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Circulating copeptin level and the clinical prognosis of patients with chronic liver disease 被引量:1
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作者 Hao-Qian Tan Ming Zhao +4 位作者 Zan Huang Yang Liu Han Li Long-Hui Ma Jun-Ying Liu 《World Journal of Gastroenterology》 SCIE CAS 2023年第31期4797-4808,共12页
BACKGROUND The relationship between copeptin and the severity of circulatory dysfunction and systemic stress response in patients with chronic liver disease(CLD)has been established.Nevertheless,the potential of serum... BACKGROUND The relationship between copeptin and the severity of circulatory dysfunction and systemic stress response in patients with chronic liver disease(CLD)has been established.Nevertheless,the potential of serum copeptin levels to predict the prognosis of CLD patients remains unclear.AIM To conduct a systematic review and meta-analysis to investigate the correlation between serum copeptin and transplant-free survival(TFS)in this population.METHODS To achieve the objective of the meta-analysis,PubMed,Embase,the Cochrane Library,and the Web of Science were searched to identify observational studies with longitudinal follow-up.The Cochrane Q test was utilized to assess betweenstudy heterogeneity,and the I2 statistic was estimated.Random-effects models were employed to combine the outcomes,taking into account the potential influence of heterogeneity.RESULTS Ten datasets including 3133 patients were involved.The follow-up durations were 1 to 48 mo(mean:12.5 mo).Overall,it was shown that a high level of serum copeptin was associated with a poor TFS[risk ratio(RR):1.82,95%confidence interval:1.52-2.19,P<0.001;I2=0%].In addition,sensitivity analysis by omitting one dataset at a time showed consistent results(RR:1.73-2.00,P<0.05).Finally,subgroup analyses according to study country,study design,patient diagnosis,cutoff of copeptin,follow-up duration,and study quality score also showed similar results(P for subgroup difference all>0.05).CONCLUSION Patients with CLD who have high serum copeptin concentrations may be associated with a poor clinical prognosis. 展开更多
关键词 Chronic liver disease Liver cirrhosis COPEPTIN PROGNOSIS MORTALITY META-ANALYSIS
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Geophysical Significance of the Senegalo-Mali Discontinuity: Evidence from Secondary Structures, Kédougou-Kéniéba Inlier, Western Mali
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作者 Mamadou Yossi Mahamadou Diallo +2 位作者 Mamoutou Ouattara Amadou Berthé Saidou Ly 《Open Journal of Geology》 CAS 2024年第10期943-962,共20页
The present study focuses on the analysis and description of lineaments interpreted as secondary structures to describe the nature of Senegalo Malian Discontinuity. These lineaments cross-cut the large north-south ori... The present study focuses on the analysis and description of lineaments interpreted as secondary structures to describe the nature of Senegalo Malian Discontinuity. These lineaments cross-cut the large north-south oriented transcurrent lithospheric structure known as the Senegalo Malian Discontinuity (SMD). Two lineaments were selected oriented NNE (N15˚ to N25˚), one at Dialafara and one at Sadiola. Four profiles on each lineament of these 2 zones, so that there were 2 on each side of the SMD. The ground data collected were processed using proper parameter and software. Some filters were applied to enhance the signal level. These ground data were later compared to the existing airborne magnetic data for consistency and accuracy using the upward continuation filter. The results show that the quality of ground data is good. In addition, the ground magnetic data show the presence of certain local anomalies that are not visible in the regional data. The analytical signal was also used to determine domain boundaries or possible contact zones. The contact zone can be highlighted on certain profiles such as L300 and L600. The study showed that the west and east sides of the SMD are not the same. Secondary structures become wide when approaching the SMD on both sides. They are also duplicated to the east of the SMD when we move progressively away. In the Dialafara area, the ground magnetic data intersect an interpreted fold. The results of this work confirm the presence of the secondary structures and their evolution in relation to the SMD. The relationships between the secondary structures in the Dailafara and Sadiola zones and their relations with the SMD are highlighted. The technique used in this study, is an important approach to better description and interpreting of regional structures using the secondary structures and proposing a structural model. 展开更多
关键词 Kédougou-Kéniéba Inlier Senegal Malian Discontinuity Secondary Structures Mapping Magnetic Data
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Renin Angiotensin System Components and Cancer: Reports of Association 被引量:2
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作者 Maria Del Carmen Garcia Molina Wolgien Silvana Aparecida Alves Correa +2 位作者 Pedro Alexandre Federico Breuel Afonso Celso Pinto Nazário Gil Facina 《Journal of Biosciences and Medicines》 2016年第5期65-75,共11页
Renin-Angiotensin System (RAS) is involved with hypertension and other cardiovascular diseases. However, the association of RAS components to cancer still causes suspicion. To try to clarify this, here we aimed to sho... Renin-Angiotensin System (RAS) is involved with hypertension and other cardiovascular diseases. However, the association of RAS components to cancer still causes suspicion. To try to clarify this, here we aimed to show this association for three important components: Angiotensin Converting Enzyme 1 (ACE1), Angiotensin Type 1 Receptor (AGTR1) and Angiotensin Type 2 Receptor (AGTR2). The first articles show that association of RAS components with cancer dates back to the 70’s. ECA1 and AGTR1 have close association with cancer and ACE1 inhibitors or AGTR1 blockers are candidates to treatment of some tumors. Moreover, the action of AGTR2 is still controversial, but most studies show that the increased expression of AGTR2 can attack the cancer cells. In breast cancer, these components have also been widely studied and many works have shown that the correlation exists. Therefore specific target using these RAS components could be a beneficial, novel therapy to various tumors. 展开更多
关键词 Renin-Angiotensin System Angiotensin Converting Enzyme Angiotensin Type 1 Receptor Angiotensin Type 2 Receptor Breast Cancer CANCER
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Field Evaluation of Non-aerated Sheep Manure and Water Jacinthe(Eichhornia crassipes)Composts Teas Effects on Tomato(Solanum lycopersicum L.)Health,Mycorrhization and Yield in Mali
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作者 Souleymane BathiéKoné Fallaye Kanté Damase Khasa 《Journal of Agricultural Science and Technology(B)》 2021年第2期89-93,共5页
This study was conducted in context to preserve tomato healthiness and to improve its yield in field.It aimed to assess some effects of non-aerated sheep manure and water jacinthe(Eichhornia crassipes)composts teas.It... This study was conducted in context to preserve tomato healthiness and to improve its yield in field.It aimed to assess some effects of non-aerated sheep manure and water jacinthe(Eichhornia crassipes)composts teas.It specifically consisted to evaluate two teas effects on tomato’s:(a)A.solani foliar disease,(b)yield and(c)mycorrhization intensity.The experiments were conducted according to completely randomized Fisher block with four repetitions.Three treatments were considered:plants receiving non-aerated sheep manure compost tea(TCFM),plants receiving non-aerated water jacinthe compost tea(TCJE),and control plants(T0)without compost tea application.The experiments were repeated twice.Teas application started at four-leaf stage of tomato plants.It was weekly and insured by manual foliar spraying and watering of the plants.To determine the preventive suppressive effects of compost teas,three days after its initial application,plants were artificially inoculated by foliar spraying with Alternaria solani sporal suspension.Data were analyzed with R software.Tukey Contrasts test at 5%threshold was used to compare means.Results showed that TCFM was the most suppressive on A.solani and also had enhanced tomato yield in field.Both teas did not have a meaningful effect on tomato mycorrhization intensity.These results showed that TCFM can serve as biopesticide and biofertilizer in tomato culture. 展开更多
关键词 Evaluation compost teas TOMATO MALI
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Thinkings on Narrowing the Music Education Gap Between Urban and Rural Areas--On the Case of the Urban and Rural Music Education in Gaocheng, Hebei Province
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作者 Huifen Zhao Lei Zhang 《International Journal of Technology Management》 2013年第4期76-78,共3页
Nowadays, the development of quality education has always been attached great importance in China, of which the music education has been an important part. However, serious polarization of the urban and rural basic mu... Nowadays, the development of quality education has always been attached great importance in China, of which the music education has been an important part. However, serious polarization of the urban and rural basic music education leads to all sorts of differences, thus seriously affecting the overall improvement of quality of all people. To find out the problems and the reasons of the backward in rural basic music education, this paper makes an analysis of the differences between urban and rural basic education development through a survey and a study of basic situation in music education of urban and rural elementary school in Gaocheng, Hebei province, and then puts forward thinkings and suggestions about narrowing the urban-rural music education gap on the basis of the analysis of internal and extemal problems. 展开更多
关键词 music education the gap between urban and rural areas LITERACY reasons and suggestions.
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Oral Contraceptives and Health Outcomes:an Umbrella Review of Systematic Reviews and Meta-analyses in Women and Offspring
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作者 Yuan Lin Zou Rui Peng +3 位作者 Ke Di Xu Xiao Ru Jiang Qiu Yu Sun Chun Hua Song 《Journal of Nutritional Oncology》 2022年第1期9-37,共29页
Aim We herein provide an umbrella review of systematic reviews(SR)and meta-analyses(MAs)of studies of the association of oral contraceptives(OCs)with the risks of multiple health outcomes in women and their descendant... Aim We herein provide an umbrella review of systematic reviews(SR)and meta-analyses(MAs)of studies of the association of oral contraceptives(OCs)with the risks of multiple health outcomes in women and their descendants.Methods Two investigators retrieved publications from four electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Database of Systematic Reviews up to March 15,2021.For each association,random/fixed-effects summary effect size and 95%CIs were estimated.Heterogeneity and publication bias were also assessed.The method quality and evidence level for each publication were respectively assessed utilizing the AMSTAR and GRADE checklists.Results A total of 68 articles with 82 unique outcomes were included based on the eligibility criteria.Numerous lines of evidence indicated that OCs had effects on nearly all cardiovascular disease-related outcomes,especially for cerebral venous sinus thrombosis(OR=7.59,95%CI:3.82-15.09).Harmful associations were also found for vulvar vestibulitis(OR=2.31,95%CI:1.03-5.16),preterm birth(OR=1.17,95%CI:1.07-1.27),miscarriage(OR=1.13,95%CI:1.02-1.72),ulcerative colitis(OR=1.22,95%CI:1.06-1.41),Crohn's disease(OR=1.24,95%CI:1.09-1.40),alveolar osteitis(RR=1.86,95%CI:1.66-2.08),dry socket(RR=1.8,95%CI:1.33-2.43),and interstitial cystitis(OR=2.1,95%CI:1.26-3.49).However,oral contraceptives did not increase the risk of cancer except breast and cervical cancer.Maternal exposure to OCs was linked to an increased risk for the development of respiratory atopic disorders such as asthma(OR=1.1,95%CI:1.02-1.19)and rhinitis(OR=1.34,95%CI:1.07-1.68).Conclusion In summary,although their use obviously reduces the risk of pregnancy-and parturition-related morbidity and mortality for women,OCs were frequently related to more harm than benefit in terms of other health outcomes.This was true for both women and their descendants in this umbrella review.More large-scale prospective studies analysing different doses,structures,and durations of treatment with estrogen and progestin are needed to confirm these effects. 展开更多
关键词 CONTRACEPTION Health outcomes Umbrella review META-ANALYSIS Systematic review
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Softw are Maintainability Prediction with UML Class Diagram
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作者 刘丽 朱小冬 郝学良 《Journal of Donghua University(English Edition)》 EI CAS 2015年第1期157-161,共5页
Software system can be classified into many function modules from the perspective of user. Unified modeling language( UML) class diagram of each function module was extracted,and design characteristic metrics which in... Software system can be classified into many function modules from the perspective of user. Unified modeling language( UML) class diagram of each function module was extracted,and design characteristic metrics which influenced software maintainability were selected based on UML class diagram.Choosing metrics of UML class diagram as predictors,and mean maintenance time of function module was regarded as software maintainability parameter. Software maintainability models were built by using back propagation( BP) neural network and radial basis function( RBF) neural network, respectively and were simulated by MATLAB. In order to evaluate the performance of models,the training results were analyzed and compared with leaveone-out cross-validation and model performance evaluation criterion. The result indicated that RBF arithmetic was superior to BP arithmetic in predicting software maintainability. 展开更多
关键词 unified modeling language(UML) class diagram software maintainability back propagation(BP) neural network radial basis function(RBF) neural network
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The Association between LINC00511 Variants and Breast Cancer Susceptibility among the Han Chinese Population
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作者 Fei Fei Chong Jing Jing Cao +6 位作者 Yan Li Wang Qiu Yu Sun Meng Meng Song Xiao Ru Jiang Kai Juan Wang Lin Ping Xu Chun Hua Song 《Journal of Nutritional Oncology》 2020年第2期87-96,共10页
Objective LINC00511 has been considered an oncogene for breast cancer,however,the association between LINC00511 Single nucleotide polymorphisms(SNPs)and breast cancer risk remains unclear.Methods A total of 504 breast... Objective LINC00511 has been considered an oncogene for breast cancer,however,the association between LINC00511 Single nucleotide polymorphisms(SNPs)and breast cancer risk remains unclear.Methods A total of 504 breast cancer patients and 505 cancer-free controls were genotyped for 12 LINC00511 SNPs.A logistic regression analysis was conducted to explore the association between LINC00511 SNPs and breast cancer susceptibility,adjusting for reproductive factors.A haplotype analysis and interaction analysis were applied to assess the role of LINC00511 in breast cancer.Results LINC00511 SNPs were significantly correlated with breast cancer.The TT genotype of rs11657109 reduced the risk of breast cancer(OR:0.454,95%CI:0.212-0.970),while the AG and GG genotypes of rs17780195 played a protective role(OR:0.723,95%CI:0.539-0.970;OR:0.398,95%CI:0.184-0.860,respectively).The mutation of rs9906859 may also lead to a reduction in breast cancer susceptibility(OR:0.682,95%CI:0.520-0.894).Furthermore,LINC00511 SNPs(rs4432291,rs1558535,rs17780195 and rs9906859)are associated with the HER-2 status(P<0.05 for all).The interaction of rs9906859,breastfeeding and age increased the breast cancer risk by 4.318(OR:5.318,95%CI:2.214-12.774).Conclusions LINC00511 SNPs were associated with the risk of breast cancer.There was an association between LINC00511 SNPs and the HER-2 status.There were interactions between LINC00511 SNPs and reproductive factors that affected the risk of breast cancer. 展开更多
关键词 LINC00511 SNPS Breast cancer HAPLOTYPE
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Revitalization of Rural Areas in the New Era:Seeking for Rural Roots and New Rural Appearance-On Qiao Ye's Baoshui Village
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作者 TAN Jie 《Frontiers of Literary Studies in China-Selected Publications from Chinese Universities》 2023年第4期358-364,共7页
With the implementation and advancement of the rural revitalization strategyyin China,literary works rooted in themes such as poverty alleviation and new rural construction have been constantly emerging in recent year... With the implementation and advancement of the rural revitalization strategyyin China,literary works rooted in themes such as poverty alleviation and new rural construction have been constantly emerging in recent years.They focus on aspects like mutual aid between urban and rural areas or learning from experience in poverty alleviation through new rural construction.In doing so,they reveal the great transformations made to villages,villagers’spiritual outlook,and shifts in traditional ideologies.Each work has its unique feature. 展开更多
关键词 RURAL mutual REVIT
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Elemene-containing hyperthermic intraperitoneal chemotherapy combined with chemotherapy for elderly patients with peritoneal metastatic advanced gastric cancer 被引量:3
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作者 Zhi-Xiong Chen Jin Li +2 位作者 Wen-Bin Liu Shou-Ru Zhang Hao Sun 《World Journal of Clinical Cases》 SCIE 2022年第5期1498-1507,共10页
BACKGROUND Almost all elderly patients with peritoneal metastatic gastric cancer(PGC)are unlikely to tolerate cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy(HIPEC)and adjuvant chemothera... BACKGROUND Almost all elderly patients with peritoneal metastatic gastric cancer(PGC)are unlikely to tolerate cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy(HIPEC)and adjuvant chemotherapy.However,determining how to optimize the treatment strategy for such patients has always been a clinical problem.Both HIPEC and palliative adjuvant chemotherapy can benefit patients with PGC.Therefore,optimizing HIPEC and chemotherapy regimens has potential clinical value in reducing side effects,and improving treatment tolerance and clinical effectiveness.AIM To explore the effect of HIPEC containing elemene,which is an anti-cancer component extracted in traditional Chinese herbal medicine,combined with reduced capecitabine and oxaliplatin(CapeOx)chemotherapy regimens,in elderly patients with PGC.METHODS In the present study,39 of 52 elderly PGC patients were included and assigned to different HIPEC treatment groups[lobaplatin group(group L)and mixed group(group M)]for analysis.Lobaplatin was used for all three HIPECs in group L.In group M,lobaplatin was used in the middle of the three HIPECs,and elemene was used for the first and third HIPEC.After HIPEC,patients received CapeOx chemotherapy.The incidence of complications(abdominal infection,lung infection,and urinary tract infection),myelosuppression,immune function(CD4/CD8 ratio),average length of hospital stay,and prognosis were compared between these two groups.RESULTS There was no significant difference in the incidence of complications between the two groups during hospitalization(P>0.05).Compared to patients in group M,patients in group L exhibited severe myelosuppression(P=0.027)and increased length of hospital stay(P=0.045).However,no overall survival benefit was observed in group M.Furthermore,the immune function of patients in group M was less affected(P<0.001),when compared to that of patients in group L.The multivariate analysis suggested that the cycles of chemotherapy after perfusion significantly affected the prognosis of patients in both groups.CONCLUSION Compared to the lobaplatin-based HIPEC regimen,the administration of elemene reduced the myelosuppression incidence in elderly PGC patients.The present study sheds light on the implementation of this therapeutic strategy for this set of patients. 展开更多
关键词 Gastric cancer Hyperthermic intraperitoneal chemotherapy Peritoneal metastasis OXALIPLATIN CAPECITABINE
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Baicalin extracted from Huangqin(Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma(Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9 被引量:14
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作者 Wang Hongwei Li Hailong +5 位作者 Chen Fengqin Luo Jun Gu Jing Wang Huping Wu Hongyan Xu Yan 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2017年第2期229-235,共7页
OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation and apoptosis assays... OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.Real time-quantitative polymerase chain reaction and Western blotting analysis were performed to elucidate the molecular mechanisms underlying the anti-tumor properties of baicalin.RESULTS:In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 μmol/L baicalin for 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed that baicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometric analysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner.Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma(Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the m RNA and protein level.CONCLUSION:Baicalin has potential as a therapeutic agent for gastric cancer by inducing apoptosis in cancer cells. 展开更多
关键词 BAICALIN Stomach neoplasms Apoptosis Lymphoma B-CELL Bcl-2-associated X protein CASPASES EFFECTOR
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