Cross-training is a phenomenon related to motor learning, where motor performance of the untrained limb shows improvement in strength and skill execution following unilateral training of the homologous contralateral l...Cross-training is a phenomenon related to motor learning, where motor performance of the untrained limb shows improvement in strength and skill execution following unilateral training of the homologous contralateral limb. We used functional MRI to investigate whether motor performance of the untrained limb could be improved using a serial reaction time task according to motor sequential learning of the trained limb, and whether these skill acquisitions led to changes in brain activation patterns. We recruited 20 right-handed healthy subjects, who were randomly allocated into training and control groups. The training group was trained in performance of a serial reaction time task using their non-dominant left hand, 40 minutes per day, for 10 days, over a period of 2 weeks. The control group did not receive training. Measurements of response time and percentile of response accuracy were performed twice during pre- and post-training, while brain functional MRI was scanned during performance of the serial reaction time task using the untrained right hand. In the training group, prominent changes in response time and percentile of response accuracy were observed in both the untrained right hand and the trained left hand between pre- and post-training. The control group showed no significant changes in the untrained hand between pre- and post-training. In the training group, the activated volume of the cortical areas related to motor function （i.e., primary motor cortex, premotor area, posterior parietal cortex） showed a gradual decrease, and enhanced cerebellar activation of the vermis and the newly activated ipsilateral dentate nucleus were observed during performance of the serial reaction time task using the untrained right hand, accompanied by the cross-motor learning effect. However, no significant changes were observed in the control group. Our findings indicate that motor skills learned over the 2-week training using the trained limb were transferred to the opposite homologous limb, and motor skill acquisition of the untrained limb led to changes in brain activation patterns in the cerebral cortex and cerebellum.展开更多
【目的】建立检测实验大鼠持续性主动注意力和冲动行为的实验系统。【方法】利用"五项选择连续反应时间任务"(5-choice serial reaction time task,5-CSRTT)的设计原理建立检测实验大鼠持续性主动注意力和冲动行为的实验系统...【目的】建立检测实验大鼠持续性主动注意力和冲动行为的实验系统。【方法】利用"五项选择连续反应时间任务"(5-choice serial reaction time task,5-CSRTT)的设计原理建立检测实验大鼠持续性主动注意力和冲动行为的实验系统。【结果】实验系统由实验箱及相应控制部分构成,并由微型电脑软件控制,能实现对大鼠相关行为的自动检测。【结论】所建立的实验系统能较好且真实地自动检测实验大鼠的持续性主动注意力和冲动行为,为注意缺陷多动障碍(ADHD)动物研究的进一步深入提供良好的条件。展开更多
目的探索5-HT2C受体在慢性间歇性饮酒导致的认知损害中的作用。方法建立小鼠慢性间歇性饮酒模型,采用5项选择连续反应时间任务(5-choice serial reaction time task,5-CSRTT)评估小鼠认知能力变化。定量检测小鼠内侧前额叶皮质(Medial P...目的探索5-HT2C受体在慢性间歇性饮酒导致的认知损害中的作用。方法建立小鼠慢性间歇性饮酒模型,采用5项选择连续反应时间任务(5-choice serial reaction time task,5-CSRTT)评估小鼠认知能力变化。定量检测小鼠内侧前额叶皮质(Medial Prefrontal Cortex,mPFC)中脑源性神经营养因子(Brain-Derived Neurotrophic Factor,BDNF)和5-羟色胺受体2C(5-Hydroxytryptamine Receptor 2C,5-HT2C)受体的表达。采用5-HT2C受体激动剂干预研究。结果模型小鼠血酒精浓度为(189.2±4.633)mg·dL-1,且饮酒组小鼠mPFC内BDNF(P<0.01)及5-HT2C受体(P<0.01)受体表达均下降。慢性间歇性饮酒可导致小鼠5-CSRTT准确率下降(P<0.01),遗漏率(P<0.01)和过早反应增加(P<0.01),而RO60-0175可逆转酒精引起的准确率下降(P<0.05),并减少饮酒导致的遗漏率增加(P<0.01),但对过早反应没有作用。结论慢性间歇性饮酒使小鼠冲动性增加的行为与mPFC内5-HT2C受体和BDNF的表达减少有关。展开更多
基金supported by the Yeungnam College of Science & Technology Research Grants in 2012
文摘Cross-training is a phenomenon related to motor learning, where motor performance of the untrained limb shows improvement in strength and skill execution following unilateral training of the homologous contralateral limb. We used functional MRI to investigate whether motor performance of the untrained limb could be improved using a serial reaction time task according to motor sequential learning of the trained limb, and whether these skill acquisitions led to changes in brain activation patterns. We recruited 20 right-handed healthy subjects, who were randomly allocated into training and control groups. The training group was trained in performance of a serial reaction time task using their non-dominant left hand, 40 minutes per day, for 10 days, over a period of 2 weeks. The control group did not receive training. Measurements of response time and percentile of response accuracy were performed twice during pre- and post-training, while brain functional MRI was scanned during performance of the serial reaction time task using the untrained right hand. In the training group, prominent changes in response time and percentile of response accuracy were observed in both the untrained right hand and the trained left hand between pre- and post-training. The control group showed no significant changes in the untrained hand between pre- and post-training. In the training group, the activated volume of the cortical areas related to motor function （i.e., primary motor cortex, premotor area, posterior parietal cortex） showed a gradual decrease, and enhanced cerebellar activation of the vermis and the newly activated ipsilateral dentate nucleus were observed during performance of the serial reaction time task using the untrained right hand, accompanied by the cross-motor learning effect. However, no significant changes were observed in the control group. Our findings indicate that motor skills learned over the 2-week training using the trained limb were transferred to the opposite homologous limb, and motor skill acquisition of the untrained limb led to changes in brain activation patterns in the cerebral cortex and cerebellum.
文摘【目的】建立检测实验大鼠持续性主动注意力和冲动行为的实验系统。【方法】利用"五项选择连续反应时间任务"(5-choice serial reaction time task,5-CSRTT)的设计原理建立检测实验大鼠持续性主动注意力和冲动行为的实验系统。【结果】实验系统由实验箱及相应控制部分构成,并由微型电脑软件控制,能实现对大鼠相关行为的自动检测。【结论】所建立的实验系统能较好且真实地自动检测实验大鼠的持续性主动注意力和冲动行为,为注意缺陷多动障碍(ADHD)动物研究的进一步深入提供良好的条件。
