中医药调控自噬治疗多囊卵巢综合征的研究进展

多囊卵巢综合征(PCOS)由于其具体机制不明,且因其发病多因素以及临床症状具有异质性,是一种复杂的内分泌代谢性疾病,近些年来通过调控自噬水平来治疗PCOS已经成为一个研究热点,且越来越多的研究发现,中医的针灸、中药单体及复方对于调控自噬水平具有显著疗效,其机制主要是通过干预自噬相关蛋白以及信号通路,降低激素、炎症水平以及胰岛素抵抗从而调控卵巢颗粒细胞的自噬水平,缓解PCOS患者的临床症状。

miRNA在糖尿病足溃疡中的作用机制及中医药干预研究进展

我国是世界上糖尿病患者最多的国家之一,糖尿病有诸多并发症,其中最常见的是糖尿病足溃疡[1]。糖尿病足溃疡常由外伤、压力性损伤等诱发,因患者局部缺血、神经病变,伴或不伴随感染等因素,导致患者踝关节以远皮肤及深部组织的溃烂,溃疡经久不愈,愈后易复发,常导致患者截肢,这严重影响了患者的生活质量,给个人、家庭及社会带来极大的负担。目前对于糖尿病足溃疡的研究已进入基因水平,越来越多的研究表明非编码小RNA(miRNA)在糖尿病足溃疡皮肤中异常表达,其参与了糖尿病足溃疡的发生发展,影响了其进程。本文通过对miRNA在糖尿病足溃疡中的作用机制,以及中医药通过调控miRNA治疗糖尿病足溃疡的研究进展进行综述,以期为中医药治疗糖尿病足溃疡提供基因层面的理论支持。

中医药治疗稳定型心绞痛伴焦虑状态的研究进展

焦虑状态常与心血管系统疾病同时发生,对患者的生活质量与身心健康都造成了严重影响。本文通过对相关文献的综合分析,发现中医药在缓解心绞痛症状、改善焦虑状态及提高患者生活质量方面具有显著疗效,且具有不良反应少、综合调理等优势。稳定型心绞痛伴焦虑状态的中医病因病机主要为心脉痹阻、气血亏虚、肝郁气滞、心肾不交。临床中医药治疗稳定型心绞痛伴焦虑状态的方法包括药物治疗和非药物治疗。药物包括单味中药、中药组方、中成药;非药物治疗包括针灸疗法、推拿按摩法、刮痧疗法、中药穴位敷贴及耳穴贴压法等。Anxiety state often occurs simultaneously with cardiovascular diseases, causing serious impacts on patients’ quality of life and physical and mental health. In this paper, through comprehensive analysis of relevant literature, it was found that traditional Chinese medicine has significant therapeutic effects in relieving angina symptoms, improving anxiety status, and enhancing patients’ quality of life. It also has advantages such as fewer adverse reactions and comprehensive regulation. The traditional Chinese medicine etiology and pathogenesis of stable angina pectoris with anxiety state mainly include obstruction of the heart meridian, deficiency of qi and blood, liver depression and qi stagnation, and heart-kidney dysfunction. The methods of clinical traditional Chinese medicine treatment for stable angina pectoris with anxiety state include drug therapy and non-drug therapy. Medicines include single Chinese medicine, Chinese medicine prescriptions and traditional Chinese patent medicines;non-drug treatment includes acupuncture and moxibustion therapy, massage, scraping therapy, traditional Chinese medicine point application and auricular point application.

中医药治疗早发性卵巢功能不全网络药理学研究进展

早发性卵巢功能不全(premature ovarian insufficiency,POI)是指女性在40岁之前出现卵巢功能减退,主要表现为雌激素水平波动性下降、促性腺激素水平升高及月经异常[1]。在POI概念产生之前,卵巢早衰(premature ovarian failure,POF)是被临床广泛使用的专业术语,但随着人们对该病研究的深入,发现其病因复杂、临床表现多样且呈进行性发展,“卵巢早衰”逐渐被“早发性卵巢功能不全”所代替[2]。最新研究显示,全球女性POI的总体患病率为3.5%,其中发展中国家POI患病率为5.3%,且处于上升趋势[3]。现代女性生育年龄普遍后移以及“三孩政策”的实施使得35岁以上女性的生育需求增加,因而POI成为影响女性生育能力的重要问题,且其与心血管疾病、骨质疏松、神经认知功能障碍以及心理社会问题等多种健康问题相关[4]。目前西医临床对POI尚无特效药物和方法,主要是使用激素替代疗法,然而激素替代疗法具有急性肝损伤、肝功能障碍、血管栓塞等风险[5],不易被患者接受。临床实践表明,中医药治疗POI疗效显著,然而其作用机制难以被揭示。网络药理学是一门以基因组学、蛋白组学等理论为基础的新兴学科,近年来运用网络药理学的方法研究中医药治疗POI的机制成为新的研究热点。基于此,本文就目前运用网络药理学研究中药治疗POI的机制研究进展进行综述,旨在揭示中医药对POI的作用机制,并为进一步的研究提供思路与方法。

中医药通过调控不同信号通路治疗围绝经期抑郁症机制研究进展

围绝经期抑郁症(PDD)在围绝经期发病率较高,发病率是绝经前的2~3倍,以围绝经期症状和抑郁症状为主要临床表现。中医药在治疗妇科疾病方面疗效显著,能有效缓解PDD症状。通过检索国内外相关文献发现,中医药可通过调控脑源性神经营养因子(BDNF)/酪氨酸激酶受体B(TrkB)、白细胞介素4受体(IL-4R)/JAK激酶1(JAK1)/信号转导和转录激活因子6(STAT6)、丝裂原活化蛋白激酶(MAPK)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体和雌激素等信号通路对PDD发挥治疗作用。今后可从PDD的发病机制入手,以中医药调控相关信号通路干预PDD的疗效及结果为依据,探索中医药对PDD各个通路的分子作用机制,为新药研发和临床应用提供参考。

中医药治疗耳胀的研究进展

分泌性中耳炎西医治疗方法多样,但由于病因复杂,疾病反复发作或者临床治疗效果不满意。本文将通过参考书籍及查找知网、万方等网站相关内容的方法,寻找中医学治疗耳胀所采取的一些治疗方法。中医学的治疗手段在一定程度上弥补了一些西医治疗中的不足。中医学通过对疾病的辩证论治,在临床上取得较好的疗效。There are various western treatment methods for secretory otitis media, but due to the complex etiology, the disease is repeated or the clinical treatment effect is not satisfactory. This paper will look for some treatment methods for the treatment of ear distension by referring to books and finding relevant methods of CNKI, Wanfang and other websites. The treatment means of traditional Chinese medicine have made up for some deficiencies in western medicine treatment to some extent. Through the dialectical treatment of diseases, traditional Chinese medicine has achieved good clinical effect.

中医药治疗盆腔炎性疾病后遗症研究进展

盆腔炎性疾病后遗症是临床上常见的妇科慢性炎性疾病,具有持续时间长、复发率高、并发症多等特点,不仅对育龄妇女的生理健康造成了严重威胁,也极大地影响了其日常生活,引发身心压力和精神负担。中医药治疗本病有其独到之处,运用中医药特色治疗,能明其病因,立其方治,准确把握疾病的根本,从而有效防止疾病的复发、改善患者的症状、提升生活质量。本文旨在对现有的临床治疗现状进行全面的审视和评估,深入探讨中医在防治盆腔炎性疾病后遗症方面的独特方法,致力于挖掘传统医学与现代临床科学相结合的潜力,为未来的临床治疗提供更为坚实的理论基础。

中医药治疗小儿夜啼的临床研究进展

夜啼是婴幼儿多发疾病,若未引起家长重视,可能会造成婴幼儿昼夜颠倒,进而影响其生长发育。小儿夜啼病位主要在心、脾,其次为肝、肾、脾、胆,寒、惊、热为本病的主要病因病机。本文总结了近年中医药治疗小儿夜啼的相关研究,临床辨证分型包括脾寒气滞、心经积热、惊恐伤神、脾虚肝郁、胆气受损、肾脏虚损;外治方法主要包括穴位贴敷、针灸、推拿,并分析了中医药治疗小儿夜啼的不足与展望,为小儿夜啼的临床治疗提供一定参考依据。

甲状腺结节的中医药治疗研究进展

甲状腺结节(Thyroid nodules, TN)是甲状腺最常见的一种临床疾病,一般由甲状腺细胞在颈部异常生长而引起,临床常以甲状腺局部出现肿块、咽喉部吞咽时有异物感、结节逐渐增大时容易导致压迫症状为主要特征。甲状腺结节的西医发病机制相对复杂,涉及多个方面。中医学认为甲状腺结节的发生与人体气血失调、脏腑功能失和密切相关。在辨证论治方面,中医学强调个体化治疗,根据患者的具体病情和体质特点进行辨证分析。因此本文主要通过分析其发病机制与危险因素,研究病因病机,探讨辨证论治以及了解临床常见的中医治疗方法,从而对之前医家治疗本病的临床经验进行总结,以求进一步完善甲状腺结节的中医药治疗理论体系。Thyroid nodules (Thyroid nodules, TN) is the most common clinical disease of thyroid, which is usually caused by abnormal growth of thyroid cells in the neck. Clinically, the local thyroid mass, foreign body sensation in the throat, and the nodules gradually increase. The western medicine pathogenesis of thyroid nodules is relatively complex and involves many aspects. Traditional Chinese medicine believes that the occurrence of thyroid nodules is closely related to the imbalance of qi and blood and the loss of viscera function. In terms of syndrome differentiation and treatment, traditional Chinese medicine emphasizes individualized treatment, and conducts syndrome differentiation analysis according to the patients’ specific conditions and physical characteristics. Therefore, this paper mainly analyzes the pathogenesis and risk factors, studies the causes and mechanisms, discusses the syndrome differentiation treatment and understands the common clinical TCM treatment methods, so as to summarize the previous clinical experience of the treatment of this disease, in order to further improve the theoretical system of TCM treatment of thyroid nodules.

中医药治疗慢性心力衰竭的研究进展

慢性心力衰竭(Chronic heart failure, CHF)出现在心血管疾病发展的严重或晚期阶段,其发病率高、死亡率高、预后差,已成为公共卫生问题。目前药物的长期服用会出现不良反应,而中医基于疾病的不同证型给予不同的治疗方法,在CHF疗效上体现出不可忽视的优势。因此,总结了近几年治疗CHF医家的学术思想,对病因病机、辩证分型以及治疗方法进行归纳,为其他医家治疗该疾病提供诊断思路,促进中医药在临床上的广泛应用。Chronic heart failure (CHF) occurs in the serious or late stage of the development of cardiovascular disease. Its high incidence rate, high mortality and poor prognosis have become a public health problem. At present, long term use of drugs can lead to adverse reactions, and traditional Chinese medicine provides different treatment methods based on the different types of diseases, which demonstrates an undeniable advantage in the efficacy of CHF. Therefore, this article summarizes the academic ideas of medical practitioners in the treatment of CHF in recent years, summarizes the etiology, pathogenesis, dialectical classification, and treatment methods, provides diagnostic ideas for other medical practitioners to treat this disease, and promotes the widespread application of traditional Chinese medicine in clinical practice.

房颤患者导管消融后的中医药治疗研究进展

心房颤动是最常见的持续性心律失常,发病率呈不断上升的趋势。目前房颤的治疗主要包括药物治疗和手术治疗,其中导管消融术因其减少房颤发作次数及负荷、改善症状、提高生活质量等优点而被广泛应用。但与此同时,患者的远期预后深受术后出现的复发及相关并发症等不良后果的影响。而针对消融术后的复发、并发症的治疗以及患者生活质量的提高,中医药具有副作用小、疗效良好、应用灵活等优势。故本文将对中医药在房颤导管消融术后的应用进行论述。

中医药治疗急性鼻窦炎相关研究进展

急性鼻窦炎是鼻腔鼻窦黏膜细菌或病毒引起的急性化脓性炎症,炎症浸润可破坏鼻腔窦腔及机体免疫功能。以鼻塞、流脓涕、嗅觉减退、头痛或局部疼痛为特征,起病较急。该病为耳鼻喉科常见病、多发病,近年其发病率呈逐年增长趋势,以北方寒冷地区多高发。本文通过整理相关文献,对中医药治疗急性鼻窦炎内外疗法研究进展进行综述,为临床诊治急性鼻窦炎提供了理论依据。Acute sinusitis is an acute suppurative inflammation caused by bacteria or viruses in the mucosa of the nasal cavity and sinus cavity. The inflammatory infiltrate can destroy the sinus cavity of the nasal cavity and the immune function of the body. Characterized by nasal congestion, discharge, hypoia, headache, or local pain, the onset is more acute. The disease is a common and frequent disease in otolaryngology department. In recent years, its incidence is increasing year by year, especially in the cold areas in northern China. This paper summarizes the research progress of Traditional Chinese Medicine (TCM) treatment for acute sinusitis by sorting out relevant literature. This research provides a theoretical basis for the clinical diagnosis and treatment of acute sinusitis.

中医药在临床治疗小儿咳嗽变异性哮喘的研究进展

咳嗽变异性哮喘(Cough variant asthma, CVA)作为以持续性干咳为主要临床表现的一种特殊类型的哮喘,是我国儿童慢性咳嗽最主要的病因之一,临床中多以西药为主,但其多有停药后疾病反复,不良反应多等问题,近年来中药以其安全、有效的特点,在治疗小儿咳嗽变异性哮喘方面取得了较好的成效。本文结合了近年来中医药治疗小儿咳嗽变异性哮喘的相关研究,旨在为小儿咳嗽变异性哮喘临床治疗提供一定参考依据。As a special type of asthma with persistent dry cough as its main clinical manifestation, cough variant asthma (CVA) is one of the most important causes of chronic cough in children in China. Western medicine is the main drug in clinical practice, but there are many problems such as repeated disease and adverse reactions after drug withdrawal. In recent years, traditional Chinese medicine, with its safe and effective characteristics, has achieved good results in the treatment of children with cough variant asthma. This article combined with the recent research on the treatment of children with cough variant asthma by traditional Chinese medicine, aiming to provide some reference for the clinical treatment of children with cough variant asthma.

中医药治疗妊娠恶阻的研究进展

为更加全面地分析和掌握妊娠恶阻的中医机制和中医临床治疗方法,作者对中医经典著作和近30年相关文献进行查阅和检索,从中医基础理论和中医治疗两方面认识其病机和相关治法方药,根据不同病机的特点采用不同的治疗方式,力求以辨证思维看待疾病。妊娠恶阻病机的论述伴随中医理论认识的发展不断完善,治疗上则基于中医内外治法两大类别进行综述。从常用经方和时方的角度去认识恶阻的中医内治法,外治法则根据经络辨证、穴位特性以及特殊外治法的特点加以认识,以冀为中医药治疗妊娠呕吐提供理论支持,并将多种治疗方法与中医理论相结合,综合论述妊娠恶阻问题。

中医药治疗肝胃不和型胃食管反流病的临床研究进展

胃食管反流病(GERD)是消化道的常见病和多发病,欧美等发达国家发病率高,但随着经济发展,我国发病率逐渐上升。经大量临床研究证明中医药治疗该病有着提高疗效、减轻副作用等作用。肝胃不和作为本病常见的中医证候类型之一,本文将对近年来中医药治疗肝胃不和型GERD的临床研究成果进行综述。Gastroesophageal reflux disease (GERD) is a common and frequently-occurring disease in digestive tract. The incidence rate is high in developed countries such as Europe and America, but with the economic development, the incidence rate in China is gradually increasing. A large number of clinical studies have proved that Chinese medicine can improve the curative effect and reduce the side effects of this disease. Liver-stomach disharmony is one of the common TCM syndrome types of this disease. This paper will review the clinical research results of treating GERD with liver-stomach disharmony in recent years.

中医药治疗神经根型颈椎病的研究进展

神经根型颈椎病在临床中很常见,主要症状包括颈痛、活动受限,伴随上肢疼痛、麻木和肌力减退,对患者生活造成重大影响。治疗手段有药物、理疗、手法、手术和中医药等多种选择,中医药在治疗中表现出显著效果。其优势包括副作用小、方便服用、简便操作等特点,在临床中被广泛应用。本文对中医药治疗神经根型颈椎病的临床研究进行了全面综述。

中医药治疗慢性乙型肝炎的研究进展

慢性乙型肝炎是全球人类健康的重大威胁,在治疗上存在较大的困难和争议,我国是乙肝大国,正在为达到世界卫生组织“2030年消除病毒性肝炎作为公共卫生危害”的目标而努力。发现中医在治疗慢性乙型肝炎有着独特的优势,为临床治疗慢性乙型肝炎提供了新思路。

肾性骨病的分子调控机制及中医药研究进展

慢性肾脏病(CKD)是由多种肾脏疾病长期发展而来的慢性进展性疾病,肾性骨病(renal osteopathy)是慢性肾脏病晚期与血液透析患者的重要并发症。通常由肾小球滤过功能下降引起钙磷代谢紊乱和继发性甲状旁腺功能亢进,进而引发骨形成与吸收的异常,以骨骼畸形、骨质疏松、骨痛、软组织和血管钙化以及皮肤瘙痒等为主要表现。该文论述了肾性骨病的相关分子通路及治疗肾性骨病方面应用较为广泛的中药单体和复方的作用机制,旨在为中药防治肾性骨病的临床应用及新药研发提供思路。Chronic kidney disease (CKD) is a progressive long-term condition that evolves from various renal disorders. Renal osteopathy, a significant complication in advanced CKD and hemodialysis patients, is typically caused by the decline in glomerular filtration rate, leading to calcium-phosphorus metabolism disorders and secondary hyperparathyroidism. This, in turn, triggers abnormalities in bone formation and resorption, characterized by skeletal deformities, osteoporosis, bone pain, soft tissue and vascular calcification, and skin itching. The article discusses the molecular pathways associated with renal osteopathy and the mechanisms of action of widely used monomers and compound formulations of traditional Chinese medicine in treating this condition. The aim is to provide insights for the clinical application and development of new drugs for the prevention and treatment of renal osteopathy using traditional Chinese medicine.

中医药诱导铁死亡在鼻咽癌中的研究进展

铁死亡是一种铁依赖性的新型细胞程序化死亡方式,发生机制主要与铁代谢紊乱、氨基酸抗氧化系统失衡、脂质过氧化物集聚有关,在许多疾病的发展中都发挥了作用。诱导铁死亡能够抑制鼻咽癌的发展,在鼻咽癌的治疗方面铁死亡也有一定的作用。近年来研究表明中草药能诱导铁死亡在治疗鼻咽癌中发挥作用,为治疗鼻咽癌提供了更多的选择。本文从铁死亡、鼻咽癌、中医药三者关系分别阐述,助力中医药的现代化研究。

功能性便秘的中医药研究进展

功能性便秘(Functional Constipation, FC)是一种慢性胃肠疾病,临床上较为常见,具有多种致病因素和诱发因素,因此难以保持稳定持久的临床疗效。大多数功能性便秘患者病情较长,且反复发作,导致生活质量下降,影响患者身心健康。研究功能性便秘的中医药治疗方法,可为临床治疗提供思路。通过从中医辨证分型、中药治疗、中医内治外治结合治疗、中西医结合治疗等方面研究中医药治疗功能性便秘的进展,发现中医药治疗功能性便秘疗效显著,相较于西医治疗有其独特的优势。