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High efficient removal of HCN over porous CuO/CeO2 micro-nano spheres at lower temperature range 被引量:1
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作者 Zhihao Yi Jie Sun +4 位作者 Jigang Li Tian Zhou Shouping Wei Hongjia Xie Yulin Yang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第10期155-164,共10页
The porous CeO2 flowerlike micro-nano spheres based materials were prepared to remove HCN effectively at lower temperature range.The CeO2 and a serious of porous flowerlike ceria based materials loaded with metal spec... The porous CeO2 flowerlike micro-nano spheres based materials were prepared to remove HCN effectively at lower temperature range.The CeO2 and a serious of porous flowerlike ceria based materials loaded with metal species including Cu,Ag,Ni,Co and Fe were synthesized by hydrothermal method and precipitation method respectively.The physicochemical properties were probed by means of XRD,H2-TPR,BET,SEM and XPS.The removal ability for 130 mg·m﹣3 HCN over CuO/CeO2 showed the highest activity,the breakthrough time of which was more than 70 min at the condition of 30℃,120,000 h-1 and b 5%(volume)H2O,owe to a higher relative atomic ratio of oxygen vacancies and Oβ,the stronger interaction between metal particle and support,the optimum redox properties.The reaction mechanism was speculated by detecting the reaction products selectivity at different reaction temperature.It was shown that the reaction system for removal of HCN over CuO/CeO2 catalytic material involved chemisorption,catalytic hydrolysis,catalytic oxidation as well as NH3-SCR reactions. 展开更多
关键词 Rice(Oryza sativa L.) Saline-alkaline stress Abscisic acid(ABA) OsABA8ox1-kd Endogenous ABA levels
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Classification of Arrhythmia Based on Convolutional Neural Networks and Encoder-Decoder Model
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作者 Jian Liu Xiaodong Xia +2 位作者 Chunyang Han Jiao Hui Jim Feng 《Computers, Materials & Continua》 SCIE EI 2022年第10期265-278,共14页
As a common and high-risk type of disease,heart disease seriously threatens people’s health.At the same time,in the era of the Internet of Thing(IoT),smart medical device has strong practical significance for medical... As a common and high-risk type of disease,heart disease seriously threatens people’s health.At the same time,in the era of the Internet of Thing(IoT),smart medical device has strong practical significance for medical workers and patients because of its ability to assist in the diagnosis of diseases.Therefore,the research of real-time diagnosis and classification algorithms for arrhythmia can help to improve the diagnostic efficiency of diseases.In this paper,we design an automatic arrhythmia classification algorithm model based on Convolutional Neural Network(CNN)and Encoder-Decoder model.The model uses Long Short-Term Memory(LSTM)to consider the influence of time series features on classification results.Simultaneously,it is trained and tested by the MIT-BIH arrhythmia database.Besides,Generative Adversarial Networks(GAN)is adopted as a method of data equalization for solving data imbalance problem.The simulation results show that for the inter-patient arrhythmia classification,the hybrid model combining CNN and Encoder-Decoder model has the best classification accuracy,of which the accuracy can reach 94.05%.Especially,it has a better advantage for the classification effect of supraventricular ectopic beats(class S)and fusion beats(class F). 展开更多
关键词 ELECTROENCEPHALOGRAPHY convolutional neural network long short-term memory encoder-decoder model generative adversarial network
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Predatory bacterial hydrogels for topical treatment of infected wounds 被引量:2
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作者 Yan Liu Bo Zhuang +7 位作者 Bochuan Yuan Hui Zhang Jingfei Li Wanmei Wang Ruiteng Li Lina Du Pingtian Ding Yiguang Jin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第1期315-326,共12页
Wound infection is becoming a considerable healthcare crisis due to the abuse of antibiotics and the substantial production of multidrug-resistant bacteria.Seawater immersion wounds usually become a mortal trouble bec... Wound infection is becoming a considerable healthcare crisis due to the abuse of antibiotics and the substantial production of multidrug-resistant bacteria.Seawater immersion wounds usually become a mortal trouble because of the infection of Vibrio vulnificus.Bdellovibrio bacteriovorus,one kind of natural predatory bacteria,is recognized as a promising biological therapy against intractable bacteria.Here,we prepared a B.bacteriovorus-loaded polyvinyl alcohol/alginate hydrogel for the topical treatment of the seawater immersion wounds infected by V.vulnificus.The B.bacteriovorus-loaded hydrogel(BG)owned highly microporous structures with the mean pore size of 90μm,improving the rapid release of B.bacteriovorus from BG when contacting the aqueous surroundings.BG showed high biosafety with no L929 cell toxicity or hemolysis.More importantly,BG exhibited excellent in vitro anti-V.vulnificus effect.The highly effective infected wound treatment effect of BG was evaluated on mouse models,revealing significant reduction of local V.vulnificus,accelerated wound contraction,and alleviated inflammation.Besides the high bacterial inhibition of BG,BG remarkably reduced inflammatory response,promoted collagen deposition,neovascularization and re-epithelization,contributing to wound healing.BG is a promising topical biological formulation against infected wounds. 展开更多
关键词 Bacterial predator Bdellovibrio bacteriovorus HYDROGEL Infected wound Polyvinyl alcohol Sodium alginate Vibrio vulnificus Wound healing
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Equipment Maintenance Material Demand Forecasting Based on Gray-Markov Model
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作者 毕坤鹏 张宏运 +1 位作者 晏国辉 唐娜 《Journal of Donghua University(English Edition)》 EI CAS 2014年第6期824-826,838,共4页
Maintenance material reserves must keep an appropriate scale,in order to meet the possible demand of support objectives.According to the sequence of maintenance material consumption,this paper establishes a Gray-Marko... Maintenance material reserves must keep an appropriate scale,in order to meet the possible demand of support objectives.According to the sequence of maintenance material consumption,this paper establishes a Gray-Markov forecasting model by combining Gray system theory and Markov model. Few data are needed in the proposed Gray-Markov forecasting model which has high prediction precision by involving small parameters. The performance of Gray-Markov forecasting model was demonstrated using practical application and the model was proved to be a valid and accurate forecasting method. This Gray-Markov forecasting model can provide reference for making material demand plan and determining maintenance material reserves. 展开更多
关键词 maintenance material gray-Markov demand forecasting material reserves
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Challenges and modification strategies of high-voltage cathode materials for Li-ion batteries
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作者 Yue Wang Caixia Xu +2 位作者 Xingtao Tian Siyu Wang Yan Zhao 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2023年第10期67-79,共13页
Li-ion batteries(LIBs)have gained wide recognition as effective energy storage devices and power supply sources due to their exceptional volumetric energy density,mass energy density and cycling performance.The cathod... Li-ion batteries(LIBs)have gained wide recognition as effective energy storage devices and power supply sources due to their exceptional volumetric energy density,mass energy density and cycling performance.The cathode materials,a key component of LIBs,play a crucial role in determining the electrochemical performance of these batteries.Therefore,there is an increasing demand to explore and investigate suitable high-energy electrode materials that can provide greater capacity and output voltage for the next generation of LIBs.This paper aims to provide a comprehensive overview of the latest researches on five typical high-voltage cathode materials.Specifically,this review will focus on the detailed analysis of their crystalline structures,reaction mechanisms during cycling,current research status and strategies aimed at improving or enhancing their overall electrochemical performance.Overall,the insights presented in this review will help researchers design and develop high-energy cathode materials with improved performance for the next generation of LIBs. 展开更多
关键词 Research advances Li-ion batteries Lithium iron phosphate Layered cathode Lithium-rich oxides Lithium manganate
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Solution-processed wafer-scale nanoassembly of conducting polymers enables selective ultratrace nerve agent detection at low power
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作者 Bin Luo Jianan Weng +11 位作者 Zhi Geng Qichao Pan Xilin Pei Yong He Chuanzhi Chen Hongxing Zhang Renbo Wei Yupeng Yuan Jin Yang Jinyi Ma Zhengwei You Bo Zhu 《Nano Research》 SCIE EI CSCD 2023年第4期5653-5664,共12页
There is a great interest in developing microelectronic devices based on nanostructured conducting polymers that can selectively electro-couple analytes at high sensitivity and low power.Nanostructured conducting poly... There is a great interest in developing microelectronic devices based on nanostructured conducting polymers that can selectively electro-couple analytes at high sensitivity and low power.Nanostructured conducting polymers have emerged as promising candidates for this technology due to their excellent stability with low redox potential,high conductivity,and selectivity endowed by chemical functionalization.However,it remains challenging to develop cost-effective and large-scale assembly approaches for functionalized conducting polymers in the practical fabrication of electronic devices.Here,we reported a straightforward waferscale assembly of nanostructured hexafluoroisopropanol functionalized poly(3,4-ethylenedioxythiophene)(PEDOT-HFIP)on smooth substrates.This approach is template-free,solution-processed,and adaptable to conductive and nonconductive substrates.By this approach,the nanostructured PEDOT-HFIPs could be easily integrated onto interdigitated electrodes with intimate ohmic contact.At the optimized space-to-volume ratio,we demonstrated a low-power,sensitive,and selective nerve agent sensing technology using this platform by detecting sarin vapor with a limit of detection(LOD)of 10 ppb and signal strength of 400 times the water interference at the same concentration,offering significant advantages over existing similar technologies.We envision that its easy scale-up,micro size,small power consumption,and combination of high sensitivity and selectivity make it attractive for various wearable platforms. 展开更多
关键词 conducting polymer PEDOT sensor NANO nerve agent
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Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples 被引量:8
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作者 Ling Leng Ruiyuan Cao +17 位作者 Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期448-456,共9页
The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-... The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. 展开更多
关键词 LUNG METABOLISM MORTALITY
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Chemo-photothermal immunotherapy for eradication of orthotopic tumors and inhibition of metastasis by intratumoral injection of polydopamine versatile hydrogels 被引量:1
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作者 Bo Zhuang Ting Chen +2 位作者 Yueqi Huang Zhimei Xiao Yiguang Jin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2022年第3期1447-1459,共13页
Cancer remains one of the leading causes of death globally and metastasis always leads to treatment failure.Here,we develop a versatile hydrogel loading photothermal agents,chemotherapeutics,and immune-adjuvants to er... Cancer remains one of the leading causes of death globally and metastasis always leads to treatment failure.Here,we develop a versatile hydrogel loading photothermal agents,chemotherapeutics,and immune-adjuvants to eradicate orthotopic tumors and inhibit metastasis by combinational therapy.Hydrogel networks were synthesized via the thiol-Michael addition of polydopamine(PDA)with thiolated hyaluronic acid.PDA acted as a cross-linking agent and endowed the hydrogel with excellent photothermal property.Meanwhile,a chemotherapeutic agent,doxorubicin(DOX),was loaded in the hydrogel viaπ-πstacking with PDA and an immune-adjuvant,CpG-ODN,was loaded via electrostatic interaction.The release of DOX from the hydrogel was initially slow but accelerated due to near infrared light irradiation.The hydrogels showed remarkably synergistic effect against 4T1 cancer cells and stimulated plenty of cytokines secreting from RAW264.7 cells.Moreover,the hydrogels eradicated orthotopic murine breast cancer xenografts and strongly inhibited metastasis after intratumoral injection and light irradiation.The high anticancer efficiency of this chemo-photothermal immunotherapy resulted from the strong synergistic effect of the versatile hydrogels,including the evoked host immune response.The combinational strategy of chemo-photothermal immunotherapy is promising for highly effective treatment of breast cancer. 展开更多
关键词 Breast cancer POLYDOPAMINE Hydrogel Intratumoral injection PHOTOTHERMAL Chemotherapy IMMUNOTHERAPY METASTASIS
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Inhaled amifostine for the prevention of radiation-induced lung injury 被引量:2
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作者 Ting Chen Bo Zhuang +2 位作者 Yueqi Huang Wanmei Wang Yiguang Jin 《Radiation Medicine and Protection》 2022年第2期72-80,共9页
Objective:To alleviate radiation-induced lung injury and prevent the related pneumonitis and pulmonary fibrosis by inhaled amifostine(AMI).Methods:15 Gy 60Coγ-ray irradiation was performed on the thoracic area of rat... Objective:To alleviate radiation-induced lung injury and prevent the related pneumonitis and pulmonary fibrosis by inhaled amifostine(AMI).Methods:15 Gy 60Coγ-ray irradiation was performed on the thoracic area of rats once to establish the radiation injury model.AMI was intraperitoneally(i.p.)injected or intratracheally(i.t.)administered to the rats 30 min preirradiation.The protective effects of the two AMI administration manners were compared in the aspects of hematopoietic system,lung edema,and histopathological examination,and the mechanisms were explored.Results:Compared to i.p.AMI,i.t.AMI remarkably alleviated radiation-induced lung injury and prevented consequent pneumonitis or pulmonary fibrosis.Specifically,i.t.AMI notably protected white blood cells and platelets,reduced the lung wet/dry weight ratio,and decreased collagen volume fractions compared to the model group(P<0.05),while i.p.AMI showed no significant difference with the model group(P>0.05).The high therapeutic efficiency of i.t.AMI was related to its high antioxidation and anti-inflammation effects with downregulation of pro-inflammatory cytokines,the enhanced superoxide dismutase activity,the low levels of malondialdehyde and total proteins.Conclusion:Inhaled AMI is a promising medicine for preventing radiation-induced lung injury,including pneumonitis and pulmonary fibrosis. 展开更多
关键词 AMIFOSTINE INHALATION Lung injury Pulmonary fibrosis Radiation pneumonitis
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Proteomic identification of new diagnostic biomarkers of early-stage cutaneousmycosis fungoides 被引量:4
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作者 Ling Leng Zhaorui Liu +9 位作者 Jie Ma Shiyu Zhang Yukun Wang Luye Lv Yunping Zhu Dunqin Gao Yujie Wang Juncheng Wang Yuehua Liu Jie Liu 《Cancer Communications》 SCIE 2022年第6期558-562,共5页
Dear editor,Mycosis fungoides(MF),the most common subtype of cutaneous T cell lymphoma,is a rare disease[1,2].Patients with early-stageMF have a 5-year overall survival between 88%and 100%[3].In patients with advanced... Dear editor,Mycosis fungoides(MF),the most common subtype of cutaneous T cell lymphoma,is a rare disease[1,2].Patients with early-stageMF have a 5-year overall survival between 88%and 100%[3].In patients with advanced MF,the skin may present with tumors and erythroderma,and the median survival of patients with lymph node and visceral metastasis is 13 months[4].Therefore,it is important to achieve an early diagnosis to improve prognosis[5]. 展开更多
关键词 DIAGNOSIS CUTANEOUS PATIENTS
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Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples 被引量:1
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作者 Ling Leng Ruiyuan Cao +7 位作者 Jie Ma Luye LV Wei Li Yunping Zhu Zhihong Wu Manli Wang Yiwu Zhou Wu Zhong 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第2期229-231,共3页
Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make i... Dear Editor,Almost one-half of COVID-19 patients have symptoms of liver injury.However,the molecular characteristics in the COVID-19 liver remain unknown.Therefore,the need for long-term medication for recovery make it imperative to study the infectivity and pathogenicity of SARS-CoV-2 in the liver.Here,we have identifed signifcant proteomic changes for the first time in the liver of COVID-19 patients.We detected differential expression levels of several proteins that mediate characteristic cellular host responses elicited by SARS-CoV-2 infection in the liver. 展开更多
关键词 LIVER patients MEDICATION
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Isolation and in vitro cultivation of Babesia venatorum(Apicomplexa:Babesiidae),a zoonotic hemoprotozoan from Ixodes persulcatus ticks in China
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作者 Yi Sun Baogui Jiang +8 位作者 Weiqing Zheng Hong Wang Ruiruo Jiang Xin Wang Na Jia Fang Yang Haiying Chen Jiafu Jiang Wuchun Cao 《Biosafety and Health》 CSCD 2021年第4期210-216,共7页
The emerging Babesia venatorum upsurges as a potential health threat occurring in China and other endemic countries.Few attempts to isolate and culture the Babesia species had been conducted in vitro.We collected the ... The emerging Babesia venatorum upsurges as a potential health threat occurring in China and other endemic countries.Few attempts to isolate and culture the Babesia species had been conducted in vitro.We collected the questing Ixodes persulcatus from identified endemic areas and allowed them to feed on the severe combined immunodeficiency(SCID)mice.The positive mice were chosen to provide positive erythrocytes with asexual B.venatorum for continuous culture in mouse or human erythrocytes in vitro,with RPMI 1640 medium and appropriate serum.With B.venatorum in the SCID mice,erythrocytes were cultured in vitro for confirmation by morphological observations with transmission electron microscopes.Sequences of B.venatorum were then identified by way of conventional PCR amplification.Parasitemia counts monitored the growth of B.venatorum on thin blood smears and real-time quantitative PCR in parallel.As expected,B.venatorum positive mice were harvested by sufficient attacks of I.persulcatus ticks.The erythrocytes of the infected mice were then inoculated and successfully cultured in donated erythrocytes from humans and mice in RPMI 1640 culture medium.Active growth of B.venatorum was well demonstrated in human erythrocytes with 3.3 times parasite-load when compared with a mouse under similar conditions.With the increased subcultures,a prolonged period of detectable parasitemia with much higher peak parasitemia and shorter time to reach peak parasitemia were observed in the following subcultures.A new strategy for isolation and in vitro culture of B.venatorum has been provided with a continuous supply of sufficient pathogens to satisfy human babesiosis's testings and clinical therapies. 展开更多
关键词 BABESIA Ixodes persulcatus Isolation and identification Culture characteristics China
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Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis 被引量:4
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作者 Ting Chen Bo Zhuang +6 位作者 Yueqi Huang Yan Liu Bochuan Yuan Wanmei Wang Tianyu Yuan Lina Du Yiguang Jin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2022年第5期2522-2532,共11页
Radiation therapy is an effective method to kill cancer cells and shrink tumors using highenergy X-ray or γ-ray. Radiation pneumonitis(RP) is one of the most serious complications of radiation therapy for thoracic ca... Radiation therapy is an effective method to kill cancer cells and shrink tumors using highenergy X-ray or γ-ray. Radiation pneumonitis(RP) is one of the most serious complications of radiation therapy for thoracic cancers, commonly leading to serious respiratory distress and poor prognosis. Here,we prepared curcumin-loaded mesoporous polydopamine nanoparticles(CMPN) for prevention and treatment of RP by pulmonary delivery. Mesoporous polydopamine nanoparticles(MPDA) were successfully synthesized with an emulsion-induced interface polymerization method and curcumin was loaded in MPDA via π-π stacking and hydrogen bonding interaction. MPDA owned the uniform spherical morphology with numerous mesopores that disappeared after loading curcumin. More than 80% curcumin released from CMPN in 6 h and mesopores recovered. CMPN remarkably protected BEAS-2 B cells from γ-ray radiation injury by inhibiting apoptosis. RP rat models were established after a single dose of15 Gy^(60)Co γ-ray radiation was performed on the chest area. Effective therapy of RP was achieved by intratracheal administration of CMPN due to free radical scavenging and anti-oxidation ability, and reduced proinflammatory cytokines, high superoxide dismutase, decreased malondialdehyde, and alleviated lung tissue damages were observed. Inhaled CMPN paves a new avenue for the treatment of RP. 展开更多
关键词 Radiation pneumonitis CURCUMIN MESOPOROUS POLYDOPAMINE NANOPARTICLE Pulmonary delivery INHALATION Free radical scavenging
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