Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure

AIM： To investigate the protective effect of stronger neo-minophafen C （SNMC） on fulminant hepatic failure （FHF） and its underlying mechanism. METHODS： A mouse model of FHF was established by intraperitoneal injection of galactosamine （D-Gal N） and lipopolysaccharide （LPS）. The survival rate, liver function, inflammatory factor and liver pathological change were obtained with and without SNMC treatment. Hepatoo/te survival was estimated by observing the stained mitochondria structure with terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate fluorescence nick end labeling （TUNEL） method and antibodies against cytochrome C （Cyt-C） and caspase-3. RESULTS： The levels of plasma tumor necrosis factor alpha （TNF-α）, nitric oxide （NO）, ET-1, interleukin-6 （IL-6）, and the degree of hepatic tissue injury were decreased in the SNMC-treated groups compared with those in the model group （P 〈 0.01）. However, there were no differences after different dosages administered at different time points. There was a significant difference in survival rates between the SNMC-treated groups and the model group （P 〈 0.01）. The apoptosis index was 32.3% at 6 h after a low dose of SNMC, which was considerably decreased from 32.3% ± 4.7% vs 5% ± 2.83% （P 〈 0.05） to 5% on d 7. The expression of Cyt-C and caspase-3 decreased with the prolongation of therapeutic time. Typical hepatocyte apoptosis was obviously ameliorated under electron microscope with the prolongation of therapeutic time. CONCLUSION： SNMC can effectively protect liver against FHF induced by LPS/D-Gal N. SNMC can prevent hepatocyte apoptosis by inhibiting inflammatory reaction and stabilizing mitochondria membrane to suppress the release of Cyt-C and sequent activation of caspase-3.

Method discussion for quick response grey prediction of stronger aftershocks of an earthquake sequence

In this paper, we take occurrence process of early strong aftershocks of a main after shock type′s earthquake sequence as a complex grey system, and introduce predicting method for its stronger aftershocks by grey predicting theory. Through inspection prediction for 1998 Zhangbei M S=6.2 earthquake sequence, it shows that the grey predicting method maybe has active significance for the investigation of quick response prediction problems of stronger aftershocks of an earthquake sequence.

Urtra-Hard Bonds in P-Carbon Stronger than Diamond

The hardness and ideal strength of P-carbon, i.e., a new carbon phase for the cold-compressed carbon with an orthogonal structure recently proposed and named as P-carbon, are investigated by means of first-principles calculations. The strength calculations reveal that the failure mode in P-carbon is dominated by the tensile type. The ideal tensile strength of P-carbon is calculated to be 76.T GPa in the [001] direction, which is higher than that of the previously known most stable Z-carbon, of 71.4 GPa. Meanwhile, the theoretical Vickers hardness of P-carbon is estimated as 89 GPa, which is comparable with that of diamond. Especially, two types of bonds in P-carbon with hardness values of 114 GPa and 105 GPa are significantly stronger than those of diamond. The results provide insight into exploration of the ultra-hard P-carbon for potentially technological applications.

Making China Stronger in the New Era

CHINESE President Xi Jinping pointed out that both China and the bigger world are in the midst of profound and complex changes in the report delivered at the 19th National Congress of the Communist Party of China(CPC)in October.As the Party’s general secretary,he presented a review of the work and historic change over the past five years,and reached the important conclusion that

Nobel Prize Winner Konstantin Novoselov: Like Graphene, the Softer, the Stronger

If one day,mobile phones and cameras can be bendable and foldable,and they are not taken as something stiff in our pockets or carried as a burden on our shoulders anymore;If one day,new energy vehicles no longer need to be recharged every night for the next day’s commute or for long-distance journeys,and we would never be embarrassed and troubled by lack of power;

Time-Tested Ties Twenty years on, FOCAC drives stronger China-Africa cooperation on multiple levels

The biggest challenge to his diplomatic career-that s how Ethiopian Ambassador to China Teshom e Toga Chanaka describes 2020.The unexpected novel coronavims pan demic resulted in 300 Ethiopian students stuck in Wuhan,the capital city of central China's Hubei Province(where the country's first case was reported).

Imagining exercise can make you stronger

A new research study suggests that just thinking of exercising can have the same effects as actually hitting the gym, officials say. A recent study published in the Journal of Neurophysiology found that simply imagining exercise can tone muscle, delay atrophy, and even make your muscles stronger.

Stronger Yuan Arouses Concern

THE exports of Beijing Haifu Trading Co. Ltd. last year were 4 percent higher than those in 2012. but the company didn＇t make much money, accord- ing to Li Haifu. owner of the company. Sitting in the Dahongmen area. Haifu is mainly engaged in the production of curtains and beddings. with most of its products being exported. According to Li. for exported products, the U.S. dollar is used at all stages from ordering to settling, and it takes four months for the company to collect the payment for goods. Owing to fierce competition in the textile market, the prices charged cannot be too high.

The People's Republic of China:At Forty-five, Stronger Than Ever

SINCE IT was founded on October 1,1949,the People's Republic of China has undergone a circui-tous process of probing,setbacks and development that has brought it to its present point in history.Forty-five years ago,after a three-year war of liberation,the Chinese people,under the leadership of the Chinese Communist Party,overthrew the oppressive rule of the Kuomintang.The victory,a welcome end to internecine war,also marked the end of colonialism,imperialism and feudal rule in China,and its people finally became masters of their own state.The country embarked on a new era.

Sino-African Ties Stronger and Deeper

The year 2016 was rich in events for China-Africa cooperation, with significant progress being made on key aspects at different levels. Major breakthroughs have been achieved for both sides dur- ing the year＇s major international events, including China＇s strong support for a plan on Africa＇s industrialization during the Hang- zhou G20 Summit.

Asia's Powerhouses Align Recent meetings have seen countries calling for stronger cooperation and promoting common development

Leaders of China and the Association of Southeast Asian Nations(ASEAN)announced the substantial conclusion of the Version 3.0 China-ASEAN Free Trade Area(FTA)upgrade negotiations on October 10.The milestone paves the way for one of the world's most populous and dynamic FTAs to further boost regional development amid rising global protectionism.

THE REVVED-UP REVOLUTION Chinese-made electric vehicles are gaining stronger momentum

China's BYD said on January1 that its sales of pure electric vehicles(EVs)hit 526,409 in the fourth quarter of 2023.The number surpassed the worldwide sales of U.S.EV maker Tesla at 484,507,making BYD the world's biggest EV maker.BYD debuted its first electric cars at the Beijing International Auto Show in 2004.

Effect of a less permeable stronger soil layer on the stability of non-homogeneous unsaturated slopes

Slope failure occurs due to an increase in the saturation level and a subsequent decrease in matric suction in unsaturated soil.This paper presents the results of a series of centrifuge experiments and numerical analyses on a 55°inclined unsaturated sandy slope with less permeable,stronger silty sand layer inclusion within it.It is observed that a less permeable,stronger silty sand layer in an otherwise homogeneous sandy soil slope hinders the infiltration of water.The water content of the slope just above the stronger layer increases significantly,compared to elsewhere.No shear band is found to initiate in a homogeneous sandy soil slope,whereas for a non-homogeneous slope,they initiate just above the less pervious,stronger layer.A discontinuity of the shear zone is also observed for the case of a non-homogeneous soil slope.The factor of safety of a non-homogeneous,unsaturated soil slope decreases because of the less permeable,stronger layer.It decreases significantly if this less permeable,stronger soil layer is located near the toe of the slope.

“Being Stronger,Better and Bigger”:The Logical Unity of Theory and Practice of State-owned Enterprise Reform-Development Course and Prospect of State-owned Enterprises in China

China’s state-owned enterprises(SOEs)have developed more than 70 years since the People’s Republic of China(PRC)was founded in 1949.From 1949 to 1978,SOEs provided material guarantee for the construction of the PRC,laid a solid foundation for the industrialization process,and ensured that the people were masters of their own affairs.From 1978 to 2012,SOEs upgraded their growth quality and increased their efficiency for improving people’s material and cultural life.Since 2012,SOEs have become“stronger,better and bigger”on all fronts for satisfying people’s growing expectations for a better life.In essence,reforming SOEs means interpreting and exercising the people-centered development philosophy,and means addressing principal social contradiction through different stages of socialist development,as SOEs care about the main needs of the people.Such a development is a process of constant exploration and continuous growth from strength to strength,which is the inherent logic of theory and practice of SOE growth in new China for more than 70 years.

SMARTER, BIGGER, STRONGER

List of China’s top 500 companies shows new trends Profitability,innovation and internationalization—these are some of the focuses of the country’s top companies.Seventy years after the founding of the People’s Republic of China in 1949,China’s corporate scene has transformed,with market forces playing a dominant role.

A Stronger Yuan in 2017

As of December 29,the last trading day in 2017,the Chinese yuan’s onshore exchange rate stood at 6.5120against the U.S.dollar,strengthening by 6.72 percent for the year,constituting the sharpest annual appreciation in nine years according to calculations by financial information provider Eastmoney.com.

Stronger Ties With Chile

Chile was the first South American country to establish diplomatic relations with China. It was also the first Latin American country to support China’s entry into the WTO,recognize China’s full

Wisdom is power: Female budgerigars prefer males with stronger cognitive abilities

Supported by the National Natural Foundation of China,the Research Group of Avian Ecology of Institute of Zoology,Chinese Academy of Sciences led by Prof.Sun YueHua(孙悦华).found that"Problem-solving males becoming more attractive to female budgerigars",which was online published in Science on January 11,2019,with the first author of Dr.Chen JiaNi and corresponding author of Prof.Sun YueHua.This is a story of male budgerigars gaining favor by learning feeding techniques.

A Stronger WTO

China puts forth a proposal based on strengthening the international trade order China submitted a new proposal on reform to the World Trade Organization(WTO)in May,where it argued that'unilateralism and the abuse of national security exemptions'have damaged the'rules-based international trade order.'It cal ed for limiting the use of national security exemptions and unilateral measures as well as resolving disputes surrounding the WTO’s Appel ate Body.The international community regarded China’s proposal with great interest,not only because opposing priorities among WTO members may make any reform process a prolonged and diffi cult one,but also because many countries may want to focus on resolving disagreements regarding the appellate body to prevent it from grinding to a halt later this year.