Neuroinformatics is a fascinating research field that applies computational models and analytical tools to high dimensional experimental neuroscience data for a better understanding of how the brain functions or dysfu...Neuroinformatics is a fascinating research field that applies computational models and analytical tools to high dimensional experimental neuroscience data for a better understanding of how the brain functions or dysfunctions in brain diseases. Neuroinformaticians work in the intersection of neuroscience and informatics supporting the integration of various sub-disciplines（behavioural neuroscience, genetics, cognitive psychology, etc.） working on brain research. Neuroinformaticians are the pathway of information exchange between informaticians and clinicians for a better understanding of the outcome of computational models and the clinical interpretation of the analysis. Machine learning is one of the most significant computational developments in the last decade giving tools to neuroinformaticians and finally to radiologists and clinicians for an automatic and early diagnosis-prognosis of a brain disease. Random forest（RF） algorithm has been successfully applied to high-dimensional neuroimaging data for feature reduction and also has been applied to classify the clinical label of a subject using single or multi-modal neuroimaging datasets. Our aim was to review the studies where RF was applied to correctly predict the Alzheimer＇s disease（AD）, the conversion from mild cognitive impairment（MCI） and its robustness to overfitting, outliers and handling of non-linear data. Finally, we described our RF-based model that gave us the 1 ^（st） position in an international challenge for automated prediction of MCI from MRI data.展开更多
The previous studies on detection of communities on complex networks were focused on nondirected graphs, such as Neural Networks, social networks, social interrelations, the contagion of diseases, and bibliographies. ...The previous studies on detection of communities on complex networks were focused on nondirected graphs, such as Neural Networks, social networks, social interrelations, the contagion of diseases, and bibliographies. However, there are also other problems whose modeling entails obtaining a weakly connected directed graph such as the student access to the university, the public transport networks, or trophic chains. Those cases deserve particularized study with an analysis and the resolution adjusted to them. Additionally, this is a challenge, since the existing algorithms in most of the cases were originally designed for non-directed graphs or symmetrical and regular graphs. Our proposal is a Benchmark Generator of Weakly Connected Directed Graphs whose properties can be defined by the end-users according to their necessities. The source code of the generators described in this article is available in GitHub under the GNU license.展开更多
基金supported by Medical Research Council(MRC)grant MR/K004360/1 to SIDMARIE CURIE COFUND EU-UK Research Fellowship to SID
文摘Neuroinformatics is a fascinating research field that applies computational models and analytical tools to high dimensional experimental neuroscience data for a better understanding of how the brain functions or dysfunctions in brain diseases. Neuroinformaticians work in the intersection of neuroscience and informatics supporting the integration of various sub-disciplines（behavioural neuroscience, genetics, cognitive psychology, etc.） working on brain research. Neuroinformaticians are the pathway of information exchange between informaticians and clinicians for a better understanding of the outcome of computational models and the clinical interpretation of the analysis. Machine learning is one of the most significant computational developments in the last decade giving tools to neuroinformaticians and finally to radiologists and clinicians for an automatic and early diagnosis-prognosis of a brain disease. Random forest（RF） algorithm has been successfully applied to high-dimensional neuroimaging data for feature reduction and also has been applied to classify the clinical label of a subject using single or multi-modal neuroimaging datasets. Our aim was to review the studies where RF was applied to correctly predict the Alzheimer＇s disease（AD）, the conversion from mild cognitive impairment（MCI） and its robustness to overfitting, outliers and handling of non-linear data. Finally, we described our RF-based model that gave us the 1 ^（st） position in an international challenge for automated prediction of MCI from MRI data.
基金supported by the Project“Complex Networks”from the Instituto Universitario de Matematica Multidisciplinar(IUMM)of the Universitat Politecnica de Valencia(UPV)[under Grant number(266500194)20170251-Complex-Networks-UPV]
文摘The previous studies on detection of communities on complex networks were focused on nondirected graphs, such as Neural Networks, social networks, social interrelations, the contagion of diseases, and bibliographies. However, there are also other problems whose modeling entails obtaining a weakly connected directed graph such as the student access to the university, the public transport networks, or trophic chains. Those cases deserve particularized study with an analysis and the resolution adjusted to them. Additionally, this is a challenge, since the existing algorithms in most of the cases were originally designed for non-directed graphs or symmetrical and regular graphs. Our proposal is a Benchmark Generator of Weakly Connected Directed Graphs whose properties can be defined by the end-users according to their necessities. The source code of the generators described in this article is available in GitHub under the GNU license.
