目的:系统评价鼻内给予右美托咪定对比口服水合氯醛用于儿童程序化镇静的有效性和安全性。方法:计算机检索Cochrane图书馆、PubMed、Embase、中国生物医学文献数据库、中国知网数据库和万方数据库,收集鼻内给予右美托咪定(试验组)对比...目的:系统评价鼻内给予右美托咪定对比口服水合氯醛用于儿童程序化镇静的有效性和安全性。方法:计算机检索Cochrane图书馆、PubMed、Embase、中国生物医学文献数据库、中国知网数据库和万方数据库,收集鼻内给予右美托咪定(试验组)对比口服水合氯醛(对照组)用于儿童程序化镇静的随机对照试验(RCT)。筛选文献、提取资料后采用Cochrane 5.1.0偏倚风险评估工具对纳入文献质量进行评价,采用Rev Man 5.3软件进行Meta分析。结果:共纳入8项RCT,共计1413例患儿。Meta分析结果显示,试验组患儿镇静成功率[RR=1.13,95%CI(1.02,1.25),P=0.02]、镇静起效时间[MD=-1.07,95%CI(-1.82,-0.31),P=0.006]、镇静持续时间[MD=-8.25,95%CI(-14.02,-2.47),P=0.005]、苏醒时间[MD=-9.63,95%CI(-15.40,-3.86),P=0.001]、恶心呕吐发生率[RR=0.05,95%CI(0.02,0.14),P<0.00001]均显著优于对照组;两组患儿血氧饱和度<95%发生率[RR=0.60,95%CI(0.24,1.54),P=0.29]、低血压发生率[RR=1.18,95%CI(0.51,2.74),P=0.71]、心动过缓发生率[RR=1.33,95%CI(0.18,9.88),P=0.78]比较,差异均无统计学意义。结论:鼻内给予右美托咪定相较于口服水合氯醛用于儿童程序化镇静的效果更优,且安全性较好。展开更多
Pharmacist-led interventions have demonstrated significant benefits for older adults,with a plethora of studies dedicated to this subject.A bibliometric study was conducted to assess the current state of research and ...Pharmacist-led interventions have demonstrated significant benefits for older adults,with a plethora of studies dedicated to this subject.A bibliometric study was conducted to assess the current state of research and summarize key themes in the domain of pharmacist-led interventions for older adults.The analysis encompassed publications available in the Web of Science Core Collection from its inception until September 8,2022.To perform the bibliometric analysis,VOSviewer and CiteSpace software were employed.The initial query yielded a substantial 6084 relevant documents spanning the period from 1995 to September 8,2022.Of these,5496(constituting 90.34%)were categorized as“Article”.Notably,the yearly output of publications displayed an upward trajectory.This body of work emanated from 120 countries and regions,with the United States being the foremost contributor,accounting for the majority of publications(n=2637).The University of Sydney in Australia emerged as the institution with the highest number of publications(n=155).Timothy F Chen,affiliated with the University of Sydney,was the most prolific author,boasting 35 publications.Joseph T Hanlon,a scholar affiliated with the University of the Sciences in Philadelphia,emerged as the most frequently co-cited author.When considering journal productivity,The Journal of Managed Care&Specialty Pharmacy stood out as the most prolific journal(n=251).Conversely,the Journal of the American Geriatrics Society garnered the highest number of co-citations(n=5293).The predominant research themes encompassed the development of new criteria,updates to existing criteria,the utilization of criteria for identifying potentially inappropriate medications in older populations,concerns surrounding inappropriate polypharmacy in this demographic,and the evaluation of the positive impact of pharmacist-led interventions for older adults.In conclusion,this comprehensive bibliometric analysis offers a panoramic view of pharmacist-led interventions for older adults,providing valuable insights into the field’s evolution over the past three decades.展开更多
文摘目的:系统评价鼻内给予右美托咪定对比口服水合氯醛用于儿童程序化镇静的有效性和安全性。方法:计算机检索Cochrane图书馆、PubMed、Embase、中国生物医学文献数据库、中国知网数据库和万方数据库,收集鼻内给予右美托咪定(试验组)对比口服水合氯醛(对照组)用于儿童程序化镇静的随机对照试验(RCT)。筛选文献、提取资料后采用Cochrane 5.1.0偏倚风险评估工具对纳入文献质量进行评价,采用Rev Man 5.3软件进行Meta分析。结果:共纳入8项RCT,共计1413例患儿。Meta分析结果显示,试验组患儿镇静成功率[RR=1.13,95%CI(1.02,1.25),P=0.02]、镇静起效时间[MD=-1.07,95%CI(-1.82,-0.31),P=0.006]、镇静持续时间[MD=-8.25,95%CI(-14.02,-2.47),P=0.005]、苏醒时间[MD=-9.63,95%CI(-15.40,-3.86),P=0.001]、恶心呕吐发生率[RR=0.05,95%CI(0.02,0.14),P<0.00001]均显著优于对照组;两组患儿血氧饱和度<95%发生率[RR=0.60,95%CI(0.24,1.54),P=0.29]、低血压发生率[RR=1.18,95%CI(0.51,2.74),P=0.71]、心动过缓发生率[RR=1.33,95%CI(0.18,9.88),P=0.78]比较,差异均无统计学意义。结论:鼻内给予右美托咪定相较于口服水合氯醛用于儿童程序化镇静的效果更优,且安全性较好。
文摘Pharmacist-led interventions have demonstrated significant benefits for older adults,with a plethora of studies dedicated to this subject.A bibliometric study was conducted to assess the current state of research and summarize key themes in the domain of pharmacist-led interventions for older adults.The analysis encompassed publications available in the Web of Science Core Collection from its inception until September 8,2022.To perform the bibliometric analysis,VOSviewer and CiteSpace software were employed.The initial query yielded a substantial 6084 relevant documents spanning the period from 1995 to September 8,2022.Of these,5496(constituting 90.34%)were categorized as“Article”.Notably,the yearly output of publications displayed an upward trajectory.This body of work emanated from 120 countries and regions,with the United States being the foremost contributor,accounting for the majority of publications(n=2637).The University of Sydney in Australia emerged as the institution with the highest number of publications(n=155).Timothy F Chen,affiliated with the University of Sydney,was the most prolific author,boasting 35 publications.Joseph T Hanlon,a scholar affiliated with the University of the Sciences in Philadelphia,emerged as the most frequently co-cited author.When considering journal productivity,The Journal of Managed Care&Specialty Pharmacy stood out as the most prolific journal(n=251).Conversely,the Journal of the American Geriatrics Society garnered the highest number of co-citations(n=5293).The predominant research themes encompassed the development of new criteria,updates to existing criteria,the utilization of criteria for identifying potentially inappropriate medications in older populations,concerns surrounding inappropriate polypharmacy in this demographic,and the evaluation of the positive impact of pharmacist-led interventions for older adults.In conclusion,this comprehensive bibliometric analysis offers a panoramic view of pharmacist-led interventions for older adults,providing valuable insights into the field’s evolution over the past three decades.
