There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of ...There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of network structure on network spreading. Motifs, as fundamental structures within a network, play a significant role in spreading. Therefore, it is of interest to investigate the influence of the structural characteristics of basic network motifs on spreading dynamics.Considering the edges of the basic network motifs in an undirected network correspond to different tie ranges, two edge removal strategies are proposed, short ties priority removal strategy and long ties priority removal strategy. The tie range represents the second shortest path length between two connected nodes. The study focuses on analyzing how the proposed strategies impact network spreading and network structure, as well as examining the influence of network structure on network spreading. Our findings indicate that the long ties priority removal strategy is most effective in controlling network spreading, especially in terms of spread range and spread velocity. In terms of network structure, the clustering coefficient and the diameter of network also have an effect on the network spreading, and the triangular structure as an important motif structure effectively inhibits the spreading.展开更多
Clarifying China’s position in the global system is an important logical basis for developing national diplomacy.Although much research has been done on China’s development status,most studies have been based on cou...Clarifying China’s position in the global system is an important logical basis for developing national diplomacy.Although much research has been done on China’s development status,most studies have been based on country comparisons or institutional en-vironment.In today’s networked era in which the global economy,trade,personnel,and information are closely connected,studies on China’s global position and its status changes and influencing factors in multiple contact networks are still insufficient.In this study,from the perspective of diverse global contact networks,we constructed economic,cultural,and political influence indices to explore the changes and influencing factors on China’s status in the global system from 2005 to 2018.The results show that during the study period,China’s global influence in the fields of economic ties,cultural exchanges,and political contacts increased significantly,but its influ-ence in the fields of cultural exchanges and political contacts lagged far economic ties.The pattern of China’s economic influence on various economies around the world has shown a transformation from an‘upright pyramid’to an‘inverted pyramid’structure.The proportion of these economies in low-influence zones has decreased from more than 60%in 2005 to less than 20%in 2018.China’s cultural and political influence on various economies around the world has increased significantly;however,for the former,the percentage of high-influence areas is still less than 20%,whereas for the latter the percentage of these economies in medium-and high-influence areas is still less than 50%.Analyses such as a scatter plot matrix show that geographical proximity,economic globalization,close cooperation with developing countries,and a proactive and peaceful foreign policy are important factors in improving China’s status in the diverse global network system.展开更多
To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used ...To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used for typical museum collection replicas have been carried out.The influence of body shape and fixed measure parameters on the seismic responses of replicas and the interaction behavior between replicas and fixed measures have been explored.Based on the results,seismic effectiveness evaluation indexes of the tie up method are proposed.Reasonable suggestions for fixed strategies are given,which provide a basis for the exhibition of delicate museum collections considering the principle of minimizing seismic responses and intervention.The analysis results show that a larger ratio of height of mass center to bottom diameter led to more intense rocking responses.Increasing the initial pretension of fishing lines was conducive to reducing the seismic responses and stress variation of the lines.Through comprehensive consideration of the interaction forces and effective securement,it is recommended to apply 20%of breaking stress as the initial pretension.For specific museum collections that cannot be effectively protected by the independent tie up method,an optimized strategy of a combination of fishing lines and fasteners is recommended.展开更多
Batik fabric is an integral part of the traditional cloth culture of the Ghanaian traditional setting. However, the batik fabric has marginal usage due to its casual visual appearance. This studio practice seeks to ex...Batik fabric is an integral part of the traditional cloth culture of the Ghanaian traditional setting. However, the batik fabric has marginal usage due to its casual visual appearance. This studio practice seeks to explore the epiphanic revival in the use of metallic finishes on batik substrate to create an enhanced visual appearance with embellished aesthetic sensibilities and diversified use. The researchers adopted the studio-based approach of the qualitative design to manipulate handmade tools, techniques (collagraph) and the batik fabrics through experimentation to produce a glittering mercurial batik fabric which is typically an industrial practice. The studio practice took place at the Textile Design and Technology studio, Takoradi Technical University, Ghana. The traditional batik fabric was manipulated through fabric decoration techniques in accordance with studio-based practices. The Addie model was adopted as a methodological approach in the analysis, design, development, implementation, and evaluation processes of the experimentation processes of the study. Findings revealed that the hand techniques used in the production process for the metallic prints produced interesting accidentals finishes and effects that machine work cannot achieve, producing new discoveries of visual enhancements of traditional batik fabric. Traditional batiks became mercurial with glittery effects. The metallic prints on the fabric also changed its consumption pattern from mere casual fabric to classic and cosmopolitan fabric for varied uses suitable for wearable to non-wearable.展开更多
"Are you kid- ding? I do not have time for that—we just registered at the household affairs office and started our life,"Chen Chao said,shrugging."Those old customs are not necessary for a Beijinger li..."Are you kid- ding? I do not have time for that—we just registered at the household affairs office and started our life,"Chen Chao said,shrugging."Those old customs are not necessary for a Beijinger like me.""Well,I haven’t had my wedding yet,but I spent thousands on the wed- ding pictures and albums,"chirped up petite and lovely He Shan."But we’ll pick an auspicious date to hold the ceremony,a combination of numbers from the展开更多
Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and...Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and the principle of shallow TTAs in soft rock have not been fully studied.Hence,a structure suitable for improving the stability of shallow TTAs in soft rock strata,named the anti-pull tie(APT),was added to the floor of the back face.Physical tests and numerical models were established to study the influence of the APT on the load transfer of TTAs,the mechanical response of the surrounding rock,the stress distribution of the interface,and the failure model.The mechanical characteristics of APTs were also studied.The results show that the ultimate bearing capacity of TTAs with an APT is increased by approximately 11.8%,as compared to the TTAs without an APT.Also,the bearing capacity of TTAs increases approximately linearly with increasing height,width,length,and quantity of APTs,and decreases approximately linearly with increasing distance from the back face and slope angle of the tie slope.The normal squeezing between the tie slope and the surrounding rock increases the shear resistance of the interface and expands the range of the surrounding rock participating in bearing sharing.Both tension and compression zones exist in the APT during loading.The tension zone extends from the tie toe to the tie bottom along the tie slope.The range of the tie body tension zone constantly expands to the deep part of the APT with an increasing load.The peak tensile stress value is located at the tie toe.The distribution of compressive stress in the tie body is the largest at the tie top,followed by the tie slope,and then the tie bottom.展开更多
This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase(SHP-2)on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2(Tie2)-expressin...This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase(SHP-2)on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2(Tie2)-expressing monocyte/macrophages(TEMs)and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)(Ang/Tie2-PI3K/Akt/mTOR)signaling pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment.In vivo,SHP-2-deficient mice were used to construct colorectal cancer(CRC)liver metastasis models.SHP-2-deficient mice had significantly more metastatic cancer and inhibited nodules on the liver surface than wild-type mice,and the high-level expression of p-Tie2 was found in the liver tissue of the macrophages’specific SHP-2-deficient mice(SHP-2MACKO)+planted tumor mice.Compared with the SHP-2 wild type mice(SHP-2WT)+planted tumor group,the SHP-2MAC-KO+planted tumor group experienced increased expression of p-Tie2,p-PI3K,p-Akt,p-mTOR,vascular endothelial growth factor(VEGF),cyclooxygenase-2(COX-2),matrix metalloproteinase 2(MMP2),and MMP9 in the liver tissue.TEMs selected by in vitro experiments were co-cultured with remodeling endothelial cells and tumor cells as carriers.It was found that when Angpt1/2 was used for stimulation,the SHP-2MAC-KO+Angpt1/2 group displayed evident increases in the expression of the Ang/Tie2-PI3K/Akt/mTOR pathway.The number of cells passing through the lower chamber and the basement membrane and the number of blood vessels formed by cells compared with the SHP-2WT+Angpt1/2 group,while these indexes were subjected to no changes under the simultaneous stimulation of Angpt1/2+Neamine.To sum up,the conditional knockout of SHP-2 can activate the Ang/Tie2-PI3K/Akt/mTOR pathway in TEMs,thereby strengthening tumor micro angiogenesis in the microenvironment and facilitating CRC liver metastasis.展开更多
Cutaneomucosal venous malformations(VMCMs)can manifest as sporadic or familial forms,following an autosomal dominant inheritance pattern.This report highlights the case of a 5-year-old girl presenting with a substanti...Cutaneomucosal venous malformations(VMCMs)can manifest as sporadic or familial forms,following an autosomal dominant inheritance pattern.This report highlights the case of a 5-year-old girl presenting with a substantial congenital VMCM attributed to a TIE2 mutation,who underwent percutaneous sclerotherapy followed by surgery.The clinical,three-dimensional computed tomographic angiography(3D-CTA),as well as pathological and genetic findings concerning a patient with an extensive VMCM in the left pro-axillary region,are elucidated.The genetic analysis in this patient verified a missense mutation(c.2545T>C)in TIE2,confirming familial VMCMs.The combined strategy integrating percutaneous sclerotherapy and surgical excision is the most efficacious approach for managing large VMCMs and can successfully attain therapeutic goals.展开更多
“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation A...“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation Agency.展开更多
The objective of this paper is to propose and illustrate feasibility, approach, validation as per prevailing codes and design standards, specification to rehabilitate bridge pier cap by using Ultra-High Performance Co...The objective of this paper is to propose and illustrate feasibility, approach, validation as per prevailing codes and design standards, specification to rehabilitate bridge pier cap by using Ultra-High Performance Concrete (UHPC). The evaluation of existing pier caps and bearings indicates that the complete removal of existing bearing is undesirable due to 1) massive size of bearing 2) difficulty in cutting through the thick components of existing bearing 3) deeply anchored lower shoe of existing bearings 4) huge cost and time required to erect temporary support system for superstructure to facilitate the construction of new piers. To overcome these difficulties, UHPC could be cast around the lower shoe up to the existing bearing pin. This UHPC cast could be used to support jacks and temporary bearings. The new low height permanent bearing could then be installed after removing the upper shoe of the existing bearing. In the present research, first properties of UHPC are summarized followed by evaluation of case studies to check feasibility of the solution to rehabilitate pier cap by using UHPC. The complex load paths in pier cap are idealized by using validated strut and tie model as per prevailing AASHTO LRFD Bridge Design Specification.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62373197 and 62203229)the Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (Grant No. KYCX24_1211)。
文摘There are various phenomena of malicious information spreading in the real society, which cause many negative impacts on the society. In order to better control the spreading, it is crucial to reveal the influence of network structure on network spreading. Motifs, as fundamental structures within a network, play a significant role in spreading. Therefore, it is of interest to investigate the influence of the structural characteristics of basic network motifs on spreading dynamics.Considering the edges of the basic network motifs in an undirected network correspond to different tie ranges, two edge removal strategies are proposed, short ties priority removal strategy and long ties priority removal strategy. The tie range represents the second shortest path length between two connected nodes. The study focuses on analyzing how the proposed strategies impact network spreading and network structure, as well as examining the influence of network structure on network spreading. Our findings indicate that the long ties priority removal strategy is most effective in controlling network spreading, especially in terms of spread range and spread velocity. In terms of network structure, the clustering coefficient and the diameter of network also have an effect on the network spreading, and the triangular structure as an important motif structure effectively inhibits the spreading.
基金Under the auspices of National Natural Science Foundation of China(No.42201181,42171181)Fundamental Research Funds for the Central Universities(No.2412022QD002)The Medium and Long-term Major Training Foundation of Philosophy and Social Sciences of Northeast Normal University(No.22FR006)。
文摘Clarifying China’s position in the global system is an important logical basis for developing national diplomacy.Although much research has been done on China’s development status,most studies have been based on country comparisons or institutional en-vironment.In today’s networked era in which the global economy,trade,personnel,and information are closely connected,studies on China’s global position and its status changes and influencing factors in multiple contact networks are still insufficient.In this study,from the perspective of diverse global contact networks,we constructed economic,cultural,and political influence indices to explore the changes and influencing factors on China’s status in the global system from 2005 to 2018.The results show that during the study period,China’s global influence in the fields of economic ties,cultural exchanges,and political contacts increased significantly,but its influ-ence in the fields of cultural exchanges and political contacts lagged far economic ties.The pattern of China’s economic influence on various economies around the world has shown a transformation from an‘upright pyramid’to an‘inverted pyramid’structure.The proportion of these economies in low-influence zones has decreased from more than 60%in 2005 to less than 20%in 2018.China’s cultural and political influence on various economies around the world has increased significantly;however,for the former,the percentage of high-influence areas is still less than 20%,whereas for the latter the percentage of these economies in medium-and high-influence areas is still less than 50%.Analyses such as a scatter plot matrix show that geographical proximity,economic globalization,close cooperation with developing countries,and a proactive and peaceful foreign policy are important factors in improving China’s status in the diverse global network system.
基金Beijing Nova Program under Grant No.2022036National Key Research and Development Program under Grant No.2019YFC1521000。
文摘To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used for typical museum collection replicas have been carried out.The influence of body shape and fixed measure parameters on the seismic responses of replicas and the interaction behavior between replicas and fixed measures have been explored.Based on the results,seismic effectiveness evaluation indexes of the tie up method are proposed.Reasonable suggestions for fixed strategies are given,which provide a basis for the exhibition of delicate museum collections considering the principle of minimizing seismic responses and intervention.The analysis results show that a larger ratio of height of mass center to bottom diameter led to more intense rocking responses.Increasing the initial pretension of fishing lines was conducive to reducing the seismic responses and stress variation of the lines.Through comprehensive consideration of the interaction forces and effective securement,it is recommended to apply 20%of breaking stress as the initial pretension.For specific museum collections that cannot be effectively protected by the independent tie up method,an optimized strategy of a combination of fishing lines and fasteners is recommended.
文摘Batik fabric is an integral part of the traditional cloth culture of the Ghanaian traditional setting. However, the batik fabric has marginal usage due to its casual visual appearance. This studio practice seeks to explore the epiphanic revival in the use of metallic finishes on batik substrate to create an enhanced visual appearance with embellished aesthetic sensibilities and diversified use. The researchers adopted the studio-based approach of the qualitative design to manipulate handmade tools, techniques (collagraph) and the batik fabrics through experimentation to produce a glittering mercurial batik fabric which is typically an industrial practice. The studio practice took place at the Textile Design and Technology studio, Takoradi Technical University, Ghana. The traditional batik fabric was manipulated through fabric decoration techniques in accordance with studio-based practices. The Addie model was adopted as a methodological approach in the analysis, design, development, implementation, and evaluation processes of the experimentation processes of the study. Findings revealed that the hand techniques used in the production process for the metallic prints produced interesting accidentals finishes and effects that machine work cannot achieve, producing new discoveries of visual enhancements of traditional batik fabric. Traditional batiks became mercurial with glittery effects. The metallic prints on the fabric also changed its consumption pattern from mere casual fabric to classic and cosmopolitan fabric for varied uses suitable for wearable to non-wearable.
文摘"Are you kid- ding? I do not have time for that—we just registered at the household affairs office and started our life,"Chen Chao said,shrugging."Those old customs are not necessary for a Beijinger like me.""Well,I haven’t had my wedding yet,but I spent thousands on the wed- ding pictures and albums,"chirped up petite and lovely He Shan."But we’ll pick an auspicious date to hold the ceremony,a combination of numbers from the
基金the financial support provided by the National Natural Science Foundation of China(Grant No.42302332)the Special Funding of Chongqing Postdoctoral Research Project(Grant No.2022CQBSHTB2061,2022CQBSHTB1010)+3 种基金the Chongqing Postdoctoral Science Foundation(Grant No.CSTB2022NSCQ-BHX0738,CSTB2023NSCQBHX0223)the China Postdoctoral Science Foundation(Grant No.2023M730432)the Natural Science Foundation of Chongqing(Grant No.CSTB2023NSCQMSX0913,cstc2021jcyj-msxm X0869)the Postdoctoral Science Foundation of Chongqing Jiaotong University(Grant No.F1220105,22JDKJC-A008)。
文摘Tunnel-type anchorages(TTAs)installed in human gathering areas are characterized by a shallow burial depth,and in many instances,they utilize soft rock as the bearing stratum.However,the stability control measures and the principle of shallow TTAs in soft rock have not been fully studied.Hence,a structure suitable for improving the stability of shallow TTAs in soft rock strata,named the anti-pull tie(APT),was added to the floor of the back face.Physical tests and numerical models were established to study the influence of the APT on the load transfer of TTAs,the mechanical response of the surrounding rock,the stress distribution of the interface,and the failure model.The mechanical characteristics of APTs were also studied.The results show that the ultimate bearing capacity of TTAs with an APT is increased by approximately 11.8%,as compared to the TTAs without an APT.Also,the bearing capacity of TTAs increases approximately linearly with increasing height,width,length,and quantity of APTs,and decreases approximately linearly with increasing distance from the back face and slope angle of the tie slope.The normal squeezing between the tie slope and the surrounding rock increases the shear resistance of the interface and expands the range of the surrounding rock participating in bearing sharing.Both tension and compression zones exist in the APT during loading.The tension zone extends from the tie toe to the tie bottom along the tie slope.The range of the tie body tension zone constantly expands to the deep part of the APT with an increasing load.The peak tensile stress value is located at the tie toe.The distribution of compressive stress in the tie body is the largest at the tie top,followed by the tie slope,and then the tie bottom.
基金Natural Science Foundation Project of Hebei Province(H2022405033).
文摘This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase(SHP-2)on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2(Tie2)-expressing monocyte/macrophages(TEMs)and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)(Ang/Tie2-PI3K/Akt/mTOR)signaling pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment.In vivo,SHP-2-deficient mice were used to construct colorectal cancer(CRC)liver metastasis models.SHP-2-deficient mice had significantly more metastatic cancer and inhibited nodules on the liver surface than wild-type mice,and the high-level expression of p-Tie2 was found in the liver tissue of the macrophages’specific SHP-2-deficient mice(SHP-2MACKO)+planted tumor mice.Compared with the SHP-2 wild type mice(SHP-2WT)+planted tumor group,the SHP-2MAC-KO+planted tumor group experienced increased expression of p-Tie2,p-PI3K,p-Akt,p-mTOR,vascular endothelial growth factor(VEGF),cyclooxygenase-2(COX-2),matrix metalloproteinase 2(MMP2),and MMP9 in the liver tissue.TEMs selected by in vitro experiments were co-cultured with remodeling endothelial cells and tumor cells as carriers.It was found that when Angpt1/2 was used for stimulation,the SHP-2MAC-KO+Angpt1/2 group displayed evident increases in the expression of the Ang/Tie2-PI3K/Akt/mTOR pathway.The number of cells passing through the lower chamber and the basement membrane and the number of blood vessels formed by cells compared with the SHP-2WT+Angpt1/2 group,while these indexes were subjected to no changes under the simultaneous stimulation of Angpt1/2+Neamine.To sum up,the conditional knockout of SHP-2 can activate the Ang/Tie2-PI3K/Akt/mTOR pathway in TEMs,thereby strengthening tumor micro angiogenesis in the microenvironment and facilitating CRC liver metastasis.
基金supported by the National Natural Science Foundation of China(grant no.8187080758).
文摘Cutaneomucosal venous malformations(VMCMs)can manifest as sporadic or familial forms,following an autosomal dominant inheritance pattern.This report highlights the case of a 5-year-old girl presenting with a substantial congenital VMCM attributed to a TIE2 mutation,who underwent percutaneous sclerotherapy followed by surgery.The clinical,three-dimensional computed tomographic angiography(3D-CTA),as well as pathological and genetic findings concerning a patient with an extensive VMCM in the left pro-axillary region,are elucidated.The genetic analysis in this patient verified a missense mutation(c.2545T>C)in TIE2,confirming familial VMCMs.The combined strategy integrating percutaneous sclerotherapy and surgical excision is the most efficacious approach for managing large VMCMs and can successfully attain therapeutic goals.
文摘“The Jakarta-Bandung High-Speed Railway(HSR)is a crucial achievement in practical cooperation between China and Indonesia,”said Paulus Rudolf Yuniarto,a researcher at the Indonesia National Research and Innovation Agency.
文摘The objective of this paper is to propose and illustrate feasibility, approach, validation as per prevailing codes and design standards, specification to rehabilitate bridge pier cap by using Ultra-High Performance Concrete (UHPC). The evaluation of existing pier caps and bearings indicates that the complete removal of existing bearing is undesirable due to 1) massive size of bearing 2) difficulty in cutting through the thick components of existing bearing 3) deeply anchored lower shoe of existing bearings 4) huge cost and time required to erect temporary support system for superstructure to facilitate the construction of new piers. To overcome these difficulties, UHPC could be cast around the lower shoe up to the existing bearing pin. This UHPC cast could be used to support jacks and temporary bearings. The new low height permanent bearing could then be installed after removing the upper shoe of the existing bearing. In the present research, first properties of UHPC are summarized followed by evaluation of case studies to check feasibility of the solution to rehabilitate pier cap by using UHPC. The complex load paths in pier cap are idealized by using validated strut and tie model as per prevailing AASHTO LRFD Bridge Design Specification.
