Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to t...Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly suggested.To systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online databases.Web of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were included.The protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte proliferation.The trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst stimulation.Few papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete rs.In what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of effects.It is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magnetic stimulation between sexes.This systematic review supports that thro ugh modulation of glial cells repetitive magnetic stimulation contributes to the neuroprotection or repair in various neurological disease models.Howeve r,it should be noted that there are still few articles focusing on the impact of repetitive magnetic stimulation on non-neuronal cells and most studies did not perform in-depth analyses of the effects,emphasizing the need for more studies in this field.展开更多
目的:探索间歇性θ短阵脉冲刺激(iTBS)对脑卒中后中重度运动功能障碍患者的即刻影响机制。方法:于2020年8月—2021年3月在复旦大学附属华山医院康复医学科门诊或病房招募脑卒中患者10例,随机分为iTBS组和安慰刺激组,i TBS组接受单次患...目的:探索间歇性θ短阵脉冲刺激(iTBS)对脑卒中后中重度运动功能障碍患者的即刻影响机制。方法:于2020年8月—2021年3月在复旦大学附属华山医院康复医学科门诊或病房招募脑卒中患者10例,随机分为iTBS组和安慰刺激组,i TBS组接受单次患侧初级运动皮层区(primary motor cortex,M1)的iTBS干预,安慰刺激组接受单次患侧M1的安慰刺激干预。干预前后对所有患者进行神经电生理评估和近红外脑功能检测。结果:与安慰刺激组相比,i TBS刺激组干预后功能连接强度在患侧M1区-健侧初级躯体感觉皮层区(primary somatosensory cortex,S1)和患侧M1区-健侧辅助运动皮层区(pre-motor and supplementary motor cortex,SMA)较干预前显著性升高(P<0.05)。然而,双侧M1区的MEP波幅并未发生显著性变化(P>0.05)。结论:针对脑卒中后中重度运动功能障碍患者,单次iTBS刺激可引起大脑发生即刻的神经可塑性改变,但未能引起大脑结构或功能的显著性变化。展开更多
基金the scope of the CICS-UBI projects UIDP/Multi/00709/2019,UIDB/Multi/00709/2019,UIDP/00709/2020,UIDB/00709/2020,financed by national funds through the Portuguese Foundation for Science and Technology/MCTESby funds to the PPBI-Portuguese Platform of Bio Imaging through the Project POCI-01-0145-FEDER-022122(to GB,MVP,NP)supported by a grant from the Portuguese Foundation for Science and Technology/MCTES(2021.07854.BD)(to IS)。
文摘Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly suggested.To systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online databases.Web of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were included.The protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte proliferation.The trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst stimulation.Few papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete rs.In what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of effects.It is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magnetic stimulation between sexes.This systematic review supports that thro ugh modulation of glial cells repetitive magnetic stimulation contributes to the neuroprotection or repair in various neurological disease models.Howeve r,it should be noted that there are still few articles focusing on the impact of repetitive magnetic stimulation on non-neuronal cells and most studies did not perform in-depth analyses of the effects,emphasizing the need for more studies in this field.
文摘目的:探索间歇性θ短阵脉冲刺激(iTBS)对脑卒中后中重度运动功能障碍患者的即刻影响机制。方法:于2020年8月—2021年3月在复旦大学附属华山医院康复医学科门诊或病房招募脑卒中患者10例,随机分为iTBS组和安慰刺激组,i TBS组接受单次患侧初级运动皮层区(primary motor cortex,M1)的iTBS干预,安慰刺激组接受单次患侧M1的安慰刺激干预。干预前后对所有患者进行神经电生理评估和近红外脑功能检测。结果:与安慰刺激组相比,i TBS刺激组干预后功能连接强度在患侧M1区-健侧初级躯体感觉皮层区(primary somatosensory cortex,S1)和患侧M1区-健侧辅助运动皮层区(pre-motor and supplementary motor cortex,SMA)较干预前显著性升高(P<0.05)。然而,双侧M1区的MEP波幅并未发生显著性变化(P>0.05)。结论:针对脑卒中后中重度运动功能障碍患者,单次iTBS刺激可引起大脑发生即刻的神经可塑性改变,但未能引起大脑结构或功能的显著性变化。
