AIM： To identify the contribution of CDKAL1 to the development of diabetic retinopathy（DR） in Chinese population.·METHODS： A case-control study was performed to investigate the genetic association between DR ...AIM： To identify the contribution of CDKAL1 to the development of diabetic retinopathy（DR） in Chinese population.·METHODS： A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus（T2DM）. A welldefined population with T2 DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant（rs10946398） of CDKAL1. Genotyping was performed by i PLEX technology. The association between rs10946398 and T2 DM was assessed by univariate and multivariate logistic regression（MLR） analysis.· RESULTS： There were significant differences in C allele frequencies of rs10946398（CDKAL1） between control and DR groups（45.06% versus 55.00%, P 〈0.05）.The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.·CONCLUSION： Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.展开更多
Case 1:Hemangioblastoma.A 51-year-old woman was admitted to our hospital with a 6-month history of headache and vision impairment.Magnetic resonance imaging (MRI) revealed a lobulated and heterogeneous intense right C...Case 1:Hemangioblastoma.A 51-year-old woman was admitted to our hospital with a 6-month history of headache and vision impairment.Magnetic resonance imaging (MRI) revealed a lobulated and heterogeneous intense right CPA mass [Figure 1],and the neuroradiology reading indicated a meningioma.The pathological diagnosis showed hemangioblastoma which is World Health Organization (WHO) grade Ⅰ.展开更多
基金Supported by National Natural Science Foundation of China(No.81270903)Science and Technology Commission of Shanghai Municipality(No.13140901600)
文摘AIM： To identify the contribution of CDKAL1 to the development of diabetic retinopathy（DR） in Chinese population.·METHODS： A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus（T2DM）. A welldefined population with T2 DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant（rs10946398） of CDKAL1. Genotyping was performed by i PLEX technology. The association between rs10946398 and T2 DM was assessed by univariate and multivariate logistic regression（MLR） analysis.· RESULTS： There were significant differences in C allele frequencies of rs10946398（CDKAL1） between control and DR groups（45.06% versus 55.00%, P 〈0.05）.The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.·CONCLUSION： Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.
基金grants from the Natural Science Foundation of China (No. 81871423)Shanghai Municipal Commission of Health and Family Planning (No. 20160064)Jing'an District Scientific Committee and Health and Family Planning Commission (No. 2016MS03).
文摘Case 1:Hemangioblastoma.A 51-year-old woman was admitted to our hospital with a 6-month history of headache and vision impairment.Magnetic resonance imaging (MRI) revealed a lobulated and heterogeneous intense right CPA mass [Figure 1],and the neuroradiology reading indicated a meningioma.The pathological diagnosis showed hemangioblastoma which is World Health Organization (WHO) grade Ⅰ.
