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Reliability analysis of carbon fiber rod-reinforced umbilical cable under tension using an improved sampling method
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作者 Yu Zhang Hong-Yu Zhang +2 位作者 Ran Xia Si-Ao Jiang Fang Wang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2769-2778,共10页
The umbilical cable is a vital component of subsea production systems that provide power,chemical agents,control signals et al.,and its requirement for reliability is exceedingly high.However,as the umbilical cable is... The umbilical cable is a vital component of subsea production systems that provide power,chemical agents,control signals et al.,and its requirement for reliability is exceedingly high.However,as the umbilical cable is a composite structure comprising multiple functional units,the reliability analysis of such cables involves numerous parameters that can impact calculation efficiency.In this paper,the reliability analysis of a new kind of umbilical cable with carbon fiber rod under tension is analyzed.The global dynamic analytical model is first established to determine the maximum tension load,then the local analytical model of umbilical cable including each unit are constructed by finite element method(FEM).Based on the mechanical analytical model,the reliability of umbilical cable under tension load is studied using response surface method(RSM)and Monte Carlo method.During the calculation process,a new tangent plane sampling method to calculate the response surface function(RSF)is proposed in this paper,which could make sampling points faster come close to the RSF curve,and it is proved that the calculation efficiency increases about 33%comparing with traditional method. 展开更多
关键词 Umbilical cable Carbon fiber rod Failure analysis Response surface method Reliability
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On the generation of high-quality Nyquist pulses in mode-locked fiber lasers
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作者 任俞宣 葛锦蔓 +2 位作者 李小军 彭俊松 曾和平 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期424-427,共4页
Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers r... Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers. 展开更多
关键词 mode locking laser SOLITON FIBER PULSE
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Effect of neutral polymeric bonding agent on tensile mechanical properties and damage evolution of NEPE propellant
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作者 M.Wubuliaisan Yanqing Wu +3 位作者 Xiao Hou Kun Yang Hongzheng Duan Xinmei Yin 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期357-367,共11页
Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of ne... Introducing Neutral Polymeric bonding agents(NPBA) into the Nitrate Ester Plasticized Polyether(NEPE)propellant could improve the adhesion between filler/matrix interface, thereby contributing to the development of new generations of the NEPE propellant with better mechanical properties. Therefore,understanding the effects of NPBA on the deformation and damage evolution of the NEPE propellant is fundamental to material design and applications. This paper studies the uniaxial tensile and stress relaxation responses of the NEPE propellant with different amounts of NPBA. The damage evolution in terms of interface debonding is further investigated using a cohesive-zone model(CZM). Experimental results show that the initial modulus and strength of the NEPE propellant increase with the increasing amount of NPBA while the elongation decreases. Meanwhile, the relaxation rate slows down and a higher long-term equilibrium modulus is reached. Experimental and numerical analyses indicate that interface debonding and crack propagation along filler-matrix interface are the dominant damage mechanism for the samples with a low amount of NPBA, while damage localization and crack advancement through the matrix are predominant for the ones with a high amount of NPBA. Finally, crosslinking density tests and simulation results also show that the effect of the bonding agent is interfacial rather than due to the overall crosslinking density change of the binder. 展开更多
关键词 Solid propellant Bonding agent Mechanical properties Damage evolution Cohesive-zone model Interface debonding
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Method of improving pedestrian navigation performance based on chest card
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作者 CHENG Hao GAO Shuang +2 位作者 CAI Xiaowen WANG Yuxuan WANG Jie 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期987-998,共12页
With the development of positioning technology,loca-tion services are constantly in demand by people.As a primary location service pedestrian navigation has two main approaches based on radio and inertial navigation.T... With the development of positioning technology,loca-tion services are constantly in demand by people.As a primary location service pedestrian navigation has two main approaches based on radio and inertial navigation.The pedestrian naviga-tion based on radio is subject to environmental occlusion lead-ing to the degradation of positioning accuracy.The pedestrian navigation based on micro-electro-mechanical system inertial measurement unit(MIMU)is less susceptible to environmental interference,but its errors dissipate over time.In this paper,a chest card pedestrian navigation improvement method based on complementary correction is proposed in order to suppress the error divergence of inertial navigation methods.To suppress atti-tude errors,optimal feedback coefficients are established by pedestrian motion characteristics.To extend navigation time and improve positioning accuracy,the step length in subsequent movements is compensated by the first step length.The experi-mental results show that the positioning accuracy of the pro-posed method is improved by more than 47%and 44%com-pared with the pure inertia-based method combined with step compensation and the traditional complementary filtering com-bined method with step compensation.The proposed method can effectively suppress the error dispersion and improve the positioning accuracy. 展开更多
关键词 pedestrian navigation micro-electro-mechanical sy-stem(MEMS) inertial navigation complementary filtering
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Mechanical Properties and Thermal Shock Resistance of SrAl_(2)Si_(2)O_(8) Reinforced BN Ceramic Composites
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作者 WANG Bo CAI Delong +7 位作者 ZHU Qishuai LI Daxin YANG Zhihua DUAN Xiaoming LI Yanan WANG Xuan JIA Dechang ZHOU Yu 《无机材料学报》 SCIE EI CAS CSCD 北大核心 2024年第10期1182-1188,共7页
Hexagonal boron nitride(h-BN)ceramics have become exceptional materials for heat-resistant components in hypersonic vehicles,owing to their superior thermal stability and excellent dielectric properties.However,their ... Hexagonal boron nitride(h-BN)ceramics have become exceptional materials for heat-resistant components in hypersonic vehicles,owing to their superior thermal stability and excellent dielectric properties.However,their densification during sintering still poses challenges for researchers,and their mechanical properties are rather unsatisfactory.In this study,SrAl_(2)Si_(2)O_(8)(SAS),with low melting point and high strength,was introduced into the h-BN ceramics to facilitate the sintering and reinforce the strength and toughness.Then,BN-SAS ceramic composites were fabricated via hot press sintering using h-BN,SrCO_(3),Al_(2)O_(3),and SiO_(2) as raw materials,and effects of sintering pressure on their microstructure,mechanical property,and thermal property were investigated.The thermal shock resistance of BN-SAS ceramic composites was evaluated.Results show that phases of as-preparedBN-SAS ceramic composites are h-BN and h-SrAl_(2)Si_(2)O_(8).With the increase of sintering pressure,the composites’densities increase,and the mechanical properties shew a rising trend followed by a slight decline.At a sintering pressure of 20 MPa,their bending strength and fracture toughness are(138±4)MPa and(1.84±0.05)MPa·m^(1/2),respectively.Composites sintered at 10 MPa exhibit a low coefficient of thermal expansion,with an average of 2.96×10^(-6) K^(-1) in the temperature range from 200 to 1200℃.The BN-SAS ceramic composites prepared at 20 MPa display higher thermal conductivity from 12.42 to 28.42 W·m^(-1)·K^(-1) within the temperature range from room temperature to 1000℃.Notably,BN-SAS composites exhibit remarkable thermal shock resistance,with residual bending strength peaking and subsequently declining sharply under a thermal shock temperature difference ranging from 600 to 1400℃.The maximum residual bending strength is recorded at a temperature difference of 800℃,with a residual strength retention rate of 101%.As the thermal shock temperature difference increase,the degree of oxidation on the ceramic surface and cracks due to thermal stress are also increased gradually. 展开更多
关键词 BN MATRIX composite hot-press SINTERING mechanical PROPERTY thermal shock resistance service reliability
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Multifunctional Integrated Organic-Inorganic-Metal Hybrid Aerogel for Excellent Thermal Insulation and Electromagnetic Shielding Performance
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作者 Zhaoqi Niu Fengjin Qu +8 位作者 Fang Chen Xiaoyan Ma Beixi Chen Luyao Wang Miao Xu Shumeng Wang Liang Jin Chengshuang Zhang Xiao Hou 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第10期163-175,共13页
Vehicles operating in space need to withstand extreme thermal and electromagnetic environments in light of the burgeoning of space science and technology.It is imperatively desired to high insulation materials with li... Vehicles operating in space need to withstand extreme thermal and electromagnetic environments in light of the burgeoning of space science and technology.It is imperatively desired to high insulation materials with lightweight and extensive mechanical properties.Herein,a boron-silica-tantalum ternary hybrid phenolic aerogel(BSiTa-PA)with exceptional thermal stability,extensive mechanical strength,low thermal conductivity(49.6 mW m^(-1)K^(-1)),and heightened ablative resistance is prepared by an expeditious method.After extremely thermal erosion,the obtained carbon aerogel demonstrates noteworthy electromagnetic interference(EMI)shielding performance with an efficiency of 31.6 dB,accompanied by notable loading property with specific modulus of 272.8 kN·m kg^(-1).This novel design concept has laid the foundation for the development of insulation materials in more complex extreme environments. 展开更多
关键词 Multi-hybrid aerogel Metal-phenolic coordination Thermal insulation EMI shielding Convertibility and multifunctionality
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Comprehensive Marine Observing Experiment Based on High-Altitude Large Unmanned Aerial Vehicle(South China Sea Experiment2020 of the “Petrel Project”) 被引量:4
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作者 Xuefen ZHANG Liangxu LI +11 位作者 Rongkang YANG Ran GUO Xia SUN Jianping LUO Hongbin CHEN Daxin LIU Kebing TANG Wenwu PENG Xiaodong HAN Qiyun GUO Xiaoxia LI Xikun FEI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第4期531-537,共7页
In collaboration with 12 other institutions, the Meteorological Observation Center of the China Meteorological Administration undertook a comprehensive marine observation experiment in the South China Sea using the Yi... In collaboration with 12 other institutions, the Meteorological Observation Center of the China Meteorological Administration undertook a comprehensive marine observation experiment in the South China Sea using the Yilong-10 high-altitude large unmanned aerial vehicle(UAV). The Yilong-10 UAV carried a self-developed dropsonde system and a millimeter-wave cloud radar system. In addition, a solar-powered unmanned surface vessel and two drifting buoys were used. The experiment was further supported by an intelligent, reciprocating horizontal drifting radiosonde system that was deployed from the Sansha Meteorological Observing Station, with the intent of producing a stereoscopic observation over the South China Sea. Comprehensive three-dimensional observations were collected using the system from 31 July to2 August, 2020. This information was used to investigate the formation and development processes of Typhoon Sinlaku(2020). The data contain measurements of 21 oceanic and meteorological parameters acquired by the five devices, along with video footage from the UAV. The data proved very helpful in determining the actual location and intensity of Typhoon Sinlaku(2020). The experiment demonstrates the feasibility of using a high-altitude, large UAV to fill in the gaps between operational meteorological observations of marine areas and typhoons near China, and marks a milestone for the use of such data for analyzing the structure and impact of a typhoon in the South China Sea. It also demonstrates the potential for establishing operational UAV meteorological observing systems in the future, and the assimilation of such data into numerical weather prediction models. 展开更多
关键词 high-altitude large UAV MARINE typhoon unmanned surface vessel horizontal drifting radiosonde drifting buoy
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Quantified simulation research on harmonious factors in the leadership teams of aerospace enterprise group
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作者 Yin Xingliang Hu Yunquan +2 位作者 Yang Fuping hao Hanping Tang Ning 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2007年第4期751-757,共7页
A brief account of basic connotation and evaluation indexes system of harmonious leadership teams is given. On this basis, a simulation model is built by using the ARENA simulation software and the quantified simulati... A brief account of basic connotation and evaluation indexes system of harmonious leadership teams is given. On this basis, a simulation model is built by using the ARENA simulation software and the quantified simulation is carried out for the factors of harmonization of aerospace enterprise leadership teams. Moreover, by taking the characteristics of aerospace enterprise leadership teams into consideration, the comparison of harmonization quantified results of several typical leadership teams, especially on the comparative analysis of influencing degrees of moral characters and capabilities on the leadership teams overall harmonization is emphatically discussed. Finally, a conclusion is drawn. 展开更多
关键词 HARMONIZATION AEROSPACE leadership teams quantified simulation ARENA
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Sequential quadratic programming-based non-cooperative target distributed hybrid processing optimization method 被引量:2
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作者 SONG Xiaocheng WANG Jiangtao +3 位作者 WANG Jun SUN Liang FENG Yanghe LI Zhi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第1期129-140,共12页
The distributed hybrid processing optimization problem of non-cooperative targets is an important research direction for future networked air-defense and anti-missile firepower systems. In this paper, the air-defense ... The distributed hybrid processing optimization problem of non-cooperative targets is an important research direction for future networked air-defense and anti-missile firepower systems. In this paper, the air-defense anti-missile targets defense problem is abstracted as a nonconvex constrained combinatorial optimization problem with the optimization objective of maximizing the degree of contribution of the processing scheme to non-cooperative targets, and the constraints mainly consider geographical conditions and anti-missile equipment resources. The grid discretization concept is used to partition the defense area into network nodes, and the overall defense strategy scheme is described as a nonlinear programming problem to solve the minimum defense cost within the maximum defense capability of the defense system network. In the solution of the minimum defense cost problem, the processing scheme, equipment coverage capability, constraints and node cost requirements are characterized, then a nonlinear mathematical model of the non-cooperative target distributed hybrid processing optimization problem is established, and a local optimal solution based on the sequential quadratic programming algorithm is constructed, and the optimal firepower processing scheme is given by using the sequential quadratic programming method containing non-convex quadratic equations and inequality constraints. Finally, the effectiveness of the proposed method is verified by simulation examples. 展开更多
关键词 non-cooperative target distributed hybrid processing multiple constraint minimum defense cost sequential quadratic programming
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Inherent relationship between process parameters,crystallization and mechanical properties of continuous carbon fiber reinforced PEEK composites 被引量:1
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作者 Xiao-long Ma Li-hua Wen +3 位作者 Shi-yu Wang Jin-you Xiao Wen-hao Li Xiao Hou 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期269-284,共16页
High-performance thermoplastic composites have been developed as significant structural materials for cutting-edge equipment in the aerospace and defence fields.However,the internal mechanism of processing parameters ... High-performance thermoplastic composites have been developed as significant structural materials for cutting-edge equipment in the aerospace and defence fields.However,the internal mechanism of processing parameters on mechanical properties in the manufacturing process of thermoplastic composite structures is still a serious challenge.The purpose of this study is to investigate the process/crystallization/property relationships for continuous carbon fiber(CF)reinforced polyether-ether-ketone(PEEK)composites.The composite laminates are fabricated according to orthogonal experiments via the thermoforming method.The mechanical performance is investigated in terms of crystallization properties and fracture morphology characterizations.Experimental results show that the mechanical performance and crystallization properties of thermoplastic composites are significantly affected by the coupling of processing parameters.The increased molding temperature,pressure,and holding time improve the degree of fiber/matrix infiltration and affect the crystallinity and crystalline morphology of the matrix,which further influences the mechanical properties of the composites.This is reflected in the test results that crystallinity has an approximately linear effect on mode-I interlaminar fracture toughness and transverse flexural modulus.As well as the higher molding temperature can destroy the pre-existent crystals to improve the toughness of the matrix,and the well-defined crystalline structures can be observed when fabricated at higher temperatures and longer periods of holding time. 展开更多
关键词 Polymer matrix composites THERMOPLASTIC Processing parameters Mechanical properties CRYSTALLIZATION
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Damage-ignition mechanism studies on modified propellant with different crosslinking density under dynamic loading
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作者 Hong-zheng Duan Yan-qing Wu +2 位作者 Xiao Hou Kun Yang Feng-lei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第10期155-164,共10页
The study of high-energy and low-vulnerability propellants is important for the power performance and safety of solid propellant rocket motors.The modified split Hopkinson pressure bar(SHPB)tests are performed on two ... The study of high-energy and low-vulnerability propellants is important for the power performance and safety of solid propellant rocket motors.The modified split Hopkinson pressure bar(SHPB)tests are performed on two kinds of propellant with different crosslinking density to study the dynamic mechanical responses and damage-ignition mechanism.SHPB apparatus is equipped with a highperformance infrared camera and high-speed camera to capture the deformation,damage-ignition feature and temperature evolution images in the impact process.The results suggested that the mechanical responses and damage-ignition mechanism of the propellants were affected by the strain rates and crosslinking density.The damage-ignition degree is more intense and the reaction occurs earlier with the increase of strain rates.For propellant 1 with higher crosslinking density,the critical ignition strain rate is 4500 s^(-1).Two kinds of propellants show different ignition mechanism,i.e.crack generation,propagation and final fracture for propellant 1 while viscous shear flow for propellant 2.Meanwhile,the SEM images also reveal the difference of damage-ignition mechanism of the two kinds of propellants.Finally,the ignition mechanism under different strain rates and critical ignition strain rate of propellants are further explained by the theoretical calculation of temperature variations. 展开更多
关键词 The modified propellants Dynamic loading Mechanical property Damage-ignition mechanism Experimental and theoretical calculation
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Robust dual-channel correlation algorithm for complex weak target detection with wideband radar
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作者 DAI Yan LIU Dan +2 位作者 LI Chuanming WEI Shaopeng HU Qingrong 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第5期1130-1146,共17页
In the scene of wideband radar,due to the spread of target scattering points,the attitude and angle of view of the target constantly change in the process of moving.It is difficult to predict,and the actual echo of mu... In the scene of wideband radar,due to the spread of target scattering points,the attitude and angle of view of the target constantly change in the process of moving.It is difficult to predict,and the actual echo of multiple scattered points is not fully matched with the transmitted signal.Therefore,it is challenging for the traditional matching filter method to achieve a complete matching effect in wideband echo detection.In addition,the energy dispersion of complex target echoes is still a problem in radar target detection under broadband conditions.Therefore,this paper proposes a wideband target detection method based on dualchannel correlation processing of range-extended targets.This method fully uses the spatial distribution characteristics of target scattering points of echo signal and the matching characteristics of the dual-channel point extension function itself.The radial accumulation of wideband target echo signal in the complex domain is realized through the adaptive correlation processing of a dual-channel echo signal.The accu-mulation effect of high matching degree is achieved to improve the detection probability and the performance of wideband detection.Finally,electromagnetic simulation experiments and measured data verify that the proposed method has the advan-tages of high signal to noise ratio(SNR)gain and high detection probability under low SNR conditions. 展开更多
关键词 wideband radar target detection DUAL-CHANNEL cor-relation
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Vegetation scattering attenuation characteristics of terahertz wave
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作者 JING Qingfeng DIAO Zhuo ZHU Zhongbo 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第6期1501-1507,共7页
A terahertz(THz)wave transmitted through vegetation experiences both absorption and scattering caused by the air molecules and leaves.This paper presents the scattering attenuation characteristics of vegetation in a T... A terahertz(THz)wave transmitted through vegetation experiences both absorption and scattering caused by the air molecules and leaves.This paper presents the scattering attenuation characteristics of vegetation in a THz range.The theoretical path loss model near the vegetation yields the average attenuation of THz waves in a mixed channel composed of air and vegetation leaves.Furthermore,a simplified model of the vegetation structure is obtained for generic vegetation types based on a variety of parameters,such as leaf size,distribution,and moisture content.Finally,based on specific vegetation species and different levels of air humidity,the attenuation characteristics under different conditions are calculated,and the influence of different model parameters on the attenuation characteristics is obtained. 展开更多
关键词 terahertz(THz) scatter attenuation VEGETATION vegetation structure model
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Trimmable bandgap reference circuit with exponential curvature compensation
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作者 Hong-Zhuan Chen Fei Chu +3 位作者 Wen-Tao Lu Tie-Liang Zhang Wen-Chang Li Wei Gao 《Journal of Electronic Science and Technology》 EI CAS CSCD 2023年第3期52-62,共11页
This paper proposes an improved exponential curvature-compensated bandgap reference circuit to exploit the exponential relationship between the current gainβof the bipolar junction transistor(BJT)and the temperature ... This paper proposes an improved exponential curvature-compensated bandgap reference circuit to exploit the exponential relationship between the current gainβof the bipolar junction transistor(BJT)and the temperature as well as reduce the influence of resistance-temperature dependency.Considering the degraded circuit performance caused by the process deviation,the trimmable module of the temperature coefficient(TC)is introduced to improve the circuit stability.The circuit has the advantages of simple structure,high linear stability,high TC accuracy,and trimmable TC.It consumes an area of 0.09 mm^(2)when fabricated by using the 0.25-μm complementary metal-oxide-semiconductor(CMOS)process.The proposed circuit achieves the simulated power supply rejection(PSR)of about-78.7 dB@1 kHz,the measured TC of~4.7 ppm/℃over a wide temperature range from-55℃to 125℃with the 2.5-V single-supply voltage,and the tested line regulation of 0.10 mV/V.Such a high-performance bandgap reference circuit can be widely applied in high-precision and high-reliability electronic systems. 展开更多
关键词 Bandgap reference Exponential curvature compensation Temperature coefficient(TC) Trimmable
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Prediction of the Wastewater’s pH Based on Deep Learning Incorporating Sliding Windows
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作者 Aiping Xu Xuan Zou Chao Wang 《Computer Systems Science & Engineering》 SCIE EI 2023年第10期1043-1059,共17页
To protect the environment,the discharged sewage’s quality must meet the state’s discharge standards.There are many water quality indicators,and the pH(Potential of Hydrogen)value is one of them.The natural water’s... To protect the environment,the discharged sewage’s quality must meet the state’s discharge standards.There are many water quality indicators,and the pH(Potential of Hydrogen)value is one of them.The natural water’s pH value is 6.0–8.5.The sewage treatment plant uses some data in the sewage treatment process to monitor and predict whether wastewater’s pH value will exceed the standard.This paper aims to study the deep learning prediction model of wastewater’s pH.Firstly,the research uses the random forest method to select the data features and then,based on the sliding window,convert the data set into a time series which is the input of the deep learning training model.Secondly,by analyzing and comparing relevant references,this paper believes that the CNN(Convolutional Neural Network)model is better at nonlinear data modeling and constructs a CNN model including the convolution and pooling layers.After alternating the combination of the convolutional layer and pooling layer,all features are integrated into a full-connected neural network.Thirdly,the number of input samples of the CNN model directly affects the prediction effect of the model.Therefore,this paper adopts the sliding window method to study the optimal size.Many experimental results show that the optimal prediction model can be obtained when alternating six convolutional layers and three pooling layers.The last full-connection layer contains two layers and 64 neurons per layer.The sliding window size selects as 12.Finally,the research has carried out data prediction based on the optimal CNN deep learning model.The predicted pH of the sewage is between 7.2 and 8.6 in this paper.The result is applied in the monitoring system platform of the“Intelligent operation and maintenance platform of the reclaimed water plant.” 展开更多
关键词 Deep learning wastewater’s pH convolution neural network(CNN) PREDICTION sliding window
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Pharmacological Monitoring of Capecitabine in a Gastric Cancer Patient with Hyperbilirubinemia
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作者 Yanting Gu Qinghua Lang +3 位作者 Dongmei Chen Jianying Zhang Zheng Liu Ling Gao 《Journal of Biosciences and Medicines》 CAS 2023年第3期120-126,共7页
Objective: To examine therapeutic drug monitoring in managing hyperbilirubinemia caused by capecitabine in patients with gastric adenocarcinoma with extensive liver metastases. Results: The initial liver function test... Objective: To examine therapeutic drug monitoring in managing hyperbilirubinemia caused by capecitabine in patients with gastric adenocarcinoma with extensive liver metastases. Results: The initial liver function tests showed an elevation of transaminases (aspartate amino transferase 615 UI/l, alanine aminotransferase 385.9 UI/l), hyperbilirubinemia (total bilirubin at 246.1 μmol/l), and alkaline phosphatase at 694.6 UI/l. We initiated capecitabine based combination chemotherapy, and the clinical pharmacist conducted a full-course medication monitoring of the patient’s treatment including design of individualized dosing regimens and monitoring of bilirubin, infection, cancer pain, parenteral nutrition support and adverse events. After 21 days of supervision by clinical pharmacist and clinicians, the patient’s bilirubin and transaminase decreased progressively, with aspartate aminotransferase, total bilirubin and alkaline phosphatase falling back to 57 UI/l, 69.8 μmol/l, 307.2 UI/l, respectively. The patient’s condition improved significantly at the time of discharge, with the jaundice subsided, and the bloating relieved. Conclusion: Due to adverse reactions, capecitabine requires medication monitoring during use. The relationship between effectiveness and adverse effects is controversial. Adverse reactions should not be the sole criterion for the use of drugs. Clinical pharmacists can improve the safety and effectiveness of patients’ medications and promote rational drug use by monitoring patients, which may be useful to help the doctors identify the high-risk patients for taking efficient treatment strategy decisions. 展开更多
关键词 Clinical Pharmacist CAPECITABINE Gastric Cancer HYPERBILIRUBINEMIA Therapeutic Drug Monitoring
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A super resolution target separation and reconstruction approach for single channel sar against deceptive jamming
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作者 Shi-qi Liu Bing Li +3 位作者 Bo Zhao Lei Huang Yue-zhou Wu Wei-min Bao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第3期164-175,共12页
The excellent remote sensing ability of synthetic aperture radar(SAR)will be misled seriously when it encounters deceptive jamming which possesses high fidelity and fraudulence.In this paper,the dynamic synthetic aper... The excellent remote sensing ability of synthetic aperture radar(SAR)will be misled seriously when it encounters deceptive jamming which possesses high fidelity and fraudulence.In this paper,the dynamic synthetic aperture(DSA)scheme is used to extract the difference between the true and false targets.A simultaneous deceptive jamming suppression and target reconstruction method is proposed for a single channel SAR system to guarantee remote sensing ability.The system model is formulated as a sparse signal recovery problem with an unknown parametric dictionary to be estimated.An iterative reweighted method is employed to jointly handle the dictionary parameter learning and target reconstruction problem in an majorization-minimization framework,where a surrogate function majorizing the Gaussian entropy in the objective function is introduced to circumvent its non-convexity.After dictionary parameter learning,the grid mismatching problem in a fixed grid based method is avoided.Therefore,the proposed method can reap a super resolution result.Besides,a simple yet effective DSA section scheme is developed for the SAR data excerpting,in which only two DSAs are required.Experimental results about location error and reconstruction power error reveal that the proposed method is able to achieve a good performance in deceptive jamming suppression. 展开更多
关键词 CHANNEL RESOLUTION SEPARATION
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A Cloud Framework for High Spatial Resolution Soil Moisture Mapping from Radar and Optical Satellite Imageries
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作者 GUO Tianhao ZHENG Jia +8 位作者 WANG Chunmei TAO Zui ZHENG Xingming WANG Qi LI Lei FENG Zhuangzhuang WANG Xigang LI Xinbiao KE Liwei 《Chinese Geographical Science》 SCIE CSCD 2023年第4期649-663,共15页
Soil moisture plays an important role in crop yield estimation,irrigation management,etc.Remote sensing technology has potential for large-scale and high spatial soil moisture mapping.However,offline remote sensing da... Soil moisture plays an important role in crop yield estimation,irrigation management,etc.Remote sensing technology has potential for large-scale and high spatial soil moisture mapping.However,offline remote sensing data processing is time-consuming and resource-intensive,and significantly hampers the efficiency and timeliness of soil moisture mapping.Due to the high-speed computing capabilities of remote sensing cloud platforms,a High Spatial Resolution Soil Moisture Estimation Framework(HSRSMEF)based on the Google Earth Engine(GEE)platform was developed in this study.The functions of the HSRSMEF include research area and input datasets customization,radar speckle noise filtering,optical-radar image spatio-temporal matching,soil moisture retrieving,soil moisture visualization and exporting.This paper tested the performance of HSRSMEF by combining Sentinel-1,Sentinel-2 images and insitu soil moisture data in the central farmland area of Jilin Province,China.Reconstructed Normalized Difference Vegetation Index(NDVI)based on the Savitzky-Golay algorithm conforms to the crop growth cycle,and its correlation with the original NDVI is about 0.99(P<0.001).The soil moisture accuracy of the random forest model(R 2=0.942,RMSE=0.013 m3/m3)is better than that of the water cloud model(R 2=0.334,RMSE=0.091 m3/m3).HSRSMEF transfers time-consuming offline operations to cloud computing platforms,achieving rapid and simplified high spatial resolution soil moisture mapping. 展开更多
关键词 soil moisture(SM) Google Earth Engine(GEE) Cloud Computing Platform High Spatial Resolution Soil Moisture Estimation Framework(HSRSMEF) remote sensing Sentienl-1 Sentinel-2 Northeast China
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Protective Effect of Silent Mating Type Information Regulation 2 Homolog 1 on TGF-β1 Pathway via mTOR in Diabetic Nephropathy
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作者 Yanting Gu Dechun Jiang +1 位作者 Pengcheng Xu Yanchun Wang 《Journal of Biosciences and Medicines》 CAS 2023年第2期194-207,共14页
Objective: To demonstrate whether the expression of silent mating type information regulation 2 homolog 1 (SIRT1) affects the level of TGF-β1 and Smad3 in HEK293 cells through regulating mTOR. Methods: First, recombi... Objective: To demonstrate whether the expression of silent mating type information regulation 2 homolog 1 (SIRT1) affects the level of TGF-β1 and Smad3 in HEK293 cells through regulating mTOR. Methods: First, recombinant plasmids DNA (rSIRT1) and siRNA targeting SIRT1 were constructed which were transfected into Human Embryonic Kidney 293 cell (HEK293) cells, respectively. Then, the generation of intracellular ROS in cells was examined by flow cytometry using the oxidation-sensitive probe. Last, the expressions of TGF-β1, smad3, P53, mTOR, p-mTOR, LC3-I and LC3-II in cells were detected to observe the effect of SIRT1 on TGF-β1 Pathway by western blot analysis. Results: We demonstrated that overexpressing of SIRT1 may decrease TGF-β1 and Smad3 expression in HEK293 cells through regulating mTOR. In addition, the result is the opposite when SIRT1 was silent in HEK293 cells. Conclusions: SIRT1 is closely related to TGF-β1/Smad3 pathway that correlates with the regulation of mTOR and ROS generation and causes diabetic nephropathy. The available evidence implies that SIRT1 has great potential as a clinical target for the prevention and treatment of renal fibrosis in the development of DN. 展开更多
关键词 Silent Mating Type Information Regulation 2 Homolog 1 MTOR Diabetic Nephropathy AUTOPHAGY Oxidative Stress
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基于自解耦三明治结构的横向运动栅场效应晶体管MEMS微力传感器
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作者 高文迪 乔智霞 +10 位作者 韩香广 王小章 Adnan Shakoor 刘存朗 卢德江 杨萍 赵立波 王永录 王久洪 蒋庄德 孙东 《Engineering》 SCIE EI CAS CSCD 2023年第2期61-74,M0004,共15页
本文介绍了一种基于横向可移动栅极场效应晶体管(LMGFET)的新型微型力传感器的开发。提出了一种精确的电气模型,用于小型LMGFET器件的性能评估,与以前的模型相比,其精度有所提高。采用了一种新型三明治结构,该结构由一个金交叉解耦栅阵... 本文介绍了一种基于横向可移动栅极场效应晶体管(LMGFET)的新型微型力传感器的开发。提出了一种精确的电气模型,用于小型LMGFET器件的性能评估,与以前的模型相比,其精度有所提高。采用了一种新型三明治结构,该结构由一个金交叉解耦栅阵列层和两个软光阻层SU-8组成。通过所提出的双差分传感结构,LMGFET横向工作在垂直干扰下的输出电流被大大消除,所提出传感器的相对输出误差从4.53%(传统差分结构)降低到0.01%。提出了一种实用的传感器制造工艺,并对其进行了模拟。基于LMGFET的力传感器的灵敏度为4.65μA·nN^(-1),可与垂直可移动栅极场效应晶体管(VMGFET)器件相媲美,但非线性度提高了0.78%,测量范围扩大了±5.10μN。这些分析为LMGFET器件的电气和结构参数提供了全面的设计优化,并证明了所提出的传感器在生物医学显微操作应用中具有良好的力传感潜力。 展开更多
关键词 力传感器 场效应晶体管 横向运动 三明治结构 电气模型 显微操作 非线性度 双差分
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