Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest:A comprehensive proteomics perspective

Cardiac arrest(CA)is a life-threatening condition with complex pathophysiology and limited treatment options.To gain deeper insights into the pathological state of vital organs,we employed a proteomics analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of CA.The brain displayed severe protein alterations in essential cellular pathways,including three major energy-generating pathways after CA,which worsened after resuscitation,resulting in the most significant overall protein changes among the organs.Conversely,the liver,experiencing the most substantial protein alterations post-CA,demonstrated significant recovery,presenting the least protein changes post-resuscitation.

工业企业R&D投入绩效研究——基于第一次全国经济普查数据的分析

近几年我国工业企业的 R&D 投入不断增加,工业企业支出的 R&D 经费占全国 R&D 经费支出的比重均在一半以上。在研发经费、人力资源有限的条件下,要缩短与发达国家的差距,不仅要合理增加 R&D 投入,更要关注 R&D 产出效率的提高。本文以2004年全国第一次经济普查规模以上工业企业科技及 R&D 活动数据为基础,分析工业企业 R&D 投入和绩效现状,并对 R&D 投入绩效进行评价,为相关部门的科学决策提供依据和参考。

工业行业R&D投入绩效分析

对行业R&D投入绩效的研究,不仅要从总量的角度进行,更应注重从"效率"的角度展开。本文利用研究效率的标准方法——DEA模型对第一次全国经济普查资料中38个工业行业的R&D投入绩效的效率进行了比较研究。

Teaching for physical literacy: Implications to instructional design and PETE

Physical education teachers play an important role in helping students＇ development of the motor skills needed to be physically literate individuals. Research suggests that teacher made instructional design decisions can lead to enhanced motor skill learning. After presenting a model of evidence-based research this paper presents information that will help teachers plan and execute lessons designed to improve students＇ motor skills. Variables that impact motor skill learning in physical education including time, type of practice, content, presentation and organizational strategies, and student skill level are presented and discussed. A brief section on student attitudes, their relation to motor skill learning and to physical literacy is included. Motor skills are needed for physically literate people to enjoy lifelong physical activity. Physical education teachers and the decisions they make contribute to students＇ learning and whether the goal of physical literacy is met.

Expression of PKC Iota Affects Neuronal Differentiation of PC12 Cells at Least Partly Independent of Kinase Function

Atypical PKC (aPKC) plays a role in establishing cell polarity and has been indicated in neuronal differentiation and polarization, including neurite formation in rat pheochromocytoma PC12 cells, albeit by unclear mechanisms. Here, the role of the aPKC isoform, PKC iota (PKCι), in the early neuronal differentiation of PC12 cells, was investigated. NGF-treated PC12 cells with stably expressed exogenous wild-type PKCι showed decreased expression of a neuroendocrine marker, increased expression of a neuronal marker and increased neurite formation. Stable expression of a kinase-inactive PKCι, but not constitutively active PKCι lacking a regulatory domain, had similar though less potent effects. Pharmacological inhibition of endogenous aPKC kinase activity in parental PC12 cells did not inhibit neurite formation, suggesting that some of the observed effects of PKCι expression on neuronal differentiation are kinase-independent. Interestingly, exogenous expression of wild-type and kinase-inactive PKCι had little effect on overall PKCι activity, but caused a decrease in PKC zeta (PKCζ) kinase activity, suggesting an interplay between the two isoforms that may underlie the observed results. Overall, these findings suggest that in PC12 and perhaps other neuroendocrine precursor cells, PKCι influences an early differentiation decision between the neuroendocrine (chromaffin) and sympathetic neuron cell lineages, potentially by affecting PKCζ function.

Stereotypes in a Foreign Language Classroom --Modifying Negative Attitudes to Enhance Foreign Language Learning

The aim of the paper is to present various aspects of the phenomenon of stereotyping in the context of FL （foreign language） learning and teaching and to discuss practical solutions to be used in a FL classroom to teach the worm about the worm by questioning the stereotypes learners have of other nations and languages. This paper is an attempt to present some ideas of FL teachers＇ role in developing students＇ socio-cultural competence with the aim of raising their cross-cultural awareness and questioning the stereotypes students bring into a FL classroom. The methodology used was an analysis of fragment of tape scripts from listening comprehension activities from a course book preparing Polish secondary students for the school leaving exam. The topics discussed concern opinions about attitudes towards and judgments of various cultural aspects, be it drinking tea or discussing the weather, impressions people have about other nations, or languages people speak.

Spanish Last Names in the Naples Periphery

The purpose of this study is to shed light on the southern part of Italy where Catalonians ruled. Great numbers of Spaniards, principally the Catalonians, headed to that country. This affected the language, and, in turn, the history of people＇s last names. At first, some of the Spanish last names were used as nicknames for Italians. The method 1 used to get the data from primary sources was from spending time in Italy for four consecutive summers and visiting towns in the Naples area while I collected surnames found on houses. The Catalonians came to rule Sardinia, and their language and subsequently Spanish were official on the island. The linguistic influence of Spanish does not stop with surnames. A list of Spanish and Basque surnames which is redolent of the history of southern Italy and Sicily is appended. The geolinguistics interest lies in the way that the study of language, both ordinary words and proper nouns, offers important clues to the lives and movements of people of ages past, reflects political and economic aspects and also explains the ethnic origin of people who live in Sicily and Italy today or are descendants of Italians who have been important immigrants in the Americas, in Australia, and indeed around the world.

Linguistic Justice and Dual Language Programs

This paper makes the case that education aimed at Hispanic or Latino children in the United States needs to recognize both their linguistic and cultural roots （raices） as well as the educational wings （alas）. The reason the author believes dual language programs could benefit all is due to the fact that if done properly, it should promote bilingualism, respect, and equity for all students in the school. Dual language programs are relatively new in the United States. These programs aim to create bilingual, bicultural students without sacrificing these students＇ success in school or beyond. The goals of dual language are to provide high-quality instruction for language-minority students and to provide instruction in a second language for English-speaking students. Schools teach children through content, with teachers adapting their instruction to ensure children＇s comprehension and using content lessons to convey vocabulary and language structure. Striving for a balance of half language minority students and half English speaking students in each classroom, dual language programs also aim to teach cross-cultural awareness. Programs vary in terms of the amount of time they devote to each language, which grade levels they serve, how much structure they impose for the division of language and curriculum, and what populations they serve.

The Education of the Children of Immigrants： A Cross-Cultural Study Between New York and Rome

Teachers of CLD （culturally and linguistically diverse） public school students New York and Rome, Italy were interviewed about their work with this unique, growing subset of learners. The 12 teachers＇ stories highlight myriad issues facing educators across the globe. Each teacher had recently participated in a research-based and government-sponsored professional development program focused on second language acquisition and culturally responsive pedagogy. Themes emerged through the analysis of individual interviews and classroom observations. These findings highlight teachers＇ perceptions of effective professional development, along with identification of institutional barriers impeding the delivery of best practices to CLD students. Cross-cultural comparisons are made which suggest an inconsistency in educational services for CLD students, along with an urgent need for professional development courses for teachers and administrators. The educators＇ voices shed light on both the challenges and rewards associated with this important work.

Could Sequential Residual Centering Resolve Low Sensitivity in Moderated Regression? Simulations and Cancer Symptom Clusters

Multicollinearity constitutes shared variation among predictors that inflates standard errors of regression coefficients. Several years ago, it was proven that the common practice of mean centering in moderated regression cannot alleviate multicollinearity among variables comprising an interaction, but merely masks it. Residual centering (orthogonalizing) is unacceptable because it biases parameters for predictors from which the interaction derives, thus precluding interpretation of moderator effects. I propose and validate residual centering in sequential re-estimations of a moderated regression—sequential residual centering (SRC)—by revealing unbiased multicollinearity conditioning across the interaction and its related terms. Across simulations, SRC reduces variance inflation factors (VIF) regardless of distribution shape or pattern of regression coefficients across predictors. For any predictor, the reduced VIF is used to derive a lower standard error of its regression coefficient. A cancer sample illustrates SRC, which allows unbiased interpretations of symptom clusters. SRC can be applied efficiently to alleviate multicollinearity after data collection and shows promise for advancing synergistic frontiers of research.

The Value of Positive Pressure Ventilations for Clients in Acute Respiratory Distress as a Result of Cardiac and Pulmonary Issues

Objective: Research was conducted to examine benefits to using non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP) early in the treatment of respiratory distress caused by pulmonary edema, chronic obstructive pulmonary disease (COPD) and asthma. Limitations to successful NIV and CPAP therapy were evaluated to determine how prolonged initiation of treatment may lead to hypoxemia (decreased oxygen in the blood) and hypercapnia (increased carbon dioxide in the blood) resulting in poor outcomes. Method: Reviews of literature from nursing and allied health data bases (CINAHL and ProQuest) with terms pulmonary edema, positive pressure device and non-invasive ventilation from 2010 to 2014 were used. Studies were conducted in the hospital and prehospital settings. Results: The literature search located 7 articles from CINAHL and 25 articles from ProQuest. A total of 6 of these articles were analyzed. Additional sources of data were obtained from Ignatavicius and Workman (2013) Medical-Surgical Nursing Patient-Centered Collaborative Care 7th edition and American Journal of Nursing (02/2013) Volume 113: 2. Conclusion: All of the articles concluded that early initiation of continuous positive airway pressure ventilations in the short-term was beneficial;however, late initiation of therapy required additional interventions. The studies indicated that early use of positive airway pressure in acute respiratory distress improved breath rate, heart rate and blood pressure. The use of positive airway pressure for respiratory distress may decrease the need for endotracheal intubation.

Sleep No More： Nightmares in Emerging Nazi Germany

Charlotte Beradt collected hundreds of dreams she gathered in Germany between 1933 and 1939, hid them, and then sent them abroad. According to her The Third Reich of Dreams, people living under the totalitarian government of Nazi Germany had fears of listening devices picking up their own thoughts even when they were asleep, of having no walls, and of being condemned for talking in their sleep. The dreams reveal fears, insecurities, confusion, guilt, and lack of trust. Dream research has often been impaired because researchers were examining dreams during REM ~Rapid Eye Movement） sleep, while many nightmares occur during non-REM sleep. The Beradt＇s study showed the advantage of retrospective accounts. Dreams of other trauma victims include the discovery of dead bodies and being killed oneself and often replicas of actual events. Such nightmares preclude the restorative function of sleep. Psychotherapy, however, using dreams from traumas when conducted in a safe environment, can be helpful and relieve patients from suffering.

Schultz Polynomials and Their Topological Indices of Jahangir Graphs J2,m

Let G = (V;E) be a simple connected graph. The Wiener index is the sum of distances between all pairs of vertices of a connected graph. The Schultz topological index is equal to and the Modified Schultz topological index is . In this paper, the Schultz, Modified Schultz polynomials and their topological indices of Jahangir graphs J2,m for all integer number m ≥ 3 are calculated.

Combating COVID-19: Nigerian Nurses’ Perspectives and Challenges Executive Summary

Coronavirus disease 2019 (COVID-19) is one of the worst deadly infections that is currently causing devastating effects and damages to humanity across the world. The global pandemic which outbroke in Wuhan in China has equally affected almost every country in the world. Over the past several months of the coronavirus crisis, cities went into lockdown, countries issued stay-at-home orders, and an increasing number of people had been practicing social distancing on a societal scale that has never been witnessed. However, nurses continue to provide care, comfort, and information to patients at all levels while risking their personal safety and well-being. This executive report provides an insight in Nigerian nurses’ perspectives and challenges in combating COVID-19 during the surge. Capturing nursing practice and nurses’ experiences during COVID-19 surge provide real-time guidance to mitigating challenges and improving well-being of nurses.

维持性血液透析患者动静脉内瘘穿刺疼痛的相关因素分析

目的：调查分析维持性血液透析患者动静脉内瘘穿刺疼痛的现状及相关影响因素。方法使用疼痛视觉模拟法评分、疼痛自我效能量表及患者一般情况调查表对180例使用动静脉内瘘进行维持性血液透析治疗的患者进行调查。结果回收有效问卷169份，有效回收率93.89%（169/180）。动静脉内瘘穿刺患者穿刺疼痛强度中位数评分为5分，疼痛自我效能得分为（31.42±14.59）分；逐步多元回归分析显示，穿刺疼痛主要与患者性别、内瘘使用时间及疼痛自我效能有关（β=0.152、-0.017、-0.409，P＜0.05），OR值（95%CI）分别为2.069（1.206~3.148）、0.803（0.710~0.984）、1.004（0.886~1.431）；穿刺疼痛强度与疼痛自我效能呈负相关，r=-0.647，P<0.01。结论动静脉内瘘穿刺维持性血液透析患者穿刺疼痛普遍存在，患者的性别、内瘘使用时间及疼痛自我效能可影响患者对疼痛的感知。

基于股价波动理论的上市房企股价与利率变动的外部相关性研究

本文笔者针对上市房企股价波动与利率变化的外部相关性．从理论上分析了利率调整对房企股价的影响因素．结合历史数据，运用事件研究方法．选取上证综指和深成指，对证监会分类下的120家上市房企公司股票进行实证比对剖析，对其内外相关关系进行分析研究．判断利率调整与房地产股价波动的外部相关关系．揭示了利率变动与房企股价波动的外部性．提出了我国利率政策对房地产市场进行调控的政策建议。

Seek and Ye Shall [eventually] Find： The End of the Search for the Auxin Receptor

The mechanism by which the plant hormone auxin regulates gene expression has been shown to involve regulated degradation, through the ubiquitin-proteasome pathway, of transcriptional repressor proteins. However, the key first component in this pathway, the receptor that binds auxin and initiates auxin signaling, has remained a mystery. Two recent papers identify the F-box protein TIR1, part of the complex that attaches ubiquitin to its targets, as an auxin receptor. This breakthrough reveals a new mode of signal transduction and lays the groundwork for a more complete understanding of auxin physiology.

A TABU SEARCH APPROACH TOWARDS CONGESTION AND TOTAL FLOW MINIMIZATION IN OPTICAL NETWORKS

This paper considers rearrangeable multihop lightwave networks whereby each network node is equipped with a number p of transmitters and receivers, and a spectrum of wavelengths is accessible by, and shared among, all nodes by using the Wavelength Division Multiplexing (WDM). Depending on input traffic flow, nodal transmitters and receivers can be re-tuned to create virtual connectivity best suited with respect to a given optimization criterion. We present an efficient heuristic algorithm that combines two criteria for optimization: throughput maximization, as well as total flow minimization. Throughput maximization criterion is equivalent to congestion minimization, while minimizing total flow under the assumption of having links with equal lengths implies minimization of the average number of hops. Taking into account lengths of the links (i.e. link costs proportional with distances), the total flow minimization becomes equivalent to the total delay minimization. Tabu search is implemented as a two-phase strategy dealing with diversification as well as intensification of search. Computational experiments include consecutive runs with different sets of weights associated with the two criteria. Results for a benchmark set of problems are presented.

A technological breakthrough in developing a state-of-the-art nutraceutical sports nutrition formulation to enhance vitality, mental acuity, vigilance, energy, and stamina

The researchers demonstrate the development of a novel Prodosome technology-derived PL425 PEC phytonutrient-enriched electrolyte formulation and its significant contribution in fluid homeostasis as well as enhanced neuromuscular function, cardio-protection, pulmonary, and other physiological cellular and organ functions. Electrolytes enriched in phytonutrients including polyphenolic bioflavonoids, anthocyanins, saccharides, sulforaphanes, carotenoids and exotic spices, in conjunction with a full spectrum of sea water-derived electrolytes, such as sodium, chloride, potassium, calcium, phosphate, magnesium and bicarbonate, along with vitamin C, all of which are encapsulated in the proprietary Prodosome technology enabling enhanced bioavailability. This technology will maintain important biological functions including metabolic and energy homeostasis, pH equilibration, free radical inhibition, cell-to-cell communication, muscular integrity, enhanced neuronal, cardiovascular, pulmonary, and kidney functions. Moreover, these phytonutrients and electrolytes enhance energy metabolism, ATP production, and activate nitric oxide production without L-Arginine. Ongoing research studies are in progress.