Construction of Two Coordination Polymers Based on Two New 5-Substitued Tetrazole-based Ligands: Structures and Luminescent Properties

Two new coordination polymers(CPs) based on two new tetrazole-based ligands, namely, [Cu(TPP)]n(HTTP = 4-(3-(2 H-tetrazol-5-yl)phenyl)pyridine, 1) and {[Cd_2(TBCA)_2(H_2O)_2]·-H_2O}n(H_2TBCA = 3?-(2 H-tetrazol-5-yl)biphenyl-4-carboxylic acid, 2), were synthesized via solvothermal reactions. Single-crystal X-ray diffraction analysis reveals that compound 1 exhibits a(3,6)-connected rtl network topology based on binuclear secondary building units(SBUs). Compound 2 presents a 2D framework composed of 1D SUBs formed by both carboxyl and tetrazole groups. The 2D network is linked into a 3D framework via various hydrogen bonds. They represent two examples of CPs construct from rigid 5-substitued tetrazole-based ligands with relatively longer spacer. The thermal stabilities and luminescent properties of compounds 1 and 2 were also explored.

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

Structure variation of cadmium naphthalene⁃diphosphonates with the changing rigidity of N⁃donor auxiliary ligands

Five cadmium naphthalene-diphosphonates,formulated as[Cd_(1.5)(1,4-ndpaH_(2))2(4,4'-bpyH)(4,4'-bpy)0.5(H_(2)O)_(2)]2(1),[Cd(1,4-ndpaH_(2))(1,4-bib)0.5(H_(2)O)](2),[Cd(1,4-ndpaH3)2(1,2-dpe)(H_(2)O)]·(1,2-dpe)·7H_(2)O(3),(1,2-bixH)[Cd3(1,4-ndpaH)(1,4-ndpaH_(2))2(H_(2)O)_(2)](4),and[Cd(1,4-ndpaH_(2))(H_(2)O)]·H_(2)O(5),have been synthesized from the selfassembly reactions of 1,4-naphthalenediphosphonic acid(1,4-ndpaH4)with Cd(NO3)2·4H_(2)O by introducing auxiliary ligands with variation of rigidity,such as 4,4'-bipyridine(4,4'-bpy),1,4-bis(1-imidazolyl)benzene(1,4-bib),1,2-di(4-pyridyl)ethylene(1,2-dpe),1,3-di(4-pyridyl)propane(1,3-dpp),and bis(imidazol-1-ylmethyl)benzene(1,2-bix),respectively.Structure resolution by single-crystal X-ray diffraction reveals that compound 1 possesses a layered framework,in which the{Cd3(PO2)2}trimers made up of corner-sharing two{CdO4N2}and one{CdO6}octahedra are connected by phosphonate groups,forming a ribbon,which are cross-linked by 4,4'-bipy ligands,forming a 2D layer.Compound 2 shows a 3D open-framework structure,where chains of corner-sharing{CdO4N}trigonal bipyramids and{PO3C}tetrahedra are cross-linked by 1,4-bib and/or phosphonate groups.A 1D ladder-like chain structure is found in compound 3,where the ladder-like chains made up of corner-sharing{CdO5N}octahedra and{PO3C}tetra hedra are connected by 1,4-ndpaH_(2)^(2-).Both compounds 4 and 5 obtained by the introduction of flexible ligands during the synthesis show a 2D layered structure,which is formed by ligand crosslinking double metal chains.Interestingly,In 4,flexible 1,2-bix was singly protonated,as guest molecules,filled between layer and layer,while flexible ligand 1,3-dpp is absent in 5.Photophysical measurements indicate that compounds 1-5 show ligand-centered emissions.

Proton‑Prompted Ligand Exchange to Achieve High‑Efficiency CsPbI_(3) Quantum Dot Light‑Emitting Diodes

CsPbI_(3)perovskite quantum dots(QDs)are ideal materials for the next generation of red light-emitting diodes.However,the low phase stability of CsPbI_(3)QDs and long-chain insulating capping ligands hinder the improvement of device performance.Traditional in-situ ligand replacement and ligand exchange after synthesis were often difficult to control.Here,we proposed a new ligand exchange strategy using a proton-prompted insitu exchange of short 5-aminopentanoic acid ligands with long-chain oleic acid and oleylamine ligands to obtain stable small-size CsPbI_(3)QDs.This exchange strategy maintained the size and morphology of CsPbI_(3)QDs and improved the optical properties and the conductivity of CsPbI_(3)QDs films.As a result,high-efficiency red QD-based light-emitting diodes with an emission wavelength of 645 nm demonstrated a record maximum external quantum efficiency of 24.45%and an operational half-life of 10.79 h.

Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor growth.Serum VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab treatment.Programmed cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and metastasis.AIM To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of PD-L1.METHODS This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with CRC.RESULTS A total of 124 patients was included in this analysis.Almost all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line chemotherapy.While 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line chemotherapy.The numbers of patients with a PD-L1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),respectively.The results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 CPS less than 1 and those with PD-L1 CPS of 1 or more(PD-L1<1%vs PD-L1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-L1 CPS less than 5 and of 5 or more(PD-L1<5%vs PD-L1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-L1 CPS less than 10 and of 10 or more(PD-L1<10%vs PD-L1≥10%;PFS:P=0.529,OS:P=0.568).CONCLUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.

Structure–performance relationship of Au nanoclusters in electrocatalysis:Metal core and ligand structure

Remarkable progress has characterized the field of electrocatalysis in recent decades,driven in part by an enhanced comprehension of catalyst structures and mechanisms at the nanoscale.Atomically precise metal nanoclusters,serving as exemplary models,significantly expand the range of accessible structures through diverse cores and ligands,creating an exceptional platform for the investigation of catalytic reactions.Notably,ligand‐protected Au nanoclusters(NCs)with precisely defined core numbers offer a distinct advantage in elucidating the correlation between their specific structures and the reaction mechanisms in electrocatalysis.The strategic modulation of the fine microstructures of Au NCs presents crucial opportunities for tailoring their electrocatalytic performance across various reactions.This review delves into the profound structural effects of Au NC cores and ligands in electrocatalysis,elucidating their underlying mechanisms.A detailed exploration of the fundamentals of Au NCs,considering core and ligand structures,follows.Subsequently,the interaction between the core and ligand structures of Au NCs and their impact on electrocatalytic performance in diverse reactions are examined.Concluding the discourse,challenges and personal prospects are presented to guide the rational design of efficient electrocatalysts and advance electrocatalytic reactions.

Design and synthesis of two coordination polymers for the rapid detection of ciprofloxacin based on triphenylpolycarboxylic acid ligands

Two coordination polymers were synthesized by hydrothermal reaction,namely,[Cd(H_(3)cpbda)(2,2′‑bipy)(H_(2)O)]_(n)(1)and[Mn(H_(3)cpbda)(phen)(H_(2)O)]_(n)(2),where H_(5)cpbda=5,5′‑[(5‑carboxy‑1,3‑phenyl)bis(oxy)]triisophthalic acid,2,2′‑bipy=2,2′‑bipyridine,phen=1,10‑phenanthroline.The two complexes were characterized by single‑crystal X‑ray diffraction,powder diffraction,infrared spectroscopy,and thermogravimetric analysis.Complexes 1 and 2 are“V”‑shaped 1D chains,and the molecules form 2D(1)and 3D framework(2)structures through weakπ…πstacking.Furthermore,complex 1 was dispersed in an aqueous solution and its fluorescence intensity demonstrated excellent stability.Complex 1 can specifically detect ciprofloxacin in urine with a detection limit of 1.91×10^(-8)mol·L^(-1).CCDC:2359498,1;2359499,2.

Transition metal coordination polymers with flexible dicarboxylate ligand:Synthesis,characterization,and photoluminescence property

Under solvothermal conditions,six new coordination polymers(CPs)[Mn(L)(phen)(H_(2)O)]_(n)(1),[Co(L)(phen)(H_(2)O)]_(n)(2),[Cu(L)(phen)(H_(2)O)]_(n)(3),[Zn_(2)(L)_(2)(phen)2(H_(2)O)]_(n)(4),[Zn(L)(phen)]_(n)(5),and[Cd(L)(phen)2]_(n)(6)were synthesized by reactions of dicarboxylate ligand 2,2'-(1,2-phenylenebis(methylene))bis(sulfanediyl)dinobutyric acid(H_(2)L)and 1,10-phenanthroline(phen)with the corresponding metal salts.Complexes 1-6 have been structurally characterized by single-crystal X-ray diffraction analyses,elemental analysis,IR,thermogravimetric analysis,and powder X-ray diffraction.The structures of 1-6 are 1D chains,which are further connected by hydrogen bonding interac-tions to form 3D supramolecular structures.Among them,1 and 2 are isomorphic with L2-of syn-conformation,while L2-shows anti-conformation in 3-6.In addition,the solid-state photoluminescence property of 4-6 was investigated.

Lewis base multisite ligand engineering in efficient and stable perovskite solar cells

Perovskite solar cells(PSCs) have stood out from many photovoltaic technologies due to their flexibility,cost-effectiveness and high-power conversion efficiency(PCE). Nevertheless, the further development of PSCs is greatly hindered by the trap-induced non-radiative recombination losses and poor long-term work stability. In the past decade, the huge advancements have been obtained on suppressing nonradiative recombination and enhancing device durability. Among them, the multisite ligands(MSLs) engineering plays a crucial role in precise control and directional modification of functional layers and interfaces,which contributes to markedly increased PCE and lifetimes of PSCs. In view of this, this review summarizes the advances of MSLs in PSCs. From the perspective of functional groups and chemical interaction,the modulation mechanisms of properties of different functional layers and interfaces and device performance via various MSLs are deeply investigated and revealed. Finally, the prospects for the application and development direction of MSLs in PSCs are legitimately proposed.

Ligand modulation of active center to promote lead-free Cs_(2)AgInCl_(6)photocatalytic CO_(2)reduction

Metal halide perovskites(MHP)are potential candidates for the photocatalytic reduction of CO_(2)due to their long photogenerated carrier lifetime and charge diffusion length.However,the conventional long-chain ligand impedes the adsorption and activation of CO_(2)molecules in practical applications.Here,a ligand modulation technology is employed to enhance the photocatalytic CO_(2)reduction activity of lead-free Cs_(2)AgInCl_(6)microcrystals(MCs).The Cs_(2)AgInCl_(6)MCs passivated by Oleic acid(OLA)and Octanoic acid(OCA)are used for photocatalytic CO_(2)reduction.The results show that the surface defects and electronic properties of Cs_(2)AgInCl_(6)MCs can be adjusted through ligand modulation.Compared with the OLA-Cs_(2)AgInCl_(6),the OCA-Cs_(2)AgInCl_(6)catalyst demonstrated a significant improvement in the catalytic yield of CO and CH_(4).The CO and CH_(4)catalytic yields of OCA-Cs_(2)AgInCl_(6)reached 171.88 and34.15μmol g^(-1)h^(-1)which were 2.03 and 12.98 times higher than those of OLA-Cs_(2)AgInCl_(6),and the total electron consumption rate of OCA-Cs_(2)AgInCl_(6)was 615.2μmol g^(-1)h^(-1)which was 3.25 times higher than that of OLA-Cs_(2)AgInCl_(6).Furthermore,in situ diffuse reflectance infrared Fourier transform spectra revealed the enhancement of photocatalytic activity in Cs_(2)AgInCl_(6)MCs induced by ligand modulation.This study illustrates the potential of lead-free Cs_(2)AgInCl_(6)MCs for efficient photocatalytic CO_(2)reduction and provides a ligand modulation strategy for the active promotion of MHP photocatalysts.

Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological characteristics.METHODS We retrospectively reviewed 284 GC patients who underwent D2-gastrectomy.PD-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive score.All PD-L1+PT staged as pN+were also tested for PD-L1 expression in their LNM.PD-L1(-)GC with pN+served as the comparison group.RESULTS Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the LNM.Regarding PD-L1(-)PT,9.1%(4/44)had PD-L1+in the LNM.The agreement between PT and LNM had a kappa value of 0.483.Larger tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both sites.There was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched LNM.This disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferationinducing ligand

BACKGROUND Recent advancements in nanomedicine have highlighted the potential of exosome(Ex)-based therapies,utilizing naturally derived nanoparticles,as a novel approach to targeted cancer treatment.AIM To explore the targetability and anticancer effectiveness of small interfering peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 RNA(siPIN1)-loaded soluble a proliferation-inducing ligand(sAPRIL)-targeted Exs(designated as tEx[p])in the treatment of colon cancer models.METHODS tEx was generated by harvesting conditioned media from adipose-derived stem cells that had undergone transformation using pDisplay vectors encoding sAPRIL-binding peptide sequences.Subsequently,tEx[p]were created by incorporating PIN1 siRNA into the tEx using the Exofect kit.The therapeutic efficacy of these Exs was evaluated using both in vitro and in vivo models of colon cancer.RESULTS The tEx[p]group exhibited superior anticancer effects in comparison to other groups,including tEx,Ex[p],and Ex,demonstrated by the smallest tumor size,the slowest tumor growth rate,and the lightest weight of the excised tumors observed in the tEx[p]group(P<0.05).Moreover,analyses of the excised tumor tissues,using western blot analysis and immunohistochemical staining,revealed that tEx[p]treatment resulted in the highest increase in Ecadherin expression and the most significant reduction in the mesenchymal markers Vimentin and Snail(P<0.05),suggesting a more effective inhibition of epithelial-mesenchymal transition tEx[p],likely due to the enhanced delivery of siPIN1.CONCLUSION The use of bioengineered Exs targeting sAPRIL and containing siPIN1 demonstrated superior efficacy in inhibiting tumor growth and epithelial-mesenchymal transition,highlighting their potential as a therapeutic strategy for colon cancer.

Syntheses,structures,and properties of three coordination polymers based on 5⁃ethylpyridine⁃2,3⁃dicarboxylic acid and N⁃containing ligands

Three coordination polymers[Mn(epda)(2,2'⁃bipy)(H_(2)O)](1),[Mn(epda)(phen)](2),and[Co_(2)(epda)2(bpe)2(H_(2)O)_(4)]·5H_(2)O(3)(H2epda=5⁃ethyl⁃pyridine⁃2,3⁃dicarboxylic acid,2,2'⁃bipy=2,2'⁃bipyridine,phen=phenanthroline,bpe=1,2⁃bis(4⁃pyridyl)ethylene)were synthesized by solvothermal reactions and characterized by single⁃crystal X⁃ray diffraction,thermogravimetric analyses,IR spectroscopy and elemental analysis.1 displays a 1D chain struc⁃ture,and these chains are joined by O-H…O hydrogen bonding andπ⁃πstacking interactions to generate a 2D layer structure.2 displays a 2D layer structure,and adjacent layers are generated 3D architecture throughπ⁃πstacking interactions.3 displays a 1D chain structure,and adjacent chains are generated double layer structure through O-H…O hydrogen bonding.The fluorescent properties of 1 and 3 indicate that they can potentially be used as a luminescent sensor.1 was highly selective and sensitive towards o⁃nitrophenol through different detection mechanisms,however,3 was highly selective and sensitive towards 2,4,6⁃trinitrophenol.In addition,the magnetic behavior of 2 has also been investigated.CCDC:2172533,1,2355773,2,2355774,3.

Comparative Study of the Efficacy of Metal Removal from Contaminated Aqueous Solutions by Solid Bidentate Ligands&Liquid Plant Materials

Heavy metal contaminated water sources pose serious health risks for humans,animals,and plants.Exposure to and ingestion of heavy metals have been associated to liver,kidney,and brain function.Objective:The aim of this research is to comparatively examine the metal removal efficacy of three solid bidentate chemicals and four plant materials.Study Design&Methods:Standard solutions of zinc(II)and lead(II)ions with concentrations of 1,000 ppm were respectively treated with OA(Oxalic Acid),dibasic bidentate ligands(sodium hydrogen phosphate and sodium carbonate).Then,the solutions were placed on a shaker for 15 h,centrifuged,and the supernatant was analyzed using ICP-AES(Inductively Coupled Plasma-Atomic Emission Spectrometry).Results:All the solid bidentate adsorbents were very effective in removing zinc and lead(>90%).However,more lead than zinc was removed across all adsorbents except for lemon where equal percent of zinc and lead(49%)were removed.OA and Na2HPO4 removed about equal amount of lead(>99%).The plant materials(SP(Spinach),bell pepper and GBP(Green Bell Pepper)),respectively and preferentially removed more lead(98.9%,98.3%,81.5%)than zinc(91.7%,46%,46%).Conclusion:Although plant materials have gained attraction for the remediation of heavy metal,however,some bidentate chemical ligands such as OA,sodium carbonate and sodium hydrogen phosphates are even more effective in removing these metals from contaminated water.Furthermore,heavier metals are preferentially removed than lighter metals.

High-density Ir single sites from rapid ligand transformation for efficient water electrolysis

The development of high-performance oxygen evolution reaction catalysts with low iridium content is the key to the scale-up of proton exchange membrane water electrolyzer(PEMWE)for green hydrogen production.Single-site electrocatalysts with maximized atomic efficiency are held as promising candidates but still suffer from inadequate activity and stability in practical electrolyzer due to the low site density.Here,we proposed a NaNO_(3)-assistant thermal decomposition strategy for the preparation of high-density Ir single sites on MnO_(2)substrate(NaNO_(3)-H-Ir-MnO_(2)).Direct spectroscopic evidence suggests the inclusion of NaNO_(3) accelerates the transformation of Ir-Cl to Ir-O coordination,thus generating uniform dispersed high-density Ir single sites in the products.The optimized H-Ir-MnO_(2)demonstrates not only high intrinsic activity in a three-electrode set-up but also boosted performance in scalable PEMWE,requiring a cell voltage of only 1.74 V to attain a high current density of 2 A cm^(-2) at a low Ir loading of 0.18 mgIr cm^(-2).This work offers a new insight for enhancing the industrial practicality of Ir-based single site catalysts.

稀土钐-聚乙二醇高分子转光剂的合成及其荧光性能

以三聚氯氰交联月桂醇、8-羟基喹啉和聚乙二醇制备高分子配体CHA(PEG),再与稀土Sm 3+中心离子配位合成了一种新型高分子转光剂Sm[CHA(PEG)].采用FTIR、XPS、XRD、荧光光谱、UV和TGA等测试方法分析了Sm[CHA(PEG)]的化学结构、荧光性能以及热稳定性等.结果表明,Sm[CHA(PEG)]在320~400 nm具有紫外宽吸收带,而荧光激发峰的最佳峰位在362 nm处,二者具有良好的吻合性;荧光发射峰在566 nm、614 nm和645 nm均出现了Sm 3+的特征发射峰,其中在645 nm处强度最大,与植物在红光区光合作用的吸收光谱具有较佳的匹配性.热失重曲线显示该转光剂的分解温度为281℃,热稳定性良好.本文合成的Sm[CHA(PEG)]具有优良的光学和热学性能,在农膜领域极具应用前景.

血清可溶性CD40配体、腱糖蛋白C、甲壳质酶蛋白-40联合检测对维持性血液透析并发心血管事件的预测作用

目的:探讨血清可溶性CD40配体(sCD40L)、腱糖蛋白C(TN-C)、甲壳质酶蛋白-40(YKL-40)联合检测对维持性血液透析(MHD)并发心血管事件的预测价值。方法:选择170例MHD患者为研究对象,依据不良心血管事件(MACE)发生情况分两组,即MACE组(n=63)和非MACE组(n=107),另选同期健康体检者为对照组(n=152)。比较各组血清sCD40L、TN-C、YKL-40水平,分析以上指标与MHD发生MACE的相关性及MHD并发MACE的危险因素,绘制受试者工作曲线(ROC)分析其预测价值。结果:MHD组血清sCD40L、TN-C、YKL-40水平高于对照组(均P<0.05)。MACE组的年龄、透析龄及血清sCD40L、TN-C、YKL-40水平高于非MACE组(均P<0.05)。MHD并发MACE与年龄、透析龄及血清sCD40L、TN-C、YKL-40水平呈正相关(均P<0.05)。多因素Logistic回归分析显示,MHD并发MACE的独立危险因素包括高水平sCD40L、TN-C、YKL-40以及高年龄和透析龄(均P<0.05)。血清sCD40L、TN-C、YKL-40单独及联合预测MHD并发MACE的AUC分别为0.701、0.679、0.754、0.875,联合预测价值最高,其次为YKL-40、sCD40L、TN-C(均P<0.05)。结论:MHD并发MACE患者血清sCD40L、TN-C、YKL-40水平有升高趋势,三者均为MACE发生独立危险因素,联合检测对MHD发生MACE有一定的预测价值。

基于配体调控技术制备荧光发射可视化分离的CdSe纳米晶体

研究了不同油酸(OA)、油胺(OLA)配体添加量在制备CdSe纳米晶体中对量子点荧光特性的影响,深入分析了OA和OLA配体在CdSe纳米晶体生长过程中的作用机理。在采用逐层生长法制备CdSe纳米晶体时,研究了OA和OLA配体对晶体尺寸及尺寸分布的影响,并制备了尺寸分布良好的较大尺寸CdSe纳米晶体。采用多种方法对CdSe纳米晶体的光学性能、晶体结构、微观形貌及尺寸分布进行表征分析。结果表明,OA配体的添加会使CdSe纳米晶体发射峰红移,且添加量与发射峰红移波长呈正相关,发射峰可调范围为548.5~604.0 nm;OLA配体添加量较少时会使CdSe纳米晶体发射峰蓝移,但随着OLA配体添加量的增加发射峰逐渐红移,发射峰可调范围为548.0~584.4 nm;在逐层生长法中引入OA和OLA配体可有效改善由于多次逐层生长而产生的发射峰双峰现象。最终通过调整制备工艺,制备了荧光发射可视化分离的4种CdSe纳米晶体,其尺寸分布良好,具有较高的光致发光量子产率(PLQY),抗光漂白性能较好。

多甲基混合茂配体茂金属催化剂合成与应用

合成了一系列茂配体,在其中的一个茂环上引入多个甲基,制备了多甲基混合茂配体茂金属催化剂,以甲基铝氧烷为助催化剂,进行了烯烃聚合评价研究,并与市售的二氯二茂锆进行对比。实验结果表明,多甲基混合茂配体茂金属催化剂的催化活性与二氯二茂锆相当,最高可达7951 kg/(mol·h);可催化乙烯与1-己烯共聚,共聚物中1-己烯含量最高可达6.8%(x)。

基于芳香羧酸配体的有机凝胶、金属凝胶的制备及流变性能

合成了四个包含胆固醇基团的芳香羧酸化合物CDCn(n=4,6,8,10),分别测试了CDCn、CDCn与Tb^(3+)/Eu^(3+)在不同溶剂中形成超分子凝胶的能力。测试结果表明,不仅CDCn在DMF/H_(2)O和DMSO/H_(2)O两种混合溶剂中能形成超分子凝胶,而且CDCn与Tb^(3+)/Eu^(3+)在这两种混合溶剂中能通过配位作用形成金属凝胶。扫描电镜(SEM)观察表明,金属配位完全改变了有机凝胶的微观形貌;红外光谱研究证明金属凝胶中羧酸配体与金属离子发生了配位作用。流变学研究表明,金属离子的引入极大地提高了小分子凝胶的强度,且形成的金属凝胶具有完全可逆的剪切触变性。