Pre-and post-selected measurements with coupling-strength-dependent modulation

Pre-and post-selected(PPS) measurement, especially the weak PPS measurement, has been proved to be a useful tool for measuring extremely tiny physical parameters. However, it is difficult to retain both the attainable highest measurement sensitivity and precision with the increase of the parameter to be measured. Here, a modulated PPS measurement scheme based on coupling-strength-dependent modulation is presented with the highest sensitivity and precision retained for an arbitrary coupling strength. This idea is demonstrated by comparing the modulated PPS measurement scheme with the standard PPS measurement scheme in the case of unbalanced input meter. By using the Fisher information metric, we derive the optimal pre-and post-selected states, as well as the optimal coupling-strength-dependent modulation without any restriction on the coupling strength. We also give the specific strategy of performing the modulated PPS measurement scheme, which may promote practical application of this scheme in precision metrology.

ROLE OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN PRE-AND POST-PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY

Transesophageal echocardiogram (TEE) was performed in 33 consecutive patients with both rheumatic mitral stenosis and chronic atrial fibrillation to evaluate tfae usefulness of this technique for the detection of left atrial thrombi, mitral regurgitation before percutaneous balloon mitral valvuloplasty and iatrogenic atrial septal defect after the procedure. TEE correctly identified thrombi in 10 (30%) patients and significant mitral regurgitation in 5 patients who underwent surgical intervention. The remaining 18 patients underwent percutaneous balloon mitral valvuloplasty without evidence of systemic embolic event and obtained adequate outcome. Transesophageal color doppler echocardiography demostrated left-o-ight shunting flow through atrial septum in 5 of 7(71%) patients 3 days after the procedure and repeated TEE in 2 of these 5 patients showed no shunting after 6 months. In conclusion, TEE plays a definite role in the selection of patients for balloon mitral valvuloplasty and assessment of iatrogenic atrial septal defect.

Analysis of groundwater level trend in Jakham River Basin of Southern Rajasthan

Groundwater accounts for about half of the water use for irrigation in India.The fluctuation pattern of the groundwater level is examined by observing rainfall replenishment and monitoring wells.The southern part of Rajasthan has experienced abrupt changes in rainfall and has been highly dependent on groundwater over decades.This study presents the impact of over-dependence on groundwater usage for irrigation and other purposes,spatially and temporally.Hence,the objective of this study is to examine the groundwater level trend by using statistical analysis and geospatial technique.Rainfall factor was also studied in groundwater level fluctuation during 2009-2019.To analyze the influence of each well during recharge or withdrawal of groundwater,thiessien polygonswere generated from them.In the Jakham River basin,75 wells have been identified for water level trend study using the Mann-Kendall statistical test.The statistics of trend analysis show that 15%wells are experiencing water level decline in pre-monsoon,while very low percentage of wells have such trend during post-monsoon season.The average rate of water level decline is 0.245 m/a in pre-monsoon and 0.05 m/a in post-monsoon.The aquifer recharge potential is also decreasing by year.it is expected that such type of studies will help the policy makers to adopt advanced management practices to ensure sustainable groundwater resource management.

High-Capacity Transport Associated with Pre- and Post-Haulage in Intermodal Road-Rail Transport

This paper develops a model for analyzing the potential of longer and heavier vehicles (LHVs) related to pre- and post-haulage in the intermodal rail-road transport chain (IRT). The paper considers the combined economic and emission costs among three different transport networks including intermodal rail-road transport with current Swedish regulatory framework for trucks, intermodal rail-road transport with LHVs, and direct-road transport. The objective is to analyse the potential of high-capacity transport associated with pre- and post-haulage for enhancing the competitiveness of intermodal transport from a full-costs perspective. The model developed is applied to a Swedish context and case study. Research findings reveal that the break-even of the IRT compared to the direct road transport could be significantly lowered, which suggests the LHVs contribute to exploring the market of IRT over smaller flows.

Linking basin-scale hydrology with climatic parameters in western Himalaya:Application of satellite data,temperature index modelling and in-situ observations

Due to limited spatial and temporal in-situ runoff data availability,Himalaya-Karakoram(HK)glaciohydrology has a significant knowledge gap between large-scale and small-scale runoff modelling studies.This study reconstructs longest basin-wide runoff series in Chandra-Bhaga Basin by applying a high-resolution glaciohydrological model SPHY(Spatial Processes in Hydrology)over 1950–2022.Two-tier model calibration is done using in-situ basin-wide runoff(1973–2006)and MODIS snow cover(2003–2018).Model validation is done against in-situ Chhota Shigri Glacier catchment-wide runoff(2010–2015).The modelled mean annual basin-wide runoff is 60.21±6.17 m^(3)/s over 1950–2022,with maximum runoff in summer-monsoon months,peaking in July(182.69 m^(3)/s).Glacier runoff(ice melt+snowmelt over glacier)contributes maximum(39%)followed by equal contributions from snowmelt runoff from non-glacierized basin area and baseflow(25%),while rainfall-runoff contributes minimum(11%)to total runoff.There is a significant volumetric increase by∼7%from pre-(59.17 m^(3)/s)to post-2000(63.47 m^(3)/s)mainly because of early onset of snowmelt post-2000 that resulted in a hydrograph shift by∼25 days earlier in spring.The glacier runoff is overestimated by 3%from RGI 7.0 inventory compared to different manually delineated inventories over 1950–2022,because of higher glacierized area from RGI 7.0.The precipitation shows a negative trend,but total runoff shows a positive trend due to positive trend of temperature that resulted in more glacier runoff and rainfall-runoff for basin over last 72 years.Basin-wide runoff is mainly governed by summer temperature which directly controls the amount of glacier and snowmelt runoffs and is supported by summer rainfall.This study highlights importance of basin-scale model calibration with in-situ data in large scale studies and stresses the need for in-situ observations in high-altitude Himalayan region.Basin-scale calibrated model parameters are transferable to glacier catchment scale within Chandra-Bhaga Basin,showing the model robustness at a small catchment scale.

Long-term Efficacy of Pulmonary Artery Desnervation Treatment in Heart Failure With Preserved Ejection Fraction:A Subgroup Analysis of 3-year Results From the PADN-5 Study

Objective:The Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure(PADN-5)study proved that pulmonary artery denervation(PADN)is associated with significant improvements in hemodynamic and clinical outcomes in patients with combined pre-and post-capillary pulmonary hypertension(CpcPH).This study aimed to assess the 3-year clinical results of PADN in patients who had heart failure with preserved ejection fraction(HFpEF)developing into CpcPH(HFpEF-CpcPH).Methods:In this post hoc analysis of the PADN-5 trial,38 patients with HFpEF were included in screening out of 98 patients with CpcPH who were randomly assigned to treatment with sildenafil and sham PADN(sham PADN(plus sildenafil)group,abbreviated as sham group)or PADN(PADN group).HFpEF in the PADN-5 trial was defined as a left ventricular ejection fraction≥50%,and CpcPH was defined as a mean pulmonary arterial pressure≥25 mmHg,a pulmonary arterial wedge pressure>15 mmHg,and a pulmonary vascular resistance>3.0 WU.The changes in the 6-minute walk distance(6-MWD)and the plasma concentration of N-terminal pro-brain natriuretic peptide(NT-proBNP)at 6-month and 3-year follow-up,as well as the clinical endpoint of the occurrence of clinical worsening,defined as cardiopulmonary-related death,rehospitalization,or heart or lung transplantation at 3-year follow-up were examined.Results:Thirty-eight patients with HFpEF-CpcPH were assigned to the PADN group(n=19)or the sham group(n=19).At the 6-month follow-up,6-MWD(433(275,580)m vs.342(161,552)m),and reductions in NT-proBNP(−47%(−99%,331%)vs.−12%(−82%,54%))were significantly improved in the PADN group(all P<0.05).Over the 3-year follow-up period,PADN treatment resulted in marked increases in 6-MWD(450(186,510)m vs.348(135,435)m)and reductions in NT-proBNP(−55%(−99%,38%)vs.−10%(−80%,95%))(all P<0.05).Clinical worsening was experienced by 12 patients(63%)in the sham group,but by only 5 patients(26%)in the PADN group(hazard ratio=0.149,95%confidence interval:0.038–0.584,P=0.006).The 6-MWD and PADN treatments were independent predictors of clinical deterioration in patients with HFpEF-CpcPH.Conclusions:PADN therapy is associated with improvements in exercise capacity and clinical outcomes.PADN therapy may have a potential role in patients with HFpEF-CpcPH for whom current treatment options are limited.

Parental awareness on myopia prevention and control among 350 children

AIM:To understand the current situation of parental perspectives,knowledge,and practices concerning myopia prevention and control for both pre-and school-aged children.METHODS:This study was a cross-sectional survey that involved children aged 0 to 15y and their parents.Participants were required to respond to an online questionnaire by scanning a quick response(QR)code.The questionnaire consisted of 25 tick-box questions and was open to response from December 22,2022,to January 5,2023.The dioptric traits of the children,the visual status and educational background of the parents,the parental perspectives towards myopia and its risks,and the parents’knowledge and practices related to myopia prevention and control were recorded and measured.The Chi-square test and binomial logistic regression were used for statistics.RESULTS:Totally 350 parents responded to the questionnaire.The prevalence and severity of myopia among the surveyed children exhibited a positive correlation with advancing age(P<0.001 and P=0.004,respectively).Nearly half of parents with myopic children considered myopia did not pose any health threat and could be effectively corrected(P<0.001).Parents who held master’s or doctoral degree demonstrated a better understanding of children’s vision standards for each age group(P=0.001),and 31.63% of them could undergo initial vision screening for their children during the age of 0 to 3y while parents with bachelor’s degree(34.04%)and below(32.43%)mainly initiated the vision examination for their children at the age of 4 to 6y(P=0.05).Parents with master’s or doctoral degree also exhibited more rational practices concerning outdoor time(P=0.048)and sleep time(P=0.044).No other significant discrepancy among the different educational groups in additional conceptions of myopia,such as hyperopia reserve,axis length,and corneal curvature alterations.Most parents preferred to employ conventional interventions,such as enhancing indoor lighting condition(80.00%)and ensuring appropriate reading posture and distance(71.71%).CONCLUSION:The current status of parental knowledge and practices about myopia prevention and control remains outdated and deficient.The administrative department should implement efficacious and adaptable measures to enhance parental awareness and foster their commitment towards myopia prevention and control.

Performance of Bt cotton evaluated in relation to mulching and weed control measures in northwest India

Background Weed infestation in cotton has been reported to offer severe competition and cause yield reduction to a large extent.Weeding via cultural practices is time consuming,tedious,and expensive due to long duration of cotton crop and regular monsoon rains during cotton production in India.Chemical weed control has been successfully utilized in cotton in the recent past.However,continuous use of similar herbicides leads to resistance in weeds against herbicides.And when sprayed to the field,herbicides not only suppress weeds but leave undesirable residues in the soil that are hazardous to the environment.Therefore,a study was performed at cotton research area at Chaudhary Charan Singh Haryana Agricultural University,Hisar,Haryana during two consecutive kharif seasons(2020 and 2021)to determine the most suitable and sustainable weed management strategy through the integration of chemical and cultural methods.Results Mulching with rice straw of 7.5 t ha^(-1)resulted in significantly higher cotton seed yield(3189 and 3084 kg ha^(-1))and better weed control in comparison to no mulch treatments(2990 and 2904 kg ha^(-1))in 2020 and 2021,respectively.Among various weed management levels,the significantly lowest cotton seed yield was recorded in untreated control(1841 and 1757 kg·ha^(-1)during 2020 and 2021,respectively)in comparison to other treatments while all other treatments were statistically at par with each other during both years of crop experimentation.Conclusion Mulching with rice straw of 7.5 t·ha^(-1)along with a pre-emergence application of pendimethalin(active ingredient)at 1.5 kg·ha^(-1)fb(followed by)one hoeings at 45 days after sowing(DAS)and fb glyphosate 2 kg·ha^(-1)(Shielded spray)at 90 DAS is a viable option for effective control of grassy and broadleaved weeds in Bt cotton in north-west India.