Early detection of cardiac allograft vasculopathy and chronic rejection after heart transplantation-Report of one case

Objective To study clinically the feasibility of early diagnosis of cardiac allograft vascularopathy(CAV) and chronic rejection. Methods A 13-year-old female patient with dilated cardiomy-opathy received orthotopic heart transplantation for advanced heart failure, and subsequent immunosuppressive therapy including cyclosporine, prednisone and mofetil, and a mondily close follow-up. Coronary angiography and left ventricular endomyocardial biopsy (EMB) was perormed 9 months after the operation. Results The clinical and follow-up data of the case showed that cardiac or systemic nonspecific symptoms such as exertional chest discomfort, palpitation, fatigue or fever of unknown reasons were the first and ignorable clinical symptoms, and found disappeared after dosage addition of cyclinsporine, which indicated a early clinical manifestations of rejection or vasculopathy. While persistent sinus tachycardia on electrocadiogram, decreased left ventricular ejection fraction(from 64% -68% down to 47% - 50% ),

Differential expression and implication of m6A methylation in mice with experimental myocardial infarction

Objective To define differentially expressed N6-adenylate methylation (m6A) genes in the myocardial tissue of mice with myocardial infarction (MI) and explore its potential impact on the pathological process of MI.Methods The random number table method was used to divide the eighteen SPF C57BL/6J male mice aged from 8 to 10 weeks into MI group(MI group,n=9)and control group(control group,n=9).

Effects of obstructive sleep apnea syndrome on myocardial work and prognosis in patients with acute myocardial infarction

Objective To investigate the influence of obstructive sleep apnea syndrome (OSAS) on myocardial work and prognosis in patients with acute myocardial infarction(AMI).Methods Patients with complete follow-up data diagnosed with AMI who were admitted to the Second Affiliated Hospital of Suzhou University due to chest pain within 24 hours attacks from February 2020 to January 2022 were retrospective enrolled in the study and were split into two groups based on sleep apnea hypoventilation index (AHI).

Long-term outcomes ofintravascular ultrasound-guided drug-eluting stents implantation in patients with acute coronary syndrome:ULTIMATE ACS subgroup

Objective To explore the long-term effects of intravascular ultrasound(IVUS)guidance on patients with acute coronary syndrome(ACS)undergoing drugeluting stents(DES)implantation.Methods Data used in this study derived from ULTIMATE trial,which was a prospective,multicenter,randomized study.A total of 1448 all-comer patients were enrolled between 2014 August and 2017 May.Primary endpoint of this study was target vessel failure(TVF)at 3 years,including cardiac death,target-vessel-related myocardial infarction,and clinically-driven target vessel revascularization.Results ACS was present in 1136(78.5%)patients,and 3-year clinical follow-up was available in 1423 patients(98.3%).TVF in the ACS group was 9.6%(109/1136),which was significantly higher than 4.5%(14/312)in the non-ACS group(log-rank P=0.005).There were 109 TVFs in the ACS patients,with 7.6%(43/569)TVFs in the IVUS group and 11.6%(66/567)TVFs in the angiography group(log-rank P=0.019).

Prognostic value of growth differentiation factor 15 and hepatocyte growth factor in 5-year mortality for patients with chronic heart failure

Objective To evaluate the value of growth differentiation factor 15 (GDF-15) and hepatocyte growth factor (HGF) in mortality prediction for patients with chronic heart failure (CHF) during a 5-year follow-up.Methods This prospective case-control study enrolled 141 CHF patients hospitalized at the First Affiliated Hospital of Anhui Medical University between August 2015 and September 2017.

OCT analysis of in-stent neointima over 5 years post-DES implantation

Objective To investigate the characteristics of neointimal hyperplasia (NIH) in patients with in-stent restenosis (ISR) over 5 years post-drug-eluting stent(DES) implantation based on optical coherence tomography (OCT).Methods In this cross-sectional study,patients with DES-ISR who underwent OCT examination at PLA General Hospital between March 2010 and March 2022 were retrospectively included.

Correlation between serum growth differentiation factor 11 level and severityof coronary artery disease in patients with acute myocardial infarction

Objective To investigate the correlation between serum growth differentiation factor 11(GDF11)level and coronary artery lesions in patients with ST-segment elevation myocardial infarction(STEMI),and the predictive efficacy of nomogram risk prediction model based on GDF11 combined with traditional risk factors on the occurrence of STEMI.Methods This study was a retrospective cross-sectional study.Patients hospitalized in the Department of Cardiology of the 904th Hospital of Joint Logistic Support Force of People's Liberation Army of China from 2016 to 2018 were selected and divided into control group and STEMI group.The demographic data,blood lipid level,laboratory indicators of blood and GDF11 level were collected.Logistic regression analysis screened out independent correlated factors for the occurrence of STEMI.Spearman correlation analysis clarified the correlation of each indicator with the SYNTAX or Gensini scores.A nomogram risk prediction model for the risk of STEMI occurrence and the receiver operating characteristic curve was used to compare the prediction efficiency of each model.Results A total of 367 patients were enrolled.

The predictive value of microvascular obstruction for adverse left ventricular remodeling after primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction:a prospective study

Objective To elucidate the predictive value of MVO in left ventricular adverse remodeling after primary percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction (STEMI).Methods A total of 167 patients with STEMI undergoing primary PCI in the Chinese PLA General Hospital from2016 to 2020 were enrolled in this prospective cohort study.

Classification,diagnosis and treatment status of pulmonary hypertension from 2012 to 2019:a single center study in Yunnan province

Objective To analyze the classification,diagnosis and treatment status of patients with pulmonary hypertension(PH) in Yunnan province.Methods Hospitalized patients with PH at Yan’an Affiliated Hospital of Kunming Medical University from January 2012 to December 2019 were enrolled.

The diagnostic value of genetic testing in familial hypercholesterolemiainpatients with premature myocardial infarction

Objective To evaluate the diagnostic value of gene testing in familial hypercholesterolemia(FH)in patients with premature myocardial infarction(PMI).Methods This study was a single center cross-sectional study.A retrospective analysis was made on PMI patients who visited the People's Hospital of Peking University from May 1,2015 to March 31,2017.Clinical data of patients were collected and gene testing of FH related genes lowdensity lipoprotei1nreceptor(LDLR),proprotein convertase subtilisin/kexin type 9(PCSK9),apolipoprotein B(APOB)and low density lipoprotein receptor adaptor protein 1(LDLRAP1)was carried out.Clinical diagnosis of FH patients was performed using Simon Broome criteria,DLCN criteria,and FH Chinese expert consensus.Results There were 188 males(83.6%)among 225 PMI patients,and the age of the first myocardial infarction was(46.6±7.2)years old.Ten patients carried FH pathogenic or possibly pathogenic mutations(4.4%).Compared with Simon Broome standard,DLCN standard and FH Chinese expert consensus,gene testing increased the diagnostic rate of FH by 53.3%,33.3%and 42.1%respectively.

Observation on the safety:clinical trail on intracoronary autologus bone marrow mononuclear cells transplantation for acute myocardiol infarction

Objective To investigate the safety of autologous bone marrow mononuclear cell (BM-MNCs) transplantation by intracoronary infusion in patients with acute myocardial infarction (AMI). Methods One hundred and eighty-four patients with AMI treated with percutaneous coronary intervention (PCI) were randomized in a 1:1 way to either intracoronary transplantation of autologous BM-MNCs (n =92) right after PCI or to sodium chloride concluding heparin (controlled, n=92) via a

Impact of orthotopic liver transplantation on serum lipid level and growing development in patients with homozygous or compound heterozygous familial hypercholesterolemia

Objective To investigate the impact of orthotopic liver transplantation on serum lipid and growing development in patients with homozygous(HoFH)or compound heterozygotes(cHeFH)familial hypercholesterolemia.Methods Patients who were treated in Peking Union Medical College Hospital from August 2019 to August 2021.

Impact of individual and combined assessment of age-and sex-specific brachial-ankle pulse wave velocity and pulse pressure on all-cause mortality

Objective To evaluate the impact of individual and combined assessment of age-and sex-specific brachialankle pulse wave velocity(baPWV)and pulse pressure(PP)on all-cause mortality.Methods This study is a prospective cohort study.Individuals participated in the Kailuan Study and completed baPWV measurements between 2010 and 2016 were included in this study.