The 2014 Editorial Council Meeting of China Communications jounal was held in Radisson Plaza Xing Guo Hotel Shanghai on October 15,2014.Present in the meeting were Stephen Weinstein,Chairman of the Council,Zhang Xinsh...The 2014 Editorial Council Meeting of China Communications jounal was held in Radisson Plaza Xing Guo Hotel Shanghai on October 15,2014.Present in the meeting were Stephen Weinstein,Chairman of the Council,Zhang Xinsheng,Vice Chairman and Secretary General of China Institute of Communications,Chen Junliang,Editor in Chief,Yang Qianli,Nim Cheung,Hao Weimin.Niu Zhisheng,Zhang Honggang,Andrzej Jajszczy,and the editorial staff.展开更多
Beginning with Issue 1,Volume 36,2018,the new title,Journal of Oceanology and Limnology will be used officially,with the new ISSN numbers of 2096-5508(print)and 2523-3521(online).In 2017,we encountered a lengthy autho...Beginning with Issue 1,Volume 36,2018,the new title,Journal of Oceanology and Limnology will be used officially,with the new ISSN numbers of 2096-5508(print)and 2523-3521(online).In 2017,we encountered a lengthy authorization procedure on the title change due to certain technical reasons.Dozens of accepted articles had to be published online under the old title of Chinese Journal of Oceanology and Limnology(ISSNs:0254-4059(print)and 1993-5005(online))to meet the strong credential need of the展开更多
The first editorial board meeting of the World Journal of Hepatology(WJH)was held on November 8,2019 at the Side Bar Grille,Sheraton Boston Hotel,Boston,MA,United States.Ruo-Yu Ma,Director of Editorial Office,on behal...The first editorial board meeting of the World Journal of Hepatology(WJH)was held on November 8,2019 at the Side Bar Grille,Sheraton Boston Hotel,Boston,MA,United States.Ruo-Yu Ma,Director of Editorial Office,on behalf of the Baishideng Publishing Group(BPG),organized the meeting with the great help of Professor Ke-Qin Hu,Journal Editor-in-Chief.There were six editorial board members,including two Editors-in-Chief and one administrative director of the editorial office at the meeting,discussing future strategies of the journal’s development.The editorial board provided BPG a number of suggestions in regard to the business plan and quality control of the WJH.Regarding the business aspect,the editorial board suggested that BPG should advertise the WJH at the international Hepatology and Gastroenterology conferences and promote the WJH via social media.On the scientific aspect,the editorial board suggested that the assessment systems for managing the reviewers and the editorial board members are necessary,and that the BPG should make efforts to attract more high-quality manuscript submissions.An additional comment was to continue to foster a scientific culture for the journal.In conclusion,it was noted that these new ideas expressed during the meeting will bring the WJH to the next level.In the future,the BPG and the editorial board will increase communication and collaboration in order to further the development of the WJH.展开更多
【正】The past 2013,the fifth year since the commencement of Journal of Arid Land(JAL),witnessed positive progress in all aspects of the journal.Notable achievements have been made under the joint efforts from Chinese...【正】The past 2013,the fifth year since the commencement of Journal of Arid Land(JAL),witnessed positive progress in all aspects of the journal.Notable achievements have been made under the joint efforts from Chinese Academy of Sciences(CAS,the superintending authority of JAL),the editorial board and the editorial staff.展开更多
The 2021 online editorial board meeting of the World Journal of Hepatology(WJH)was held on January 16,2021.Xiang Li,Director of Production Office on behalf of the Baishideng Publishing Group,organized the meeting.Thre...The 2021 online editorial board meeting of the World Journal of Hepatology(WJH)was held on January 16,2021.Xiang Li,Director of Production Office on behalf of the Baishideng Publishing Group,organized the meeting.Three Editors-in-Chiefs(EiCs)and 15 Baishideng Publishing Group staff attended the meeting.The meeting goal was to brief EiCs on journal performance and gather ideas for journal development in 2021.In 2020,WJH published 204 articles,a 20%increase compared to 2019,authors were from 32 countries and regions,and the average citation per article was three times.However,attracting high quality original article submissions remains a challenge.The EiCs provided feedback and suggestions centered on four topics:(1)Improve journal quality by building editorial;(2)Improve board engagement by establishing a clear policy and consistent internal communications;(3)Improve peer review quality and efficiency;and(4)Refine the current journal marketing strategy to increase visibility and discoverability.展开更多
In the occasion of the 14th National Symposium of Catalysis of China, a meeting of the China's Mainland members of the fourth Editorial Board of Journal of Natural Gas Chemistry (JNGC) was held in Nanjing on Oct...In the occasion of the 14th National Symposium of Catalysis of China, a meeting of the China's Mainland members of the fourth Editorial Board of Journal of Natural Gas Chemistry (JNGC) was held in Nanjing on October 17, 2008. Xinhe Bao, Editor-in-Chief of JNGC, Liwu Lin, Member of the Consultant Board of JNGC, and other China's Mainland members of the Editorial Board Can Li, Huilin Wan, Wei Chu, Shuanshi Fan, Yuan Kou, Dezheng Wang, Ye Wang, Xiaoming Zheng, Xiaoping Zhou, and Fengshou Xiao attended the meeting. The meeting was chaired by Prof. Xinhe Bao.展开更多
The third Earth&Space:from Infrared to Terahertz International Conference(ESIT 2024)successfully took place in Hangzhou,China,from September 20 to 22,2024.Co-hosted by the Shanghai Institute of Technical Physics,C...The third Earth&Space:from Infrared to Terahertz International Conference(ESIT 2024)successfully took place in Hangzhou,China,from September 20 to 22,2024.Co-hosted by the Shanghai Institute of Technical Physics,Chinese'Academy of Sciences(SITP)along with five prestigious institutions,the conference provided a premier platform for international collaboration on cutting-edge developments in infrared,terahertz,and space exploration technologies.展开更多
A letter to the editor constitutes a short communication addressing a range of topics pertinent to the readership of a journal(Dkhar,2018).This format offers several benefits,such as timeliness,accessibility,innovatio...A letter to the editor constitutes a short communication addressing a range of topics pertinent to the readership of a journal(Dkhar,2018).This format offers several benefits,such as timeliness,accessibility,innovation,and conciseness,thereby serving as an effective means to disseminate cuttingedge scientific ideas.Over the past five years,there has been a considerable increase in the number of letters published,representing the highest growth rate(approximately 20%)observed in the last three decades(Figure 1A).In the field of academic publishing,letters to the editor are typically more concise than typical research papers.展开更多
Digital Chinese medicine refers to a comprehensive system that utilizes unified scientific technologies to fully explore and reproduce human phenomenology, patterns of physical changes, and related human experiences. ...Digital Chinese medicine refers to a comprehensive system that utilizes unified scientific technologies to fully explore and reproduce human phenomenology, patterns of physical changes, and related human experiences. It encompasses the acquisition, storage, and processing of traditional Chinese medicine (TCM) data, information.展开更多
To accelerate our endeavors to overcome cancer,Chinese Journal of Cancer has launched a program of publishing 150most important questions in cancer research and clinical oncology.In this article,10 more questions are ...To accelerate our endeavors to overcome cancer,Chinese Journal of Cancer has launched a program of publishing 150most important questions in cancer research and clinical oncology.In this article,10 more questions are presented as follows.Question 15:Can tumor-induced erythrogenesis provide qualified red blood cells for carrying oxygen to distant organs?Question 16:Can we overcome tumor resistance to platinum-containing antineoplastic drugs by activating the sensitivity factors in the tumor?Question 17:How can a cancer cell stay dormant for years?Question 18:Why do cancer cells use distinct transcriptomic and proteomic programs to reach the same metastatic phenotype?Question 19:Why do some cancers regress spontaneously?Question 20:What are the regulatory mechanisms occurring in donor cells that determine selective sorting of biological content into vesicles and their biological consequences in recipient cells?Are the genetic transfer and exchange of biological messages between cells transient?Is the phenotypic manipulation of recipient cells temporary or prolonged and persistent?If extracellular vesicles possess immune-modulatory potential,how could they be exploited for immune interventions and cancer immunotherapy?Presumably the cargo of extracellular vesicles reflects the cells of their origin and can be used for cancer diagnosis,how could the uniform/stringent capture criteria be met universally for applying EVs in point-of-care diagnostics for cancer patients?Question 21:Can we use self-sampling technologies to monitor the tumor genetic alterations for more precise targeted therapy?Can we cure a heterogeneous tumor by sequentially targeting the driver molecules?Question 22:Can we postpone the onset of non-infection-related cancers?Question 23:How many types of cells can jointly form the tumor vasculature to provide blood supply for tumor progression?Question 24:How tumor cells transmit their epigenetic features to daughter cells and maintain the malignant phenotype?展开更多
Myopia is a significant public health problem and its prevalence is increasing over time and genetic factors in disease development are important. The prevalence and incidence of myopia within sampled population often...Myopia is a significant public health problem and its prevalence is increasing over time and genetic factors in disease development are important. The prevalence and incidence of myopia within sampled population often varies with age, country, sec race, ethnicity, occupation, environment, and other factors. Myopia growth is under a combination of genes and their products in time and space to complete the coordination role of the guidance. Myopia-related genes include about 70 genetic loci to which primary myopias have been mapped, although the number is constantly increasing and depends to some extent on definition. Of these, several are associated with additional abnormalities, mostly as part of developmental syndromes. These tend to result from mutations in genes encoding transcriptional activators, and most of these have been identified by sequencing candidate genes in patients with developmental anomalies. Currently, collagen alpha-1 chain of type I(COL1A1), collagen alpha-1 chain of type II(COL2A1), actin, alpha, cardiac muscle 1 (ACTC1), paired box gene 6 (PAX6) and NIPBL (nipped-B homolog), and so on have been mapped. Myopia is most commonly treated with spectacles or glasses. The most common surgical procedure performed to correct myopia is laser keratomileusis (LASIK). This review of the recent advances on epidemiology, genetic locations and treatments of myopia are summarized.展开更多
Objective:To investigate the prevalence and analyze the risk factors of postpartum depression(PPD)in Tangxia Community.Guangzhou,a community representative of the process of urbanization in China.Methods:A total of 1 ...Objective:To investigate the prevalence and analyze the risk factors of postpartum depression(PPD)in Tangxia Community.Guangzhou,a community representative of the process of urbanization in China.Methods:A total of 1 823 delivery women in Tangxia Community.Guangzhou were screened with the Chinese Version of Edinburgh Postnatal Depression Scale,Hamilton Depression Scale and Social Support Rating Scale.The risk factors were evaluated by self-made questionnaire based on literature interview combined with expert consultation.The data collected were analyzed using Student's t test and logistic regression in SPSS16.0.Results:The prevalence of PPD in Tangxia Community,Guangzhou was 27.37%.Mutivariant logistic regression analysis identified mode of delivery,puerperanl from one-child family,relationship between mother-in-law atul daughter-in-law and fetus gender as the risk factors of PPD while housing condition was negatively correlated with the incidence of PPD with OR value of 0.82.The the total score of social support rating scale,the score of objective support,subjective support and social utilization degree were significantly reduced in women with PPD in contrast with women without PPD.Conclusions:The incidence of PPD was slightly higher than other regions of China.It's of great importance to distinguish risk factors in regional culture context and develop health promotion program in order to enhance the well-being of delivery women.展开更多
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 6 more questions a...To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 6 more questions are presented as followed. Question 25: Does imprinting of immune responses to infections early in life predict future risk of childhood and adult cancers? Question 26: How to induce homogeneous tumor antigen expression in a heterogeneous tumor mass to enhance the efficacy of cancer immunotherapy? Question 27: Could we enhance the therapeutic effects of immunotherapy by targeting multiple tumor antigens simultaneously or sequentially? Question 28: Can immunotargeting to cytokines halt cancer metastasis? Question 29: How can we dynamically and less-invasively monitor the activity of CD8^+ T killer cells at tumor sites and draining lymph nodes? Question 30: How can the immune system destroy the niches for cancer initiation?展开更多
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, ...Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77.How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pancreatic cancer and hepatocellular carcinoma? Question 79. What are the true beneficial mechanisms of antiangiogenic therapy in cancer patients? Question 80. How to approach the complex mechanisms of interplay among various cellular and molecular components in the tumor microenvironment? Question 81. Can tissue oxygenation improve the efficacy of conventional chemotherapy on cancer? Question 82. Can tissue oxygenation improve the efficacy of radiotherapy on digestive system tumors including liver cancer? Question 83. Can we integrate metabolic priming into multimodal management of liver cancer? Question 84. Has the limit of anti-androgen strategy in prostate cancer treatment been reached by the new generation of anti-androgen drugs? Question 85. Can we identify individuals with early-stage cancers via analyzing their clinical and non-clinical information collected from social media, shopping history, and clinical, pathological, and molecular traces?展开更多
Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164...Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164 m3 of natural gas. Thus, natural gas hydrates are characterized by their high-energy density and huge resource potential. It is estimated that the world's total natural gas hydrates resource amount is equivalent to twice the total carbon amount of the global proven conventional fuels and can meet the human energy requirement in the future for 1000 years. They are thus the first choice to replace conventional energy of petroleum and coal.展开更多
Congenital cataract is a crystallin severe blinding disease and genetic factors in disease development are important. Crystallin growth is under a combination of genes and their products in time and space to complete ...Congenital cataract is a crystallin severe blinding disease and genetic factors in disease development are important. Crystallin growth is under a combination of genes and their products in time and space to complete the coordination role of the guidance. Congenital cataract-related genes, included crystallin protein gene (CRYAA, CRYAB, CRYBA1/A3, CRYBA4, CRYBB1, CRYBB2, CRYBB3, CRYGC, CRYGD, CRYGS), gap junction channel protein gene (GJA1, GJA3, GJA8), membrane protein gene (GJA3, GJA8, MIP, LIM2), cytoskeletal protein gene (BF-SP2), transcription factor genes (HSF4, MAF, PITX3, PAX6), ferritin light chain gene (FTL), fibroblast growth factor (FGF) and so on. Currently, there are about 39 genetic loci isolated to which primary cataracts have been mapped, although the number is constantly increasing and depends to some extent on definition. We summarized the recent advances on epidemiology and genetic locations of congenital cataract in this review.展开更多
With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, tradit...With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, traditional metal materials cannot meet the functional requirements. Consequently, "three rare mineral resources", regarded as the best altemative for current and future new industries, have received much attention among industrial circles and have become a new focus during the present geological prospecting in China.展开更多
On July 22,2014,the Chinese Journal of Cancer(CJC)received a notification from Thomson Reuters that the publications of our journal starting from 2012 have been accepted for coverage in Science Citation Index Expanded...On July 22,2014,the Chinese Journal of Cancer(CJC)received a notification from Thomson Reuters that the publications of our journal starting from 2012 have been accepted for coverage in Science Citation Index Expanded,available at the Web of Science,Core Collection,Biological Abstracts,and Biosis Previews.What this means in practical terms is that CJC will receive its first official impact factor(IF)in 2015.This is an important milestone in the history展开更多
AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were ra...AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were randomly assigned to propofol (n = 41) and urapidil groups (n = 41). Their gender, age, body mass, operation time and dosage of anesthetics had no significant difference between the two groups (P > 0.05). The patients of propofol and urapidil groups were given propofol (1.5mg/kg) and urapidil (2.5mg/kg) respectively; and two drugs were all diluted with normal saline to 8mL. Then the drugs were given to patients by slow intravenous injection. After treatment, the patients were conducted immediate suction, tracheal extubation, and then patients wore oxygen masks for 10 minutes. By double-blind methods, before the induction medication, at the suction, and 5, 10 minutes after the extubation, we recorded the systolic and diastolic blood pressure (BP), heart rate (HR), pH, PaO2, PaCO2, SaO(2) and intraocular pressure (TOP) respectively. The complete recovery time of the patients with restlessness (on the command they could open eyes and shaking hands) was also recorded during the extubation. The data were analyzed by using a professional SPSS 15.0 statistical software. RESULTS: The incidence of cough, restlessness and glossocoma was significantly lower in the propofol group than that in the urapidil group after extubation (P < 0.05). There were no episodes of hypotension, laryngospasm, or severe respiratory depression. There was no statistical difference in recovery time between two groups (P > 0.05). In propofol group, the BP and HR during extubation and thereafter had no significant difference compared with those before induction, while they were significantly lower than those before giving propofol (P < 0.05), and had significant difference compared with those in urapidil group (P < 0.05). Compared to preinduction, the BP of urapidil group showed no obvious increase during aspiration and extubation. The HR of urapidil group had little changes after being given urapidil, and it was obviously increased compared with that before induction. The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P < 0.05). The IOP of propofol group showed no obvious increase during extubation compared with that in preinduction, while in the urpidil group, extubation caused IOP significantly increased (P < 0.05). The changes in these indicators between the two groups had no significant difference (P > 0.05). CONCLUSION: Compared to urapidil, propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmic patients. Moreover, it has no effects on patient's recovery.展开更多
文摘The 2014 Editorial Council Meeting of China Communications jounal was held in Radisson Plaza Xing Guo Hotel Shanghai on October 15,2014.Present in the meeting were Stephen Weinstein,Chairman of the Council,Zhang Xinsheng,Vice Chairman and Secretary General of China Institute of Communications,Chen Junliang,Editor in Chief,Yang Qianli,Nim Cheung,Hao Weimin.Niu Zhisheng,Zhang Honggang,Andrzej Jajszczy,and the editorial staff.
文摘Beginning with Issue 1,Volume 36,2018,the new title,Journal of Oceanology and Limnology will be used officially,with the new ISSN numbers of 2096-5508(print)and 2523-3521(online).In 2017,we encountered a lengthy authorization procedure on the title change due to certain technical reasons.Dozens of accepted articles had to be published online under the old title of Chinese Journal of Oceanology and Limnology(ISSNs:0254-4059(print)and 1993-5005(online))to meet the strong credential need of the
文摘The first editorial board meeting of the World Journal of Hepatology(WJH)was held on November 8,2019 at the Side Bar Grille,Sheraton Boston Hotel,Boston,MA,United States.Ruo-Yu Ma,Director of Editorial Office,on behalf of the Baishideng Publishing Group(BPG),organized the meeting with the great help of Professor Ke-Qin Hu,Journal Editor-in-Chief.There were six editorial board members,including two Editors-in-Chief and one administrative director of the editorial office at the meeting,discussing future strategies of the journal’s development.The editorial board provided BPG a number of suggestions in regard to the business plan and quality control of the WJH.Regarding the business aspect,the editorial board suggested that BPG should advertise the WJH at the international Hepatology and Gastroenterology conferences and promote the WJH via social media.On the scientific aspect,the editorial board suggested that the assessment systems for managing the reviewers and the editorial board members are necessary,and that the BPG should make efforts to attract more high-quality manuscript submissions.An additional comment was to continue to foster a scientific culture for the journal.In conclusion,it was noted that these new ideas expressed during the meeting will bring the WJH to the next level.In the future,the BPG and the editorial board will increase communication and collaboration in order to further the development of the WJH.
文摘【正】The past 2013,the fifth year since the commencement of Journal of Arid Land(JAL),witnessed positive progress in all aspects of the journal.Notable achievements have been made under the joint efforts from Chinese Academy of Sciences(CAS,the superintending authority of JAL),the editorial board and the editorial staff.
文摘The 2021 online editorial board meeting of the World Journal of Hepatology(WJH)was held on January 16,2021.Xiang Li,Director of Production Office on behalf of the Baishideng Publishing Group,organized the meeting.Three Editors-in-Chiefs(EiCs)and 15 Baishideng Publishing Group staff attended the meeting.The meeting goal was to brief EiCs on journal performance and gather ideas for journal development in 2021.In 2020,WJH published 204 articles,a 20%increase compared to 2019,authors were from 32 countries and regions,and the average citation per article was three times.However,attracting high quality original article submissions remains a challenge.The EiCs provided feedback and suggestions centered on four topics:(1)Improve journal quality by building editorial;(2)Improve board engagement by establishing a clear policy and consistent internal communications;(3)Improve peer review quality and efficiency;and(4)Refine the current journal marketing strategy to increase visibility and discoverability.
文摘In the occasion of the 14th National Symposium of Catalysis of China, a meeting of the China's Mainland members of the fourth Editorial Board of Journal of Natural Gas Chemistry (JNGC) was held in Nanjing on October 17, 2008. Xinhe Bao, Editor-in-Chief of JNGC, Liwu Lin, Member of the Consultant Board of JNGC, and other China's Mainland members of the Editorial Board Can Li, Huilin Wan, Wei Chu, Shuanshi Fan, Yuan Kou, Dezheng Wang, Ye Wang, Xiaoming Zheng, Xiaoping Zhou, and Fengshou Xiao attended the meeting. The meeting was chaired by Prof. Xinhe Bao.
文摘The third Earth&Space:from Infrared to Terahertz International Conference(ESIT 2024)successfully took place in Hangzhou,China,from September 20 to 22,2024.Co-hosted by the Shanghai Institute of Technical Physics,Chinese'Academy of Sciences(SITP)along with five prestigious institutions,the conference provided a premier platform for international collaboration on cutting-edge developments in infrared,terahertz,and space exploration technologies.
文摘A letter to the editor constitutes a short communication addressing a range of topics pertinent to the readership of a journal(Dkhar,2018).This format offers several benefits,such as timeliness,accessibility,innovation,and conciseness,thereby serving as an effective means to disseminate cuttingedge scientific ideas.Over the past five years,there has been a considerable increase in the number of letters published,representing the highest growth rate(approximately 20%)observed in the last three decades(Figure 1A).In the field of academic publishing,letters to the editor are typically more concise than typical research papers.
文摘Digital Chinese medicine refers to a comprehensive system that utilizes unified scientific technologies to fully explore and reproduce human phenomenology, patterns of physical changes, and related human experiences. It encompasses the acquisition, storage, and processing of traditional Chinese medicine (TCM) data, information.
基金FAPESP(Sao Paulo Research Foundation, Proc.No.12/24574–3)CAPES(Coordination for the Improvement of Higher Education Personnel, Proc.No.BEX 7057/15-6)-Brazil
文摘To accelerate our endeavors to overcome cancer,Chinese Journal of Cancer has launched a program of publishing 150most important questions in cancer research and clinical oncology.In this article,10 more questions are presented as follows.Question 15:Can tumor-induced erythrogenesis provide qualified red blood cells for carrying oxygen to distant organs?Question 16:Can we overcome tumor resistance to platinum-containing antineoplastic drugs by activating the sensitivity factors in the tumor?Question 17:How can a cancer cell stay dormant for years?Question 18:Why do cancer cells use distinct transcriptomic and proteomic programs to reach the same metastatic phenotype?Question 19:Why do some cancers regress spontaneously?Question 20:What are the regulatory mechanisms occurring in donor cells that determine selective sorting of biological content into vesicles and their biological consequences in recipient cells?Are the genetic transfer and exchange of biological messages between cells transient?Is the phenotypic manipulation of recipient cells temporary or prolonged and persistent?If extracellular vesicles possess immune-modulatory potential,how could they be exploited for immune interventions and cancer immunotherapy?Presumably the cargo of extracellular vesicles reflects the cells of their origin and can be used for cancer diagnosis,how could the uniform/stringent capture criteria be met universally for applying EVs in point-of-care diagnostics for cancer patients?Question 21:Can we use self-sampling technologies to monitor the tumor genetic alterations for more precise targeted therapy?Can we cure a heterogeneous tumor by sequentially targeting the driver molecules?Question 22:Can we postpone the onset of non-infection-related cancers?Question 23:How many types of cells can jointly form the tumor vasculature to provide blood supply for tumor progression?Question 24:How tumor cells transmit their epigenetic features to daughter cells and maintain the malignant phenotype?
文摘Myopia is a significant public health problem and its prevalence is increasing over time and genetic factors in disease development are important. The prevalence and incidence of myopia within sampled population often varies with age, country, sec race, ethnicity, occupation, environment, and other factors. Myopia growth is under a combination of genes and their products in time and space to complete the coordination role of the guidance. Myopia-related genes include about 70 genetic loci to which primary myopias have been mapped, although the number is constantly increasing and depends to some extent on definition. Of these, several are associated with additional abnormalities, mostly as part of developmental syndromes. These tend to result from mutations in genes encoding transcriptional activators, and most of these have been identified by sequencing candidate genes in patients with developmental anomalies. Currently, collagen alpha-1 chain of type I(COL1A1), collagen alpha-1 chain of type II(COL2A1), actin, alpha, cardiac muscle 1 (ACTC1), paired box gene 6 (PAX6) and NIPBL (nipped-B homolog), and so on have been mapped. Myopia is most commonly treated with spectacles or glasses. The most common surgical procedure performed to correct myopia is laser keratomileusis (LASIK). This review of the recent advances on epidemiology, genetic locations and treatments of myopia are summarized.
基金supported by Medical Science and Technology Foundation of Guangzhou
文摘Objective:To investigate the prevalence and analyze the risk factors of postpartum depression(PPD)in Tangxia Community.Guangzhou,a community representative of the process of urbanization in China.Methods:A total of 1 823 delivery women in Tangxia Community.Guangzhou were screened with the Chinese Version of Edinburgh Postnatal Depression Scale,Hamilton Depression Scale and Social Support Rating Scale.The risk factors were evaluated by self-made questionnaire based on literature interview combined with expert consultation.The data collected were analyzed using Student's t test and logistic regression in SPSS16.0.Results:The prevalence of PPD in Tangxia Community,Guangzhou was 27.37%.Mutivariant logistic regression analysis identified mode of delivery,puerperanl from one-child family,relationship between mother-in-law atul daughter-in-law and fetus gender as the risk factors of PPD while housing condition was negatively correlated with the incidence of PPD with OR value of 0.82.The the total score of social support rating scale,the score of objective support,subjective support and social utilization degree were significantly reduced in women with PPD in contrast with women without PPD.Conclusions:The incidence of PPD was slightly higher than other regions of China.It's of great importance to distinguish risk factors in regional culture context and develop health promotion program in order to enhance the well-being of delivery women.
文摘To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 6 more questions are presented as followed. Question 25: Does imprinting of immune responses to infections early in life predict future risk of childhood and adult cancers? Question 26: How to induce homogeneous tumor antigen expression in a heterogeneous tumor mass to enhance the efficacy of cancer immunotherapy? Question 27: Could we enhance the therapeutic effects of immunotherapy by targeting multiple tumor antigens simultaneously or sequentially? Question 28: Can immunotargeting to cytokines halt cancer metastasis? Question 29: How can we dynamically and less-invasively monitor the activity of CD8^+ T killer cells at tumor sites and draining lymph nodes? Question 30: How can the immune system destroy the niches for cancer initiation?
文摘Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77.How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pancreatic cancer and hepatocellular carcinoma? Question 79. What are the true beneficial mechanisms of antiangiogenic therapy in cancer patients? Question 80. How to approach the complex mechanisms of interplay among various cellular and molecular components in the tumor microenvironment? Question 81. Can tissue oxygenation improve the efficacy of conventional chemotherapy on cancer? Question 82. Can tissue oxygenation improve the efficacy of radiotherapy on digestive system tumors including liver cancer? Question 83. Can we integrate metabolic priming into multimodal management of liver cancer? Question 84. Has the limit of anti-androgen strategy in prostate cancer treatment been reached by the new generation of anti-androgen drugs? Question 85. Can we identify individuals with early-stage cancers via analyzing their clinical and non-clinical information collected from social media, shopping history, and clinical, pathological, and molecular traces?
文摘Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164 m3 of natural gas. Thus, natural gas hydrates are characterized by their high-energy density and huge resource potential. It is estimated that the world's total natural gas hydrates resource amount is equivalent to twice the total carbon amount of the global proven conventional fuels and can meet the human energy requirement in the future for 1000 years. They are thus the first choice to replace conventional energy of petroleum and coal.
文摘Congenital cataract is a crystallin severe blinding disease and genetic factors in disease development are important. Crystallin growth is under a combination of genes and their products in time and space to complete the coordination role of the guidance. Congenital cataract-related genes, included crystallin protein gene (CRYAA, CRYAB, CRYBA1/A3, CRYBA4, CRYBB1, CRYBB2, CRYBB3, CRYGC, CRYGD, CRYGS), gap junction channel protein gene (GJA1, GJA3, GJA8), membrane protein gene (GJA3, GJA8, MIP, LIM2), cytoskeletal protein gene (BF-SP2), transcription factor genes (HSF4, MAF, PITX3, PAX6), ferritin light chain gene (FTL), fibroblast growth factor (FGF) and so on. Currently, there are about 39 genetic loci isolated to which primary cataracts have been mapped, although the number is constantly increasing and depends to some extent on definition. We summarized the recent advances on epidemiology and genetic locations of congenital cataract in this review.
文摘With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, traditional metal materials cannot meet the functional requirements. Consequently, "three rare mineral resources", regarded as the best altemative for current and future new industries, have received much attention among industrial circles and have become a new focus during the present geological prospecting in China.
文摘On July 22,2014,the Chinese Journal of Cancer(CJC)received a notification from Thomson Reuters that the publications of our journal starting from 2012 have been accepted for coverage in Science Citation Index Expanded,available at the Web of Science,Core Collection,Biological Abstracts,and Biosis Previews.What this means in practical terms is that CJC will receive its first official impact factor(IF)in 2015.This is an important milestone in the history
基金National Natural Science Foundation of China (No.39580683)
文摘AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were randomly assigned to propofol (n = 41) and urapidil groups (n = 41). Their gender, age, body mass, operation time and dosage of anesthetics had no significant difference between the two groups (P > 0.05). The patients of propofol and urapidil groups were given propofol (1.5mg/kg) and urapidil (2.5mg/kg) respectively; and two drugs were all diluted with normal saline to 8mL. Then the drugs were given to patients by slow intravenous injection. After treatment, the patients were conducted immediate suction, tracheal extubation, and then patients wore oxygen masks for 10 minutes. By double-blind methods, before the induction medication, at the suction, and 5, 10 minutes after the extubation, we recorded the systolic and diastolic blood pressure (BP), heart rate (HR), pH, PaO2, PaCO2, SaO(2) and intraocular pressure (TOP) respectively. The complete recovery time of the patients with restlessness (on the command they could open eyes and shaking hands) was also recorded during the extubation. The data were analyzed by using a professional SPSS 15.0 statistical software. RESULTS: The incidence of cough, restlessness and glossocoma was significantly lower in the propofol group than that in the urapidil group after extubation (P < 0.05). There were no episodes of hypotension, laryngospasm, or severe respiratory depression. There was no statistical difference in recovery time between two groups (P > 0.05). In propofol group, the BP and HR during extubation and thereafter had no significant difference compared with those before induction, while they were significantly lower than those before giving propofol (P < 0.05), and had significant difference compared with those in urapidil group (P < 0.05). Compared to preinduction, the BP of urapidil group showed no obvious increase during aspiration and extubation. The HR of urapidil group had little changes after being given urapidil, and it was obviously increased compared with that before induction. The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P < 0.05). The IOP of propofol group showed no obvious increase during extubation compared with that in preinduction, while in the urpidil group, extubation caused IOP significantly increased (P < 0.05). The changes in these indicators between the two groups had no significant difference (P > 0.05). CONCLUSION: Compared to urapidil, propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmic patients. Moreover, it has no effects on patient's recovery.