Dopamine （DA） is one of the brain＇s fundamental neurotransmitters. Despite the fact that the dopaminergic synapses constitute less than 1% of all brain synapses, DA is implicated in a number of critical physiologic...Dopamine （DA） is one of the brain＇s fundamental neurotransmitters. Despite the fact that the dopaminergic synapses constitute less than 1% of all brain synapses, DA is implicated in a number of critical physiological functions and in the pathogenesis of important psychiatric diseases such as schizophrenia, attention-deficit/hyperactivity disorder （ADHD）, Parkinson＇s disease （PD） and others.展开更多
Trace amines are the class of endogenous biogenic amines that traditionally include beta-phenylethylamine,p-tyramine,tryptamine,octopamine,and o thers.Many t race amines represent products of amino acids decarboxylati...Trace amines are the class of endogenous biogenic amines that traditionally include beta-phenylethylamine,p-tyramine,tryptamine,octopamine,and o thers.Many t race amines represent products of amino acids decarboxylation by bacterial decarboxylases during tissue putrefaction or by endogenous decarboxylases in the body.Production of trace amines by gut microbiota is also known(Berry et al.,2017;Gainetdinov et al.,2018).Thus,trace amines are enriched during the decomposition of proteins and concentrated in certain bodily fluids.展开更多
基金supported by the Russian Science Foundation,No.17-75-20177(to IS) and No.14-50-00069(to RRG)
文摘Dopamine （DA） is one of the brain＇s fundamental neurotransmitters. Despite the fact that the dopaminergic synapses constitute less than 1% of all brain synapses, DA is implicated in a number of critical physiological functions and in the pathogenesis of important psychiatric diseases such as schizophrenia, attention-deficit/hyperactivity disorder （ADHD）, Parkinson＇s disease （PD） and others.
基金Russian Science Foundation grant 19-75-30008(to RRG).
文摘Trace amines are the class of endogenous biogenic amines that traditionally include beta-phenylethylamine,p-tyramine,tryptamine,octopamine,and o thers.Many t race amines represent products of amino acids decarboxylation by bacterial decarboxylases during tissue putrefaction or by endogenous decarboxylases in the body.Production of trace amines by gut microbiota is also known(Berry et al.,2017;Gainetdinov et al.,2018).Thus,trace amines are enriched during the decomposition of proteins and concentrated in certain bodily fluids.
