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Genetic testing vs microforceps biopsy in pancreatic cysts:Systematic review and meta-analysis 被引量:1
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作者 Sandra Faias Luisa Pereira +2 位作者 Angelo Luis Paula Chaves Marilia Cravo 《World Journal of Gastroenterology》 SCIE CAS 2019年第26期3450-3467,共18页
BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms.Genetic testing and microforceps biopsy are promising tools for pre-operativ... BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms.Genetic testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is unknown.AIM To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for surgery.METHODS We performed a literature search in Medline,Scopus,and Web of Science for studies evaluating genetic testing of cystic fluid and microforceps biopsy of pancreatic cysts,with endoscopic ultrasound with fine-needle aspiration(EUSFNA)prior to surgery and surgical pathology as reference standard for diagnosis.We evaluated the diagnostic accuracy for:1-benign cysts;2-mucinous low-risk cysts;3-high-risk cysts,and the diagnostic yield and rate of correctly identified cysts with microforceps biopsy and molecular analysis.We also assessed publication bias,heterogeneity,and study quality.RESULTS Eight studies,including 1206 patients,of which 203(17%)referred for surgery who met the inclusion criteria were analyzed in the systematic review,and seven studies were included in the meta-analysis.Genetic testing and microforceps biopsies were identical for diagnosis of benign cysts.Molecular analysis was superior for diagnosis of both low and high-risk mucinous cysts,with sensitivities of 0.89(95%CI:0.79-0.95)and 0.57(95%CI:0.42-0.71),specificities of 0.88(95%CI:0.75-0.95)and 0.88(95%CI:0.80-0.93)and AUC of 0.9555 and 0.92,respectively.The diagnostic yield was higher in microforceps biopsies than in genetic analysis(0.73 vs 0.54,respectively)but the rates of correctly identified cysts were identical(0.73 with 95%CI:0.62-0.82 vs 0.71 with 95%CI:0.49-0.86,respectively).CONCLUSION Genetic testing and microforceps biopsies are useful second tests,with identical results in benign pancreatic cysts.Genetic analysis performs better for low-and high-risk cysts but has lower diagnostic yield. 展开更多
关键词 Pancreatic CYSTS ENDOSCOPIC ULTRASOUND ENDOSCOPIC ULTRASOUND with fineneedle ASPIRATION Genetic testing Microforceps BIOPSY Molecular analysis KRAS Carcinoembryonic antigen CYTOLOGY
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On the Cauchy Problem Describing an Electron-Phonon Interaction
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作者 Joao-Paulo DIAS Mário FIGUEIRA Filipe OLIVEIRA 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2011年第4期483-496,共14页
In this paper, a model is derived to describe a quartic anharmonic interatomic interaction with an external potential involving a pair electron-phonon. The authors study the corresponding Cauchy Problem in the semilin... In this paper, a model is derived to describe a quartic anharmonic interatomic interaction with an external potential involving a pair electron-phonon. The authors study the corresponding Cauchy Problem in the semilinear and quasilinear cases. 展开更多
关键词 SchrSoinger-like equations Cauchy problem BLOW-UP Phonon-electroninteraction
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