卵巢畸胎瘤是卵巢生殖细胞肿瘤中最常见的良性肿瘤,卵巢囊性畸胎瘤又称成熟性囊性畸胎瘤,是常见的畸胎瘤类型。卵巢畸胎瘤的内容物可由2~3个胚层的组织形成,含有皮肤及其附件、毛发、牙齿、神经、脂肪、骨骼等。虽然这些成分在理论上可...卵巢畸胎瘤是卵巢生殖细胞肿瘤中最常见的良性肿瘤,卵巢囊性畸胎瘤又称成熟性囊性畸胎瘤,是常见的畸胎瘤类型。卵巢畸胎瘤的内容物可由2~3个胚层的组织形成,含有皮肤及其附件、毛发、牙齿、神经、脂肪、骨骼等。虽然这些成分在理论上可以来自任何胚层,但实际上,完整地包含各种组织的畸胎瘤较为罕见。本文报道了一例合并美尼尔氏综合征、高血压、肥胖、II型糖尿病的女性患者,经过超声影像学提示卵巢畸胎瘤并手术治疗后发现畸胎瘤中含有皮肤、毛发、骨骼、牙齿、甲状腺组织的特殊病例。关于您提到的具体病例,即合并美尼尔氏综合征、高血压、肥胖、II型糖尿病的女性患者,超声影像学提示卵巢畸胎瘤,并在手术治疗后发现畸胎瘤中含有皮肤、毛发、骨骼、牙齿、甲状腺组织,这在临床诊疗中确实是一种罕见的病例。Ovarian teratoma is the most common benign tumor among ovarian germ cell tumors, and ovarian cystic teratoma, also known as mature cystic teratoma, is the most common type of teratoma. The contents of ovarian teratomas can be formed by tissues from two or three germ layers, including skin and its appendages, hair, teeth, nerves, fat, bones, etc. Although theoretically, these components can come from any germ layer, teratomas that fully contain various tissues are rare in practice. This article reports a special case of a female patient with Meniere’s syndrome, hypertension, obesity, and type II diabetes. Ultrasound imaging suggested an ovarian teratoma, and after surgical treatment, the teratoma was found to contain skin, hair, bones, teeth, and thyroid tissue. Regarding the specific case you mentioned, a female patient with Meniere’s syndrome, hypertension, obesity, and type II diabetes, in which ultrasound imaging suggested an ovarian teratoma, and post-surgery revealed the presence of skin, hair, bones, teeth, and thyroid tissue, this indeed represents a rare case in clinical practice.展开更多
目的探讨多囊卵巢综合征(PCOS)卵巢间质血流变化特点,分析其与胰岛素抵抗(IR)、血管内皮生长因子(VEGF)、内皮抑素(ES)的相关性。方法选择PCOS女性患者148例作为疾病组,年龄22~35岁,平均年龄28.98岁;体质量指数19.89~29.30 kg/m^(2),平...目的探讨多囊卵巢综合征(PCOS)卵巢间质血流变化特点,分析其与胰岛素抵抗(IR)、血管内皮生长因子(VEGF)、内皮抑素(ES)的相关性。方法选择PCOS女性患者148例作为疾病组,年龄22~35岁,平均年龄28.98岁;体质量指数19.89~29.30 kg/m^(2),平均体质量指数25.03 kg/m^(2)。另选择健康女性82例作为对照组,年龄21~35岁,平均年龄29.33岁;体质量指数20.09~29.12 kg/m^(2),平均体质量指数24.76 kg/m^(2)。疾病组患者按照稳态模型的胰岛素抵抗指数(HOMA-IR)大小分为IR组(HOMA-IR≥2.69,n=72)和非胰岛素抵抗组(NIR组,HOMA-IR<2.69,n=72)。比较疾病组与对照组血清促卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、VEGF、ES水平及HOMA-IR、卵巢间质血流搏动指数(PI)和阻力指数(RI),并比较IR组、NIR组上述指标,分析PCOS患者卵巢动脉PI、RI与VEGF、ES、HOMA-IR的相关性。结果疾病组血清FSH水平低于对照组[(5.78±1.26)U/L vs(7.39±1.47)U/L](P<0.05),LH、E2、T水平均高于对照组[(13.16±3.42)U/L vs(5.26±1.22)U/L、(124.29±22.11)pmol/L vs(114.05±21.62)pmol/L、(0.54±0.14)nmol/L vs(0.19±0.06)nmol/L](P<0.05),IR组血清T水平高于NIR组[(0.62±0.21)nmol/L vs(0.49±0.16)nmol/L](P<0.05)。疾病组平均卵巢体积、卵泡体积大于对照组[(13.47±3.35)cm^(3)vs(7.15±2.32)cm^(3)、(2.01±0.43)cm^(3)vs(1.09±0.24)cm^(3)](P<0.05),平均卵泡个数多于对照组(26.52±5.73 vs 8.28±2.05)(P<0.05),PI、RI均低于对照组(1.46±0.33 vs 2.29±0.40、0.53±0.16 vs 0.92±0.24)(P<0.05)。IR组卵巢体积、卵泡体积大于NIR组[(15.55±3.40)cm^(3)vs(12.39±3.29)cm^(3)、(2.26±0.41)cm^(3)vs(1.77±0.38)cm^(3)](P<0.05),PI、RI均低于NIR组(1.32±0.29 vs1.53±0.34、0.45±0.14 vs 0.62±0.16)。疾病组血清VEGF、ES水平及HOMA-IR均高于对照组[(968.37±85.44)ng/L vs(633.45±66.29)ng/L、(271.09±24.55)μg/L vs(181.70±21.69)μg/L、4.90±1.63 vs 1.96±0.42](P<0.05),而IR组血清VEGF、ES水平及HOMA-IR均高于NIR组[(1089.95±94.83)ng/L vs(887.06±74.24)ng/L、(294.85±26.06)μg/L vs(248.90±22.62)μg/L、6.44±1.95 vs 2.15±0.67](P<0.05)。相关性分析显示,PCOS患者卵巢间质血流PI、RI与VEGF、ES、HOMA-IR均呈负相关(P<0.05)。结论PCOS患者存在着卵巢间质血流异常灌注,血液中VEGF、ES表达失衡及IR可能是卵巢间质血流动力学改变的重要因素。展开更多
文摘卵巢畸胎瘤是卵巢生殖细胞肿瘤中最常见的良性肿瘤,卵巢囊性畸胎瘤又称成熟性囊性畸胎瘤,是常见的畸胎瘤类型。卵巢畸胎瘤的内容物可由2~3个胚层的组织形成,含有皮肤及其附件、毛发、牙齿、神经、脂肪、骨骼等。虽然这些成分在理论上可以来自任何胚层,但实际上,完整地包含各种组织的畸胎瘤较为罕见。本文报道了一例合并美尼尔氏综合征、高血压、肥胖、II型糖尿病的女性患者,经过超声影像学提示卵巢畸胎瘤并手术治疗后发现畸胎瘤中含有皮肤、毛发、骨骼、牙齿、甲状腺组织的特殊病例。关于您提到的具体病例,即合并美尼尔氏综合征、高血压、肥胖、II型糖尿病的女性患者,超声影像学提示卵巢畸胎瘤,并在手术治疗后发现畸胎瘤中含有皮肤、毛发、骨骼、牙齿、甲状腺组织,这在临床诊疗中确实是一种罕见的病例。Ovarian teratoma is the most common benign tumor among ovarian germ cell tumors, and ovarian cystic teratoma, also known as mature cystic teratoma, is the most common type of teratoma. The contents of ovarian teratomas can be formed by tissues from two or three germ layers, including skin and its appendages, hair, teeth, nerves, fat, bones, etc. Although theoretically, these components can come from any germ layer, teratomas that fully contain various tissues are rare in practice. This article reports a special case of a female patient with Meniere’s syndrome, hypertension, obesity, and type II diabetes. Ultrasound imaging suggested an ovarian teratoma, and after surgical treatment, the teratoma was found to contain skin, hair, bones, teeth, and thyroid tissue. Regarding the specific case you mentioned, a female patient with Meniere’s syndrome, hypertension, obesity, and type II diabetes, in which ultrasound imaging suggested an ovarian teratoma, and post-surgery revealed the presence of skin, hair, bones, teeth, and thyroid tissue, this indeed represents a rare case in clinical practice.
文摘目的探讨多囊卵巢综合征(PCOS)卵巢间质血流变化特点,分析其与胰岛素抵抗(IR)、血管内皮生长因子(VEGF)、内皮抑素(ES)的相关性。方法选择PCOS女性患者148例作为疾病组,年龄22~35岁,平均年龄28.98岁;体质量指数19.89~29.30 kg/m^(2),平均体质量指数25.03 kg/m^(2)。另选择健康女性82例作为对照组,年龄21~35岁,平均年龄29.33岁;体质量指数20.09~29.12 kg/m^(2),平均体质量指数24.76 kg/m^(2)。疾病组患者按照稳态模型的胰岛素抵抗指数(HOMA-IR)大小分为IR组(HOMA-IR≥2.69,n=72)和非胰岛素抵抗组(NIR组,HOMA-IR<2.69,n=72)。比较疾病组与对照组血清促卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、VEGF、ES水平及HOMA-IR、卵巢间质血流搏动指数(PI)和阻力指数(RI),并比较IR组、NIR组上述指标,分析PCOS患者卵巢动脉PI、RI与VEGF、ES、HOMA-IR的相关性。结果疾病组血清FSH水平低于对照组[(5.78±1.26)U/L vs(7.39±1.47)U/L](P<0.05),LH、E2、T水平均高于对照组[(13.16±3.42)U/L vs(5.26±1.22)U/L、(124.29±22.11)pmol/L vs(114.05±21.62)pmol/L、(0.54±0.14)nmol/L vs(0.19±0.06)nmol/L](P<0.05),IR组血清T水平高于NIR组[(0.62±0.21)nmol/L vs(0.49±0.16)nmol/L](P<0.05)。疾病组平均卵巢体积、卵泡体积大于对照组[(13.47±3.35)cm^(3)vs(7.15±2.32)cm^(3)、(2.01±0.43)cm^(3)vs(1.09±0.24)cm^(3)](P<0.05),平均卵泡个数多于对照组(26.52±5.73 vs 8.28±2.05)(P<0.05),PI、RI均低于对照组(1.46±0.33 vs 2.29±0.40、0.53±0.16 vs 0.92±0.24)(P<0.05)。IR组卵巢体积、卵泡体积大于NIR组[(15.55±3.40)cm^(3)vs(12.39±3.29)cm^(3)、(2.26±0.41)cm^(3)vs(1.77±0.38)cm^(3)](P<0.05),PI、RI均低于NIR组(1.32±0.29 vs1.53±0.34、0.45±0.14 vs 0.62±0.16)。疾病组血清VEGF、ES水平及HOMA-IR均高于对照组[(968.37±85.44)ng/L vs(633.45±66.29)ng/L、(271.09±24.55)μg/L vs(181.70±21.69)μg/L、4.90±1.63 vs 1.96±0.42](P<0.05),而IR组血清VEGF、ES水平及HOMA-IR均高于NIR组[(1089.95±94.83)ng/L vs(887.06±74.24)ng/L、(294.85±26.06)μg/L vs(248.90±22.62)μg/L、6.44±1.95 vs 2.15±0.67](P<0.05)。相关性分析显示,PCOS患者卵巢间质血流PI、RI与VEGF、ES、HOMA-IR均呈负相关(P<0.05)。结论PCOS患者存在着卵巢间质血流异常灌注,血液中VEGF、ES表达失衡及IR可能是卵巢间质血流动力学改变的重要因素。