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血清降钙素原与C反应蛋白检测用于糖尿病足重度感染患者中的临床价值研究 被引量:2
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作者 刘会 《双足与保健》 2019年第20期27-28,共2页
目的研究血清降钙素原(PCT)与C反应蛋白(CRP)检测用于糖尿病足重度感染患者中的临床价值。方法回顾性分析2018年3月-2019年3月该院收治的157例糖尿病足患者临床资料,根据不同感染程度分为3组,轻度感染组41例,中度感染组79例,重度感染组3... 目的研究血清降钙素原(PCT)与C反应蛋白(CRP)检测用于糖尿病足重度感染患者中的临床价值。方法回顾性分析2018年3月-2019年3月该院收治的157例糖尿病足患者临床资料,根据不同感染程度分为3组,轻度感染组41例,中度感染组79例,重度感染组37例,测定三组患者治疗前后的PCT及CRP水平。结果与治疗前相比,治疗后各组PCT及CRP水平均降低,差异有统计学意义(P<0.05);治疗前及治疗后,轻度感染组PCT及CRP水平<中度感染组<重度感染组,差异有统计学意义(P<0.05)。结论 PCT及CRP与炎症反应具有紧密正相关性,可作为糖尿病足患者感染严重程度判断的科学、精准依据。 展开更多
关键词 糖尿病足 重度感染 血清降钙素原 C反应蛋白 诊断
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Some Implications of Theoretical Relation between RAW and RRW Measures on Risk Reduction Strategies
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作者 Ivan Vrbanic Pranab Samanta Ivica Basic 《Journal of Physical Science and Application》 2018年第3期38-45,共8页
In using risk-informed approaches for ensuring safety of operating NPPs(nuclear power plants),risk importance measures obtained from PRAs(probabilistic risk assessments)of the plants are integral elements of considera... In using risk-informed approaches for ensuring safety of operating NPPs(nuclear power plants),risk importance measures obtained from PRAs(probabilistic risk assessments)of the plants are integral elements of consideration in many cases.In PSA models and applications associated with NPPs the risk importance of a particular feature(e.g.function,system,component,failure mode or operator action)can be,most generally,divided into two categories:importance with respect to risk increase potential and importance with respect to risk decrease potential.The representative of the first category,as used for practical purposes,is RAW(risk achievement worth).Representative of the second category,as mentioned in consideration of risk importance,is RRW(risk reduction worth).It can be shown that the two risk importance measures,RAW and RRW,are dependent on each other.The only parameter in this mutual dependency is probability of failure of the considered feature.The paper discusses the relation between RAW and RRW and some of its implications,including those on the general strategies for the reduction of risk imposed for the operation of the considered facility.Two general risk reduction strategies which are considered in the discussion are:a)risk reduction by decreasing the failure probability of the considered feature;and b)risk reduction while keeping the failure probability of the considered feature at the same level.Simple examples are provided to illustrate the differences between two strategies and point to main issues and conclusions. 展开更多
关键词 Probabilistic RISK assessment RISK IMPORTANCE measures RISK ACHIEVEMENT WORTH RISK REDUCTION WORTH RISK REDUCTION strategy
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A Framework for Modern Risk-Informed Root Cause Analysis Process
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作者 Dorian Conger Ivan Vrbanic +1 位作者 Ivica Basic Kenneth J.Elsea 《Journal of Energy and Power Engineering》 2020年第7期211-224,共14页
The paper discusses the framework for a risk-informed root cause analysis process.Such process enables scaling of the analysis performed based on the risk associated with the undesired event or condition,thereby creat... The paper discusses the framework for a risk-informed root cause analysis process.Such process enables scaling of the analysis performed based on the risk associated with the undesired event or condition,thereby creating tiers of analysis where the greater the risk,the more sophisticated the analysis.In a risk-informed root cause analysis process,a situation is normally not analyzed at a level less than what actually occurred.However,a situation may be investigated as though the consequence were greater than actually happened,especially if only slight differences in circumstances could result in a significantly higher consequence.While operational events or safety issues are normally expected to result only with negligible or marginal actual consequences,many of those would actually have certain potential to develop or propagate into catastrophic events.This potential can be expressed qualitatively or quantitatively.Risk-informing of root cause analysis relies on mapping the event or safety issue into a risk matrix which,traditionally,is a two-dimensional probability-consequence matrix.A new concept employed in the risk matrix for root cause analysis is that,while the probability reflects the observed or expected range of values(retaining,thus,its“traditional”meaning),the consequence reflects not only the observed or materialized impact(such as failure of equipment)but,also,its potential to propagate or develop into highly undesirable final state.The paper presents main elements of risk-informed root cause analysis process and discusses qualitative and quantitative aspects and approaches to determination of risk significance of operational events or safety issues. 展开更多
关键词 Root cause risk-inform RISK probability cause analysis safety precedence significance determination risk matrix probabalistic margin conditional probability conditional risk ANALYST training methods
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Upgrade to Nuclear Power Plant Krsko Internal Flooding Probabilistic Safety Analysis
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作者 I. Vrbanic I. Basic R. Prosen 《Journal of Energy and Power Engineering》 2010年第1期35-42,共8页
The original internal flooding probabilistic safety analysis (PSA) study of Krsko Nuclear Power Plant (two-loop Pressurized Water Reactor (PWR) plant of Westinghouse design) was performed in mid nineties and lim... The original internal flooding probabilistic safety analysis (PSA) study of Krsko Nuclear Power Plant (two-loop Pressurized Water Reactor (PWR) plant of Westinghouse design) was performed in mid nineties and limited to reactor core damage risk (Level 1 PSA). In 2003, it was, together with other safety and hazard analyses, subject to the Periodic Safety Review (PSR). In the PSR, it was stated that methodological PSA approaches and guidelines have evoluted during the past decade and several observations were provided, concerning the area screening process, residual risk and treatment of plant damage states and risk from radioactivity releases (i.e., Level 2 PSA). In order to address the PSR observations, upgrade ofKrsko NPP internal flooding PSA was undertaken. The area screening process was revisited in order to cover the areas without automatic reactor trip equipment. The model was extended to Level 2. Residual risk was estimated at both Level 1 and Level 2, in terms of core damage frequency (CDF) and large early release frequency (LERF), respectively. 展开更多
关键词 Internal flooding hazard probabilistic safety analysis nuclear power plant.
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