非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病,其定义为肝脏脂肪富集超过肝脏重量的5%至10%。疾病的演变过程可以从脂肪蓄积开始,逐渐进展为脂肪肝炎,肝硬化,最终可能导致肝衰竭甚至肝细胞癌的发生。肥胖伴随胰岛素抵抗、2型糖尿...非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病,其定义为肝脏脂肪富集超过肝脏重量的5%至10%。疾病的演变过程可以从脂肪蓄积开始,逐渐进展为脂肪肝炎,肝硬化,最终可能导致肝衰竭甚至肝细胞癌的发生。肥胖伴随胰岛素抵抗、2型糖尿病、高脂血症和代谢综合征是其主要危险因素。目前,西药治疗NAFLD主要采用水飞蓟宾胶囊、多烯磷脂酰胆碱等常规药物。中医药在治疗NAFLD方面具有很大优势。本文总结概述了中药内服、中医特色疗法以及中西医结合治疗的进展,旨在为治疗NAFLD提供参考和思路。Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is defined as an enrichment of liver fat in excess of 5 to 10 per cent of liver weight. The evolution of the disease can start with fat accumulation and progress to steatohepatitis, cirrhosis, which may eventually lead to liver failure and even hepatocellular carcinoma. Obesity accompanied by insulin resistance, type 2 diabetes mellitus, hyperlipidaemia and metabolic syndrome is its major risk factor. Currently, western medicine is mainly used in the treatment of NAFLD with conventional drugs such as silymarin capsules and polyene phosphatidylcholine. Chinese medicine has great advantages in the treatment of NAFLD. This article summarizes and outlines the progress of internal administration of Chinese medicines, characteristic therapies of Chinese medicine as well as the combination of Chinese and Western medicines, aiming to provide references and ideas for the treatment of NAFLD.展开更多
原发性痛经是妇科常见疾病,其特点是周期性的下腹部疼痛,或伴有腰骶酸痛、恶心呕吐等症状,给患者身心健康及生活质量带来严重负面影响。药物治疗是应对原发性痛经的主要干预措施,但非甾体抗炎药存在副作用大、停药易反复等缺点。原发性...原发性痛经是妇科常见疾病,其特点是周期性的下腹部疼痛,或伴有腰骶酸痛、恶心呕吐等症状,给患者身心健康及生活质量带来严重负面影响。药物治疗是应对原发性痛经的主要干预措施,但非甾体抗炎药存在副作用大、停药易反复等缺点。原发性痛经属于中医“经行腹痛”范畴,祖国医学在治疗原发性痛经方面积累了丰富的经验,包括内服法和外治法,疗效显著且毒副作用小。近年来,大量动物或组织细胞模型实验研究发现,中医药防治原发性痛经发生进展的作用机制与多信号通路密切相关,包括MAPK/ERK、PI3K/Akt/mTOR、TLR4/MyD88/NF-κB、COX-2/PGF2a、EP2/NLRP3/caspase-1等信号通路,中医药的调控作用已成为大量研究的焦点,本文综述近年来的研究成果,以期为原发性痛经的临床治疗及中医药防治原发性痛经的作用机制提供思路和参考。Primary dysmenorrhea is a common gynecological disease, which is characterized by periodic lower abdominal pain, or accompanied by lumbosacral pain, nausea and vomiting and other symptoms, which has a serious negative impact on the physical and mental health and quality of life of patients. Drug therapy is the main intervention for primary dysmenorrhea, but NSAIDs have the disadvantages of large side effects and easy recurrence of drug withdrawal. Primary dysmenorrhea belongs to the category of “menstrual abdominal pain” in traditional Chinese medicine, and Chinese medicine has accumulated rich experience in the treatment of primary dysmenorrhea, including internal and external treatment, with significant efficacy and few toxic side effects. In recent years, a large number of experimental studies in animal or tissue cell models have found that the mechanism of action of TCM in the prevention and treatment of the progression of primary dysmenorrhea is closely related to multiple signaling pathways, including MAPK/ERK, PI3K/Akt/mTOR, TLR4/MyD88/NF-κB, COX-2/PGF2a and other signaling pathways, the regulatory role of traditional Chinese medicine has become the focus of a large number of researches. This article reviews the research results in recent years, in order to provide ideas and references for the clinical treatment of primary dysmenorrhea and the mechanism of action of traditional Chinese medicine in the prevention and treatment of primary dysmenorrhea.展开更多
文摘非酒精性脂肪性肝病(NAFLD)是全球最常见的慢性肝病,其定义为肝脏脂肪富集超过肝脏重量的5%至10%。疾病的演变过程可以从脂肪蓄积开始,逐渐进展为脂肪肝炎,肝硬化,最终可能导致肝衰竭甚至肝细胞癌的发生。肥胖伴随胰岛素抵抗、2型糖尿病、高脂血症和代谢综合征是其主要危险因素。目前,西药治疗NAFLD主要采用水飞蓟宾胶囊、多烯磷脂酰胆碱等常规药物。中医药在治疗NAFLD方面具有很大优势。本文总结概述了中药内服、中医特色疗法以及中西医结合治疗的进展,旨在为治疗NAFLD提供参考和思路。Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is defined as an enrichment of liver fat in excess of 5 to 10 per cent of liver weight. The evolution of the disease can start with fat accumulation and progress to steatohepatitis, cirrhosis, which may eventually lead to liver failure and even hepatocellular carcinoma. Obesity accompanied by insulin resistance, type 2 diabetes mellitus, hyperlipidaemia and metabolic syndrome is its major risk factor. Currently, western medicine is mainly used in the treatment of NAFLD with conventional drugs such as silymarin capsules and polyene phosphatidylcholine. Chinese medicine has great advantages in the treatment of NAFLD. This article summarizes and outlines the progress of internal administration of Chinese medicines, characteristic therapies of Chinese medicine as well as the combination of Chinese and Western medicines, aiming to provide references and ideas for the treatment of NAFLD.
文摘原发性痛经是妇科常见疾病,其特点是周期性的下腹部疼痛,或伴有腰骶酸痛、恶心呕吐等症状,给患者身心健康及生活质量带来严重负面影响。药物治疗是应对原发性痛经的主要干预措施,但非甾体抗炎药存在副作用大、停药易反复等缺点。原发性痛经属于中医“经行腹痛”范畴,祖国医学在治疗原发性痛经方面积累了丰富的经验,包括内服法和外治法,疗效显著且毒副作用小。近年来,大量动物或组织细胞模型实验研究发现,中医药防治原发性痛经发生进展的作用机制与多信号通路密切相关,包括MAPK/ERK、PI3K/Akt/mTOR、TLR4/MyD88/NF-κB、COX-2/PGF2a、EP2/NLRP3/caspase-1等信号通路,中医药的调控作用已成为大量研究的焦点,本文综述近年来的研究成果,以期为原发性痛经的临床治疗及中医药防治原发性痛经的作用机制提供思路和参考。Primary dysmenorrhea is a common gynecological disease, which is characterized by periodic lower abdominal pain, or accompanied by lumbosacral pain, nausea and vomiting and other symptoms, which has a serious negative impact on the physical and mental health and quality of life of patients. Drug therapy is the main intervention for primary dysmenorrhea, but NSAIDs have the disadvantages of large side effects and easy recurrence of drug withdrawal. Primary dysmenorrhea belongs to the category of “menstrual abdominal pain” in traditional Chinese medicine, and Chinese medicine has accumulated rich experience in the treatment of primary dysmenorrhea, including internal and external treatment, with significant efficacy and few toxic side effects. In recent years, a large number of experimental studies in animal or tissue cell models have found that the mechanism of action of TCM in the prevention and treatment of the progression of primary dysmenorrhea is closely related to multiple signaling pathways, including MAPK/ERK, PI3K/Akt/mTOR, TLR4/MyD88/NF-κB, COX-2/PGF2a and other signaling pathways, the regulatory role of traditional Chinese medicine has become the focus of a large number of researches. This article reviews the research results in recent years, in order to provide ideas and references for the clinical treatment of primary dysmenorrhea and the mechanism of action of traditional Chinese medicine in the prevention and treatment of primary dysmenorrhea.
