Improved Electro Search Algorithm with Intelligent Controller Control System:ESPID Algorithm

Studies have established that hybrid models outperform single models.The particle swarm algorithm(PSO)-based PID(proportional-integral-derivative)controller control system is used in this study to determine the parameters that directly impact the speed and performance of the Electro Search(ESO)algorithm to obtain the global optimum point.ESPID algorithm was created by integrating this system with the ESO algorithm.The improved ESPID algorithm has been applied to 7 multi-modal benchmark test functions.The acquired results were compared to those derived using the ESO,PSO,Atom Search Optimization(ASO),and Vector Space Model(VSM)algorithms.As a consequence,it was determined that the ESPID algorithm’s mean score was superior in all functions.Additionally,while comparing the mean duration value and standard deviations,it is observed that it is faster than the ESO algorithm and produces more accurate results than other algorithms.ESPID algorithm has been used for the least cost problem in the production of pressure vessels,which is one of the real-life pro-blems.Statistical results were compared with ESO,Genetic algorithm and ASO.ESPID was found to be superior to other methods with the least production cost value of 5885.452.

Translational perspective: is cinnamon a suitable agent for cognitive impairment and Alzheimer’s disease associated with brain trauma?

Cinnamon, is an exotic spice and a major constituent of our food which is commonly used in different areas of the world for the treatment of various diseases (Kawatra et al., 2015). Besides 让s anti-inflammatory, anti-diabetic and anti-cancer properties, cinnamon also exerts strong brain protective and pro-cogrdtive effects in various models of neurodegeneration (Kawatra et al., 2015;Kelestemur et al., 2016)(Figure 1).

An investigation of gamma ray mass attenuation from 80.1 to 834.86 keV for fabric coating pastes used in textile sector

In the present study,we investigate several textile coating pastes used in the market based on their radiation protection capability for gamma rays.The gamma ray mass absorption coefficients of some coating pastes doped with antimony,boron and silver elements have been investigated.It has been determined that the gamma ray mass attenuation coefficient decreases rapidly as the energy of the gamma rays increases.It was determined that the doping of the main printing paste with silver and antimony considerably increased the gamma ray absorption capability of main paste.However,the doping of the paste with boron reduces the mass absorption of gamma rays.In particular,the gamma ray mass absorption power of the main paste doped with silver and antimony was determined to be useful in the gamma energy range from 80 to 140keV.This indicates that the newly doped textile material may be considered for radiation protection in the case of low-energy gamma rays.

A different view on the pathophysiology of Parkinson’s disease:a descendent neurochemical hypothesis?

It has been already shown that Parkinson’s disease (PD) is characterized by a prominent degeneration in substantia nigra (SN) neurons. Growing evidence suggests that there is a latent period of PD associated with slight non-motor findings such as olfactory dysfunction (Dickson et al., 2018). However, the potential biomarker role of olfactory dysfunction in PD has been a topic of great interest in the last years (Raskin et al., 1990;Dickson et al., 2018). The classical hypothesis of Braak suggests that PD begins as a synucleinopathy in the lower brainstem or in the olfactory bulb (OB) that progresses rostrally to the SN and amygdala to cause parkinsonism at a later stage of the disease (Burke et al., 2008).

Effectiveness of vedolizumab treatment in two different anti-tumor necrosis factor alpha refractory pouchitis: A case report

BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent diversion.We aimed to show the effect of vedolizumab on treatment of the patient with refractory pouchitis.CASE SUMMARY A 32-year-old male with pancolonic ulcerative colitis since the age of 25 with primary failure of infliximab and mesalamine and intolerance of azathioprine,underwent a total proctocolectomy with ileal pouch-anal anastomosis in 2012.He developed chronic diarrhea in 2014,which was watery,30 per day and accompanied with blood and mucus affecting his quality of life.CONCLUSION Vedolizumab is safe and effective in the management of anti-tumor necrosis factor alpha refractory pouchitis.

Examination of Polymeric Azomethine Compounds and Their Transition Metal Complexes by Using XRF and XRD Technique

In this study,the electronic transition properties and structural analysis of the metal complexes(Ni(Ⅱ),Co(Ⅱ),Cu(Ⅱ)and Mn(Ⅱ))of three different polymer ligands were performed by using XRF and X-ray diffraction(XRD)techniques,respectively.The structural analysis of the polymers and their complexes were performed by XRD technique and some of the polymers were found to be in the face-centred cubic(fcc)structure.In addition,the values of the present K X-ray intensity ratios are significantly greater than the values reported in literature.

Determinants of Export Performance in East Africa Countries

The main objectives of this study are to identify and analyze variables which have impact on export performances of seven East Africa countries and suggest possible solutions to improve export performance in East Africa. Usingdata from World Development Indicators database we conducted panel data analysis for the period of 1990-2014.Empirical results show that labor force, industrialization, foreign direct investment, and exchange rate have positiveimpact on export value. On the other hand, inflation has negative impact on export performance while GDP growthis the only variable that does not affect the export value of East Africa countries. Finally, we suggest somerecommendations, including the need of replacing agricultural exports by the industrial export, improving infrastructural facility as well as the quality of human capital and the need of policies for attracting internationalinvestors.

A self-employed taxpayer experimental study on trust,power,and tax compliance in eleven countries

The slippery slope framework explains tax compliance along two main dimensions,trust in authorities and power of authorities,which influence taxpayers’compliance attitudes.Through frequentist and Bayesian analyses,we investigated the framework’s assumptions on a sample of 2786 self-employed taxpayers from eleven post-communist and non-post-communist countries doing business in five economic branches.After using scenarios that experimentally manipulated trust and power,our results confirmed the framework’s assumptions regarding the attitudes of the self-employed taxpayers;trust and power fostered intended tax compliance and diminished tax evasion,trust boosted voluntary tax compliance,whereas power increased enforced tax compliance.Additionally,self-employed taxpayers from post-communist countries reported higher intended tax compliance and lower tax evasion than those from non-post-communist countries.Our results offer tax authorities insights into how trust and power may contribute to obtaining and maintaining high tax compliance levels amid global economic challenges,downturns,and increasing tax compliance costs.

Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients:a randomised,double-blinded,placebo-controlled phase-II trial

Background Alzheimer’s disease(AD)is associated with metabolic abnormalities linked to critical elements of neurodegeneration.We recently administered combined metabolic activators(CMA)to the AD rat model and observed that CMA improves the AD-associated histological parameters in the animals.CMA promotes mitochondrial fatty acid uptake from the cytosol,facilitates fatty acid oxidation in the mitochondria,and alleviates oxidative stress.Methods Here,we designed a randomised,double-blinded,placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD patients.One-dose CMA included 12.35 g L-serine(61.75%),1 g nicotinamide riboside(5%),2.55 g N-acetyl-L-cysteine(12.75%),and 3.73 g L-carnitine tartrate(18.65%).AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day 84.The primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment arms.The secondary aim of this study was to evaluate the safety and tolerability of CMA.A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD patients.Results We showed a significant decrease of AD Assessment Scale-cognitive subscale(ADAS-Cog)score on day 84 vs day 0(P=0.00001,29%improvement)in the CMA group.Moreover,there was a significant decline(P=0.0073)in ADAS-Cog scores(improvement of cognitive functions)in the CMA compared to the placebo group in patients with higher ADAS-Cog scores.Improved cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging analysis.Moreover,the plasma levels of proteins and metabolites associated with NAD+and glutathione metabolism were significantly improved after CMA treatment.Conclusion Our results indicate that treatment of AD patients with CMA can lead to enhanced cognitive functions and improved clinical parameters associated with phenomics,metabolomics,proteomics and imaging analysis.

Unveiling the reaction products in heat treated Si3N4–Ti joined ceramics by transmission electron microscopy

Joining is a crucial process for the production of complex-shaped advanced engineering materials.Deep understanding of ceramic–metal interfaces during joining or following heat-treatment steps is therefore of important concern in designing the new systems.Capacitor discharge joining(CDJ)method was firstly carried out to compose the ceramic–metal joint material by silicon nitride(Si3N4)–titanium(Ti)constituents.Afterwards,heat treatment was performed on the Si3N4-Ti joints in air atmosphere at 1000℃temperature to reveal the interface reactions and phases.Reaction layer that occurred between the Si3N4 and Ti interfaces and new phase formations were examined by transmission electron microscopy(TEM)-based various imaging and chemical analysis techniques.Electron transparent samples for TEM characterization were prepared by focused ion beam(FIB)milling and lifting method.Based on the detailed TEM results,Si and N diffusion arising from the Si3N4 ceramic was observed towards Ti metal foil side and further interacted with Ti atoms.The upshot of current diffusion was that Ti3N2 reaction layer with 50 nm thickness was formed at the interface while titanium silicon nitride(Ti6Si3N)matrix phase including dendritic-shaped Ti2 N grains occurred in the Ti interlayer.It is believed that our TEM-based microscopy results not only provide the knowledge on ceramic–metal joint materials by CDJ method,but also contribute new insights on the development of various new joint systems.

Dual-holomorphic Functions and Problems of Lifts

The main purpose of this paper is to study the differential geometrical objects on tangent bundle corresponding to dual-holomorphic objects of dual-holomorphic manifold.As a result of this approach,the authors find a new class of lifts(deformed complete lifts)in the tangent bundle.