磁振热治疗仪凭借温热效应、磁场效应以及振动作用,激发穴位经气,依循穴位–经络–脏腑之径,畅达经络气血,调摄脏腑虚实,进而调整体内阴阳的相对平衡。与此同时,经由体表–神经–体液传导途径,刺激神经组织,提升神经兴奋性,引发神经体...磁振热治疗仪凭借温热效应、磁场效应以及振动作用,激发穴位经气,依循穴位–经络–脏腑之径,畅达经络气血,调摄脏腑虚实,进而调整体内阴阳的相对平衡。与此同时,经由体表–神经–体液传导途径,刺激神经组织,提升神经兴奋性,引发神经体液对人体内环境的调节作用。该疗法与诸多治疗方式结合,构筑起一种更为全面且高效的综合治疗模式,以实现预防与保健的多重效能。目前研究显示,磁振热治疗仪在慢性疾病的防治方面具有显著的无侵入性、无创伤性以及安全高效等突出特性。鉴于此,本文将基于经络腧穴理论,深入阐释磁振热治疗仪的作用原理及其在慢性疾病中的应用。The magnetic resonance thermal therapy instrument relies on the thermal effect, magnetic field effect and vibration to stimulate the meridian qi of the acupuncture points, and through the path of acupuncture points-meridians-viscera, smooth the meridian qi and blood, and adjust the deficiency and reality of the viscera, so as to achieve the relative balance of yin and yang in the body. At the same time, through the conduction of body surface-nerve-humoral fluids, it stimulates nerve tissue, improves the excitability of nerves, and triggers the regulation of neurohumoral humoral to the human internal environment. This therapy is combined with a variety of treatment modalities to build a more comprehensive and effective integrated treatment model to achieve multiple effects of prevention and health care. The current research shows that the magnetic resonance thermal therapy instrument has the remarkable characteristics of non-invasive, non-invasive, safe and efficient in the prevention and treatment of chronic diseases. Therefore, this article will elaborate on the principle of action of magnetic resonance thermotherapy devices and their application in chronic diseases based on the theory of meridians and acupoints.展开更多
该研究旨在揭示舒肝宁注射液在正常大鼠体内的药代动力学特征。实验采用超高液相色谱-电喷雾-串联质谱(UPLC-ESI-MS/MS)技术建立大鼠血浆样品中同时测定绿原酸、栀子苷、千层纸素A及黄芩苷4个活性成分的分析方法,并使用WinN onL in 6.4...该研究旨在揭示舒肝宁注射液在正常大鼠体内的药代动力学特征。实验采用超高液相色谱-电喷雾-串联质谱(UPLC-ESI-MS/MS)技术建立大鼠血浆样品中同时测定绿原酸、栀子苷、千层纸素A及黄芩苷4个活性成分的分析方法,并使用WinN onL in 6.4软件中的非房室模型(NCA)进行药代动力学参数的拟合。经方法学验证,大鼠血浆样品中各成分的线性关系良好(r>0.995),低、中、高剂量的血浆样品的提取回收率和基质效应在79.14%~101.4%。日内、日间精密度、准确度和稳定性均符合生物样品分析要求。药代动力学参数结果表明,绿原酸、栀子苷、千层纸素A在实验剂量下的半衰期(t1/2)没有发生显著性变化,药时曲线下面积(AUC0-t)与剂量成正比,提示3种成分在体内表现出线性动力学的特征,而黄芩苷表现出非线性动力学特征,且各成分在大鼠体内的滞留时间短。建立的UPLC-MS/MS定量分析方法快速、灵敏、准确,可用于大鼠血浆中绿原酸、栀子苷、千层纸素A以及黄芩苷的测定及舒肝宁注射液的药代动力学研究。展开更多
文摘磁振热治疗仪凭借温热效应、磁场效应以及振动作用,激发穴位经气,依循穴位–经络–脏腑之径,畅达经络气血,调摄脏腑虚实,进而调整体内阴阳的相对平衡。与此同时,经由体表–神经–体液传导途径,刺激神经组织,提升神经兴奋性,引发神经体液对人体内环境的调节作用。该疗法与诸多治疗方式结合,构筑起一种更为全面且高效的综合治疗模式,以实现预防与保健的多重效能。目前研究显示,磁振热治疗仪在慢性疾病的防治方面具有显著的无侵入性、无创伤性以及安全高效等突出特性。鉴于此,本文将基于经络腧穴理论,深入阐释磁振热治疗仪的作用原理及其在慢性疾病中的应用。The magnetic resonance thermal therapy instrument relies on the thermal effect, magnetic field effect and vibration to stimulate the meridian qi of the acupuncture points, and through the path of acupuncture points-meridians-viscera, smooth the meridian qi and blood, and adjust the deficiency and reality of the viscera, so as to achieve the relative balance of yin and yang in the body. At the same time, through the conduction of body surface-nerve-humoral fluids, it stimulates nerve tissue, improves the excitability of nerves, and triggers the regulation of neurohumoral humoral to the human internal environment. This therapy is combined with a variety of treatment modalities to build a more comprehensive and effective integrated treatment model to achieve multiple effects of prevention and health care. The current research shows that the magnetic resonance thermal therapy instrument has the remarkable characteristics of non-invasive, non-invasive, safe and efficient in the prevention and treatment of chronic diseases. Therefore, this article will elaborate on the principle of action of magnetic resonance thermotherapy devices and their application in chronic diseases based on the theory of meridians and acupoints.
文摘该研究旨在揭示舒肝宁注射液在正常大鼠体内的药代动力学特征。实验采用超高液相色谱-电喷雾-串联质谱(UPLC-ESI-MS/MS)技术建立大鼠血浆样品中同时测定绿原酸、栀子苷、千层纸素A及黄芩苷4个活性成分的分析方法,并使用WinN onL in 6.4软件中的非房室模型(NCA)进行药代动力学参数的拟合。经方法学验证,大鼠血浆样品中各成分的线性关系良好(r>0.995),低、中、高剂量的血浆样品的提取回收率和基质效应在79.14%~101.4%。日内、日间精密度、准确度和稳定性均符合生物样品分析要求。药代动力学参数结果表明,绿原酸、栀子苷、千层纸素A在实验剂量下的半衰期(t1/2)没有发生显著性变化,药时曲线下面积(AUC0-t)与剂量成正比,提示3种成分在体内表现出线性动力学的特征,而黄芩苷表现出非线性动力学特征,且各成分在大鼠体内的滞留时间短。建立的UPLC-MS/MS定量分析方法快速、灵敏、准确,可用于大鼠血浆中绿原酸、栀子苷、千层纸素A以及黄芩苷的测定及舒肝宁注射液的药代动力学研究。
