.05).The two groups were compared after the intervention;the interaction effects between the total scores of posttraumatic growth,family resilience,and self-disclosure and the time term were statistically significant(p<0.05),indicating that the trend of change in total scores of post-traumatic growth,family resilience,and self-disclosure differed between the experimental and control groups over time,and the scores improved in the experimental group were significantly higher than those in the control group.The comparison of psychological resilience and total score of rumination at each time point was statistically significant(p<0.05),indicating that group intervention based on the PTG model could improve the psychological recovery ability and rumination level of the experimental group.Conclusion:The psychological group intervention based on the PTG model significantly improved post-traumatic growth,family resilience,and self-disclosure in patients with breast cancer.However,the impact on psychological resilience and rumination was relatively small.Long-term intervention is needed to further test the effect of the PTG model on psychological resilience and rumination. 展开更多
关键词 post-traumatic growth psychological group intervention resilience RUMINATION SELF-DISCLOSURE breast cancer Tech Science Press
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Relationship between perceived social support and post-traumatic growth in coronavirus disease 2019 patients discharged from the hospital
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作者 MeltemŞirin Gök BaharÇiftçi 《World Journal of Psychiatry》 SCIE 2023年第4期171-181,共11页
BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has affected mental health and physical health negatively in some individuals.Examining perceived social support and post-traumatic growth(PTG)in COVID-19 pati... BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has affected mental health and physical health negatively in some individuals.Examining perceived social support and post-traumatic growth(PTG)in COVID-19 patients could facilitate our understanding of how patients maintain their mental health.AIM To examine the relationship between the level of perceived social support and PTG in COVID-19 patients discharged from the hospital.METHODS This descriptive study was carried out between August and September 2022 with patients who were hospitalized due to COVID-19 in a university hospital in Erzurum and who were discharged at least 3 mo prior to the beginning of the study.The study was completed by 196 patients.Study data were collected faceto-face using a personal information form,multidimensional scale of perceived social support and PTG inventory.RESULTS The total mean score of the multidimensional scale of perceived social support was 63.82±15.72.The PTG inventory total mean score was 47.77±19.85.In addition,a direct significant correlation was found between perceived social support in COVID-19 patients and PTG.CONCLUSION The study results showed that perceived social support variables affected PTG significantly.Therefore,it is recommended for healthcare professionals to implement interventions to promote social support from healthcare professionals and the patient’s family and friends.Considering the negative effects of the ongoing COVID-19 pandemic,it is very important and necessary to implement effective public health interventions to promote PTG to reduce mental health problems. 展开更多
关键词 COVID-19 patients Perceived social support post-traumatic growth COVID-19
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Current status and influencing factors of post-traumatic growth in maintenance hemodialysis 被引量:2
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作者 Chuyun Cui Kuijie Wang +1 位作者 Jinye An Changde Jin 《International Journal of Nursing Sciences》 2017年第4期362-366,共5页
Objective:To study the post-traumatic growth level and influencing factors in patients with maintenance hemodialysis.Methods:A total of 179 patients receiving maintenance hemodialysis from a third-level grade A hospit... Objective:To study the post-traumatic growth level and influencing factors in patients with maintenance hemodialysis.Methods:A total of 179 patients receiving maintenance hemodialysis from a third-level grade A hospital in Tianjin,China were investigated using Post-traumatic Growth Inventory(PTGI),Perceived Social Support Scale,and Medical Coping Modes Questionnaire.Results:The total score for the PTGI was 53.73±16.45.Multiple linear regression analysis showed that social support,coping style,marital status,and family income significantly influenced the post-traumatic growth level in patients undergoing maintenance hemodialysis.These factors explained 41.4%of the variance.Conclusion:Medical staff should help patients under maintenance hemodialysis to fulfill their potentials by boosting the level of social support and to effectively cope with internal conflicts.In addition,nursing staff should provide relevant psychological health education to patients to improve their post-traumatic growth. 展开更多
关键词 Maintenance hemodialysis PATIENTS post-traumatic growth Root cause analysis
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Addressing trauma,post-traumatic stress disorder,and posttraumatic growth in breast cancer patients
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作者 Amos Nnaemeka Amedu 《World Journal of Experimental Medicine》 2024年第3期108-118,共11页
BACKGROUND Breast cancer(BC)is a common cancer among females in Africa.Being infected with BC in Africa seems like a life sentence and brings devastating experiences to patients and households.As a result,BC is comorb... BACKGROUND Breast cancer(BC)is a common cancer among females in Africa.Being infected with BC in Africa seems like a life sentence and brings devastating experiences to patients and households.As a result,BC is comorbid with trauma,post-traumatic stress disorder(PTSD),and post-traumatic growth(PTG).AIM To identify empirical evidence from peer-reviewed articles on the comorbidity trajectories between BC and trauma,BC and PTSD,and BC and PTG.METHODS This review adhered to the PRISMA guidelines of conducting a systematic review.Literature searches of the National Library of Medicine,Scopus,PubMed,Google Scholar,and Scopus databases were conducted using search terms developed for the study.The search hint yielded 769 results,which were screened based on inclusion and exclusion criteria.At the end of the screening,24 articles were included in the systematic review.RESULTS BC patients suffered trauma and PTSD during the diagnosis and treatment stages.These traumatic events include painful experiences during and after diagnosis,psychological distress,depression,and cultural stigma against BC patients.PTSD occurrence among BC patients varies across African countries,as this review disclosed:90%was reported in Kenya,80%was reported in Zimbabwe,and 46%was reported in Nigeria.The severity of PTSD among BC patients in Africa was based on the test results communicated to the patients.Furthermore,this review revealed that BC patients experience PTG,which involves losing,regaining,and surrendering final control over the body,rebuilding a personified identity,and newfound appreciation for the body.CONCLUSION Patients with BC undergo numerous traumatic experiences during their diagnosis and treatment.Psychological interventions are needed in SSA to mitigate trauma and PTSD,as well as promote PTG. 展开更多
关键词 TRAUMA post-traumatic stress disorder post-traumatic growth Breast cancer PATIENTS Sub-Saharan Africa
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Promoting Post-Traumatic Growth in Colorectal Cancer Patients:Exploring the Role of Social Support through a Chain Mediation Model
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作者 Xia Sun Qin Li +3 位作者 Yang Li Wenjun Yan Shuai Gong Wenjing Yan 《Psycho-Oncologie》 SCIE 2024年第3期233-240,共8页
Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the ef... Colorectal cancer(CRC)poses significant physical and psychological challenges that necessitate an exploration of factors influencing post-traumatic growth(PTG)for patient well-being.This study aims to investigate the effects of positive psychological capital(PsyCap)and perceived stress on mediating the social support-PTG relation among 673 CRC patients.Social support,positive PsyCap,perceived stress,and PTG were assessed through questionnaires.The results indicated a direct prediction effect of social support on PTG(LICI=0.481,ULCI=0.644),with the direct effect being 59.5%.Both positive PsyCap and perceived stress exerted a mediating role in the correlation between social support and PTG,with the mediating effects occupying 29.4%(LICI=0.217,ULCI=0.343)and 5.7%(LICI=0.030,ULCI=0.082),respectively.Positive PsyCap further had a chain mediating effect on perceived stress(LICI=0.031,ULCI=0.074),with the chain effect accounting for 5.4%.The total impact of social support on PTG was 100%(LICI=0.882,ULCI=1.008).This model underscores the pivotal role of social support in promoting PTG in CRC patients.Positive PsyCap serves as a crucial mediator in the social support-PTG link,with perceived stress playing a sequential mediating role.Thesefindings suggest that strengthening social support networks and cultivating positive PsyCap may reduce perceived stress and promote the development of PTG in CRC patients.Consequently,intervention programs are recommended to improve the psychosocial well-being of CRC patients. 展开更多
关键词 Social support positive psychological capital perceived stress mediating effect post-traumatic growth
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The Effect of Psychological Resilience on Hopelessness and Post-Traumatic Growth in Individuals Experienced by Earthquake
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作者 Hacer Kabakoğlue Fatma Nuray Kuşçu Sahin 《International Journal of Mental Health Promotion》 2024年第10期855-863,共9页
Background:Disasters have effects that leave great negative marks on our lives,even after many years have passed.Individuals who experience an earthquake experience physical and psychological difficulties.The purpose ... Background:Disasters have effects that leave great negative marks on our lives,even after many years have passed.Individuals who experience an earthquake experience physical and psychological difficulties.The purpose of this study is to determine how psychological resilience levels affect the feeling of hopelessness and post-traumatic growth in adults who experienced the 06 February,2023 Turkey-Syria earthquake.Methods:Data were collected using the“Personal Information Form(PIF)”,“Turkish forms of Adult Resilience Measure(ARM)”,“Dispositional Hope Scale(DHS)”and“Post-Traumatic Growth Inventory(PTGI)”.In order to determine whether there is a significant difference in the effect of psychological resilience of earthquake victims participating in the study on hope and post-traumatic growth levels in terms of socio-demographic variables,after determining that the data was normally distributed,total score average,minimum and maximum values,standard deviation(SD),independent sample t-test,ANOVA,correlation analysis to determine the relationship between the scales and multiple regression analysis to determine the effect between the scales were performed.Results:Of the 202 earthquake victims who participated in the study,65.8%were between the ages of 18–34,67.3%were female,92.1%were not trapped under the rubble,and 34.2%had second-degree relatives trapped under the rubble.It was determined that 77.8%of them lost their relatives in the earthquake and 77.8%of them lost a serious amount of property and money due to the earthquake.As a result of the analysis,it was determined that psychological resilience had a statistically significant and positive effect on hopelessness and post-traumatic growth in individuals who experienced the 06 February earthquake.In this regard,it has been determined that as the psychological resilience of individuals increases,their hope levels and post-traumatic growth will also increase.Conclusion:Based on the research results,increasing hope and increasing psychological resilience in psychosocial support studies carried out by mental health professionals for traumatic events will contribute to the spiritual recovery of individuals. 展开更多
关键词 Earthquake psychological resilience hope post-traumatic growth
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Vicarious Post-traumatic Growth in Healthcare Professionals: A Scoping Review
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作者 Blandine Lucrece Jongo Fouelefack Yun-Xian Zhou 《Journal of Cerebrovascular Disease》 2023年第2期8-14,共7页
Objective:This scoping review aims to provide a comprehensive overview of the existing literature on vicarious post-traumatic growth(VPTG)among healthcare professionals and its influencing factors.Methods:Using electr... Objective:This scoping review aims to provide a comprehensive overview of the existing literature on vicarious post-traumatic growth(VPTG)among healthcare professionals and its influencing factors.Methods:Using electronic databases PubMed,PsycInfo,Science Direct,CINHAHL,Web of Science,Scopus,and CNKI,a search was performed for articles on VPTG among healthcare professionals.Relevant articles were included and summarized.Results:This review mapped 29 studies that highlighted positive outcomes of VPTG in healthcare professionals.Factors likely to influence VPTG were identified,such as age,gender,occupation,years of experience,others factors and their importance in understanding well-being.Gaps in the literature,practical recommendations,and future research direction were suggested.Conclusion:This review highlights the nature of research on VPTG and its influencing factors in healthcare professionals.It emphasizes the importance of further research to explore the complex interactions between psychological and physiological responses to vicarious trauma.This review can inform interventions to improve VPTG and support the holistic health of healthcare professionals. 展开更多
关键词 Healthcare professional Vicarious trauma Vicarious post-traumatic growth Scoping review Influencing factor
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Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury 被引量:1
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作者 Dan Yang Bin-Bin Nie +6 位作者 Jin-Gang He Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen Tao Tao 《Zoological Research》 SCIE CSCD 2024年第3期648-662,共15页
Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact... Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact underlying mechanism remains largely unknown.Identifying potential biomarkers may prompt the diagnosis and development of effective treatments for mTBI-induced PTH.In this study,a mouse model of mTBI-induced PTH was established to investigate its effects on cerebral structure and function during short-term recovery.Results indicated that mice with mTBI-induced PTH exhibited balance deficits during the early post-injury stage.Metabolic kinetics revealed that variations in neurotransmitters were most prominent in the cerebellum,temporal lobe/cortex,and hippocampal regions during the early stages of PTH.Additionally,variations in brain functional activities and connectivity were further detected in the early stage of PTH,particularly in the cerebellum and temporal cortex,suggesting that these regions play central roles in the mechanism underlying PTH.Moreover,our results suggested that GABA and glutamate may serve as potential diagnostic or prognostic biomarkers for PTH.Future studies should explore the specific neural circuits involved in the regulation of PTH by the cerebellum and temporal cortex,with these two regions potentially utilized as targets for non-invasive stimulation in future clinical treatment. 展开更多
关键词 post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics FMRI CEREBELLUM
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Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder
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作者 Xingshuang Song Yizhi Zhang +7 位作者 Ziyan Tang Jing Dai Yanping Wu Guiyu Huang Hong Niu Yaxin Wang Xu Jin Lina Du 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第3期316-329,共14页
Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used gi... Objective:To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient compliance.Methods: In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil patches.High-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,6-gingerol.Transdermal absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and concentration.Subsequently,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock method.The therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results: The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF levels.Pharmacokinetic experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic efficacy.Conclusions: Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral administration.It can improve PTSD with good patient compliance and ease of administration.Therefore,it is a promising therapeutic formulation for the treatment of PTSD. 展开更多
关键词 post-traumatic stress disorder 6-GINGEROL Pressure sensitive adhesive patch Transdermal delivery
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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS 2025年第7期1957-1970,共14页
Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with... Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events.Currently,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress disorder.In addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate treatment.Evidence suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress disorder.We performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December 2023.These included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum exosomes.One of these studies had also used whole plasma.Two studies were excluded as they did not involve microRNA biomarkers.Most of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult subjects.In measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString panels.Only six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to controls.The miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/exosomes;and miR-18a-3p and-7-1-5p in blood plasma.Several important limitations identified in the studies need to be taken into account in future studies.Further studies are warranted with war veterans and recently traumatized children,adolescents,and adults having PTSD and use of animal models subjected to various stressors and the effects of suppressing or overexpressing specific microRNAs. 展开更多
关键词 BIOMARKER DIAGNOSIS microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma
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Post-Traumatic Stress Disorder among Defence and Security Forces in Northern Benin (2023)
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作者 Ireti Nethania Elie Ataigba Guy Gérard Aza Gnandji +6 位作者 David Sinet Koivogui Dalmace Fauste Adjaho Eurydice Elvire Djossou Anselme Djidonou Francis Tognon Tchegnonsi Prosper Gandaho Josiane Ezin Houngbe 《Open Journal of Psychiatry》 2024年第2期142-161,共20页
Introduction: Post-traumatic stress disorder (PTSD) is defined as “actual exposure to death or the threat of death, serious injury or sexual violence”, either directly or indirectly, resulting in a symptomatic proce... Introduction: Post-traumatic stress disorder (PTSD) is defined as “actual exposure to death or the threat of death, serious injury or sexual violence”, either directly or indirectly, resulting in a symptomatic procession of repetition, avoidance, neurovegetative hyperactivity and individualized symptoms, with or without negative cognitive and mood changes. It therefore goes without saying that the defence and security forces constitute a high-risk population in need of attention. Objective: To study post-traumatic stress disorder in defence and security forces in the city of Parakou in 2023. Methods: Descriptive cross-sectional study conducted from December 2022 to July 2023. The study population consisted of active military, republican police and firefighters in the city of Parakou in 2023. Non-proportional stratified sampling was used, given the inaccessibility of the source population size for national security reasons. Post-traumatic stress disorder was assessed using the “post-traumatic stress disorder checklist-5 (PCLS-5) scale. Results: A total of 305 subjects participated in the survey. Males dominated 90.2%. The most represented corps was the Republican Police (41.6%), most of whom were non-commissioned officers (46.6%). The majority count between 11 and 20 years of service (48.9%), with 2 to 5 missions completed (67.5%). The calculated prevalence of post-traumatic stress disorder was 11.8%, based on the post-traumatic stress disorder checklist-5 (PCL-5). Of the 36 respondents with post-traumatic stress disorder, 20 (55.6%) had experienced an armed attack, 25 (69.4%) had witnessed a violent death, 18 (50.0%) had witnessed the agony of a colleague, 15 (41.7%) had been exposed to a fire or explosion, while 26 (72.2%) had been traumatized by physical and/or verbal aggression. 5 (13.9%) had consulted a specialist psychiatrist, while 6 (16.7%) were on medication and 26 (72.2%) used sport as a means of maintaining physical and mental health. Respectively 22 (61.1%) and 21 (58.3%) had definite symptoms of anxiety and depression. Multivariate analysis revealed a significant association between post-traumatic stress disorder and the following variables: total number of children ≤ 2 (p = 0.015), comorbidities such as arterial hypertension (p = 0.007), history of hepatitis (p = 0.017), work accidents (p = 0.016), alcohol dependence (p = 0.004), domestic violence (p = 0.004), psychological violence (p = 0.017) and anxiety disorders (p Conclusion: Defence and security personnel can also be prey to post-traumatic stress disorder (PTSD), which needs to be systematically taken into account when they are subjected to trauma in the course of their duties. Mental health should be an integral part of the periodic medical check-up objectives for defence and security forces throughout the country. 展开更多
关键词 post-traumatic Stress Disorder FORCES DEFENCE SECURITY BENIN 2023
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Effects of Pearl Yangxin Anshen Decoction on HAMD and PTSD-SS Scores, Cytokines and Related Metabolites in Patients with Post-Traumatic Stress Disorder
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作者 Yu Feng Min Guo 《Journal of Behavioral and Brain Science》 2024年第3期93-102,共10页
Objective: This paper aims to observe the Pearl Yangxin Anshen Decoction to influence the score of HAMD and PTSD-SS, the changes of the cytokines and the related metabolic product in patients with PTSD. Methods: From ... Objective: This paper aims to observe the Pearl Yangxin Anshen Decoction to influence the score of HAMD and PTSD-SS, the changes of the cytokines and the related metabolic product in patients with PTSD. Methods: From June 2015 to May 2016, in the traditional Chinese medicine clinics of Hainan Province People’s Hospital, there were 50 patients with PTSD, the age were from 30 to 60, they were randomly divided into treatment group (25 cases) and control group (25 cases), then compared the scores of HAMD and PTSD-SS between the two groups, searched the changes of cytokines and the related metabolic product. Results: In the treatment group: before and after treatment the scores of PTSD-SS were 65.64 ± 7.02, 28.32 ± 4.18, and the scores of HAMD were 29.28 ± 1.97, 11.72 ± 2.13;In the control group: before and after treatment the scores of PTSD-SS were 63.24 ± 6.16, 31.40 ± 4.29, the scores of HAMD were 30.24 ± 2.05, 13.08 ± 2.30. After 3 months patients in treatment group the scores of PTSD-SS and HAMD were lower than the control group (t = 2.570, P = 0.013, t = -2.1640, P = 0.035). In the control group: before and after 3 months treatment the IL-2 levels respectively were 79.84 ± 26.46 pg/ml, 56.18 ± 22.67 pg/ml, the IL-6 levels respectively were 110.83 ± 47.65 pg/ml, 59.67 ± 44.68 pg/ml, the IL-8 levels respectively were 73.11 ± 78.51 pg/ml, 55.83 ± 81.94 pg/ml, the NE levels respectively were 420.04 ± 674.75 pg/ml, 185.31 ± 417.91 pg/ml, the MDA levels respectively were 112.35 ± 62.87 ng/ml, 60.42.33 ± 53.64 ng/ml, the NO levels were 126.6 ± 47.4 μmol/L, 78.6 ± 45.7 μmol/L, the VIP levels were 396.6 ± 144.4 pg/ml, 122.4 ± 111.5 pg/ml. In the treatment group: before and after 3 months treatment the IL-2 levels respectively were 86.00 ± 32.29 pg/ml, 53.84 ± 27.01 pg/ml, the IL-6 levels respectively were 108.21 ± 44.60 pg/ml, 42.46 ± 42.16 pg/ml, the IL-8 levels respectively were 81.48 ± 94.19 pg/ml, 54.07 ± 84.15 pg/ml, the NE levels respectively were 392.93 ± 592.84 pg/ml, 243.85 ± 588.45 pg/ml, the MDA levels respectively were 117.58 ± 63.37 ng/ml, 45.91 ± 38.94 ng/ml, the NO levels respectively were 135.9 ± 46.4 μmol/L, 72.6 ± 46.6 μmol/L, the VIP levels respectively were 414.0 ± 140.1 pg/ml, 185.8 ± 105.3 pg/ml. In the two groups as the extension of treatment time, the content of IL-2, IL-8, IL-6, NE, MDA, NO, and VIP were gradually reduced, and the level of reduction of the treatment group patients was higher than the control group, the change of ACTH and SOD levels just the opposite. Conclusion: The Pearl Yangxin Anshen Decoction could improve the symptoms of psychological anxiety, depression and other psychological problems in patients with PTSD, and influence the change of cytokines and related metabolites product. 展开更多
关键词 post-traumatic Stress Disorder Psychological Intervention Serological Detection
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Correlation Study of Neurotransmitter and Immune Levels in Pre-Hospital Emergency Nurses with Post-Traumatic Stress Disorder
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作者 Yanling Zhou Min Guo +1 位作者 Xiangling Jiang Long Li 《Journal of Behavioral and Brain Science》 2024年第1期12-22,共11页
Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, and to compare the differences of neurotransmitter and immune-related factors between pre-hospital emergency n... Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, and to compare the differences of neurotransmitter and immune-related factors between pre-hospital emergency nurses who experienced traumatic events and those who did not develop PTSD and healthy people. How: Post-traumatic Stress Disorder Self-Rating Scale (PCL-C) tests were performed on pre-hospital emergency nurses in PTSD group, non-PTSD group and healthy control group, and the plasma monoamine neurotransmitters and serum cytokines were determined by double-antibody sandwich ABC-ELISA assay using enzyme-linked adsorption kit provided by Shanghai Xitang Biotechnology Co., Ltd. Results: 1) There were statistically significant differences in PCL-C scores between PTSD group, non-PTSD group and healthy group (p α between PTSD group, non-PTSD group and healthy group (p Conclusion: Pre-hospital emergency nurses should have early psychological intervention and guidance to reduce the occurrence of PTSD in emergency and emergency nurses. 展开更多
关键词 Pre-Hospital First Aid NURSE post-traumatic Stress Disorder NEUROIMMUNOLOGY
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Principles and Techniques of Post-Traumatic Rhinoplasty: A Review of the Literature
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作者 Maroua Berrezouk Fiqhi Mohammed Kamal +2 位作者 Samir Maidam Mohamed Lakouichmi Abdeljalil Abouchadi 《Modern Plastic Surgery》 2024年第4期74-86,共13页
Post-traumatic rhinoplasty is the surgical treatment of the complex functional and aesthetic sequelae of nasal trauma. Correcting a post-traumatic nose is a challenging task, requiring the surgeon to employ a range of... Post-traumatic rhinoplasty is the surgical treatment of the complex functional and aesthetic sequelae of nasal trauma. Correcting a post-traumatic nose is a challenging task, requiring the surgeon to employ a range of techniques and grafts to adequately address the deformities observed. The results of our research show that restoring pre-traumatic form and function remains complex, although many guidelines have been established to refine and optimize the management of the after-effects of nasal trauma. But it is achievable with the right techniques. The objective of our review is to highlight the various post-traumatic nasal sequelae, describe the fundamental principles in the field of post-traumatic rhinoplasty and provide the surgeon with the various existing surgical techniques and strategies so that he or she can make an appropriate choice for the patient. 展开更多
关键词 Nasal Trauma SEQUELAE post-traumatic Rhinoplasty Deviation Saddle Nose
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基于FP-growth算法的交通事故数据关联规则挖掘研究
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作者 马健 谢雨晴 +2 位作者 张丽岩 王燕 周欢生 《科技创新与生产力》 2024年第9期95-97,共3页
为了探寻多种事故影响因素共同作用下诱发交通事故的某种规律以及各因素间的关系,本文采用FP-growth算法对收集到的交通事故数据进行分析研究,挖掘其中的潜在价值信息,找出事故发生的原因,根据分析结果给相关部门提出建议,帮助城市交通... 为了探寻多种事故影响因素共同作用下诱发交通事故的某种规律以及各因素间的关系,本文采用FP-growth算法对收集到的交通事故数据进行分析研究,挖掘其中的潜在价值信息,找出事故发生的原因,根据分析结果给相关部门提出建议,帮助城市交通管理者制定更有效的管理措施,以达到降低交通事故发生频率的目的。 展开更多
关键词 交通事故 关联规则 FP-growth
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基于FP-growth的老年行人交通事故损伤致因研究
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作者 刘永涛 张慧臣 +3 位作者 袁诗泉 高隆鑫 王鹏 赵晨 《中国安全生产科学技术》 CAS CSCD 北大核心 2024年第6期176-182,共7页
为研究老年行人交通事故相关因素及其对损伤程度的影响,以中国交通事故深度调查数据库中2013—2023年710起机动车-老年行人事故为分析对象,利用FP-growth算法挖掘出4类影响因素28个类型变量共5594项关联规则。研究结果表明:行人年龄、... 为研究老年行人交通事故相关因素及其对损伤程度的影响,以中国交通事故深度调查数据库中2013—2023年710起机动车-老年行人事故为分析对象,利用FP-growth算法挖掘出4类影响因素28个类型变量共5594项关联规则。研究结果表明:行人年龄、碰撞速度、事故时间段及事故地点是影响老年行人事故死亡率的显著因素。特别是,行人年龄和碰撞速度对死亡率有显著影响,随着碰撞速度的增加,死亡率显著上升;60岁及以上老年行人年龄每增加1岁,其死亡率提升0.037倍。此外,事故发生在夜间、郊区或村庄的死亡率更高。研究结果可为提高老年行人交通安全,制定相关安全措施提供一定参考。 展开更多
关键词 FP-growth算法 逻辑回归模型 老年行人安全 交通事故数据分析
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Analysis of post-traumatic growth status and its influencing factors in patients with facial palsy 被引量:2
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作者 Qian Li Pengwei Lu +3 位作者 Yanzhu Fan Lei Wang Fei Yao Diya Su 《Chinese Neurosurgical Journal》 CSCD 2019年第1期30-38,共9页
Background:Facial nerve paralysis in patients occurs in varying degrees of self-image disorders,both physically and mentally,resulting in low self-esteem,anxiety,depression,and even suicide;however,there were few rese... Background:Facial nerve paralysis in patients occurs in varying degrees of self-image disorders,both physically and mentally,resulting in low self-esteem,anxiety,depression,and even suicide;however,there were few researches on psychological problems in facial palsy patients at home and abroad.This study's objective was to investigate post-traumatic growth(PTG)in facial nerve palsy patients and analyze its influencing factors.Methods:Using the convenience sampling method,a total of 47 patients with facial nerve paralysis were enrolled in the current study between June 1,2016,and May 31,2017.Post-traumatic growth rating scale was utilized to investigate the post-traumatic growth of these patients,and factors influencing patients'post-traumatic growth were analyzed through collecting the general sociological information,disease-related information,simple coping style questionnaire,and social support rating scale.Results:The total score of post-traumatic growth in patients with facial nerve paralysis was mean(M)=63.1,standard deviation(SD)=19.14.The ranking of five dimensional scores from high to low was as follows:new possibilities,personal strength enhancement,appreciation of life,mental changes,and improvement of relationships with others.Multiple linear regression analysis showed that six variables,namely,the personality type,duration with facial nerve paralysis,and four coping styles,consisting of three types of positive coping styles and one negative coping style,could explain 71.6%of the total post-traumatic growth score.Conclusions:Post-traumatic growth in facial nerve palsy patients is moderate.The personality type of patients,the disease duration,and the coping style are the primary influencing factors.Therefore,clinical staffs should perform personalized nursing protocol and psychological intervention for facial nerve palsy patients to reduce their negative mood,improve their compliance with treatment,and help them recover more rapidly. 展开更多
关键词 FACIAL NERVE PALSY post-traumatic growth COPING style SOCIAL support
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Post-traumatic heterotopic ossification in front of the ankle joint for 23 years:A case report and review of literature
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作者 Zheng Xu Zhou-Zhou Rao +4 位作者 Zhong-Wen Tang Zhen-Qi Song Ming Zeng Hao-Li Gong Jie Wen 《World Journal of Clinical Cases》 SCIE 2023年第1期193-200,共8页
BACKGROUND Heterotopic ossification(HO)refers to the formation of new bone in non-skeletal tissues such as muscles,tendons or other soft tissues.Severe muscle and soft tissue injury often lead to the formation of HO.H... BACKGROUND Heterotopic ossification(HO)refers to the formation of new bone in non-skeletal tissues such as muscles,tendons or other soft tissues.Severe muscle and soft tissue injury often lead to the formation of HO.However,anterior HO of the ankle is rarely reported.CASE SUMMARY We report a patient with massive HO in front of the ankle joint for 23 years.In 1998,the patient was injured by a falling object on the right lower extremity,which gradually formed a massive heterotopic bone change in the right calf and dorsum of the foot.The patient did not develop gradual ankle function limitations until nearly 36 mo ago,and underwent resection of HO.Even after 23 years and resection of HO,the ankle joint was still able to move.CONCLUSION It is recommended that the orthopedist should be aware of HO and distinguish it from bone tumor. 展开更多
关键词 Heterotopic ossification post-traumatic Ankle joint Case report
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Molecular and cellular changes in the post-traumatic spinal cord remodeling after autoinfusion of a genetically-enriched leucoconcentrate in a mini-pig model 被引量:2
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作者 Maria Aleksandrovna Davleeva Ravil Rasimovich Garifulin +9 位作者 Farid Vagizovich Bashirov Andrei Aleksandrovich Izmailov Leniz Faritovich Nurullin Ilnur Ildusovich Salafutdinov Dilara Zilbarovna Gatina Dmitrij Nikolaevich Shcherbinin Andrei Aleksandrovich Lysenko Irina Leonidovna Tutykhina Maksim Mikhailovich Shmarov Rustem Robertovich Islamov 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第7期1505-1511,共7页
Post-traumatic spinal cord remodeling includes both degenerating and regenerating processes,which affect the potency of the functional recovery after spinal cord injury(SCI).Gene therapy for spinal cord injury is prop... Post-traumatic spinal cord remodeling includes both degenerating and regenerating processes,which affect the potency of the functional recovery after spinal cord injury(SCI).Gene therapy for spinal cord injury is proposed as a promising therapeutic strategy to induce positive changes in remodeling of the affected neural tissue.In our previous studies for delivering the therapeutic genes at the site of spinal cord injury,we developed a new approach using an autologous leucoconcentrate transduced ex vivo with chimeric adenoviruses(Ad5/35)carrying recombinant cDNA.In the present study,the efficacy of the intravenous infusion of an autologous genetically-enriched leucoconcentrate simultaneously producing recombinant vascular endothelial growth factor(VEGF),glial cell line-derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)was evaluated with regard to the molecular and cellular changes in remodeling of the spinal cord tissue at the site of damage in a model of mini-pigs with moderate spinal cord injury.Experimental animals were randomly divided into two groups of 4 pigs each:the therapeutic(infused with the leucoconcentrate simultaneously transduced with a combination of the three chimeric adenoviral vectors Ad5/35‐VEGF165,Ad5/35‐GDNF,and Ad5/35‐NCAM1)and control groups(infused with intact leucoconcentrate).The morphometric and immunofluorescence analysis of the spinal cord regeneration in the rostral and caudal segments according to the epicenter of the injury in the treated animals compared to the control mini-pigs showed:(1)higher sparing of the grey matter and increased survivability of the spinal cord cells(lower number of Caspase-3-positive cells and decreased expression of Hsp27);(2)recovery of synaptophysin expression;(3)prevention of astrogliosis(lower area of glial fibrillary acidic protein-positive astrocytes and ionized calcium binding adaptor molecule 1-positive microglial cells);(4)higher growth rates of regeneratingβIII-tubulin-positive axons accompanied by a higher number of oligodendrocyte transcription factor 2-positive oligodendroglial cells in the lateral corticospinal tract region.These results revealed the efficacy of intravenous infusion of the autologous genetically-enriched leucoconcentrate producing recombinant VEGF,GDNF,and NCAM in the acute phase of spinal cord injury on the positive changes in the post-traumatic remodeling nervous tissue at the site of direct injury.Our data provide a solid platform for a new ex vivo gene therapy for spinal cord injury and will facilitate further translation of regenerative therapies in clinical neurology. 展开更多
关键词 autologous genetically-enriched leucoconcentrate chimeric adenoviral vector gene therapy glial cell line-derived neurotrophic factor MINI-PIG neural cell adhesion molecule spinal cord contusion injury vascular endothelial growth factor
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Effects of thinning on the understory light environment of different stands and the photosynthetic performance and growth of the reforestation species Phoebe bournei 被引量:2
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作者 Shicheng Su Nianqing Jin Xiaoli Wei 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第1期12-28,共17页
Light levels determine regeneration in stands and a key concern is how to regulate the light environment of different stand types to the requirements of the understory.In this study,we selected three stands typical in... Light levels determine regeneration in stands and a key concern is how to regulate the light environment of different stand types to the requirements of the understory.In this study,we selected three stands typical in south China(a Cryptomeria japonica plantation,a Quercus acutissima plantation,and a mixed stand of both)and three thinning intensities to determine the best understory light environ-ment for 3-year-old Phoebe bournei seedlings.The canopy structure,understory light environment,and photosynthe-sis and growth indicators were assessed following thin-ning.Thinning improved canopy structure and understory light availability of each stand;species composition was the reason for differences in the understory light environ-ment.Under the same thinning intensity,the mixed stand had the greatest light radiation and most balanced spectral composition.P.bournei photosynthesis and growth were closely related to the light environment;all three stands required heavy thinning to create an effective and sustained understory light environment.In a suitable understory light environment,the efficiency of light interception,absorption,and use by seedlings was enhanced,resulting in a higher carbon assimilation the main limiting factor was stomatal conductance.As a shade-avoidance signal,red/far-red radia-tion is a critical factor driving changes in photosynthesis and growth of P.bournei seedlings,and a reduction increased light absorption and use capacity and height:diameter ratios.The growth advantage transformed from diameter to height,enabling seedlings to access more light.Our findings suggest that the regeneration of shade-tolerant species such as P.bournei could be enhanced if a targeted approach to thinning based on stand type was adopted. 展开更多
关键词 THINNING Understory light environment Phoebe bournei Photosynthetic performance growth performance
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