Hypoxia-inducible factors(HIFs)a re transcriptional regulators playing important roles in adapting various types of cells to physiological and pathological hypoxia cues.Three structurally related,oxygen-sensitive HIF...Hypoxia-inducible factors(HIFs)a re transcriptional regulators playing important roles in adapting various types of cells to physiological and pathological hypoxia cues.Three structurally related,oxygen-sensitive HIFαproteins have been identified(HIF1α,HIF2α,and HIF3α),among which HIF3αhas weak transcriptional capacity because of the absence of the C-terminal transactivation domain as present in HIF1αand HIF2α.展开更多
基金supported by NIH/NINDS(R21NS109790 and R01NS094559)(to FG)Shriners Hospitals for Children(85107-NCA-19 to FG,and 84307-NCAL to SZ)。
文摘Hypoxia-inducible factors(HIFs)a re transcriptional regulators playing important roles in adapting various types of cells to physiological and pathological hypoxia cues.Three structurally related,oxygen-sensitive HIFαproteins have been identified(HIF1α,HIF2α,and HIF3α),among which HIF3αhas weak transcriptional capacity because of the absence of the C-terminal transactivation domain as present in HIF1αand HIF2α.
