目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/t...目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/topical/intra-wound”,“spine/spinal/lumbar/cervical/thoracolumbar surgery”,“infection”,“SSI”,“脊柱”,“腰椎”,“颈椎”,“手术”,“万古霉素”,“感染”等关键词查找相关术中预防性应用万古霉素粉末对术后感染发生率影响方面的病例对照研究论文,并利用Revman5.3荟萃分析软件比较文献中总体感染率,并按不同亚组分析是否应用万古霉素对不同部位、不同类型的脊柱手术的感染率的影响。结果:共查出论文1713篇,其中病例对照试验有38篇,最后筛选出符合要求的文献25篇;有25个研究比较了预防性使用万古霉素粉末对脊柱手术后感染率的影响。总病例16,688例,其中预防性使用万古霉素组7048例,对照组9640例。其荟萃分析结果提示术中预防性使用万古霉素粉末后术后出现感染的可能性为不使用万古霉素时的0.38倍,二者之间的差异有显著性(P Objective: To systematically evaluate the effect of this method in reducing the infection rate after spinal surgery by reviewing the comparative literature of prophylactic vancomycin powder surgery, so as to provide a basis for future clinical work. Methods: Pubmed, Medline, Elseveir, Wanfang, CNKI and other databases, with the following methods: “vancomycin”, “local/intraoperative/topical/intra-wound”, “spine/spinal/lumbar/cervical/thoracolumbar surgery”, “infection”, “SSI”, “spine”, “lumbar spine”, “cervical spine”, “surgery”, “vancomycin”, “infection” and other keywords were used to find case-control research papers on the effect of intraoperative prophylactic vancomycin powder on the incidence of postoperative infection, and the Revman5.3 meta-analysis software was used to compare the overall infection rate in the literature, and the effect of vancomycin application on the infection rate of different parts and different types of spine surgery was analyzed according to different subgroups. Results: A total of 1713 papers were identified, including 38 case-control trials, and 25 papers were screened to meet the requirements. Twenty-five studies compared the effect of prophylactic use of vancomycin powder on infection rates after spinal surgery. The total number of cases was 16,688, including 7048 cases in the prophylactic vancomycin group and 9640 cases in the control group. The results of meta-analysis showed that the probability of postoperative infection after intraoperative prophylactic use of vancomycin powder was 0.38 times higher than that of vancomycin without vancomycin, and the difference between the two was significant (P < 0.01). At the same time, the incidence of infection after vancomycin was 0.28 times higher (0.17, 0.45) than that of vancomycin in patients treated with internal fixation (P < 0.01). However, vancomycin utilization in patients without internal fixation had no significant effect on postoperative infection (P = 0.61). Conclusion: The local prophylactic use of vancomycin powder in spine surgery can significantly reduce the incidence of postoperative infection, and this effect is more obvious in patients with internal fixation, which can be popularized and applied in clinical practice of spine surgery.展开更多
目的:比较前路与后路手术治疗胸腰椎结核的临床效果。方法:收集2021年1月至2023年6月在我院收住接受前路和后路治疗的40例胸腰椎感染性疾病患者的临床资料进行回顾性研究。根据两种术式不同,将患者分为两组。两组分别为前路组(n = 20)...目的:比较前路与后路手术治疗胸腰椎结核的临床效果。方法:收集2021年1月至2023年6月在我院收住接受前路和后路治疗的40例胸腰椎感染性疾病患者的临床资料进行回顾性研究。根据两种术式不同,将患者分为两组。两组分别为前路组(n = 20)和后路组(n = 20)。前路组和后路组疗效的影响进行统计分析,两组一般资料包括:患者性别、年龄、身体质量指数、受累节段、吸烟史及既往史等。结果:术前资料:两组患者年龄,性别,身体质量指数,受累节段,既往史(心脑血管疾病、呼吸系统疾病、内分泌系统疾病、代谢性疾病及结核病史),吸烟史,饮酒史,腰部VAS评分,腰部ODI评分及JOA评分等指标均无统计学差异(P > 0.05)。两组患者术后1月和末次随访腰部VAS评分相比差异均无显著性意义(P > 0.05);两组患者术后3月腰部VAS评分相比差异有显著性意义(P 0.05)。两组患者术后发生硬脊膜撕裂、下肢肌间静脉血栓、下肢深静脉血栓、切口感染、窦道形成及术后复发率相比差异均无显著性意义(P > 0.05),上述数据结果提示两种手术安全性方面无差异。前路组手术时间为121.50 ± 54.63,后路组为111.75 ± 49.84,后路组手术时间明显少于前路组组,两组间差异有统计学意义(t = 0.590, P > 0.05);后路组术中出血量为197.50 ± 92.95,前路组为314.00 ± 131.76,后路组术中出血量明显少于前路组,两组间差异有统计学意义(t = 3.231, P 0.05)。结论:前路手术和后路手术在治疗脊柱感染性疾病时,均被视为有效的治疗方式选择。这两种手术方法各有其特点,但它们在安全性和疗效性上并无显著的差异。Objective: To compare the clinical effects of anterior and posterior surgery in the treatment of thoracolumbar tuberculosis. Methods: The clinical data of 40 patients receiving anterior and posterior treatment for thoracolumbar infectious disease from January 2021 to June 2023 were collected for retrospective study. Patients were divided into two groups according on the two different procedures. The two groups were anterior group (n = 20) and posterior group (n = 20). The effect of efficacy in the anterior and posterior groups was analyzed statistically. General data in the two groups included patient gender, age, body mass index, affected segments, smoking history and past history. Results: preoperative data: two groups of patient’s age, gender, body mass index, affected segments, past history (cardiovascular and cerebrovascular disease, respiratory diseases, endocrine system disease, metabolic disease and tuberculosis history), smoking history, drinking history, waist VAS score, waist ODI score and JOA score are no statistical difference (P > 0.05). No difference in lumbar VAS scores between 1 month and last follow-up (P > 0.05);the difference between lumbar VAS scores was significant (P 0.05). There were no significant differences in dural tear, intermuscular venous thrombosis, deep vein thrombosis, incision infection, sinus formation and postoperative recurrence rate (P > 0.05). The above data suggest no difference in the safety of the two procedures. The operation time was 121.50 ± 54.63, 111.75 ± 49.84, posterior and less (t = 0.590, P > 0.05);197.50 ± 92.95, and 314.00 ± 131.76 in the anterior group (t = 3.231, P 0.05). Conclusion: Both anterior surgery and posterior surgery are considered as effective treatment options in the treatment of spinal infections. These two surgical methods each have their own characteristics, but there is no significant difference in their safety and efficacy.展开更多
丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现...丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析;该领域发表研究论文最多的国家是中国,美国和澳大利亚,而发表论文最多的机构为中国医科大学,中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高,研究类型主要以应用基础研究,临床研究和技术开发为主,出现频率最多的关键词为凋亡,表达,激活,氧化应激,炎症反应等,体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分,显示出广泛的临床应用前景,而当前研究的局限性和挑战需要我们在未来的研究中予以重视,通过多学科合作和创新研究方法,共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in cardiovascular diseases and nervous system diseases, and the research types are mainly applied basic research, clinical research and technology development, and the most frequent keywords are apoptosis, expression, activation, oxidative stress, inflammatory response, etc., reflecting its research enthusiasm and clinical application value in these fields. As a traditional Chinese medicine ingredient with multiple pharmacological activities, tanshinone IIA has shown a wide range of clinical application prospects, but the limitations and challenges of current research need to be paid attention to in future research, and jointly promote the further application and development of tanshinone IIA in disease treatment through multidisciplinary cooperation and innovative research methods.展开更多
丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗...丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗中,TanIIA已经显示出了一定的疗效,但其具体的作用机制尚未完全阐明。基于现有的研究成果,我们推测TanIIA可能通过多种药理途径,包括抗炎、抗氧化、抗细胞凋亡以及保护血管,来促进脊髓损伤后的神经细胞存活和修复。Tanshinone IIA, also known as TanIIA, plays multiple roles in the metabolic process of living organisms, and its products can affect a variety of biochemical reactions. In these reactions, TanIIA is sometimes involved as a coenzyme, and sometimes it may facilitate or interfere with these reaction processes, thus exhibiting diverse pharmacological properties. Although TanIIA has shown some efficacy in the treatment of neurological diseases such as spinal cord injury, its specific mechanism of action has not been fully elucidated. Based on the existing research results, we speculate that TanIIA may promote the survival and repair of nerve cells after spinal cord injury through multiple pharmacological pathways, including anti-inflammatory, antioxidant, anti-apoptosis, and vascular protection.展开更多
腰椎间盘突出症是一种常见的脊柱疾病,教育患者对疾病和康复的理解至关重要。本综述探讨了不同健康教育模型在腰椎间盘突出症患者教育中的应用。Teachback法和思维导图等交互式教育模式能提高患者对康复信息的理解和记忆,增强自我管理...腰椎间盘突出症是一种常见的脊柱疾病,教育患者对疾病和康复的理解至关重要。本综述探讨了不同健康教育模型在腰椎间盘突出症患者教育中的应用。Teachback法和思维导图等交互式教育模式能提高患者对康复信息的理解和记忆,增强自我管理能力。然而,应用这些方法在实际临床中面临着一些挑战和限制,包括培训医务人员需具备高技能水平、需要更多资源和时间,以及个体差异可能影响教育效果。未来研究需关注长期效果和实际应用的可行性,以优化腰椎间盘突出症患者的健康教育策略。选择适当的健康教育模型应考虑患者的需求,以提升康复效果和患者满意度。Lumbar disc herniation is a common spinal disorder, and educating patients about the disease and rehabilitation is crucial. This review examines the application of different health education models in the education of patients with lumbar disc herniation. Interactive education models such as the Teachback method and mind mapping can improve patients’ understanding and retention of rehabilitation information and enhance self-management skills. However, the application of these methods faces some challenges and limitations in actual clinical practice, including the need for a high skill level to train medical staff, the need for more resources and time, and the possibility that individual differences may affect educational outcomes. Future studies need to focus on the long-term effects and feasibility of practical application to optimize health education strategies for patients with lumbar disc herniation. Selection of appropriate health education models should take into account the needs of patients to enhance rehabilitation outcomes and patient satisfaction.展开更多
文摘目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/topical/intra-wound”,“spine/spinal/lumbar/cervical/thoracolumbar surgery”,“infection”,“SSI”,“脊柱”,“腰椎”,“颈椎”,“手术”,“万古霉素”,“感染”等关键词查找相关术中预防性应用万古霉素粉末对术后感染发生率影响方面的病例对照研究论文,并利用Revman5.3荟萃分析软件比较文献中总体感染率,并按不同亚组分析是否应用万古霉素对不同部位、不同类型的脊柱手术的感染率的影响。结果:共查出论文1713篇,其中病例对照试验有38篇,最后筛选出符合要求的文献25篇;有25个研究比较了预防性使用万古霉素粉末对脊柱手术后感染率的影响。总病例16,688例,其中预防性使用万古霉素组7048例,对照组9640例。其荟萃分析结果提示术中预防性使用万古霉素粉末后术后出现感染的可能性为不使用万古霉素时的0.38倍,二者之间的差异有显著性(P Objective: To systematically evaluate the effect of this method in reducing the infection rate after spinal surgery by reviewing the comparative literature of prophylactic vancomycin powder surgery, so as to provide a basis for future clinical work. Methods: Pubmed, Medline, Elseveir, Wanfang, CNKI and other databases, with the following methods: “vancomycin”, “local/intraoperative/topical/intra-wound”, “spine/spinal/lumbar/cervical/thoracolumbar surgery”, “infection”, “SSI”, “spine”, “lumbar spine”, “cervical spine”, “surgery”, “vancomycin”, “infection” and other keywords were used to find case-control research papers on the effect of intraoperative prophylactic vancomycin powder on the incidence of postoperative infection, and the Revman5.3 meta-analysis software was used to compare the overall infection rate in the literature, and the effect of vancomycin application on the infection rate of different parts and different types of spine surgery was analyzed according to different subgroups. Results: A total of 1713 papers were identified, including 38 case-control trials, and 25 papers were screened to meet the requirements. Twenty-five studies compared the effect of prophylactic use of vancomycin powder on infection rates after spinal surgery. The total number of cases was 16,688, including 7048 cases in the prophylactic vancomycin group and 9640 cases in the control group. The results of meta-analysis showed that the probability of postoperative infection after intraoperative prophylactic use of vancomycin powder was 0.38 times higher than that of vancomycin without vancomycin, and the difference between the two was significant (P < 0.01). At the same time, the incidence of infection after vancomycin was 0.28 times higher (0.17, 0.45) than that of vancomycin in patients treated with internal fixation (P < 0.01). However, vancomycin utilization in patients without internal fixation had no significant effect on postoperative infection (P = 0.61). Conclusion: The local prophylactic use of vancomycin powder in spine surgery can significantly reduce the incidence of postoperative infection, and this effect is more obvious in patients with internal fixation, which can be popularized and applied in clinical practice of spine surgery.
文摘目的:比较前路与后路手术治疗胸腰椎结核的临床效果。方法:收集2021年1月至2023年6月在我院收住接受前路和后路治疗的40例胸腰椎感染性疾病患者的临床资料进行回顾性研究。根据两种术式不同,将患者分为两组。两组分别为前路组(n = 20)和后路组(n = 20)。前路组和后路组疗效的影响进行统计分析,两组一般资料包括:患者性别、年龄、身体质量指数、受累节段、吸烟史及既往史等。结果:术前资料:两组患者年龄,性别,身体质量指数,受累节段,既往史(心脑血管疾病、呼吸系统疾病、内分泌系统疾病、代谢性疾病及结核病史),吸烟史,饮酒史,腰部VAS评分,腰部ODI评分及JOA评分等指标均无统计学差异(P > 0.05)。两组患者术后1月和末次随访腰部VAS评分相比差异均无显著性意义(P > 0.05);两组患者术后3月腰部VAS评分相比差异有显著性意义(P 0.05)。两组患者术后发生硬脊膜撕裂、下肢肌间静脉血栓、下肢深静脉血栓、切口感染、窦道形成及术后复发率相比差异均无显著性意义(P > 0.05),上述数据结果提示两种手术安全性方面无差异。前路组手术时间为121.50 ± 54.63,后路组为111.75 ± 49.84,后路组手术时间明显少于前路组组,两组间差异有统计学意义(t = 0.590, P > 0.05);后路组术中出血量为197.50 ± 92.95,前路组为314.00 ± 131.76,后路组术中出血量明显少于前路组,两组间差异有统计学意义(t = 3.231, P 0.05)。结论:前路手术和后路手术在治疗脊柱感染性疾病时,均被视为有效的治疗方式选择。这两种手术方法各有其特点,但它们在安全性和疗效性上并无显著的差异。Objective: To compare the clinical effects of anterior and posterior surgery in the treatment of thoracolumbar tuberculosis. Methods: The clinical data of 40 patients receiving anterior and posterior treatment for thoracolumbar infectious disease from January 2021 to June 2023 were collected for retrospective study. Patients were divided into two groups according on the two different procedures. The two groups were anterior group (n = 20) and posterior group (n = 20). The effect of efficacy in the anterior and posterior groups was analyzed statistically. General data in the two groups included patient gender, age, body mass index, affected segments, smoking history and past history. Results: preoperative data: two groups of patient’s age, gender, body mass index, affected segments, past history (cardiovascular and cerebrovascular disease, respiratory diseases, endocrine system disease, metabolic disease and tuberculosis history), smoking history, drinking history, waist VAS score, waist ODI score and JOA score are no statistical difference (P > 0.05). No difference in lumbar VAS scores between 1 month and last follow-up (P > 0.05);the difference between lumbar VAS scores was significant (P 0.05). There were no significant differences in dural tear, intermuscular venous thrombosis, deep vein thrombosis, incision infection, sinus formation and postoperative recurrence rate (P > 0.05). The above data suggest no difference in the safety of the two procedures. The operation time was 121.50 ± 54.63, 111.75 ± 49.84, posterior and less (t = 0.590, P > 0.05);197.50 ± 92.95, and 314.00 ± 131.76 in the anterior group (t = 3.231, P 0.05). Conclusion: Both anterior surgery and posterior surgery are considered as effective treatment options in the treatment of spinal infections. These two surgical methods each have their own characteristics, but there is no significant difference in their safety and efficacy.
文摘丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析;该领域发表研究论文最多的国家是中国,美国和澳大利亚,而发表论文最多的机构为中国医科大学,中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高,研究类型主要以应用基础研究,临床研究和技术开发为主,出现频率最多的关键词为凋亡,表达,激活,氧化应激,炎症反应等,体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分,显示出广泛的临床应用前景,而当前研究的局限性和挑战需要我们在未来的研究中予以重视,通过多学科合作和创新研究方法,共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in cardiovascular diseases and nervous system diseases, and the research types are mainly applied basic research, clinical research and technology development, and the most frequent keywords are apoptosis, expression, activation, oxidative stress, inflammatory response, etc., reflecting its research enthusiasm and clinical application value in these fields. As a traditional Chinese medicine ingredient with multiple pharmacological activities, tanshinone IIA has shown a wide range of clinical application prospects, but the limitations and challenges of current research need to be paid attention to in future research, and jointly promote the further application and development of tanshinone IIA in disease treatment through multidisciplinary cooperation and innovative research methods.
文摘丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗中,TanIIA已经显示出了一定的疗效,但其具体的作用机制尚未完全阐明。基于现有的研究成果,我们推测TanIIA可能通过多种药理途径,包括抗炎、抗氧化、抗细胞凋亡以及保护血管,来促进脊髓损伤后的神经细胞存活和修复。Tanshinone IIA, also known as TanIIA, plays multiple roles in the metabolic process of living organisms, and its products can affect a variety of biochemical reactions. In these reactions, TanIIA is sometimes involved as a coenzyme, and sometimes it may facilitate or interfere with these reaction processes, thus exhibiting diverse pharmacological properties. Although TanIIA has shown some efficacy in the treatment of neurological diseases such as spinal cord injury, its specific mechanism of action has not been fully elucidated. Based on the existing research results, we speculate that TanIIA may promote the survival and repair of nerve cells after spinal cord injury through multiple pharmacological pathways, including anti-inflammatory, antioxidant, anti-apoptosis, and vascular protection.
文摘腰椎间盘突出症是一种常见的脊柱疾病,教育患者对疾病和康复的理解至关重要。本综述探讨了不同健康教育模型在腰椎间盘突出症患者教育中的应用。Teachback法和思维导图等交互式教育模式能提高患者对康复信息的理解和记忆,增强自我管理能力。然而,应用这些方法在实际临床中面临着一些挑战和限制,包括培训医务人员需具备高技能水平、需要更多资源和时间,以及个体差异可能影响教育效果。未来研究需关注长期效果和实际应用的可行性,以优化腰椎间盘突出症患者的健康教育策略。选择适当的健康教育模型应考虑患者的需求,以提升康复效果和患者满意度。Lumbar disc herniation is a common spinal disorder, and educating patients about the disease and rehabilitation is crucial. This review examines the application of different health education models in the education of patients with lumbar disc herniation. Interactive education models such as the Teachback method and mind mapping can improve patients’ understanding and retention of rehabilitation information and enhance self-management skills. However, the application of these methods faces some challenges and limitations in actual clinical practice, including the need for a high skill level to train medical staff, the need for more resources and time, and the possibility that individual differences may affect educational outcomes. Future studies need to focus on the long-term effects and feasibility of practical application to optimize health education strategies for patients with lumbar disc herniation. Selection of appropriate health education models should take into account the needs of patients to enhance rehabilitation outcomes and patient satisfaction.
