As the unmanned weap system-of systems(UWSoS)becomes complex,the inevitable uncertain interference gradu-ally increases,which leads to a strong emphasis on the resilience of UWSoS.Hence,this paper presents a resilienc...As the unmanned weap system-of systems(UWSoS)becomes complex,the inevitable uncertain interference gradu-ally increases,which leads to a strong emphasis on the resilience of UWSoS.Hence,this paper presents a resilience-driven cooperative reconfiguration strategy to enhance the resilience of UWSoS.First,a unified resilience-driven coopera-tive reconfiguration strategy framework is designed to guide the UWSoS resilience enhancement.Subsequently,a cooperative reconfiguration strategy algorithm is proposed to identify the optimal cooperative reconfiguration sequence,combining the cooperative pair resilience contribution index(CPRCI)and coop-erative pair importance index(CPII).At last,the effectiveness and superiority of the proposed algorithm are demonstrated through various attack scenario simulations that include differ-ent attack modes and intensities.The analysis results can pro-vide a reference for decision-makers to manage UWSoS.展开更多
The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that cov...The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS.However,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 months.One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of activity.Accordingly,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal degradation.Several of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not clear.The CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental animals.Resistance to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin ligase.Although highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.展开更多
Increasing soil salinization seriously impairs plant growth and development,resulting in crop loss.The Salt-Overly-Sensitive(SOS)pathway is indispensable to the mitigation of Na+toxicity in plants under high salinity....Increasing soil salinization seriously impairs plant growth and development,resulting in crop loss.The Salt-Overly-Sensitive(SOS)pathway is indispensable to the mitigation of Na+toxicity in plants under high salinity.However,whether natural variations of SOS2 contribute to salt tolerance has not been reported.Here a natural variation in the SlSOS2 promoter region was identified to be associated with root Na+/K+ratio and the loss of salt resistance during tomato domestication.This natural variation contains an ABI4-binding cis-element and plays an important role in the repression of SlSOS2 expression.Genetic evidence revealed that SlSOS2 mutations increase root Na+/K+ratio under salt stress conditions and thus attenuate salt resistance in tomato.Together,our findings uncovered a critical but previously unknown natural variation of SOS2 in salt resistance,which provides valuable natural resources for genetic breeding for salt resistance in cultivated tomatoes and other crops.展开更多
The contribution rate of equipment system-of-systems architecture(ESoSA)is an important index to evaluate the equipment update,development,and architecture optimization.Since the traditional ESoSA contribution rate ev...The contribution rate of equipment system-of-systems architecture(ESoSA)is an important index to evaluate the equipment update,development,and architecture optimization.Since the traditional ESoSA contribution rate evaluation method does not make full use of the fuzzy information and uncertain information in the equipment system-of-systems(ESoS),and the Bayesian network is an effective tool to solve the uncertain information,a new ESoSA contribution rate evaluation method based on the fuzzy Bayesian network(FBN)is proposed.Firstly,based on the operation loop theory,an ESoSA is constructed considering three aspects:reconnaissance equipment,decision equipment,and strike equipment.Next,the fuzzy set theory is introduced to construct the FBN of ESoSA to deal with fuzzy information and uncertain information.Furthermore,the fuzzy importance index of the root node of the FBN is used to calculate the contribution rate of the ESoSA,and the ESoSA contribution rate evaluation model based on the root node fuzzy importance is established.Finally,the feasibility and rationality of this method are validated via an empirical case study of aviation ESoSA.Compared with traditional methods,the evaluation method based on FBN takes various failure states of equipment into consideration,is free of acquiring accurate probability of traditional equipment failure,and models the uncertainty of the relationship between equipment.The proposed method not only supplements and improves the ESoSA contribution rate assessment method,but also broadens the application scope of the Bayesian network.展开更多
A system of systems(SoS)composes a set of independent constituent systems(CSs),where the degree of authority to control the independence of CSs varies,depending on different SoS types.Key researchers describe four SoS...A system of systems(SoS)composes a set of independent constituent systems(CSs),where the degree of authority to control the independence of CSs varies,depending on different SoS types.Key researchers describe four SoS types with descending levels of central authority:directed,acknowledged,collaborative and virtual.Although the definitions have been recognized in SoS engineering,what is challenging is the difficulty of translating these definitions into models and simulation environments.Thus,we provide a goal-based method including a mathematical baseline to translate these definitions into more effective agent-based modeling and simulations.First,we construct the theoretical models of CS and SoS.Based on the theoretical models,we analyze the degree of authority influenced by SoS characteristics.Next,we propose a definition of SoS types by quantitatively explaining the degree of authority.Finally,we recognize the differences between acknowledged SoS and collaborative SoS using a migrating waterfowl flock by an agentbased model(ABM)simulation.This paper contributes to the SoS body of knowledge by increasing our understanding of the degree of authority in an SoS,so we may identify suitable SoS types to achieve SoS goals by modeling and simulation.展开更多
IEEE Serious Open Source for the Benefit of Humanity (SOSH) is hosted by the IEEE Standards Association, which gathers industry experts, innovators, and engineering leaders from around the world to explore the profoun...IEEE Serious Open Source for the Benefit of Humanity (SOSH) is hosted by the IEEE Standards Association, which gathers industry experts, innovators, and engineering leaders from around the world to explore the profound benefits of open source technology for industries and their customers.展开更多
基金This work was supported by Ph.D.Intelligent Innovation Foundation Project(201-CXCY-A01-08-19-01)Science and Technology on Information System Engineering Laboratory(05202007).
文摘As the unmanned weap system-of systems(UWSoS)becomes complex,the inevitable uncertain interference gradu-ally increases,which leads to a strong emphasis on the resilience of UWSoS.Hence,this paper presents a resilience-driven cooperative reconfiguration strategy to enhance the resilience of UWSoS.First,a unified resilience-driven coopera-tive reconfiguration strategy framework is designed to guide the UWSoS resilience enhancement.Subsequently,a cooperative reconfiguration strategy algorithm is proposed to identify the optimal cooperative reconfiguration sequence,combining the cooperative pair resilience contribution index(CPRCI)and coop-erative pair importance index(CPII).At last,the effectiveness and superiority of the proposed algorithm are demonstrated through various attack scenario simulations that include differ-ent attack modes and intensities.The analysis results can pro-vide a reference for decision-makers to manage UWSoS.
文摘The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung cancer.Now,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS.However,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 months.One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of activity.Accordingly,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal degradation.Several of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not clear.The CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental animals.Resistance to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin ligase.Although highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.
基金This work was supported by the National Natural Science Foun-dation of China(grant 32000206 to Z.W.)the Natural Science Foundation of Anhui Province(grant 2208085Y08 to Z.W.).
文摘Increasing soil salinization seriously impairs plant growth and development,resulting in crop loss.The Salt-Overly-Sensitive(SOS)pathway is indispensable to the mitigation of Na+toxicity in plants under high salinity.However,whether natural variations of SOS2 contribute to salt tolerance has not been reported.Here a natural variation in the SlSOS2 promoter region was identified to be associated with root Na+/K+ratio and the loss of salt resistance during tomato domestication.This natural variation contains an ABI4-binding cis-element and plays an important role in the repression of SlSOS2 expression.Genetic evidence revealed that SlSOS2 mutations increase root Na+/K+ratio under salt stress conditions and thus attenuate salt resistance in tomato.Together,our findings uncovered a critical but previously unknown natural variation of SOS2 in salt resistance,which provides valuable natural resources for genetic breeding for salt resistance in cultivated tomatoes and other crops.
基金supported by the National Key Research and Development Project(2018YFB1700802)the National Natural Science Foundation of China(72071206)the Science and Technology Innovation Plan of Hunan Province(2020RC4046).
文摘The contribution rate of equipment system-of-systems architecture(ESoSA)is an important index to evaluate the equipment update,development,and architecture optimization.Since the traditional ESoSA contribution rate evaluation method does not make full use of the fuzzy information and uncertain information in the equipment system-of-systems(ESoS),and the Bayesian network is an effective tool to solve the uncertain information,a new ESoSA contribution rate evaluation method based on the fuzzy Bayesian network(FBN)is proposed.Firstly,based on the operation loop theory,an ESoSA is constructed considering three aspects:reconnaissance equipment,decision equipment,and strike equipment.Next,the fuzzy set theory is introduced to construct the FBN of ESoSA to deal with fuzzy information and uncertain information.Furthermore,the fuzzy importance index of the root node of the FBN is used to calculate the contribution rate of the ESoSA,and the ESoSA contribution rate evaluation model based on the root node fuzzy importance is established.Finally,the feasibility and rationality of this method are validated via an empirical case study of aviation ESoSA.Compared with traditional methods,the evaluation method based on FBN takes various failure states of equipment into consideration,is free of acquiring accurate probability of traditional equipment failure,and models the uncertainty of the relationship between equipment.The proposed method not only supplements and improves the ESoSA contribution rate assessment method,but also broadens the application scope of the Bayesian network.
基金supported by the National Key Research and Development Program of China(61873236)the Natural Science Foundation of Zhejiang Province(LZ21F020003,LY18F030001)the Civil Aerospace Pre-research Project(D020101).
文摘A system of systems(SoS)composes a set of independent constituent systems(CSs),where the degree of authority to control the independence of CSs varies,depending on different SoS types.Key researchers describe four SoS types with descending levels of central authority:directed,acknowledged,collaborative and virtual.Although the definitions have been recognized in SoS engineering,what is challenging is the difficulty of translating these definitions into models and simulation environments.Thus,we provide a goal-based method including a mathematical baseline to translate these definitions into more effective agent-based modeling and simulations.First,we construct the theoretical models of CS and SoS.Based on the theoretical models,we analyze the degree of authority influenced by SoS characteristics.Next,we propose a definition of SoS types by quantitatively explaining the degree of authority.Finally,we recognize the differences between acknowledged SoS and collaborative SoS using a migrating waterfowl flock by an agentbased model(ABM)simulation.This paper contributes to the SoS body of knowledge by increasing our understanding of the degree of authority in an SoS,so we may identify suitable SoS types to achieve SoS goals by modeling and simulation.
文摘IEEE Serious Open Source for the Benefit of Humanity (SOSH) is hosted by the IEEE Standards Association, which gathers industry experts, innovators, and engineering leaders from around the world to explore the profound benefits of open source technology for industries and their customers.
