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Unital辛代数的分解(英文)
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作者 白喜梅 刘文丽 《河北大学学报(自然科学版)》 CAS 2002年第3期291-293,共3页
考查了辛代数的分解 ,在此过程中充分运用了辛代数、李三系、李代数的关系 ,建立了三者之间的根基关系 ,并由此证明了unital辛代数的分解 .
关键词 unital辛代数 分解 根基 可解理想 李三系 李代数
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Hermitian unital中的两个无限2-设计族
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作者 李荣荣 詹小秦 《湖北大学学报(自然科学版)》 CAS 2022年第4期496-500,共5页
本研究证明Hermitian unital中以3维特殊射影酉群PSU(3,q)作为旗传递自同构群的两个无限2-设计族的存在性,为旗传递2-设计的分类提供新的分类方法.
关键词 2-设计 Hermitian unital 自同构群 旗传递 PSU(3 q)
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Property T and strong property T for unital*-homomorphisms
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作者 Qing MENG 《Frontiers of Mathematics in China》 SCIE CSCD 2020年第2期385-398,共14页
We introduce and study property T and strong property T for unital*-homomorphisms between two unital C^*-algebras.We also consider the relations between property T and invariant subspaces for some canonical unital^-re... We introduce and study property T and strong property T for unital*-homomorphisms between two unital C^*-algebras.We also consider the relations between property T and invariant subspaces for some canonical unital^-representations.As a corollary,we show that when G is a discrete group,G is finite if and only if G is amenable and the inclusion map i:Cr^*(G)→B(l^2(G))has property T.We also give some new equivalent forms of property T for countable discrete groups and strong property T for unital C^*-algebras. 展开更多
关键词 unital*-homomorphism unital C^*-algebra *-bimodule property T strong property T
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The Ext-Group of Unitary Equivalence Classes of Unital Extensions
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作者 Yi Feng XUE 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2011年第12期2329-2342,共14页
Let A be a unital separable nuclear C*-algebra which belongs to the bootstrap category N and B be a separable stable C*-algebra. In this paper, we consider the group Ext,(A, B) consisting of the unitary equivalenc... Let A be a unital separable nuclear C*-algebra which belongs to the bootstrap category N and B be a separable stable C*-algebra. In this paper, we consider the group Ext,(A, B) consisting of the unitary equivalence classes of unital extensions T: A→ Q(B). The relation between Ext,(A, B) and Ext(A, B) is established. Using this relation, we show the half-exactness of Ext,(-, B) and the (UCT) for Ext,(A, B). Furthermore, under certain conditions, we obtain the half-exactness and Bott periodicity of Extu (A, .). 展开更多
关键词 unital extension multiplier algebra Ext-group quasi-unital -homomorphism
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Approximately unital operator systems
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作者 HUANG XuJian 《Science China Mathematics》 SCIE 2011年第6期1243-1257,共15页
The main theme of this paper is to consider a notion of 'approximately unital operator systems' including both C*-algebras and unital operator systems.The goals are to prove a version of the Choi-Effros theore... The main theme of this paper is to consider a notion of 'approximately unital operator systems' including both C*-algebras and unital operator systems.The goals are to prove a version of the Choi-Effros theorem for these systems,to introduce a functorial process for forming an approximately unital operator systems from a given matrix ordered vector space with a proper approximate order unit,to study second duals of these objects and to prove that a C*-algebra can be characterized as an approximately unital operator system that is also an approximately unital matrix ordered *-algebra. 展开更多
关键词 approximately unital operator systems approximately unital matrix order *-algebras
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Challenges and improvement strategies in the hospitalization of chronic multimorbid patients
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作者 Andres Fontalba-Navas Francisco Pozo Muñoz +4 位作者 Rogelio Garcia Cisneros Maria Jose Garcia Larrosa Maria del Mar Callejon Gil Ignacio Garcia Delgado Maria Belen Jimenez Martinez 《World Journal of Clinical Cases》 SCIE 2025年第3期35-41,共7页
BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot program.Chron... BACKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot program.Chronic diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient outcomes.If proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid patients.AIM To evaluate the effectiveness of the high complexity unit(HCU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital care.METHODS The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.RESULTS The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HCU,the Internal Medicine Service,and other services at Antequera Hospital throughout 2022.The HCU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity post-discharge.CONCLUSION This study demonstrates the effectiveness of the HCU in managing patients with complex chronic diseases through a multidisciplinary approach.The coordinated care provided by the HCU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient complexity.The superiority of the HCU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of care to be replicated. 展开更多
关键词 High complexity unit Chronic multimorbidity Patient-centered care Integrated care Healthcare management
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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit
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作者 Mai-Qing Shi Jun Chen +6 位作者 Fu-Hai Ji Hao Zhou Ke Peng Jun Wang Chun-Lei Fan Xu Wang Yang Wang 《World Journal of Clinical Cases》 SCIE 2025年第7期28-38,共11页
BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevanc... BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains uncertain.AIM To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic shock.METHODS In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were analyzed.Patients were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with normonatremia.Moreover,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of IAH.Notably,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the ICU.It is highly recommended that hypernatremia be considered a potentially important prognostic indicator for the outcome of septic shock. 展开更多
关键词 HYPERNATREMIA Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation IMMUNOSUPPRESSION Catabolism syndrome Chronic critical illness Prognosis
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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice
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作者 Yanli Zhang Tian Li +8 位作者 Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo 《Neural Regeneration Research》 SCIE CAS 2025年第2期533-547,共15页
In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A... In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease. 展开更多
关键词 Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1
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Effect of external and internal cues on core muscle activation during the Sahrmann five-level core stability test
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作者 Skyla Stifter Jessie McCaffrey +2 位作者 Tyler Nichols Ayse Ozcan Edeer Justine Ward 《World Journal of Methodology》 2025年第1期95-104,共10页
BACKGROUND Pain in the back or pelvis or fear of back pain may affect the timing or cocontraction of the core muscles.In both static and dynamic movements,the Sahrmann core stability test provides an assessment of cor... BACKGROUND Pain in the back or pelvis or fear of back pain may affect the timing or cocontraction of the core muscles.In both static and dynamic movements,the Sahrmann core stability test provides an assessment of core muscle activation and a person's ability to stabilize the lumbopelvic complex.Preparatory cues and images can be used to increase the activation of these muscles.To attain optimal movement patterns,it will be necessary to determine what cueing will give the most effective results for core stability.AIM To investigate the effects of external and internal cues on core muscle activation during the Sahrmann five-level core stability test.METHODS Total 68 participants(21.83±3.47 years)were randomly allocated to an external(n=35)or internal cue group(n=33).Participants performed the Sahrmann fivelevel core stability test without a cue as baseline and the five-level stability exercises with an internal or external cue.External cue group received a pressure biofeedback unit(PBU),and the internal cue group received an audio cue.A Delsys Trigno^(TM)surface electromyography unit was used for muscle activation from the rectus abdominis,external oblique,and transverse abdominis/internal oblique muscles.RESULTS Linear mixed effects model analysis showed that cueing had a significant effect on core muscle activation(P=0.001);however,there was no significant difference between cue types(internal or external)(P=0.130).CONCLUSION Both external and internal cueing have significant effects on core muscle activation during the Sahrmann five-level core stability test and the PBU does not create higher muscle activation than internal cueing. 展开更多
关键词 External cue Internal cue Muscle activation Core muscles Lumbopelvic stability Pressure biofeedback unit
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Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation
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作者 Raquel Hohenreuther Andresa ThoméSilveira +4 位作者 Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni 《World Journal of Transplantation》 2025年第1期86-94,共9页
BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To... BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To provide fair organ distribution,predictive mortality scores have been developed.AIM To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of mortality.METHODS Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.RESULTS The transplant recipients were mainly male,with a mean age of 58.1 years.Donors were mostly male,with a mean age of 41.6 years.The median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 days.For APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD 24.2.The 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<0.008.At 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and survivors.As for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients. 展开更多
关键词 Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease MORTALITY Intensive care unit
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Non-Markovianity Measure Based on Brukner–Zeilinger Invariant Information for Unital Quantum Dynamical Maps
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作者 贺志 朱烈强 李莉 《Communications in Theoretical Physics》 SCIE CAS CSCD 2017年第3期255-260,共6页
A non-Markovianity measure based on Brukner–Zeilinger invariant information to characterize nonMarkovian effect of open systems undergoing unital dynamical maps is proposed. The method takes advantage of non-increasi... A non-Markovianity measure based on Brukner–Zeilinger invariant information to characterize nonMarkovian effect of open systems undergoing unital dynamical maps is proposed. The method takes advantage of non-increasing property of the Brukner–Zeilinger invariant information under completely positive and trace-preserving unital maps. The simplicity of computing the Brukner–Zeilinger invariant information is the advantage of the proposed measure because of mainly depending on the purity of quantum state. The measure effectively captures the characteristics of non-Markovianity of unital dynamical maps. As some concrete application, we consider two typical non-Markovian noise channels, i.e., the phase damping channel and the random unitary channel to show the sensitivity of the proposed measure. By investigation, we find that the conditions of detecting the non-Markovianity for the phase damping channel are consistent with the results of existing measures for non-Markovianity, i.e., information flow, divisibility and quantum mutual information. However, for the random unitary channel non-Markovian conditions are same to that of the information flow, but is different from that of the divisibility and quantum mutual information. 展开更多
关键词 non-Markovianity measure Brukner-Zeilinger invariant information unital maps
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Universal C*-algebras Defined by Completely Bounded Unital Homomorphisms
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作者 Wen Hua QIAN Don HADWIN 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2015年第12期1825-1844,共20页
Suppose A is a unital C*-algebra and r 1.In this paper,we define a unital C*-algebra C(cb)*(A,r) and a completely bounded unital homomorphism αr:A → C(cb)*(A,r)with the property that C(cb)*(A,r)=C... Suppose A is a unital C*-algebra and r 1.In this paper,we define a unital C*-algebra C(cb)*(A,r) and a completely bounded unital homomorphism αr:A → C(cb)*(A,r)with the property that C(cb)*(A,r)=C*(αr(A))and,for every unital C*-algebra B and every unital completely bounded homomorphism φ:A→ B,there is a(unique)unital *-homomorphism π:C(cb)*(A,r)→B such thatφ=πoαr.We prove that,if A is generated by a normal set {tλ:λ∈Λ},then C(cb)*(A,r)is generated by the set {αr(tλ):λ∈Λ}.By proving an equation of the norms of elements in a dense subset of C(cb)*(A,r)we obtain that,if Β is a unital C*-algebra that can be embedded into A,then C(cb)*(B,r)can be naturally embedded into C(cb)*(A,r).We give characterizations of C(cb)*(A,r)for some special situations and we conclude that C(cb)*(A,r)will be "nice" when dim(A)≤ 2 and "quite complicated" when dim(A)≥ 3.We give a characterization of the relation between K-groups of A and K-groups of C(cb)*(A,r).We also define and study some analogous of C(cb)*(A,r). 展开更多
关键词 Completely bounded unital homomorphisms universal C*-algebras K-groups
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基于GRU-DRSN的双通道人体活动识别
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作者 邵小强 原泽文 +3 位作者 杨永德 刘士博 李鑫 韩泽辉 《科学技术与工程》 北大核心 2024年第2期676-683,共8页
人体活动识别(human activity recognizition, HAR)在医疗、军工、智能家居等领域有很大的应用空间。传统机器学习方法特征提取难度较大且精度不高。针对上述问题并结合传感器时序特性,提出了一种融合CBAM(convolutional block attentio... 人体活动识别(human activity recognizition, HAR)在医疗、军工、智能家居等领域有很大的应用空间。传统机器学习方法特征提取难度较大且精度不高。针对上述问题并结合传感器时序特性,提出了一种融合CBAM(convolutional block attention module)注意力机制的GRU-DRSN双通道并行模型,有效避免了传统串行模型因网络深度加深引起梯度爆炸和消失问题。同时并行结构使得两条支路具有相同的优先级,使用深度残差收缩网络(deep residual shrinkage network, DRSN)提取数据的深层空间特征,同时使用门控循环结构(gated recurrent unit, GRU)学习活动样本在时间序列上的特征,同时进行提取样本不同维度的特征,并通过CBAM模块进行特征的权重分配,最后通过Softmax层进行识别,实现了端对端的人体活动识别。使用公开数据集(wireless sensor data mining, WISDM)进行验证,模型平均精度达到了97.6%,与传统机器学习模型和前人所提神经网络模型相比,有更好的识别效果。 展开更多
关键词 人体活动识别(human activity recognizition HAR) 门控循环结构(gated recurrent unit GRU) 深度残差收缩网络(deep residual shrinkage network DRSN) CBAM 双通道并行
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基于CAM-YOLOX的大场景SAR图像近岸场景舰船目标检测
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作者 张慧敏 李锋 +1 位作者 黄炜嘉 彭珊珊 《电子测量技术》 北大核心 2024年第6期86-93,共8页
针对大场景SAR图像近岸场景舰船目标检测中遇到的陆地目标虚警和岸边目标漏检等问题,基于YOLOX设计了一种轻量化的改进模型CAM-YOLOX。首先,在骨干部分嵌入CAM,增强舰船特征提取以保持较高的检测性能;其次,在特征金字塔网络结构中增加... 针对大场景SAR图像近岸场景舰船目标检测中遇到的陆地目标虚警和岸边目标漏检等问题,基于YOLOX设计了一种轻量化的改进模型CAM-YOLOX。首先,在骨干部分嵌入CAM,增强舰船特征提取以保持较高的检测性能;其次,在特征金字塔网络结构中增加一个浅层分支,以增强对小目标特征的提取能力;最后,在特征融合网络中用Shuffle unit替换CSPLayer中的CBS和堆叠的Bottleneck结构,实现了模型压缩。在LS-SSDD-v1.0遥感数据集上进行实验,实验结果表明,本文改进算法相较于原始算法在近岸场景舰船检测的精确率P提高了5.51%,召回率R提高了3.68%,模型参数量减小了16.33%。本文算法能在不增加模型参数量的情况下,有效抑制近岸场景中陆地上的虚警和减少岸边舰船漏检率。 展开更多
关键词 近岸场景 SAR图像 舰船检测 注意力机制 Shuffle unit
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Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units 被引量:4
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作者 Yifang Wu Jun Sun +2 位作者 Qi Lin Dapeng Wang Jian Hai 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期887-894,共8页
Upregulation of vascular endothelial growth factor A/basic fibroblast growth factor(VEGFA/b FGF)expression in the penumbra of cerebral ischemia can increase vascular volume,reduce lesion volume,and enhance neural cell... Upregulation of vascular endothelial growth factor A/basic fibroblast growth factor(VEGFA/b FGF)expression in the penumbra of cerebral ischemia can increase vascular volume,reduce lesion volume,and enhance neural cell proliferation and differentiation,thereby exerting neuroprotective effects.However,the beneficial effects of endogenous VEGFA/b FGF are limited as their expression is only transiently increased.In this study,we generated multilayered nanofiber membranes loaded with VEGFA/b FGF using layer-by-layer self-assembly and electrospinning techniques.We found that a membrane containing 10 layers had an ideal ultrastructure and could efficiently and stably release growth factors for more than 1 month.This 10-layered nanofiber membrane promoted brain microvascular endothelial cell tube formation and proliferation,inhibited neuronal apoptosis,upregulated the expression of tight junction proteins,and improved the viability of various cellular components of neurovascular units under conditions of oxygen/glucose deprivation.Furthermore,this nanofiber membrane decreased the expression of Janus kinase-2/signal transducer and activator of transcription-3(JAK2/STAT3),Bax/Bcl-2,and cleaved caspase-3.Therefore,this nanofiber membrane exhibits a neuroprotective effect on oxygen/glucose-deprived neurovascular units by inhibiting the JAK2/STAT3 pathway. 展开更多
关键词 brain ischemia brain microvascular endothelial cell nanofiber membrane neurovascular unit
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基于CVCS的浮法玻璃冷端机械手堆垛系统调度问题
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作者 段雯娟 徐震浩 顾幸生 《华东理工大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第5期708-719,共12页
采用目前生产线上常用的高速堆垛机(High-Speed-Stacker, HSS)和即时分拣机(Pick-on-the-Fly,POF)两种机械手分别堆垛不同规格的玻璃原片,目标是最小化玻璃的废料率。针对切割和抓取自动化过程,提出了一种组合Unit的方法最大化生产效率... 采用目前生产线上常用的高速堆垛机(High-Speed-Stacker, HSS)和即时分拣机(Pick-on-the-Fly,POF)两种机械手分别堆垛不同规格的玻璃原片,目标是最小化玻璃的废料率。针对切割和抓取自动化过程,提出了一种组合Unit的方法最大化生产效率,并在此基础上采用了平衡Unit的优化方法。根据两种类型机械手是否同时工作,提出了混合抓取和分类抓取两种解决方案。最后针对抓取阶段的特点提出了一种组合变异布谷鸟搜索(Combination Variation Cuckoo Search,CVCS)算法,引入了内外逆序和多领域插入变异操作,防止算法陷入局部最优。仿真实验采用响应面分析法对CVCS进行参数标定。并将CVCS与MMGA、BPSO、DABC、CS算法进行了对比分析,实验结果验证了CVCS算法解决该问题的优越性。 展开更多
关键词 堆垛系统 平衡Unit 混合抓取 分类抓取 响应面分析法
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Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease:beyond the role of amyloid beta 被引量:3
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作者 Madia Lozupone Francesco Panza 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期80-83,共4页
The impact of apolipoprotein E(ApoE)isoforms on sporadic Alzheimer's disease has long been studied;however,the influences of apolipoprotein E gene(APOE)on healthy and pathological human brains are not fully unders... The impact of apolipoprotein E(ApoE)isoforms on sporadic Alzheimer's disease has long been studied;however,the influences of apolipoprotein E gene(APOE)on healthy and pathological human brains are not fully understood.ApoE exists as three common isoforms(ApoE2,ApoE3,and ApoE4),which differ in two amino acid residues.Traditionally,ApoE binds cholesterol and phospholipids and ApoE isoforms display diffe rent affinities for their receptors,lipids transport and distribution in the brain and periphery.The role of ApoE in the human depends on ApoE isoforms,brain regions,aging,and neural injury.APOE E4 is the strongest genetic risk factor for sporadic Alzheimer's disease,considering its role in influencing amyloid-beta metabolism.The exact mechanisms by which APOE gene variants may increase or decrease Alzheimer's disease risk are not fully understood,but APOE was also known to affect directly and indirectly tau-mediated neurodegeneration,lipids metabolism,neurovascular unit,and microglial function.Consistent with the biological function of ApoE,ApoE4 isoform significantly alte red signaling pathways associated with cholesterol homeostasis,transport,and myelination.Also,the rare protective APOE variants confirm that ApoE plays an important role in Alzheimer's disease pathogenesis.The objectives of the present mini-review were to describe classical and new roles of various ApoE isoforms in Alzheimer's disease pathophysiology beyond the deposition of amyloid-beta and to establish a functional link between APOE,brain function,and memory,from a molecular to a clinical level.APOE genotype also exerted a heterogeneous effect on clinical Alzheimer's disease phenotype and its outcomes.Not only in learning and memory but also in neuro psychiatric symptoms that occur in a premorbid condition.Cla rifying the relationships between Alzheimer's disease-related pathology with neuropsychiatric symptoms,particularly suicidal ideation in Alzheimer's disease patients,may be useful for elucidating also the underlying pathophysiological process and its prognosis.Also,the effects of anti-amyloid-beta drugs,recently approved for the treatment of Alzheimer's disease,could be influenced by the APOE genotype. 展开更多
关键词 Alzheimer's disease AMYLOID-BETA apolipoprotein E DEMENTIA glymphatic transport LIPIDS neuropsychiatric symptoms neurovascular unit tau protein
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Blood-brain barrier pathology in cerebral small vessel disease 被引量:5
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作者 Ruxue Jia Gemma Solé-Guardia Amanda J.Kiliaan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1233-1240,共8页
Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly.Although at first it was considered innocuous,small vessel disease is no... Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly.Although at first it was considered innocuous,small vessel disease is nowadays regarded as one of the major vascular causes of dementia.Radiological signs of small vessel disease include small subcortical infarcts,white matter magnetic resonance imaging hyperintensities,lacunes,enlarged perivascular spaces,cerebral microbleeds,and brain atrophy;however,great heterogeneity in clinical symptoms is observed in small vessel disease patients.The pathophysiology of these lesions has been linked to multiple processes,such as hypoperfusion,defective cerebrovascular reactivity,and blood-brain barrier dysfunction.Notably,studies on small vessel disease suggest that blood-brain barrier dysfunction is among the earliest mechanisms in small vessel disease and might contribute to the development of the hallmarks of small vessel disease.Therefore,the purpose of this review is to provide a new foundation in the study of small vessel disease pathology.First,we discuss the main structural domains and functions of the blood-brain barrier.Secondly,we review the most recent evidence on blood-brain barrier dysfunction linked to small vessel disease.Finally,we conclude with a discussion on future perspectives and propose potential treatment targets and interventions. 展开更多
关键词 blood-brain barrier dysfunction cerebral blood flow cerebral hypoperfusion endothelial dysfunction HYPERTENSION inflammation magnetic resonance imaging neurovascular unit oxidative stress small vessel disease tight junctions TRANSCYTOSIS
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Assessment of Wet Season Precipitation in the Central United States by the Regional Climate Simulation of the WRFG Member in NARCCAP and Its Relationship with Large-Scale Circulation Biases 被引量:1
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作者 Yating ZHAO Ming XUE +2 位作者 Jing JIANG Xiao-Ming HU Anning HUANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第4期619-638,共20页
Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional climate.Here,we assess the performance and discuss pos... Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional climate.Here,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are available.The RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of precipitation.This dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the simulation.Inaccuracy in reproducing large-scale circulation and environmental conditions is another contributing factor.The too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great Plains.The simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as well.Therefore,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios. 展开更多
关键词 NARCCAP Central United States PRECIPITATION low-level jet large-scale environment diurnal variation
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Reducing Operation Emissions and Improving Work Efficiency Using a Pure Electric Wheel Drive Tractor 被引量:1
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作者 Chang-Kai Wen Wen Ren +5 位作者 Qing-Zhen Zhu Chun-Jiang Zhao Zhen-Hao Luo Sheng-Li Zhang Bin Xie Zhi-Jun Meng 《Engineering》 SCIE EI CAS CSCD 2024年第6期230-245,共16页
In response to the problems of excessive greenhouse-gas and particulate emissions and the low traction efficiency of conventional diesel tractors in the field,a purely electric wheel-side drive tractor was studied,inc... In response to the problems of excessive greenhouse-gas and particulate emissions and the low traction efficiency of conventional diesel tractors in the field,a purely electric wheel-side drive tractor was studied,including an electric motor drive system,a battery ballast system,and an electro–hydraulic suspension system.This paper develops a dynamics model of an electric tractor-ploughing unit under complex soil conditions,leading to the proposal of an active control method for drive wheel torque and a joint control method for the traction force of the suspension system and the front-and rear-axle loads of a tractor.Finally,the tractor is prototyped and assembled,and ploughing tests are carried out.The ploughing results show that the active torque-distribution control method proposed in this study reduces the tractor slip by 14.83%and increases the traction efficiency by 10.28%compared with the average torquedistribution mode.Compared with the conventional traction control mode,the joint control method for traction and ballast proposed in this paper results in a 3.7%increase in traction efficiency,a 15.05%decrease in slip,and a 4.9%reduction in total drive motor energy consumption.This study will help to improve the operation quality and traction efficiency of electric tractors in complex soil conditions. 展开更多
关键词 Electric tractor Ploughing unit Torque distribution Active ballast Traction performance
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