Effects of different flui replacements on serum HSP70 and lymphocyte DNA damage in college athletes during exercise at high ambient temperatures

Purpose：The aim of this study was to investigate the effects of flui replacement by water or sports drinks on serum heat shock protein 70（HSP70） levels and DNA damage during exercise at a high ambient temperature.Methods：Ten male college athletes with an athletic career ranging from 6 to 11 years were recruited from Yonsei University.The subjects ran on a treadmill at 75% of heart rate reserve during 4 different trials：thermoneutral temperature at 18℃（T）,high ambient temperature at 32℃ without flui replacement（H）,high ambient temperature at 32℃ with water replacement（HW）,and high ambient temperature at 32℃ with sports drink replacement（HS）.During each condition,blood samples were collected at the pre-exercise baseline（PEB）,immediately after exercise（IAE）,and60 min post-exercise.Results：Skin temperature significant y increased during exercise and was significant y higher in H compared to T and HS at IAE.Meanwhile,serum HSP70 was significant y increased in all conditions at IAE compared to PEB and was higher in H compared to T at the former time point.Significant y increased lymphocyte DNA damage（DNA in the tail,tail length,tail moment） was observed in all trials at IAE compared to PEB,and attenuated DNA damage（tail moment） was observed in HS compared to H at IAE.Conclusion：Acute exercise elevates serum HSP70 and induces lymphocyte DNA damage.Fluid replacement by sports drink during exercise at high ambient temperature can attenuate HSP response and DNA damage by preventing dehydration and reducing thermal stress.

Construction of a Computational Scheme for the Fuzzy HIV/AIDS Epidemic Model with a Nonlinear Saturated Incidence Rate

This work aimed to construct an epidemic model with fuzzy parameters.Since the classical epidemic model doesnot elaborate on the successful interaction of susceptible and infective people,the constructed fuzzy epidemicmodel discusses the more detailed versions of the interactions between infective and susceptible people.Thenext-generation matrix approach is employed to find the reproduction number of a deterministic model.Thesensitivity analysis and local stability analysis of the systemare also provided.For solving the fuzzy epidemic model,a numerical scheme is constructed which consists of three time levels.The numerical scheme has an advantage overthe existing forward Euler scheme for determining the conditions of getting the positive solution.The establishedscheme also has an advantage over existing non-standard finite difference methods in terms of order of accuracy.The stability of the scheme for the considered fuzzy model is also provided.From the plotted results,it can beobserved that susceptible people decay by rising interaction parameters.

Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

BACKGROUND Colorectal cancer has a low 5-year survival rate and high mortality.Humanβ-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer cells.Long non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and growth.AIM To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 cells.METHODS CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug concentration.Colony formation assay was employed to assess the effect of hBD-1 on SW620 cell proliferation.Bioinformatics was used to screen potentially biologically significant lncRNAs related to the mTOR pathway.Additionally,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot analysis.RESULTS hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to hBD-1.hBD-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I protein.Furthermore,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR pathway.The lncRNA TCONS_00014506 was ultimately selected.Following the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein expression.CONCLUSION hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

Study on Existing Problems and Countermeasures of Translation Classroom Teaching in College

In recent years,college English teaching in China has made some achievements,but there are still existing many problems,such as inadequate teaching conditions,differences of teachers’professional knowledge and students’lack of interest in translation course,all of which make it difficult to improve the quality of English translation teaching.Therefore,strengthening college English teaching,especially translation teaching is necessary.

Introduction of Western Medicines into China and Improvement on Decoctions during Modern China

During the late Qing dynasty(1840 A.D.-1912 A.D.),a large quantity of Western medicines entered China,which continuously impacted the traditional Chinese medicine(TCM)market and revealed the shortcomings of Chinese medicines.Some personages in the TCM community followed the trend of learning from the West,and attempted to reform TCM,with the improvement on decoction becoming an important aspect of this effort.Through debates and trials,the improvement on decoction underwent three stages of conceptual evolution:“taking Chinese medicines as the foundation and referring to the dosage forms of Western medicines”,“introducing Western techniques to serve the preparation of decoctions”and“integrating the theories of TCM and Western medicine to improve decoctions”.The study highlights the effective complementarity between modern TCM and Western medicine in the field of pharmacy,and provides valuable experience and support for the reevaluation of the value of TCM in contemporary society.

Effect of sodium hyaluronate combined with rehabilitation training on knee joint injury caused by golf

BACKGROUND In high-intensity sports like golf,knee joints are prone to injury,leading to pain,limited mobility,and decreased quality of life.Traditional treatment methods typically involve rehabilitation exercises,but their effectiveness may be limited.In recent years,sodium hyaluronate has emerged as a widely used biomedical material in the treatment of joint diseases.AIM To explore the effect of sodium hyaluronate combined with rehabilitation training on pain degree,flexion range of motion and motor function of knee joint injured by golf.METHODS Eighty patients with knee joint injury caused by golf were randomly divided into control(group B)and observation group(group A).The group B was treated with rehabilitation training,and the group A was treated with sodium hyaluronate combined with rehabilitation training.The clinical efficacy,range of motion and function of knee joint,quality of life and inflammatory factors were compared.RESULTS The excellent and good rate of rehabilitation in the group A was raised than group B.At 6 weeks and 3 months after treatment,the range of motion of the two groups was raised than that before treatment,and that of the group A was raised than group B.After treatment,the scores of Lysholm and International Knee Documentation Committee(IKDC)in the group A were raised,and those in the group A were raised than group B.The VAS score of the two groups was reduced than that of the group B,and the SF-36 score of the group A was reduced than group B.The interleukin(IL)-1β,IL-8 and tumor necrosis factor-αin the two groups were reduced,and those in the group A were reduced than group B.CONCLUSION Sodium hyaluronate combined with rehabilitation training has a good clinical effect in the treatment of patients with knee joint injury caused by golf,which relieve pain,maintain knee joint function and improve patients'life quality.

Physical activity with or without dietary intervention for the prevention of cardiovascular diseases

We and others have published extensively on the benefits of physical activity(PA),exercise training,and cardiorespiratory fitness(CRF)to decrease the prevalence of cardiovascular diseases(CVDs)and CVD and all-cause morbidity and mortality.^(1-5)Both PA and CRF are important;however,CRF,which is mostly obtained through PA,although there is a genetic component,seems to be even more important than PA for predicting prognosis.^(1,4-6)Certainly,the wealth of data from across the world has indicated that increasing PA to enhance CRF while mitigating sedentary behavior would go a long way to lessen the world-wide obesity epidemic and reduce CVD and all-cause mortality.

Experimental and computational study of annealed nickel sulfide quantum dots for catalytic and antibacterial activity

This research investigates the hydrothermal synthesis and annealing duration effects on nickel sulfide(NiS_(2) quantum dots(QDs)for catalytic decolorization of methylene blue(MB)dye and antimicrobial efficacy.QD size increased with longer annealing,reducing catalytic activity.UV–vis,XRD,TEM,and FTIR analyses probed optical structural,morphological,and vibrational features.XRD confirmed NiS2's anorthic structure,with crystallite size growing from 6.53 to 7.81 nm during extended annealing.UV–Vis exhibited a bathochromic shift,reflecting reduced band gap energy(Eg)in NiS_(2).TEM revealed NiS_(2)QD formation,with agglomerated QD average size increasing from 7.13 to 9.65 nm with prolonged annealing.Pure NiS_(2) showed significant MB decolorization(89.85%)in acidic conditions.Annealed NiS_(2) QDs demonstrated notable antibacterial activity,yielding a 6.15mm inhibition zone against Escherichia coli(E.coli)compared to Ciprofloxacin.First-principles computation supported a robust interaction between MB and NiS_(2),evidenced by obtained adsorption energies.This study highlights the nuanced relationship between annealing duration,structural changes,and functional properties in NiS_(2)QDs,emphasizing their potential applications in catalysis and antibacterial interventions.

Strategies and Paths for Constructing Rural Landscape Ecological Security Pattern in the Context of Rural Revitalization

It is one of the fundamental research contents of rural revitalization by constructing a ecological security pattern of rural landscape,providing important basis for scientifically formulating rural spatial planning and sustainable rural development.The research on ecological security patterns of landscape at home and abroad is mainly focused on urban areas.In the context of rural revitalization,the research on strategies and paths for constructing the ecological security pattern of rural landscapes aims to provide important references for the overall planning and design of rural areas and the optimization of rural resource allocation.Using 3S(GPS,RS,GIS)technology methods,this paper systematically analyzes and elaborates on the construction strategies and paths of rural water ecological security pattern,rural biological protection security pattern,rural geological disaster security pattern,and local cultural landscape security pattern.Through the comprehensive superposition of the patterns,a comprehensive ecological security pattern of rural landscape is finally constructed.In the process of constructing and improving the ecological security pattern of rural landscape,emphasis is placed on top-level design,long-term planning,multi-party participation,mechanism improvement,technological innovation,and the strategy of“integrating knowledge with action”.

Nanofluid Heat Transfer in Irregular 3D Surfaces under Magnetohydrodynamics andMulti-Slip Effects

This study employs the Buongiorno model to explore nanoparticle migration in a mixed convection second-grade fluid over a slendering(variable thickness)stretching sheet.The convective boundary conditions are applied to the surface.In addition,the analysis has been carried out in the presence of Joule heating,slips effects,thermal radiation,heat generation and magnetohydrodynamic.This study aimed to understand the complex dynamics of these nanofluids under various external influences.The governing model has been developed using the flow assumptions such as boundary layer approximations in terms of partial differential equations.Governing partial differential equations are first reduced into ordinary differential equations and then numerically solved using the Runge-Kutta-Fehlberg method(RK4)in conjunction with a shooting scheme.Our results indicate significant increases in Nusselt and Sherwood numbers by up to 14.6%and 23.2%,respectively,primarily due to increases in the Brownian motion parameter and thermophoresis parameter.Additionally,increases in the magnetic field parameter led to a decrease in skin friction coefficients by 37.5%.These results provide critical insights into optimizing industrial processes such as chemical production,automotive cooling systems,and energy generation,where efficient heat andmass transfer are crucial.Buongiornomodel;velocity-slip effects;Joule heating;convective boundary conditions;Runge-Kutta-Fehlberg method(RK4).

The Intervention Path of Fundamental Rights under the Scope of International Private Law

In recent years, international private law scholars have argued for the radiating effect of fundamental rights on international private law by introducing constitutional theory. However,there remains a lack of systematic research on how fundamental rights should be integrated into judicial practices concerning foreign-related civil and commercial cases. Throughout the development of international private law, public policy has served as a historical carrier of substantive values for judicial entities and has consistently played a crucial role in value review. In cases of international private law where conflicts arise with the values of fundamental rights, public policy indirectly excludes the legal choice outcomes to safeguard the human rights values inherent in fundamental rights from infringement.However, due to limitations imposed by the degree of connection and relative conditions, traditional paths of public policy have certain constraints and cannot provide comprehensive protection for fundamental rights. Therefore, there is a need for judges to shift their logical paradigms, transcend bilateral choice-of-law models, and introduce a direct intervention path for fundamental rights. This direct intervention path utilizes the logical analysis framework of the protection scope,intervention, and justification of fundamental rights. It can effectively balance conflicting legal interests and maximize the protection of the fundamental rights of the parties involved.

Discussion on the Current Situation of Inclusive Education in Chinese Preschools

At present,the public is beginning to pay attention to education and the growth of young children,and inclusive education is gradually being valued by the public.Society needs to treat everyone equally,include all children,oppose discrimination and exclusion,and protect the right to education of children with special needs.By discovering and eliminating various learning obstacles,all children have more opportunities to participate in learning and realize the personalization of teaching models.The implementation of inclusive education in kindergartens can enable more children with special needs to adapt to and integrate into society.The article discusses the challenges faced by inclusive education in Chinese preschool under the perspective of inclusive education,in order to improve the quality of inclusive education and promote the healthy physical and mental development of children.

Research on the Work-for-Relief Policy within the Scope of Comprehensive Rural Revitalization:Quantitative Analysis of Policy Texts Based on 71 Policy Documents

Work-for-relief plays a unique role in China’s journey toward modernization.From the perspectives of policy tools and interest analysis,this paper uses quantitative analysis of policy texts and integrates grounded theory to build a policy expression analysis model to discuss the current work-for-relief policy system.The study found that China’s use of the work-for-relief policy is unbalanced,and it is necessary to enhance the involvement of non-governmental sectors,as well as to fully consider the policy’s target groups and the social issues that need addressing.

Optimization of Rural Settlement Distributions Based On the Ecological Security Pattern: A Case Study of Da’an City in Jilin Province of China

Following the trends of Chinese rural transformation development, and the sustainable development goals for resources and environment, reasonable arranging the potential development space and the ecological space, so as to optimize the distributions of rural settlement would be the key challenge for rural areas in ecologically fragile regions. From the perspective of maintaining regional ecological security, this paper takes Da’an City, a typical ecological fragile region in Jilin Province, as the case area, constructing the comprehensive ecological security pattern(ESP) on basis of landscape ecology, and applying the landscape pattern indexes to quantitative analysis the spatial distribution characteristics of rural settlements. Then, different optimization directions and management strategies are put forward for rural settlements in each secure zone under the comprehensive ESP. The experimental results showed that 1) the area of the low security zone, the general security zone, the moderate security zone and the extreme security zone was 1570.18 km^2, 1463.36 km^2, 1215.80 km^2 and 629.77 km^2, representing 32.18%, 29.99%, 24.92% and 12.91% of the total area of the target area, respectively. 2) The rural settlements in Da’an City were characterized by a high degree of fragmentation with a large number of small-scale patches. 3) The area of rural settlements in the ecological relocation zone, the in situ remediation zone, the limited development zone and the key development zone was 22.80 km^2, 42.31 km^2, 36.28 km^2 and 19.40 km^2, accounting for 18.88%, 35.03%, 30.04% and 16.06% of the total area of rural settlements, respectively. Then, different measures were proposed for settlements in different optimization zones in order to scientifically plan important ecological space, production space and living space in rural areas. This paper aims to provide fundamental support for rural settlements based on redistribution from the perspective of landscape ecology and provide insights for rural planning and rural habitat environmental improvement.

Tourism resource assessment and spatial analysis of wine tourism development： a case study of the eastern foothills of China＇s Helan Mountains

The reasonable development and utilization of mountainous regions closely relates to local economic development and ecological security. The wine production region in the eastern foothills of the Helan Mountains in Ningxia, Ningxia Hui Autonomous Region, with its excellent terroir, is emerging as one of China's three major geographical attractions. Based on surveys of tourism resources and spatial analysis for this wine producing region, we propose a highly representative and practicable path for wine tourism development. Based on China's national standard in Classification, Investigation and Evaluation of Tourism Resources(GB/T 18972-2003), which recommended the types and grades of tourism resources in one area, we conduct an analysis of resource characteristics and the current state of development. Using Arc GIS software, spatialautocorrelation analysis, average nearest neighbor analysis, as well as clustering and outlier analysis, we are able to derive the spatial distribution characteristics of tourism resources. Our survey showed that tourism resources in this area are relatively abundant and have good quality and clear combination advantages. Nonetheless, there are resources shortage for wine tourism and poor integration of wine production with the tourism industry. Regarding the spatial distribution of resources, we revealed the current states of and issues surrounding regions with concentrated resources, as well as characteristics of this clustering. Finally, we proposed a development path for wine tourism in this region based on the five dimensions of management mode, industrial path, product development, spatial optimization, and market development.

Recreational value of glacier tourism resources：A travel cost analysis for Yulong Snow Mountain

Glaciers, with their unique and spectacular appearances and rich and varied terrain, have received widespread attention and become important tourist attractions. This paper uses the travel cost method to estimate the recreational value of the glacier tourism resources of Yulong Snow Mountain(also called Jade Dragon Snow Mountain), which is the most developed glacier tourist attraction in China. First-hand information was obtained through field surveys, and the travel costs of visitors visiting the Yulong Snow Mountain glacier were calculated before the method was applied to evaluate the recreational value of the focal glacier resource. The results show that the Yulong Snow Mountain consumer surplus associated with its glacier resources in 2016 ranged from 645.59-3439.10 million CNY, and the total recreational value ranged from 1.97-8.17 billion CNY. Approaches allocating travel costs across multiple recreational sites, however, can vary, and there is large difference in estimated results depending on used approaches. Nevertheless, the results of the analysis can help understand the socio-economic value of glacier resources and provide a reference for their development and protection.

Spatial-temporal Evolution and Determinants of the Belt and Road Initiative: A Maximum Entropy Gravity Model Approach

The spatial interaction model is an effective way to explore the geographical disparities inherent in the Belt and Road Initiative(BRI) by simulating spatial flows. The traditional gravity model implies the hypothesis of equilibrium points without any reference to when or how to achieve it. In this paper, a dynamic gravity model was established based on the Maximum Entropy(MaxEnt) theory to estimate and monitor the interconnection intensity and dynamic characters of bilateral relations. In order to detect the determinants of interconnection intensity, a Geodetector method was applied to identify and evaluate the determinants of spatial networks in five dimensions. The empirical study clearly demonstrates a heterogeneous and non-circular spatial structure. The main driving forces of spatial-temporal evolution are foreign direct investment, tourism and railway infrastructure construction, while determinants in different sub-regions show obvious spatial differentiation. Southeast Asian countries are typically multi-island area where aviation infrastructure plays a more important role. North and Central Asian countries regard oil as a pillar industry where power and port facilities have a greater impact on the interconnection. While Western Asian countries are mostly influenced by the railway infrastructure, Eastern European countries already have relatively robust infrastructure where tariff policies provide a greater impetus.

The effects of social security expenditure on reducing income inequality and rural poverty in China

Social security has,as one of its primary aims,the provision of financial support to those deemed to be poor or facing the threat of poverty.Based on China's national statistical data covering social insurance,social assistance,and social welfare between the period 1978–2018,this paper evaluates the effect of social security expenditure in reducing income inequality and rural poverty with cointegration analysis.It was found that there is a positive correlation between social security expenditure and the income gap of urban and rural residents in the long run,but the effect is very limited;nearly 99%of the changes of the urban–rural income gap come from its own contributions.Further research also shows that the elasticity of rural poverty incidence to social security expenditure is–0.2255,which indicates social security expenditure helps reduce rural absolute poverty.Based on these findings,the policy implications can be that much social security expenditure and a more equitable social security system should be encouraged.It will become one of the major anti-poverty strategies after 2020 in China when we win the battle against absolute poverty.

Application of evidence theory in information fusion of multiple sources in bayesian analysis

How to obtain proper prior distribution is one of the most critical problems in Bayesian analysis. In many practical cases, the prior information often comes from different sources, and the prior distribution form could be easily known in some certain way while the parameters are hard to determine. In this paper, based on the evidence theory, a new method is presented to fuse the information of multiple sources and determine the parameters of the prior distribution when the form is known. By taking the prior distributions which result from the information of multiple sources and converting them into corresponding mass functions which can be combined by Dempster-Shafer (D-S) method, we get the combined mass function and the representative points of the prior distribution. These points are used to fit with the given distribution form to determine the parameters of the prior distribution. And then the fused prior distribution is obtained and Bayesian analysis can be performed. How to convert the prior distributions into mass functions properly and get the representative points of the fused prior distribution is the central question we address in this paper. The simulation example shows that the proposed method is effective.

The contribution of cooperative irrigation scheme to poverty reduction in Tanzania

Irrigation system is a scare resource in most of drought-stricken Africa.How to manage and maintain the existing irrigation facilities in Africa is a debatable issue to both policy makers and beneficiaries.Irrigation facilities run by farmer cooperatives are considered ineffective,unsuccessful and dysfunctional in Tanzania by many researchers.A cooperative irrigation scheme is a mechanism that features the collective management of rural irrigation facilities by farmers'cooperative with some government intervention and external support.There is an increasing emphasis on the roles of cooperative irrigation scheme in the development of the agriculture sector and poverty reduction of smallholder farmers.In this study,the authors investigated the management and services of this scheme and analyzed its contribution to poverty reduction of smallholder rice farmers and community development in Tanzania through both quantitative and qualitative methods.The results showed that the scheme helped smallholder farmers increase the rice production and brought better market opportunities.The farmers'net income was also increased.Profit generated from rice farming not only improved the livelihoods of smallholder farmers but also created more employment opportunities in the rural communities.The research also revealed that the scheme was faced with a number of challenges due to resource and institutional constraints and low-level human capacity for both management and members.The research provides a feasible approach to effective management of small-scale agricultural infrastructure for poverty reduction in Africa.