Mandated state newborn screening (NBS) programs for the approximately 4 million infants born each year in the United States detect nearly 3000 new cases of metabolic disorders such as phenylketonuria (PKU), hematologi...Mandated state newborn screening (NBS) programs for the approximately 4 million infants born each year in the United States detect nearly 3000 new cases of metabolic disorders such as phenylketonuria (PKU), hematologic disorders such as sickle-cell disease, and endocrinopathies such as congenital hypothyroidism. NBS leads directly to improving the ability to prevent disease and disability in childhood and throughout life. Currently, there are differences from one state to another with respect to conditions included in newborn screening programs: many states screen for less than 10 conditions, whereas other states include over 35 conditions. Tandem mass spectrometry (MS/MS) as a more accurate analytical method than conventional newborn blood-spot screening has greatly increased the number of diseases that can be detected. A potential technology, DNA microarray, could be developed and put in place to correct the existing shortcomings.展开更多
目的 从形态学上判定淋巴管肌脂瘤病 (L ym phangioleiom yomastosis,L AM)细胞与平滑肌细胞的关联性。方法 用荧光抗体染色法和激光共焦显微镜观察收缩蛋白在 L AM细胞的分布。结果 α平滑肌肌动蛋白 (α- sm ooth m uscle actin,...目的 从形态学上判定淋巴管肌脂瘤病 (L ym phangioleiom yomastosis,L AM)细胞与平滑肌细胞的关联性。方法 用荧光抗体染色法和激光共焦显微镜观察收缩蛋白在 L AM细胞的分布。结果 α平滑肌肌动蛋白 (α- sm ooth m uscle actin,α- SMA)、平滑肌肌球蛋白重链 (sm ooth m uscle myosin heavy chains,SMHC)、结蛋白(desmin)和非肌性肌球蛋白重链 B(nonmuscle m yosin heavy chain B,NMHC- B)存在于 L AM细胞。结论L AM细胞属平滑肌细胞类型。这为进一步研究激素及其它药物对 L展开更多
文摘Mandated state newborn screening (NBS) programs for the approximately 4 million infants born each year in the United States detect nearly 3000 new cases of metabolic disorders such as phenylketonuria (PKU), hematologic disorders such as sickle-cell disease, and endocrinopathies such as congenital hypothyroidism. NBS leads directly to improving the ability to prevent disease and disability in childhood and throughout life. Currently, there are differences from one state to another with respect to conditions included in newborn screening programs: many states screen for less than 10 conditions, whereas other states include over 35 conditions. Tandem mass spectrometry (MS/MS) as a more accurate analytical method than conventional newborn blood-spot screening has greatly increased the number of diseases that can be detected. A potential technology, DNA microarray, could be developed and put in place to correct the existing shortcomings.
文摘目的 从形态学上判定淋巴管肌脂瘤病 (L ym phangioleiom yomastosis,L AM)细胞与平滑肌细胞的关联性。方法 用荧光抗体染色法和激光共焦显微镜观察收缩蛋白在 L AM细胞的分布。结果 α平滑肌肌动蛋白 (α- sm ooth m uscle actin,α- SMA)、平滑肌肌球蛋白重链 (sm ooth m uscle myosin heavy chains,SMHC)、结蛋白(desmin)和非肌性肌球蛋白重链 B(nonmuscle m yosin heavy chain B,NMHC- B)存在于 L AM细胞。结论L AM细胞属平滑肌细胞类型。这为进一步研究激素及其它药物对 L
