The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in p...The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate DR.Fenofibrate has also been found to reduce maculopathy,and the need for laser treatment in these patients.Considering these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in DR.The findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of DR.The statements were rated based on the GRADE criteria.An algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the algorithm.The expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.展开更多
Inflammatory myoblastic tumour (IMT) is a rare benign neoplasm that can affect any part of the body including the head and neck. When it is affecting the head and neck region, the clinical presentations can mimic othe...Inflammatory myoblastic tumour (IMT) is a rare benign neoplasm that can affect any part of the body including the head and neck. When it is affecting the head and neck region, the clinical presentations can mimic other common head and neck pathology. If the tumour involves the upper airway it can cause stridor and hoarseness. Other presenting features are neck swelling and dysphagia. This tumour may mimic other chronic granulomatous diseases. This case report described a rare IMT arising from the vocal cord and presents with hoarseness and stridor for six months duration. The patient has no known risk factors. Despite surgical resection, the tumour recurred within six month and further surgical resection was performed, but yet the tumour recurred after one year following second surgery. She was then further treated with mass excision by Endolaryngeal Microsurgery (ELMS) with steroid laryngeal injection. Currently she is still being followed up and remains asymptomatic.展开更多
文摘The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate DR.Fenofibrate has also been found to reduce maculopathy,and the need for laser treatment in these patients.Considering these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in DR.The findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of DR.The statements were rated based on the GRADE criteria.An algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the algorithm.The expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.
文摘Inflammatory myoblastic tumour (IMT) is a rare benign neoplasm that can affect any part of the body including the head and neck. When it is affecting the head and neck region, the clinical presentations can mimic other common head and neck pathology. If the tumour involves the upper airway it can cause stridor and hoarseness. Other presenting features are neck swelling and dysphagia. This tumour may mimic other chronic granulomatous diseases. This case report described a rare IMT arising from the vocal cord and presents with hoarseness and stridor for six months duration. The patient has no known risk factors. Despite surgical resection, the tumour recurred within six month and further surgical resection was performed, but yet the tumour recurred after one year following second surgery. She was then further treated with mass excision by Endolaryngeal Microsurgery (ELMS) with steroid laryngeal injection. Currently she is still being followed up and remains asymptomatic.
