1.What is mediation analysis?In mediation,we consider an intermediate variable,called the mediator,that helps explain how or why an independent variable influences an outcome.In the context of a treatment study,it is ...1.What is mediation analysis?In mediation,we consider an intermediate variable,called the mediator,that helps explain how or why an independent variable influences an outcome.In the context of a treatment study,it is often of great interest to identify and study the mechanisms by which an intervention achieves its effect.By investigating mediational processes that clarify how the treatment achieves the study outcome,not only can we further our understanding of the pathology of the disease展开更多
1.Introduction Power and sample size estimation constitutes an important component of designing and planning modern scientific studies.It provides information for assessing the feasibility of a study to detect treatme...1.Introduction Power and sample size estimation constitutes an important component of designing and planning modern scientific studies.It provides information for assessing the feasibility of a study to detect treatment effects and for estimating the resources needed to conduct the project.This tutorial discusses the basic concepts of power analysis and the major differences between hypothesis testing and power analyses.We also展开更多
Coronavirus disease 2019(COVID-19)remains a global epidemic.As of August 18,2021,the number of reported cases has exceeded 207 million globally,with more than 4.3 million deaths.COVID-19 has brought devastating losses...Coronavirus disease 2019(COVID-19)remains a global epidemic.As of August 18,2021,the number of reported cases has exceeded 207 million globally,with more than 4.3 million deaths.COVID-19 has brought devastating losses to human society.The overall crude mortality rate is 1-3%.Although pediatric deaths from COVID-19 are rare,they do occur,as over 9,000 children have died from COVID-19 globally to date[1].With the gradual and broad application of COVID-19 vaccines around the world,the rising proportion of cases among children and unvaccinated young adults demands attention.According to World Health Organization surveillance data.展开更多
基金provided by a grant from NIH/NCRR CTSA KL2TR000440
文摘1.What is mediation analysis?In mediation,we consider an intermediate variable,called the mediator,that helps explain how or why an independent variable influences an outcome.In the context of a treatment study,it is often of great interest to identify and study the mechanisms by which an intervention achieves its effect.By investigating mediational processes that clarify how the treatment achieves the study outcome,not only can we further our understanding of the pathology of the disease
基金supported in part by the Clinical and Translational Science Collaborative of Cleveland,UL1TR000439the University of Rochester,5-27607,from the National Institutes of Health
文摘1.Introduction Power and sample size estimation constitutes an important component of designing and planning modern scientific studies.It provides information for assessing the feasibility of a study to detect treatment effects and for estimating the resources needed to conduct the project.This tutorial discusses the basic concepts of power analysis and the major differences between hypothesis testing and power analyses.We also
文摘Coronavirus disease 2019(COVID-19)remains a global epidemic.As of August 18,2021,the number of reported cases has exceeded 207 million globally,with more than 4.3 million deaths.COVID-19 has brought devastating losses to human society.The overall crude mortality rate is 1-3%.Although pediatric deaths from COVID-19 are rare,they do occur,as over 9,000 children have died from COVID-19 globally to date[1].With the gradual and broad application of COVID-19 vaccines around the world,the rising proportion of cases among children and unvaccinated young adults demands attention.According to World Health Organization surveillance data.
