Efficacy of a Nutritional Cream Intervention to Treat Depression in Rescuers:A Randomized Controlled Trial

Objective To explore the effectiveness of a nutritional intervention in rescuers who screened positive for depression.Methods A randomized controlled trial design was employed.From June to August,2022,4,460 rescuers were screened using the Self-Rating Depression Scale(SDS),and 1,615 positive cases were identified.Thirty-one volunteers were recruited and randomly divided into a nutritional intervention group and a control group.The intervention group received health education and nutritional intervention(a compound paste therapy primarily composed of red roses and Seville orange flowers),while the control group received psychological education.SDS scores were assessed before and after the intervention.Results There was a statistically significant decline in SDS scores in the nutritional intervention group after the intervention(P<0.05).Furthermore,the SDS scores of the intervention group were significantly lower than those of the control group,both before and after the intervention(P<0.05).No severe adverse reactions were observed during safety evaluation.Conclusion The nutritional intervention effectively reduced the depression scores in rescuers.Early nutritional intervention is recommended for rescuers who initially screen positive for depression.

Overlapping infections of Mycobacterium canariasense and Nocardia farcinica in an immunocompetent patient:A case report

BACKGROUND Infections by non-tuberculous mycobacteria(NTM)have become more common in recent years.Mycobacterium canariasense(M.canariasense)was first reported as an opportunistic pathogen in 2004,but there have been very few case reports since then.Nocardia is a genus of aerobic and Gram-positive bacilli,and these species are also opportunistic pathogens and in the Mycobacteriales order.Conventional methods for diagnosis of NTM are inefficient.Metagenomic next-generation sequencing(mNGS)can rapidly detect many pathogenic microorganisms,even rare species.Most NTM and Nocardia infections occur in immunocompromised patients with atypical clinical symptoms.There are no previous reports of infection by M.canariasense and Nocardia farcinica(N.farcinica),especially in immunocompetent patients.This case report describes an immunocompetent 52-year-old woman who had overlapping infections of M.canariasense,N.farcinica,and Candida parapsilosis(C.parapsilosis)based on mNGS.CASE SUMMARY A 52-year-old woman presented with a productive cough and chest pain for 2 wk,and recurrent episodes of moderate-grade fever for 1 wk.She received antibiotics for 1 wk at a local hospital,and experienced defervescence,but the productive cough and chest pain persisted.We collected samples of a lung lesion and alveolar lavage fluid for mNGS.The lung tissue was positive for M.canariasense,N.farcinica,and C.parapsilosis,and the alveolar lavage fluid was positive for M.canariasense.The diagnosis was pneumonia,and application of appropriate antibiotic therapy cured the patient.CONCLUSION Etiological diagnosis is critical for patients with infectious diseases.mNGS can identify rare and novel pathogens,and does not require a priori knowledge.

Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride

Objective:To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia.Methods:Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects.The patients were divided into two groups based on different treatment methods:the control group(treated with memantine hydrochloride,34 cases)and the treatment group(treated with sodium oligomannate+memantine hydrochloride,34 cases).Cognitive function,activities of daily living,neurotransmitters,serum intestinal flora metabolic markers,inflammatory factors,neurotrophic factors,and adverse reactions were compared between the two groups.Results:The treatment group showed better cognitive function,quality of life scores,and levels of relevant metabolic markers in the body compared to the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions between the two groups(treatment group:2%;control group:4%)was not statistically significant(χ^(2)=0.731,P=0.393).Conclusion:Sodium oligomannate combined with memantine hydrochloride has better efficacy than the control group for treating senile Alzheimer’s dementia.It significantly improves and restores cognitive function and daily living abilities,benefits neurotransmitter secretion and internal regulation,upregulates the expression of neurotrophic factors,and has fewer adverse reactions,making it a treatment worthy of further clinical promotion and application.

Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome

We present a case of Cronkhite-Canada syndrome(CCS) in which the entire intestine was observed using a prototype of magnifying single-balloon enteroscope(SIF Y-0007, Olympus). CCS is a rare, non-familial gastrointestinal polyposis with ectodermal abnormalities. To our knowledge, this is the first report showing magnified intestinal lesions of CCS. A 73-year-old female visited our hospital with complaints of diarrhea and dysgeusia. The blood test showed mild anemia and hypoalbuminemia. The esophagogastroduodenoscopy and colonoscopy revealed diffuse and reddened sessile to semi-pedunculated polyps, resulting in the diagnosis of CCS. In addition to the findings of conventional balloon-assisted enteroscopy or capsule endoscopy, magnifying observation revealed tiny granular structures, non-uniformity of the villus, irregular caliber of the loop-like capillaries, scattered white spots in the villous tip, and patchy redness of the villus. Histologically, the scattered white spots and patchy redness of the villus reflect lymphangiectasia and bleeding to interstitium, respectively.

Analysis of laboratory and imaging examination results of patients with COVID-192 years after discharge in Chengdu

Objective:To summarize the follow-up results of laboratory examination,echocardiographic and chest CT of patients with COVID-19 at the time of 2 years after discharge in Chengdu.Methods:A total of 29 COVID-19 survivors who have participated in the 1-year follow-up and 2-year follow-up at Public Health Clinical Center of Chengdu were included in our study.Their blood laboratory tests,echocardiography and chest CT results were analyzed in order to evaluate the long-term recovery of COVID-19 survivors.Results:The most common abnormal laboratory test results at the 2-year follow-up were increased serum fibronectin(21 cases,72.4%)and decreased NK cell counts(19 cases,65.5%).Compared with laboratory test results at the 1-year follow-up,platelet count,hydroxybutyrate dehydrogenase and creatine kinase isoenzyme were decreased(all P<0.05),while serum fibrinogen,triglyceride,insulin and non-specific immunoglobulin A were increased(all P<0.05).Serum specific total SARS-CoV-2 antibody amount in COVID-19 survivors at half a year after COVID-19 vaccine was significantly higher than that before vaccination.More than half of patients(55.2%)had normal echocardiography results at the 2-year follow-up,the main abnormal results of them were valve regurgitation(7 cases,24.1%)and reduced left ventricular diastolic function(9 cases,31.0%).Compared with 1-year follow-up,7 patients had fewer abnormal cardiac ultrasound results.28 cases underwent chest CT at the 2-year follow-up,the mainly abnormal results were ground glass shadow(17.9%),pulmonary nodules(diameter<6mm)(32.1%)and scattered cable shadow(39.3%).71.4%(20/28)of them had no significant change between the two chest CT results.Conclusion:The mainly abnormal blood laboratory indicators in COVID-19 survivors at 2-year follow-up after discharge were increased serum fibronectin and decreased NK cell counts.Although echocardiography and chest CT results were no significant change between 1-year follow-up and 2-year follow-up among COVID-19 survivors,there were still some patients whose abnormal results were decreasing.Serum specific total SARS-CoV-2 antibody amount in COVID-19 survivors at half a year after COVID-19 vaccine was still significantly higher than that before vaccination,but the amount of specific antibody had a downward trend with time.

Clinical characteristics of 290 foreign-imported cases infected with SARS-CoV-2 in Chengdu, China

Objective:To analyze the epidemiological and clinical characteristics of foreign-imported patients infected with SARS-CoV-2 in Chengdu City.Methods:A total of 290 foreign-imported patients infected with SARS-CoV-2 and discharged from Public Health Clinical Center of Chengdu were included in our study,they were divided into asymptomatic infection group(131 cases)and confirmed cases group(159 cases)in order to compare the epidemiology,clinical characteristics and laboratory tests between two groups.Multi-factor logistic regression analysis was used to investigate the influence factors of becoming a dominant infection after infected with SARS-CoV-2.Results:Among the 290 cases aged from 2 months to 68 years old,83.4%were males,62.1%came from Asia,and 43.8%were complicated with fatty liver disease,the age group of 14-49 years old had the largest number(247 cases).80.5%confirmed case group cases were general type,there was only 1 severe patient.Hospital stays in asymptomatic infection group was shorter than that in confirmed cases group,lymphocyte count,CD4+T count,CD8+T count,CD4+T/CD8+T creatine kinase in two groups half a month after discharge were relatively lower than those on admission,and alanine aminotransferase,aspartate aminotransferase,albumin,lactate dehydrogenase,creatine kinase isoenzyme were relatively higher than those on admission(P<0.05).Logistic regression analysis showed that increased age,decreased lymphocyte count on admission and increased lactate dehydrogenase on admission were associated with dominant infection.Chest CT of 13 general type cases indicated an increase in lesions compared with that at discharge and 3 of them had re-detectable positive RNA test.Conclusion:The majority of foreign-imported cases in Chengdu are mainly from Asia,fewer of them are severe patients.In the early stage of recovery,some SARS-CoV-2 infected patients still have intermittent viral replication.Early isolation and early treatment of imported patients is not only conducive to epidemic prevention and control,but also may change the natural course of the disease.

Neoplastic polyps in gallbladder: a retrospective study to determine risk factors and treatment strategy for gallbladder polyps

Background:Preoperative differentiation of malignant and premalignant gallbladder polyps(GBPs)from benign lesions is a key imperative to guide treatment decision-making.We aimed to characterize the various types of GBPs and sought to identify the risk factors for neoplastic polyps.Our findings may help optimize treatment strategy.Methods:Retrospective analysis of 686 patients with post-cholecystectomy pathologically-proven GBPs between January 2003 and December 2016.The patients were classified into non-neoplastic polyp group,benign neoplastic polyp group,and adenoma canceration group.Clinical features,ultrasound findings,and results of laboratory investigations and histopathological examination were reviewed and compared between the groups.Results:Out of 686 patients,542(79.0%)had non-neoplastic polyps,134(19.5%)had neoplastic polyps,and 10(1.5%)had adenoma canceration.The mean age was 46.06±12.12 years;383(55.8%)patients were female.The median(25th percentile,75th percentile)time between diagnosis and surgery in the cholesterol polyp group[24(3.5,60)months]was significantly longer than that in adenoma[12(2,60)months]and adenoma canceration[5(0.475,12)months]groups.The mean diameter was 1.14±0.61 cm(range,0.5–8.4 cm).Three hundred twelve(45.5%)patients had solitary polyps and intralesional blood flow was observed in 41(6.0%)patients.On univariate analysis,age>49.5 years,polyp size>1.15 cm,solitary polyp,intralesional blood flow,absence of symptoms,and lack of cholecystitis showed a significant association with adenoma.On multivariate analysis,polyp size(>1.15 cm),intralesional blood flow,and lack of cholecystitis were independent predictors of adenoma.Conclusions:Polyp size>1.15 cm,intralesional blood flow,and lack of cholecystitis were predictors of neoplastic polyps.Malignant transformation of adenoma may occur over a relatively short time.