采用用计算化学方法研究金丝桃素分子结构特征,并用分子动力学方法研究其与HIV蛋白酶的相互作用,探讨其可能的抗HIV病毒作用机理.结果表明,金丝桃素分子结构具有刚性特征,与HIV蛋白酶在酶的催化活性位点与ASP-A25 and ASP-B25以氢键作...采用用计算化学方法研究金丝桃素分子结构特征,并用分子动力学方法研究其与HIV蛋白酶的相互作用,探讨其可能的抗HIV病毒作用机理.结果表明,金丝桃素分子结构具有刚性特征,与HIV蛋白酶在酶的催化活性位点与ASP-A25 and ASP-B25以氢键作用相结合.展开更多
It has been reported that the polysaccharide is the main active constituent of Hericium erinaceur.A series of oligosaccharide(mixtures of disaccharide and heptasaccharide of Hericium erinaceur) were separated from Her...It has been reported that the polysaccharide is the main active constituent of Hericium erinaceur.A series of oligosaccharide(mixtures of disaccharide and heptasaccharide of Hericium erinaceur) were separated from Hericium erinaceur by empty-fibrin filtration.Disaccharide and trisaccharide were purified via HPLC with NH2 column.Component sugars and glycosidic linkage ways were analysed via GC and GC-MS.Electrospray ionization tandem mass spectrometry(MSn) was used for the oligosaccharides structure study and the result shows that the disaccharide has two kind of structural styles and trisaccharide has one kind of structural style.展开更多
文摘It has been reported that the polysaccharide is the main active constituent of Hericium erinaceur.A series of oligosaccharide(mixtures of disaccharide and heptasaccharide of Hericium erinaceur) were separated from Hericium erinaceur by empty-fibrin filtration.Disaccharide and trisaccharide were purified via HPLC with NH2 column.Component sugars and glycosidic linkage ways were analysed via GC and GC-MS.Electrospray ionization tandem mass spectrometry(MSn) was used for the oligosaccharides structure study and the result shows that the disaccharide has two kind of structural styles and trisaccharide has one kind of structural style.
