The practice of soccer involves carrying-out actions of high intensity, which demand a great generation of eccentric strength, which in turn results in an increase in the inflammatory response after training practice ...The practice of soccer involves carrying-out actions of high intensity, which demand a great generation of eccentric strength, which in turn results in an increase in the inflammatory response after training practice and game matches. The study aimed to investigate, in combination and individually, the association of 28 polymorphisms with the inflammatory responses of soccer athletes. The sample consisted of 47 male under-20 soccer athletes who belong to clubs in the first division of Brazilian soccer. Blood samples were collected at Pre, and 03, 24, and 48 hours after the training session to evaluate the inflammatory responses (hematological analyzes (hemogram), creatine phosphokinase (CK), high sensitivity quantitative C-reactive protein (CRP), tumor necrosis factor-alpha, (TNFα), interleukin 6 (IL-6) and insulin-like growth factor 1 (IGF-1)). DNA was obtained through scraping of buccal cells, where a sterile swab was rubbed on the inner side of the mouth of each participant 06 times. The database was built using the TruSeq DNA PCRFree kit (Illumina®) and the Covaris equipment for shearing genomic DNA (gDNA) by ultrasound. Of the analyzed SNPs, 09 (ACTN3 rs1815739, COL5A1 rs12722, COL5A1 rs3196378, HGF rs5745697, IGF1 rs35767, IL-6 rs1800795, MMP3 rs679620, SLC30A8 rs13266634, SOX15 rs4227) were individually associated with biomarkers and 07 SNPs, (COL5A1 rs12722, COL5A1 rs3196378, COL5A1 rs1800012, HGF rs5745697, IGF1 rs35767, IL-6 rs1800795 and MMP3 rs679620) analyzed in combination, explained 16% to 40% of the variation of inflammatory responses in soccer athletes. The results suggest that the genotypic profile can be taken into account for a more individualized distribution of the training load, along with the elaboration of recovery strategies for high-level athletes between training sessions and games of high physical and physiological demand.展开更多
Purpose The aims of this study were to propose an alternative method to assess an optimal performance improvement rate(PIR)that would be used as a tool for coaches and elite athletes willing to reach their personal be...Purpose The aims of this study were to propose an alternative method to assess an optimal performance improvement rate(PIR)that would be used as a tool for coaches and elite athletes willing to reach their personal best,mainly those seeking for national,continental or even world record(WR)in middle-distance events.We further compared the improvement rate of women vs.men of the top-10 ranked athletes in the IAAF running these middle-distance events Method The top 10 athletes in the IAAF ranking of 800 m,1500 m,and 3000 m events for each sex were assessed for their history of race times before achieving their personal record(PR).The difference between PR(‘actual’season)and the best race time in the last season was defined as the 1st season improvement rate(1-SIR),whereas the average improvement rate in the last and preceding seasons was the multi-season improvement rate(M-SIR).1-SIR and M-SIR were calculated for each athlete.Result There were sex differences in the 1500 m with a large effect size(d=−0.746)in 1-SIR(P=0.001)and very large(d=−2.249)in M-SIR(P=0.001).Women improved more than men before the PR/WR achievements in the 800 m and 1500 m events(P=0.001)and had similar improvement rates before performing PR/WR in 3000 m events(P=0.533).Conclusion Women improve more before PR/WR achievement in 800 m and 1500 m races.However,in the 3000 m men and women have similar improvement rates in previous seasons before the PR/WR achievement.展开更多
文摘The practice of soccer involves carrying-out actions of high intensity, which demand a great generation of eccentric strength, which in turn results in an increase in the inflammatory response after training practice and game matches. The study aimed to investigate, in combination and individually, the association of 28 polymorphisms with the inflammatory responses of soccer athletes. The sample consisted of 47 male under-20 soccer athletes who belong to clubs in the first division of Brazilian soccer. Blood samples were collected at Pre, and 03, 24, and 48 hours after the training session to evaluate the inflammatory responses (hematological analyzes (hemogram), creatine phosphokinase (CK), high sensitivity quantitative C-reactive protein (CRP), tumor necrosis factor-alpha, (TNFα), interleukin 6 (IL-6) and insulin-like growth factor 1 (IGF-1)). DNA was obtained through scraping of buccal cells, where a sterile swab was rubbed on the inner side of the mouth of each participant 06 times. The database was built using the TruSeq DNA PCRFree kit (Illumina®) and the Covaris equipment for shearing genomic DNA (gDNA) by ultrasound. Of the analyzed SNPs, 09 (ACTN3 rs1815739, COL5A1 rs12722, COL5A1 rs3196378, HGF rs5745697, IGF1 rs35767, IL-6 rs1800795, MMP3 rs679620, SLC30A8 rs13266634, SOX15 rs4227) were individually associated with biomarkers and 07 SNPs, (COL5A1 rs12722, COL5A1 rs3196378, COL5A1 rs1800012, HGF rs5745697, IGF1 rs35767, IL-6 rs1800795 and MMP3 rs679620) analyzed in combination, explained 16% to 40% of the variation of inflammatory responses in soccer athletes. The results suggest that the genotypic profile can be taken into account for a more individualized distribution of the training load, along with the elaboration of recovery strategies for high-level athletes between training sessions and games of high physical and physiological demand.
文摘Purpose The aims of this study were to propose an alternative method to assess an optimal performance improvement rate(PIR)that would be used as a tool for coaches and elite athletes willing to reach their personal best,mainly those seeking for national,continental or even world record(WR)in middle-distance events.We further compared the improvement rate of women vs.men of the top-10 ranked athletes in the IAAF running these middle-distance events Method The top 10 athletes in the IAAF ranking of 800 m,1500 m,and 3000 m events for each sex were assessed for their history of race times before achieving their personal record(PR).The difference between PR(‘actual’season)and the best race time in the last season was defined as the 1st season improvement rate(1-SIR),whereas the average improvement rate in the last and preceding seasons was the multi-season improvement rate(M-SIR).1-SIR and M-SIR were calculated for each athlete.Result There were sex differences in the 1500 m with a large effect size(d=−0.746)in 1-SIR(P=0.001)and very large(d=−2.249)in M-SIR(P=0.001).Women improved more than men before the PR/WR achievements in the 800 m and 1500 m events(P=0.001)and had similar improvement rates before performing PR/WR in 3000 m events(P=0.533).Conclusion Women improve more before PR/WR achievement in 800 m and 1500 m races.However,in the 3000 m men and women have similar improvement rates in previous seasons before the PR/WR achievement.
