In this paper, we conduct theoretical research on the listed company financial management mode innovation trend under the registration system background. Cycles of the core macroeconomic environment is each enterprise...In this paper, we conduct theoretical research on the listed company financial management mode innovation trend under the registration system background. Cycles of the core macroeconomic environment is each enterprise that must face the reality of the problem, for the listed companies, the macroeconomic environment is set up financial strategy need to consider problems listed companies must be good at making scientific financial strategy to avoid and reduce the negative influence of the macro-economic changes. Under the condition of the socialist market economy, as the listed company financial management is to maximize the value of the company ultimate goal. Our research combines the registration system background to propose the novel perspective that is meaningful.展开更多
The border gateway protocol(BGP)has become the indispensible infrastructure of the Internet as a typical inter-domain routing protocol.However,it is vulnerable to misconfigurations and malicious attacks since BGP does...The border gateway protocol(BGP)has become the indispensible infrastructure of the Internet as a typical inter-domain routing protocol.However,it is vulnerable to misconfigurations and malicious attacks since BGP does not provide enough authentication mechanism to the route advertisement.As a result,it has brought about many security incidents with huge economic losses.Exiting solutions to the routing security problem such as S-BGP,So-BGP,Ps-BGP,and RPKI,are based on the Public Key Infrastructure and face a high security risk from the centralized structure.In this paper,we propose the decentralized blockchain-based route registration framework-decentralized route registration system based on blockchain(DRRS-BC).In DRRS-BC,we produce a global transaction ledge by the information of address prefixes and autonomous system numbers between multiple organizations and ASs,which is maintained by all blockchain nodes and further used for authentication.By applying blockchain,DRRS-BC perfectly solves the problems of identity authentication,behavior authentication as well as the promotion and deployment problem rather than depending on the authentication center.Moreover,it resists to prefix and subprefix hijacking attacks and meets the performance and security requirements of route registration.展开更多
Based on the Online Registration System (ORS) characteristics and key technology analysis, this paper points out that that a good performance and high stability of the ORS lies in the choice of the system database. Da...Based on the Online Registration System (ORS) characteristics and key technology analysis, this paper points out that that a good performance and high stability of the ORS lies in the choice of the system database. Database clustering technology which has merits such as concurrent processing, easy expansion, and high security is proposed to achieve database subsystem of ORS, and the design of the database cluster system framework is available in this paper. Finally, we also explore the database load balancing of the cluster system, heterogeneous database replication technology.展开更多
Clinic Appointment Registration System is an important way to see a doctor, and it’s also a preliminary tool for storage and management of clinic medical records. This new system was developed using Visual Studio 200...Clinic Appointment Registration System is an important way to see a doctor, and it’s also a preliminary tool for storage and management of clinic medical records. This new system was developed using Visual Studio 2008 and C#.NET as the development environment and tools and Microsoft Access 2003 as the database to store the medical data based on Browse/Server (B/S) model. The system consists of several data operation functions including appointment registration, data management (e.g. addition, deletion and searching), data backup and recovery, etc., thus, achieve key research ob-jectives.展开更多
Under the comprehensive deepening reform and promoting new urbanization,China launched a new round of reform of household registration system.Reform has a major breakthrough in five areas:to implement new urbanization...Under the comprehensive deepening reform and promoting new urbanization,China launched a new round of reform of household registration system.Reform has a major breakthrough in five areas:to implement new urbanization strategy of human-centric,to achieve equalization of basic public services gradually,to break up land rights and rural migrants,to provide protection for family migrants,and to increase financial support by governments.But the reform still faces many difficulties,how to determine the conditions settled by city size is difficult to implement effectively,financial transfer payment system reform is facing enormous diffi culties,as well as the size of the urban population is diffi cult to determine etc.展开更多
Although land registration systems are constantly changing based on entrenched institutional frameworks,they cannot fulfill their technical objectives.Technical designs based on loopholes in the existing land registra...Although land registration systems are constantly changing based on entrenched institutional frameworks,they cannot fulfill their technical objectives.Technical designs based on loopholes in the existing land registration system are the common steps in advanced countries.However,the missing link between the implementation of technical designs and their uses and users,affect the prospects of land registration decentralisation in developing countries.User and System requirements are used to integrate and enhance land registration services delivery across land information systems.This study assesses and develops framework for decentralised electronic land registration systems in Ghana.Semi-structured interviews were used to collect user and system requirement data from clients and technical staff of the Lands Commission in Accra.The framework pointed out five main policy outline strategies.These include land registration process modeling(process reduction and turnaround time monitoring),technical function(file tracking),the effect of changes in the registration loupe and absorption of land registration report,land registration workflow improvement,and the use of aerial images.The study recommends a systemic monitoring and evaluation of staff job roles.展开更多
Whether registration system reform(RSR)can curb administrative intervention and create a fair market environment has long been a concern in China.We explore this issue from the perspective of the initial public offeri...Whether registration system reform(RSR)can curb administrative intervention and create a fair market environment has long been a concern in China.We explore this issue from the perspective of the initial public offering(IPO)preference based on the entropy balancing method,and findings are as follows.First,an IPO ownership preference exists under approval system.That is,state-owned enterprises(SOEs)are more likely than private enterprises to obtain IPO approval.However,RSR significantly changes this preference,especially for non-politically connected private enterprises.Second,the post-IPO market performance of SOEs is inferior to that of private enterprises under approval system,thus excluding the view that approval is prioritized for SOEs because of superior performance.Third,compared with SOEs,private enterprises are more likely to switch the issuance system from approval system to registration system;this change makes it easier for them to obtain IPO approval,indicating that private enterprise owners perceive the registration channel to be fairer.Fourth,the effect of RSR on IPO ownership preference mainly occurs in companies in three major urban agglomerations in China—the Pearl River Delta,the Yangtze River Delta,and the Beijing–Tian jin–Hebei region—and in technology-intensive industries.Collectively,our findings reveal that RSR cultivates a fairer IPO approval process.展开更多
In recent years,there has been a growing interest in real estate investments that utilize blockchain technology.Traditional real estate investments usually involve third-party intermediaries for verifying and recordin...In recent years,there has been a growing interest in real estate investments that utilize blockchain technology.Traditional real estate investments usually involve third-party intermediaries for verifying and recording informal real estate transactions.This paper proposes a blockchain-based real estate investment model and presents a detailed description of the real estate register authentication aspect of the model.The model uses blockchain technology to create tamper-evident records of real estate transactions and provide secure authentication and verification for informal real estate transactions.Meanwhile,each real estate transaction is recorded in a block,and all transaction records are kept on the blockchain.This means that inventors can access these transaction records and verify their authenticity and validity.The system can also use smart contracts to automate the process of real estate transactions,which further improves transaction efficiency and reduces costs.Furthermore,the model’s timestamp and authentication mechanism can eliminate third-party intermediaries and ensure the authenticity and validity of real estate transactions through distributed ledgers and verification mechanisms.Overall,blockchain-based real estate systems offer advantages of security,transparency,efficiency,and cost reduction.With ongoing blockchain advancements,these systems are expected to play a crucial role in future real estate investment transactions.展开更多
Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of tissue.Convolutional neural network(CNN)and generative adversarial ne...Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of tissue.Convolutional neural network(CNN)and generative adversarial network(GAN)are pivotal inmedical image registration.However,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s disease.We argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator inGAN.In this study,we propose a novel multi-modal registration approach GAN-DIRNet based on GAN for deformable histological image registration.To begin with,the discriminators of two GANs are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific modalities.Additionally,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise results.Lastly,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s disease.Experimental results demonstrate that our proposed GAN-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types.展开更多
Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D volumes.However,these methods often lack constraint information and overlook se...Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D volumes.However,these methods often lack constraint information and overlook semantic consistency,limiting their performance.To address these issues,we present a novel approach for medical image registration called theDual-VoxelMorph,featuring a dual-channel cross-constraint network.This innovative network utilizes both intensity and segmentation images,which share identical semantic information and feature representations.Two encoder-decoder structures calculate deformation fields for intensity and segmentation images,as generated by the dual-channel cross-constraint network.This design facilitates bidirectional communication between grayscale and segmentation information,enabling the model to better learn the corresponding grayscale and segmentation details of the same anatomical structures.To ensure semantic and directional consistency,we introduce constraints and apply the cosine similarity function to enhance semantic consistency.Evaluation on four public datasets demonstrates superior performance compared to the baselinemethod,achieving Dice scores of 79.9%,64.5%,69.9%,and 63.5%for OASIS-1,OASIS-3,LPBA40,and ADNI,respectively.展开更多
The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic growth.According to the European Union(EU)directives,under the EU framework for(traditional)herbal medicina...The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic growth.According to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in EU.However,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing authorization.In author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world populations.With this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where TCM is originated.Countries like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the region.Furthermore,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing authorization.These are valuable information for future drug development.The therapeutic value of TCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the EU regulatory framework.An early establishment of a harmonized risk-based registration process for TCM in Asian countries is important.This will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.展开更多
Registrations based on the manual placement of spherical targets are still being employed by many professionals in the industry.However,the placement of those targets usually relies solely on personal experience witho...Registrations based on the manual placement of spherical targets are still being employed by many professionals in the industry.However,the placement of those targets usually relies solely on personal experience without scientific evidence supported by numerical analysis.This paper presents a comprehensive investigation,based on Monte Carlo simulation,into determining the optimal number and positions for efficient target placement in typical scenes consisting of a pair of facades.It demonstrates new check-up statistical rules and geometrical constraints that can effectively extract and analyze massive simulations of unregistered point clouds and their corresponding registrations.More than 6×10^(7) sets of the registrations were simulated,whereas more than IOO registrations with real data were used to verify the results of simulation.The results indicated that using five spherical targets is the best choice for the registration of a large typical registration site consisting of two vertical facades and a ground,when there is only a box set of spherical targets available.As a result,the users can avoid placing extra targets to achieve insignificant improvements in registration accuracy.The results also suggest that the higher registration accuracy can be obtained when the ratio between the facade-to-target distance and target-to-scanner distance is approximately 3:2.Therefore,the targets should be placed closer to the scanner rather than in the middle between the facades and the scanner,contradicting to the traditional thought. Besides,the results reveal that the accuracy can be increased by setting the largest projected triangular area of the targets to be large.展开更多
Objective To analyze the research status and hot spots in the field of drug registration in China,and to provide some suggestions for the follow-up research.Methods CiteSpace was used to conduct literature quantitativ...Objective To analyze the research status and hot spots in the field of drug registration in China,and to provide some suggestions for the follow-up research.Methods CiteSpace was used to conduct literature quantitative analysis on 684 related articles from 2012 to 2022,and the knowledge map was drawn.Based on this,the main characteristics and development trends of the related studies were summarized.Results and Conclusion The number of articles published was closely related to the regulatory policy of drug registration reform.The authors of these articles did not have good continuity.Besides,research hot spots were closely related to the actual work,which was mainly around the improvement of the review and approval policy,encouraging innovative drug research and development,improving the level of new drug development and other directions.The follow-up studies should further strengthen the continuity of research and inter-agency collaboration.In addition,biomedical registration may become a new research focus in the future.展开更多
The household registration system has been a basic institutional arrangement in Chinese society. Under this system, registered residence (hukou) plays an important role in resource allocation and interest distributi...The household registration system has been a basic institutional arrangement in Chinese society. Under this system, registered residence (hukou) plays an important role in resource allocation and interest distribution, and thus exerts a significant impact on social stratification and mobility. After nearly three decades of reform and opening up, does it still play a role, and, if so, what is this role? Drawing on data from the China General Social Survey, we find that China's social stratification is characterized by the simultaneous existence of differentiation between urban and rural hukou and hierarchy within urban hukou; furthermore, there is a positive correlation between one's opportunities for social mobility and the possibility of changing and transferring one's hukou. Despite the increasing social mobility ensuing from market-oriented transformation, the hukou hierarchy and its structural influence on mobility within the institutional framework persist. The strongly conglutinative nature of the household registration system has given rise to social disparities. The basic direction for reform of the system should be unification ofhukou and free choice of movement from one place to another.展开更多
The government plans to lift re-strictions on where people work andlive.The move wi1l create a more mo-bile workforce it is hoped.The ministries of public security,construction and agriculture as well asthe State Comm...The government plans to lift re-strictions on where people work andlive.The move wi1l create a more mo-bile workforce it is hoped.The ministries of public security,construction and agriculture as well asthe State Commission for Restructur-ing the Economy have started surveysas a first step to reforming the systemof household registration in smalltowns and cities.展开更多
From "the case that three girls have some fate but have different value" to "the case that Hai Cheng took a police substation to court with three times", currently the household registration system of our country ...From "the case that three girls have some fate but have different value" to "the case that Hai Cheng took a police substation to court with three times", currently the household registration system of our country not only plays the role of account registration and account management, but also undertakes the limitation of migration movement, and for the additional functions of the lowest life guarantee, social insurance, compulsory education, employment and other social security benefits, it also makes a difference between local registered permanent residence habitant and nonlocal registered permanent residence habitant. Just because of these additional functions, the household registration system has become complicated, which originally has clear nature. Therefore, only it is necessary to define the legal nature of our country's current household registration system, can executive power be supervised and the rights of citizens get relief.展开更多
Zhang Gaoli,Member of the Standing Committee of the Political Bureau of the CPC Central Committee and Vice Premier of the State Council,attended a teleconference on promoting the national household registration system...Zhang Gaoli,Member of the Standing Committee of the Political Bureau of the CPC Central Committee and Vice Premier of the State Council,attended a teleconference on promoting the national household registration system reform and made a speech on Jul 7,2017.Zhang said that the CPC Central Committee and the State Council attached great importance to the reform of the household registration system。展开更多
文摘In this paper, we conduct theoretical research on the listed company financial management mode innovation trend under the registration system background. Cycles of the core macroeconomic environment is each enterprise that must face the reality of the problem, for the listed companies, the macroeconomic environment is set up financial strategy need to consider problems listed companies must be good at making scientific financial strategy to avoid and reduce the negative influence of the macro-economic changes. Under the condition of the socialist market economy, as the listed company financial management is to maximize the value of the company ultimate goal. Our research combines the registration system background to propose the novel perspective that is meaningful.
基金This work was supported by the National Natural Science Foundation of China(61601041)the Fundamental Research Funds for the Central Universities(2019PTB-003).
文摘The border gateway protocol(BGP)has become the indispensible infrastructure of the Internet as a typical inter-domain routing protocol.However,it is vulnerable to misconfigurations and malicious attacks since BGP does not provide enough authentication mechanism to the route advertisement.As a result,it has brought about many security incidents with huge economic losses.Exiting solutions to the routing security problem such as S-BGP,So-BGP,Ps-BGP,and RPKI,are based on the Public Key Infrastructure and face a high security risk from the centralized structure.In this paper,we propose the decentralized blockchain-based route registration framework-decentralized route registration system based on blockchain(DRRS-BC).In DRRS-BC,we produce a global transaction ledge by the information of address prefixes and autonomous system numbers between multiple organizations and ASs,which is maintained by all blockchain nodes and further used for authentication.By applying blockchain,DRRS-BC perfectly solves the problems of identity authentication,behavior authentication as well as the promotion and deployment problem rather than depending on the authentication center.Moreover,it resists to prefix and subprefix hijacking attacks and meets the performance and security requirements of route registration.
文摘Based on the Online Registration System (ORS) characteristics and key technology analysis, this paper points out that that a good performance and high stability of the ORS lies in the choice of the system database. Database clustering technology which has merits such as concurrent processing, easy expansion, and high security is proposed to achieve database subsystem of ORS, and the design of the database cluster system framework is available in this paper. Finally, we also explore the database load balancing of the cluster system, heterogeneous database replication technology.
文摘Clinic Appointment Registration System is an important way to see a doctor, and it’s also a preliminary tool for storage and management of clinic medical records. This new system was developed using Visual Studio 2008 and C#.NET as the development environment and tools and Microsoft Access 2003 as the database to store the medical data based on Browse/Server (B/S) model. The system consists of several data operation functions including appointment registration, data management (e.g. addition, deletion and searching), data backup and recovery, etc., thus, achieve key research ob-jectives.
文摘Under the comprehensive deepening reform and promoting new urbanization,China launched a new round of reform of household registration system.Reform has a major breakthrough in five areas:to implement new urbanization strategy of human-centric,to achieve equalization of basic public services gradually,to break up land rights and rural migrants,to provide protection for family migrants,and to increase financial support by governments.But the reform still faces many difficulties,how to determine the conditions settled by city size is difficult to implement effectively,financial transfer payment system reform is facing enormous diffi culties,as well as the size of the urban population is diffi cult to determine etc.
文摘Although land registration systems are constantly changing based on entrenched institutional frameworks,they cannot fulfill their technical objectives.Technical designs based on loopholes in the existing land registration system are the common steps in advanced countries.However,the missing link between the implementation of technical designs and their uses and users,affect the prospects of land registration decentralisation in developing countries.User and System requirements are used to integrate and enhance land registration services delivery across land information systems.This study assesses and develops framework for decentralised electronic land registration systems in Ghana.Semi-structured interviews were used to collect user and system requirement data from clients and technical staff of the Lands Commission in Accra.The framework pointed out five main policy outline strategies.These include land registration process modeling(process reduction and turnaround time monitoring),technical function(file tracking),the effect of changes in the registration loupe and absorption of land registration report,land registration workflow improvement,and the use of aerial images.The study recommends a systemic monitoring and evaluation of staff job roles.
基金support from the Natural Science Foundation of China(72062012)the Natural Science Foundation of Hainan Province(722RC636)+2 种基金Hainan Province Doctoral Students Innovative Scientific Research Project(Qhyb2022-25)Key Research Project on Higher Education and Teaching Reform in Hainan Province(Hnjg2023ZD-2)Key Subject of Education and Teaching Reform in Hainan University(hdyj2303).
文摘Whether registration system reform(RSR)can curb administrative intervention and create a fair market environment has long been a concern in China.We explore this issue from the perspective of the initial public offering(IPO)preference based on the entropy balancing method,and findings are as follows.First,an IPO ownership preference exists under approval system.That is,state-owned enterprises(SOEs)are more likely than private enterprises to obtain IPO approval.However,RSR significantly changes this preference,especially for non-politically connected private enterprises.Second,the post-IPO market performance of SOEs is inferior to that of private enterprises under approval system,thus excluding the view that approval is prioritized for SOEs because of superior performance.Third,compared with SOEs,private enterprises are more likely to switch the issuance system from approval system to registration system;this change makes it easier for them to obtain IPO approval,indicating that private enterprise owners perceive the registration channel to be fairer.Fourth,the effect of RSR on IPO ownership preference mainly occurs in companies in three major urban agglomerations in China—the Pearl River Delta,the Yangtze River Delta,and the Beijing–Tian jin–Hebei region—and in technology-intensive industries.Collectively,our findings reveal that RSR cultivates a fairer IPO approval process.
文摘In recent years,there has been a growing interest in real estate investments that utilize blockchain technology.Traditional real estate investments usually involve third-party intermediaries for verifying and recording informal real estate transactions.This paper proposes a blockchain-based real estate investment model and presents a detailed description of the real estate register authentication aspect of the model.The model uses blockchain technology to create tamper-evident records of real estate transactions and provide secure authentication and verification for informal real estate transactions.Meanwhile,each real estate transaction is recorded in a block,and all transaction records are kept on the blockchain.This means that inventors can access these transaction records and verify their authenticity and validity.The system can also use smart contracts to automate the process of real estate transactions,which further improves transaction efficiency and reduces costs.Furthermore,the model’s timestamp and authentication mechanism can eliminate third-party intermediaries and ensure the authenticity and validity of real estate transactions through distributed ledgers and verification mechanisms.Overall,blockchain-based real estate systems offer advantages of security,transparency,efficiency,and cost reduction.With ongoing blockchain advancements,these systems are expected to play a crucial role in future real estate investment transactions.
文摘Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of tissue.Convolutional neural network(CNN)and generative adversarial network(GAN)are pivotal inmedical image registration.However,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s disease.We argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator inGAN.In this study,we propose a novel multi-modal registration approach GAN-DIRNet based on GAN for deformable histological image registration.To begin with,the discriminators of two GANs are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific modalities.Additionally,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise results.Lastly,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s disease.Experimental results demonstrate that our proposed GAN-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types.
基金National Natural Science Foundation of China(Grant Nos.62171130,62172197,61972093)the Natural Science Foundation of Fujian Province(Grant Nos.2020J01573,2022J01131257,2022J01607)+3 种基金Fujian University Industry University Research Joint Innovation Project(No.2022H6006)in part by the Fund of Cloud Computing and BigData for SmartAgriculture(GrantNo.117-612014063)NationalNatural Science Foundation of China(Grant No.62301160)Nature Science Foundation of Fujian Province(Grant No.2022J01607).
文摘Many deep learning-based registration methods rely on a single-stream encoder-decoder network for computing deformation fields between 3D volumes.However,these methods often lack constraint information and overlook semantic consistency,limiting their performance.To address these issues,we present a novel approach for medical image registration called theDual-VoxelMorph,featuring a dual-channel cross-constraint network.This innovative network utilizes both intensity and segmentation images,which share identical semantic information and feature representations.Two encoder-decoder structures calculate deformation fields for intensity and segmentation images,as generated by the dual-channel cross-constraint network.This design facilitates bidirectional communication between grayscale and segmentation information,enabling the model to better learn the corresponding grayscale and segmentation details of the same anatomical structures.To ensure semantic and directional consistency,we introduce constraints and apply the cosine similarity function to enhance semantic consistency.Evaluation on four public datasets demonstrates superior performance compared to the baselinemethod,achieving Dice scores of 79.9%,64.5%,69.9%,and 63.5%for OASIS-1,OASIS-3,LPBA40,and ADNI,respectively.
文摘The traditional Chinese medicine(TCM)industry is critical to not only for public health but also for economic growth.According to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in EU.However,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing authorization.In author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world populations.With this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where TCM is originated.Countries like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for TCM within the region.Furthermore,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing authorization.These are valuable information for future drug development.The therapeutic value of TCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of TCM that are qualified to be registered under the EU regulatory framework.An early establishment of a harmonized risk-based registration process for TCM in Asian countries is important.This will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of TCM within and beyond the Asian region.
基金Key Research and Development Program of Guangdong Province (No.2020B0101130009)
文摘Registrations based on the manual placement of spherical targets are still being employed by many professionals in the industry.However,the placement of those targets usually relies solely on personal experience without scientific evidence supported by numerical analysis.This paper presents a comprehensive investigation,based on Monte Carlo simulation,into determining the optimal number and positions for efficient target placement in typical scenes consisting of a pair of facades.It demonstrates new check-up statistical rules and geometrical constraints that can effectively extract and analyze massive simulations of unregistered point clouds and their corresponding registrations.More than 6×10^(7) sets of the registrations were simulated,whereas more than IOO registrations with real data were used to verify the results of simulation.The results indicated that using five spherical targets is the best choice for the registration of a large typical registration site consisting of two vertical facades and a ground,when there is only a box set of spherical targets available.As a result,the users can avoid placing extra targets to achieve insignificant improvements in registration accuracy.The results also suggest that the higher registration accuracy can be obtained when the ratio between the facade-to-target distance and target-to-scanner distance is approximately 3:2.Therefore,the targets should be placed closer to the scanner rather than in the middle between the facades and the scanner,contradicting to the traditional thought. Besides,the results reveal that the accuracy can be increased by setting the largest projected triangular area of the targets to be large.
基金2024 Scientific Research Project of Liaoning Provincial Department of Education(Humanities and Social Sciences).
文摘Objective To analyze the research status and hot spots in the field of drug registration in China,and to provide some suggestions for the follow-up research.Methods CiteSpace was used to conduct literature quantitative analysis on 684 related articles from 2012 to 2022,and the knowledge map was drawn.Based on this,the main characteristics and development trends of the related studies were summarized.Results and Conclusion The number of articles published was closely related to the regulatory policy of drug registration reform.The authors of these articles did not have good continuity.Besides,research hot spots were closely related to the actual work,which was mainly around the improvement of the review and approval policy,encouraging innovative drug research and development,improving the level of new drug development and other directions.The follow-up studies should further strengthen the continuity of research and inter-agency collaboration.In addition,biomedical registration may become a new research focus in the future.
文摘The household registration system has been a basic institutional arrangement in Chinese society. Under this system, registered residence (hukou) plays an important role in resource allocation and interest distribution, and thus exerts a significant impact on social stratification and mobility. After nearly three decades of reform and opening up, does it still play a role, and, if so, what is this role? Drawing on data from the China General Social Survey, we find that China's social stratification is characterized by the simultaneous existence of differentiation between urban and rural hukou and hierarchy within urban hukou; furthermore, there is a positive correlation between one's opportunities for social mobility and the possibility of changing and transferring one's hukou. Despite the increasing social mobility ensuing from market-oriented transformation, the hukou hierarchy and its structural influence on mobility within the institutional framework persist. The strongly conglutinative nature of the household registration system has given rise to social disparities. The basic direction for reform of the system should be unification ofhukou and free choice of movement from one place to another.
文摘The government plans to lift re-strictions on where people work andlive.The move wi1l create a more mo-bile workforce it is hoped.The ministries of public security,construction and agriculture as well asthe State Commission for Restructur-ing the Economy have started surveysas a first step to reforming the systemof household registration in smalltowns and cities.
文摘From "the case that three girls have some fate but have different value" to "the case that Hai Cheng took a police substation to court with three times", currently the household registration system of our country not only plays the role of account registration and account management, but also undertakes the limitation of migration movement, and for the additional functions of the lowest life guarantee, social insurance, compulsory education, employment and other social security benefits, it also makes a difference between local registered permanent residence habitant and nonlocal registered permanent residence habitant. Just because of these additional functions, the household registration system has become complicated, which originally has clear nature. Therefore, only it is necessary to define the legal nature of our country's current household registration system, can executive power be supervised and the rights of citizens get relief.
文摘Zhang Gaoli,Member of the Standing Committee of the Political Bureau of the CPC Central Committee and Vice Premier of the State Council,attended a teleconference on promoting the national household registration system reform and made a speech on Jul 7,2017.Zhang said that the CPC Central Committee and the State Council attached great importance to the reform of the household registration system。