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In advanced pancreatic cancer: The value and significance of interventional therapy 被引量:4
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作者 Chao Hu Maoquan Li 《Journal of Interventional Medicine》 2020年第3期118-121,共4页
Pancreatic cancer is famous as“the king of cancer”due to its high degree of malignancy,rapid course of disease development,and poor prognosis.Relevant epidemiological studies have indicated that with improvement in ... Pancreatic cancer is famous as“the king of cancer”due to its high degree of malignancy,rapid course of disease development,and poor prognosis.Relevant epidemiological studies have indicated that with improvement in people’s standard of living,the morbidity and mortality of pancreatic cancer has increased.At the same time,the disease shows an obvious upward trend worldwide.Pancreatic cancer has become a major public health problem that seriously affects the life and health of people.The present review focuses on the recent advances in interventional therapy such as transcatheter arterial infusion,radiofrequency ablation,microwave ablation,and irreversible electroporation of pancreatic cancer. 展开更多
关键词 Pancreatic cancer Interventional therapy PROGRESS
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Radiomic advances in the transarterial chemoembolization related therapy for hepatocellular carcinoma
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作者 Tian-You Chen Zong-Guo Yang +1 位作者 Ying Li Mao-Quan Li 《World Journal of Radiology》 2023年第4期89-97,共9页
Radiomics is a hot topic in the research on customized oncology treatment,efficacy evaluation,and tumor prognosis prediction.To achieve the goal of mining the heterogeneity information within the tumor tissue,the imag... Radiomics is a hot topic in the research on customized oncology treatment,efficacy evaluation,and tumor prognosis prediction.To achieve the goal of mining the heterogeneity information within the tumor tissue,the image features concealed within the tumoral images are turned into quantifiable data features.This article primarily describes the research progress of radiomics and clinicalradiomics combined model in the prediction of efficacy,the choice of treatment modality,and survival in transarterial chemoembolization(TACE)and TACE combination therapy for hepatocellular carcinoma. 展开更多
关键词 Transarterial chemoembolization Hepatocellular carcinoma Radiomics Magnetic resonance imaging Computed tomography
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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001) 被引量:41
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作者 Hai-Dong Zhu Hai-Liang Li +61 位作者 Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第3期1198-1207,共10页
There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessar... There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. 展开更多
关键词 HEPATOCELLULAR TARGETED MATCHING
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