Nano-particle capture is a key process in filtration, separation, and biomedical applications. Here we explored the mechanisms of soft particle capture using nanofiber networks. We identified possible states of the ca...Nano-particle capture is a key process in filtration, separation, and biomedical applications. Here we explored the mechanisms of soft particle capture using nanofiber networks. We identified possible states of the capture process, which are defined by their structural and material parameters. By performing numerical analysis, we provided a phase diagram in the parametric space of the network structure and interracial adhesion. The work provides a conceptual model for rational design of synthetic materials in related applications that focus on the protection against or removal of virus, as well as other soft particles.展开更多
The motion and deformation of soft particles are commonly encountered and important in many appli-cations.A discrete element-embedded finite element model(DEFEM)is proposed to solve soft particle motion and deformatio...The motion and deformation of soft particles are commonly encountered and important in many appli-cations.A discrete element-embedded finite element model(DEFEM)is proposed to solve soft particle motion and deformation,which combines discrete element and finite element methods.The collisional surface of soft particles is covered by several dynamical embedded discrete elements(EDEs)to model the collisional external forces of the particles.The particle deformation,motion,and rotation are inde-pendent of each other in the DEFEM.The deformation and internal forces are simulated using the finite element model,whereas the particle rotation and motion calculations are based on the discrete element model.By inheriting the advantages of existing coupling methods,the contact force and contact search between soft particles are improved with the aid of the EDE.Soft particle packing is simulated using the DEFEM for two cases:particle accumulation along a rectangular straight wall and a wall with an inclined angle.The large particle deformation in the lower layers can be simulated using current meth-ods,where the deformed particle shape is either irregular in the marginal region or nearly hexagonal in the tightly packed central region.This method can also be used to simulate the deformation,motion,and heat transfer of non-spherical soft particles.展开更多
The influence of the magnetization of a soft magnetic sphere on the surrounding magnetic field is measured and characterized.The interaction force between two soft magnetic particles is directly measured using an ultr...The influence of the magnetization of a soft magnetic sphere on the surrounding magnetic field is measured and characterized.The interaction force between two soft magnetic particles is directly measured using an ultra precision load sensor in uniform and non-uniform magnetic fields. The interaction force largely follows an inverse fourth power law as a function of separation distance between particle centers. At small distances,the effect of magnetization of one particle on the magnetization of its adjacent particle causes the attractive(repulsive) force to be larger(smaller) than that predicted by the inverse fourth power law.The theoretical prediction based on a modified dipole model,that takes into account the coupling effect of the magnetization among soft magnetic particles,gives excellent agreement with the measured force in a uniform magnetic field.The interaction force under a non-uniform applied magnetic field can be reasonably predicted using the dipole-dipole interaction model when the local magnetic field is used to determine the magnetization.展开更多
A novel mesoscopic simulation model is proposed to study the liquid crystal phase behavior of the anisotropic rodlike particles with a soft repulsive interaction,which possesses a modified anisotropic conservative for...A novel mesoscopic simulation model is proposed to study the liquid crystal phase behavior of the anisotropic rodlike particles with a soft repulsive interaction,which possesses a modified anisotropic conservative force type used in dissipative particle dynamics.The influences of the repulsion strength and the particle shape on the phase behavior of soft rodlike particles are examined.In the simulations,we observe the formation of the nematic phase and smectic-A phase from the initially isotropic phase.Moreover,we find that shorter soft rodlike particles with anisotropic repulsive interactions can form a stable smectic-B phase.Our results demonstrate that the soft anisotropic purely-repulsive potential between the rodlike particles can reflect the interaction nature between soft rodlike particles in a simple way and is sufficient to produce a range of ordered LC-like mesophases.展开更多
Objective:To study the intervention effect of Zhuangfang Soft Liver and Fibrous Granules on CCl_(4)compound factor-induced liver fibrosis rat model and its effect onα-SMA and E-Cadherin protein expression.Methods:For...Objective:To study the intervention effect of Zhuangfang Soft Liver and Fibrous Granules on CCl_(4)compound factor-induced liver fibrosis rat model and its effect onα-SMA and E-Cadherin protein expression.Methods:Forty-eight male Wistar rats were randomly divided into a blank group,a pathological model group and a group of 16 rats in each group.The rats in the pathological model group and the pellet group were injected subcutaneously with 40%carbon tetrachloride(CCl_(4))oil combined with peanut oil to establish an animal model of rat liver fibrosis,and the pellets were administered by gavage three times a week for 8 weeks from the 5th week.The expression of oxidative stress oxidase dismutase(SOD)and malondialdehyde(MDA)was detected by enzyme-linked immunoassay(ELISA),and the expression ofα-smooth muscle actin(α-SMA)and E-calmodulin(E-Cadherin)was detected by RT-PCR andWestern Blot.expression.Results:Compared with the blank group,the serum ALT and AST levels of the rats in the pathological model group were significantly increased,and the serum ALT and AST levels of the rats in the soft liver and fibrous pellet group were significantly decreased(P<0.001).In the pathological model group,the lobular structure of liver tissue was mutilated and numerous liver fibrous tissues were abnormally proliferated,and the collagen fibers formed by the proliferation were confluent into dense fibrous intervals,thus turning into pseudolobular structure,and a large number of fatty degenerated hepatocytes of different shapes and sizes appeared inside the pseudolobular structure,and the diffuse infiltration of inflammatory cells was significant.Compared with the pathological model group,the degree of destruction of hepatic lobular structure was significantly reduced in the LBP group,and there were different degrees of proliferation of collagen fibrous tissue concentrated in the area from the central vein to the confluent area,and the fibrous septum was relatively loose,with a small amount of inflammatory cell infiltration,and the degree of infiltration was reduced compared with the pathological model group.Compared with the pathological model group,the SOD level was significantly higher in the group of liver softener and fibrous pellets compared with the pathological model group and the blank group(P<0.001),the MDA level was significantly lower in the group of liver softener and fibrous pellets compared with the pathological model group(P<0.001),the expression level ofα-SMA was significantly lower in the group of liver softener and fibrous pellets(P<0.001),and the expression level of E-Cadherin was significantly higher in the group of liver softener and fibrous pellets(P<0.001).Conclusion:Soft Liver Fibro Pellets can effectively inhibit liver fibrous tissue proliferation and reduce the serum ALT and AST levels in rats with CCl_(4)combined with peanut oil compound solution induced liver fibrosis,and its anti-liver fibrosis mechanism may be through protecting liver function,reducing the level of oxidative stress,down-regulating the expression ofα-SMA protein,up-regulating the expression of E-cadherin protein,and inhibiting epithelial-mesenchymal transition epithelial mesenchymal transformation(EMT)and thus exerting therapeutic effects on CCl_(4)compound-induced hepatic fibrosis in rats.展开更多
Most conventional aerosol neutralizers are based on radioactive sources, which are controlled by strict regulations restricting their handling, transport, and storage. The TSI 3087 soft X-ray (SXR) neutralizer circu...Most conventional aerosol neutralizers are based on radioactive sources, which are controlled by strict regulations restricting their handling, transport, and storage. The TSI 3087 soft X-ray (SXR) neutralizer circumvents these legal restrictions. The aim of the present work is to compare the performance of a standalone SXR aerosol neutralizer with that of conventional radioactive aerosol neutralizers based on 85Kr (TSI 3077) and 241Am (Grimm 5522) by performing field tests in a real environmental scenario. The results obtained when the SXR neutralizer was connected to a mobility particle sizer spectrometer (MPS), different from the device suggested by the manufacturer, were comparable with those obtained with the use of radioactive aerosol neutralizers. In changing the neutralizer, the particle number concentrations, measured with the MPS connected to the SXR neutralizer, almost remained within the 10% uncertainty bounds for the particle size interval 10-300 nm, when diffusion losses inside the SXR tube were considered. Based on our comparisons, the SXR neutralizer can be regarded as a standalone instrument that could solve the problems associated with legal restrictions on radioactive neutralizers and fulfil the need for a portable instrument for different field test purposes.展开更多
First, the characteristics of low-velocity conveying of particles having different hardness are experimentally investigated in a horizontal pipeline in terms of flow pattern and pressure drop to show that the slug flo...First, the characteristics of low-velocity conveying of particles having different hardness are experimentally investigated in a horizontal pipeline in terms of flow pattern and pressure drop to show that the slug flow can be classified into two types depending on the settling of particles along the pipeline, and the period is small for slug flow without the settled layer, which is called solitary slug flow. The pressure drop for soft particles is shown to be larger than that for hard particles. Then, experimental results are presented on horizontal fluidized-bed conveying of fine powders to show that air release from the top surface of the conveying channel is an imnortant factor for high mass flow rate of particles.展开更多
基金supported by the Boeing Company,the National Natural Science Foundation of China (11222217 and 11002079)Tsinghua University Initiative Scientific Research Program (2011Z02174)the Tsinghua National Laboratory for Information Science and Technology of China
文摘Nano-particle capture is a key process in filtration, separation, and biomedical applications. Here we explored the mechanisms of soft particle capture using nanofiber networks. We identified possible states of the capture process, which are defined by their structural and material parameters. By performing numerical analysis, we provided a phase diagram in the parametric space of the network structure and interracial adhesion. The work provides a conceptual model for rational design of synthetic materials in related applications that focus on the protection against or removal of virus, as well as other soft particles.
基金the support of this research by the National Science and Technology Major Project(grant No.2011ZX06901-003)the National Natural Science Foundation of China(grant No.51576211)+1 种基金the National High Technology Research and Development Program of China(863)(grant No.2014AA052701)the funds of Nuclear Power Technology Innovation Centre(grant Nos.HDLCXZX-2020-HD-022 and HDLCXZX-2021-ZH-024).
文摘The motion and deformation of soft particles are commonly encountered and important in many appli-cations.A discrete element-embedded finite element model(DEFEM)is proposed to solve soft particle motion and deformation,which combines discrete element and finite element methods.The collisional surface of soft particles is covered by several dynamical embedded discrete elements(EDEs)to model the collisional external forces of the particles.The particle deformation,motion,and rotation are inde-pendent of each other in the DEFEM.The deformation and internal forces are simulated using the finite element model,whereas the particle rotation and motion calculations are based on the discrete element model.By inheriting the advantages of existing coupling methods,the contact force and contact search between soft particles are improved with the aid of the EDE.Soft particle packing is simulated using the DEFEM for two cases:particle accumulation along a rectangular straight wall and a wall with an inclined angle.The large particle deformation in the lower layers can be simulated using current meth-ods,where the deformed particle shape is either irregular in the marginal region or nearly hexagonal in the tightly packed central region.This method can also be used to simulate the deformation,motion,and heat transfer of non-spherical soft particles.
基金supported by the U.S.Department of Energy under Award(DE-FE0001321).
文摘The influence of the magnetization of a soft magnetic sphere on the surrounding magnetic field is measured and characterized.The interaction force between two soft magnetic particles is directly measured using an ultra precision load sensor in uniform and non-uniform magnetic fields. The interaction force largely follows an inverse fourth power law as a function of separation distance between particle centers. At small distances,the effect of magnetization of one particle on the magnetization of its adjacent particle causes the attractive(repulsive) force to be larger(smaller) than that predicted by the inverse fourth power law.The theoretical prediction based on a modified dipole model,that takes into account the coupling effect of the magnetization among soft magnetic particles,gives excellent agreement with the measured force in a uniform magnetic field.The interaction force under a non-uniform applied magnetic field can be reasonably predicted using the dipole-dipole interaction model when the local magnetic field is used to determine the magnetization.
基金supported by the National Natural Science Foundation of China (21025416, 20974040, 50930001)the Program for New Century Excellent Talents in University of China,and Fok Ying Tung Education Foundation (114018)
文摘A novel mesoscopic simulation model is proposed to study the liquid crystal phase behavior of the anisotropic rodlike particles with a soft repulsive interaction,which possesses a modified anisotropic conservative force type used in dissipative particle dynamics.The influences of the repulsion strength and the particle shape on the phase behavior of soft rodlike particles are examined.In the simulations,we observe the formation of the nematic phase and smectic-A phase from the initially isotropic phase.Moreover,we find that shorter soft rodlike particles with anisotropic repulsive interactions can form a stable smectic-B phase.Our results demonstrate that the soft anisotropic purely-repulsive potential between the rodlike particles can reflect the interaction nature between soft rodlike particles in a simple way and is sufficient to produce a range of ordered LC-like mesophases.
基金National Natural Science Foundation of China(Project No.81960910,81660745,81860839,8176150106)Guangxi Natural Science Foundation of China(Project Book No.:2020GXNSFDA297021,2020GXNSFAA238020)Dai Ming Guangxi Famous Chinese Medicine Doctor Workshop Construction Project(2022004‑005‑009)。
文摘Objective:To study the intervention effect of Zhuangfang Soft Liver and Fibrous Granules on CCl_(4)compound factor-induced liver fibrosis rat model and its effect onα-SMA and E-Cadherin protein expression.Methods:Forty-eight male Wistar rats were randomly divided into a blank group,a pathological model group and a group of 16 rats in each group.The rats in the pathological model group and the pellet group were injected subcutaneously with 40%carbon tetrachloride(CCl_(4))oil combined with peanut oil to establish an animal model of rat liver fibrosis,and the pellets were administered by gavage three times a week for 8 weeks from the 5th week.The expression of oxidative stress oxidase dismutase(SOD)and malondialdehyde(MDA)was detected by enzyme-linked immunoassay(ELISA),and the expression ofα-smooth muscle actin(α-SMA)and E-calmodulin(E-Cadherin)was detected by RT-PCR andWestern Blot.expression.Results:Compared with the blank group,the serum ALT and AST levels of the rats in the pathological model group were significantly increased,and the serum ALT and AST levels of the rats in the soft liver and fibrous pellet group were significantly decreased(P<0.001).In the pathological model group,the lobular structure of liver tissue was mutilated and numerous liver fibrous tissues were abnormally proliferated,and the collagen fibers formed by the proliferation were confluent into dense fibrous intervals,thus turning into pseudolobular structure,and a large number of fatty degenerated hepatocytes of different shapes and sizes appeared inside the pseudolobular structure,and the diffuse infiltration of inflammatory cells was significant.Compared with the pathological model group,the degree of destruction of hepatic lobular structure was significantly reduced in the LBP group,and there were different degrees of proliferation of collagen fibrous tissue concentrated in the area from the central vein to the confluent area,and the fibrous septum was relatively loose,with a small amount of inflammatory cell infiltration,and the degree of infiltration was reduced compared with the pathological model group.Compared with the pathological model group,the SOD level was significantly higher in the group of liver softener and fibrous pellets compared with the pathological model group and the blank group(P<0.001),the MDA level was significantly lower in the group of liver softener and fibrous pellets compared with the pathological model group(P<0.001),the expression level ofα-SMA was significantly lower in the group of liver softener and fibrous pellets(P<0.001),and the expression level of E-Cadherin was significantly higher in the group of liver softener and fibrous pellets(P<0.001).Conclusion:Soft Liver Fibro Pellets can effectively inhibit liver fibrous tissue proliferation and reduce the serum ALT and AST levels in rats with CCl_(4)combined with peanut oil compound solution induced liver fibrosis,and its anti-liver fibrosis mechanism may be through protecting liver function,reducing the level of oxidative stress,down-regulating the expression ofα-SMA protein,up-regulating the expression of E-cadherin protein,and inhibiting epithelial-mesenchymal transition epithelial mesenchymal transformation(EMT)and thus exerting therapeutic effects on CCl_(4)compound-induced hepatic fibrosis in rats.
文摘Most conventional aerosol neutralizers are based on radioactive sources, which are controlled by strict regulations restricting their handling, transport, and storage. The TSI 3087 soft X-ray (SXR) neutralizer circumvents these legal restrictions. The aim of the present work is to compare the performance of a standalone SXR aerosol neutralizer with that of conventional radioactive aerosol neutralizers based on 85Kr (TSI 3077) and 241Am (Grimm 5522) by performing field tests in a real environmental scenario. The results obtained when the SXR neutralizer was connected to a mobility particle sizer spectrometer (MPS), different from the device suggested by the manufacturer, were comparable with those obtained with the use of radioactive aerosol neutralizers. In changing the neutralizer, the particle number concentrations, measured with the MPS connected to the SXR neutralizer, almost remained within the 10% uncertainty bounds for the particle size interval 10-300 nm, when diffusion losses inside the SXR tube were considered. Based on our comparisons, the SXR neutralizer can be regarded as a standalone instrument that could solve the problems associated with legal restrictions on radioactive neutralizers and fulfil the need for a portable instrument for different field test purposes.
文摘First, the characteristics of low-velocity conveying of particles having different hardness are experimentally investigated in a horizontal pipeline in terms of flow pattern and pressure drop to show that the slug flow can be classified into two types depending on the settling of particles along the pipeline, and the period is small for slug flow without the settled layer, which is called solitary slug flow. The pressure drop for soft particles is shown to be larger than that for hard particles. Then, experimental results are presented on horizontal fluidized-bed conveying of fine powders to show that air release from the top surface of the conveying channel is an imnortant factor for high mass flow rate of particles.