A global weak solution to the isentropic Navier-Stokes equation with initial data around a constant state in the L^(1)∩BV class was constructed in[1].In the current paper,we will continue to study the uniqueness and ...A global weak solution to the isentropic Navier-Stokes equation with initial data around a constant state in the L^(1)∩BV class was constructed in[1].In the current paper,we will continue to study the uniqueness and regularity of the constructed solution.The key ingredients are the Holder continuity estimates of the heat kernel in both spatial and time variables.With these finer estimates,we obtain higher order regularity of the constructed solution to Navier-Stokes equation,so that all of the derivatives in the equation of conservative form are in the strong sense.Moreover,this regularity also allows us to identify a function space such that the stability of the solutions can be established there,which eventually implies the uniqueness.展开更多
This paper studies the reachability problem of the switched linear discrete singular (SLDS) systems. Under the condition that all subsystems are regular, the reachability of the SLDS systems is characterized based o...This paper studies the reachability problem of the switched linear discrete singular (SLDS) systems. Under the condition that all subsystems are regular, the reachability of the SLDS systems is characterized based on a peculiar repeatedly introduced switching sequence. The necessary and sufficient conditions are obtained for the reachability of the SLDS systems.展开更多
Why heavily parameterized neural networks(NNs) do not overfit the data is an important long standing open question. We propose a phenomenological model of the NN training to explain this non-overfitting puzzle. Our li...Why heavily parameterized neural networks(NNs) do not overfit the data is an important long standing open question. We propose a phenomenological model of the NN training to explain this non-overfitting puzzle. Our linear frequency principle(LFP) model accounts for a key dynamical feature of NNs: they learn low frequencies first, irrespective of microscopic details. Theory based on our LFP model shows that low frequency dominance of target functions is the key condition for the non-overfitting of NNs and is verified by experiments. Furthermore,through an ideal two-layer NN, we unravel how detailed microscopic NN training dynamics statistically gives rise to an LFP model with quantitative prediction power.展开更多
In this paper we deal with a nonlinear interaction problem between an incompressible viscous fluid and a nonlinear thermoelastic plate.The nonlinearity in the plate equation corresponds to nonlinear elastic force in v...In this paper we deal with a nonlinear interaction problem between an incompressible viscous fluid and a nonlinear thermoelastic plate.The nonlinearity in the plate equation corresponds to nonlinear elastic force in various physically relevant semilinear and quasilinear plate models.We prove the existence of a weak solution for this problem by constructing a hybrid approximation scheme that,via operator splitting,decouples the system into two sub-problems,one piece-wise stationary for the fluid and one time-continuous and in a finite basis for the structure.To prove the convergence of the approximate quasilinear elastic force,we develop a compensated compactness method that relies on the maximal monotonicity property of this nonlinear function.展开更多
Supercapacitors(SCs)have become increasingly important in electrical energy storage and delivery owing to their high power densities and long lifetimes.Aqueous SCs are promising for large-scale engineering application...Supercapacitors(SCs)have become increasingly important in electrical energy storage and delivery owing to their high power densities and long lifetimes.Aqueous SCs are promising for large-scale engineering applications because of their low cost and safety.However,the low operating voltage and low energy density of aqueous SCs severely limit their practical applications.In this study,a nanoscale dielectric layer is grafted onto a graphene electrode to achieve both a high operating voltage and enhanced capacitance.Compared with an SC without dielectric grafting,a dielectric-enhanced SC(DESC)shows a higher capacitance by 2200%.The mechanism of the capacitance enhancement can be attributed to three factors:the dielectric polarization,the ions desolvation by the dielectric,and the enhanced quantum capacitance from charge transfer and ion adsorption in the polymer molecules.In addition,a 2.5 V pouch DESC with a 1 M KCl electrolyte is confirmed to cycle up to 50,000 times with a capacitance retention of 87.5%.The DESC presents the optimal electrochemical properties after it is grafted with a 5 nm dielectric layer.This study provides new insights into the design of high-voltage and high-energy-density aqueous SCs.展开更多
The attitude control and momentum management(ACMM)problem is quite fundamental for many spacecrafts including space stations,sky laboratories and etc.Instead of single attitude control problem,ACMM problem has to take...The attitude control and momentum management(ACMM)problem is quite fundamental for many spacecrafts including space stations,sky laboratories and etc.Instead of single attitude control problem,ACMM problem has to take account of both disturbance rejection and energy optimization.This paper studies the ACMM problem for general spacecraft.A practical active disturbance rejection control architecture is proposed with hierarchical compensation to different kinds of uncertain dynamics or disturbances.In particular,by integrating RLS into ESO,the constant and sinusoidal disturbance terms to be compensated are reconstructed.Also,the LQR law is implemented to achieve the desired performance of control systems after disturbance compensation.Furthermore,quantitative performances of the generalized ESO,the RLS algorithm and the closed-loop tracking system are rigorously analyzed.Finally,the results under 9-DOF semi-physical test environment show the effectiveness of our control method.展开更多
Distance-based regression model,as a nonparametric multivariate method,has been widely used to detect the association between variations in a distance or dissimilarity matrix for outcomes and predictor variables of in...Distance-based regression model,as a nonparametric multivariate method,has been widely used to detect the association between variations in a distance or dissimilarity matrix for outcomes and predictor variables of interest in genetic association studies,genomic analyses,and many other research areas.Based on it,a pseudo-F statistic which partitions the variation in distance matrices is often constructed to achieve the aim.To the best of our knowledge,the statistical properties of the pseudo-F statistic has not yet been well established in the literature.To fill this gap,the authors study the asymptotic null distribution of the pseudo-F statistic and show that it is asymptotically equivalent to a mixture of chi-squared random variables.Given that the pseudo-F test statistic has unsatisfactory power when the correlations of the response variables are large,the authors propose a square-root F-type test statistic which replaces the similarity matrix with its square root.The asymptotic null distribution of the new test statistic and power of both tests are also investigated.Simulation studies are conducted to validate the asymptotic distributions of the tests and demonstrate that the proposed test has more robust power than the pseudo-F test.Both test statistics are exemplified with a gene expression dataset for a prostate cancer pathway.展开更多
Multiple response regression model is commonly employed to investigate the relationship between multiple outcomes and a set of potential predictors,where single-response analysis and multivariate analysis of variance(...Multiple response regression model is commonly employed to investigate the relationship between multiple outcomes and a set of potential predictors,where single-response analysis and multivariate analysis of variance(MANOVA)are two frequently used methods for association analysis.However,both methods have their own limitations.The basis of the former method is independence of multiple responses and the latter one assumes that multiple responses are normally distributed.In this work,the authors propose a test statistic for multiple response association analysis in high-dimensional situations based on F statistic.It is free of normal distribution assumption and the asymptotic normal distribution is obtained under some regular conditions.Extensive computer simulations and four real data applications show its superiority over single-response analysis and MANOVA methods.展开更多
We investigated the false-negative,true-negative,false-positive,and true-positive predictive values from a general group testing procedure for a heterogeneous population.We show that its false(true)-negative predictiv...We investigated the false-negative,true-negative,false-positive,and true-positive predictive values from a general group testing procedure for a heterogeneous population.We show that its false(true)-negative predictive value of a specimen is larger(smaller),and the false(true)-positive predictive value is smaller(larger)than that from individual testing procedure,where the former is in aversion.Then we propose a nested group testing procedure,and show that it can keep the sterling characteristics and also improve the false-negative predictive values for a specimen,not larger than that from individual testing.These characteristics are studied from both theoretical and numerical points of view.The nested group testing procedure is better than individual testing on both false-positive and false-negative predictive values,while retains the efficiency as a basic characteristic of a group testing procedure.Applications to Dorfman’s,Halving and Sterrett procedures are discussed.Results from extensive simulation studies and an application to malaria infection in microscopy-negative Malawian women exemplify the findings.展开更多
Retinoic acid inducible gene-I(RIG-I)is a caspase recruitment domain(CARD)containing protein that acts as an intracellular RNA receptor and senses virus infection.After binding to double stranded RNA(dsRNA)or 5′-trip...Retinoic acid inducible gene-I(RIG-I)is a caspase recruitment domain(CARD)containing protein that acts as an intracellular RNA receptor and senses virus infection.After binding to double stranded RNA(dsRNA)or 5′-triphosphate single stranded RNA(ssRNA),RIG-I transforms into an open conformation,translocates onto mitochondria,and interacts with the downstream adaptor mitochondrial antiviral signaling(MAVS)to induce the production of type Ⅰ interferon and inflammatory factors via IRF3/7 and NF-κB pathways,respectively.Recently,accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events,such as inflammation and inflammation related diseases,cell proliferation,apoptosis and even senescence.Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields.展开更多
Node dynamics and network topologies play vital roles in determining the network features and network dynamical behaviors.Thus it is of great theoretical significance and practical value to recover the topology struct...Node dynamics and network topologies play vital roles in determining the network features and network dynamical behaviors.Thus it is of great theoretical significance and practical value to recover the topology structures and system parameters of uncertain complex networks with available information. This paper presents an adaptive anticipatory synchronization-based approach to identify the unknown system parameters and network topological structures of uncertain time-varying delayed complex networks in the presence of noise. Moreover, during the identification process, our proposed scheme guarantees anticipatory synchronization between the uncertain drive and constructed auxiliary response network simultaneously. Particularly, our method can be extended to several special cases. Furthermore, numerical simulations are provided to verify the effectiveness and applicability of our method for reconstructing network topologies and node parameters. We hope our method can provide basic insight into future research on addressing reconstruction issues of uncertain realistic and large-scale complex networks.展开更多
In this paper, PID(proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimens...In this paper, PID(proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.展开更多
The distance-based regression model has many applications in analysis of multivariate response regression in various ?elds, such as ecology, genomics, genetics, human microbiomics, and neuroimaging. It yields a pseudo...The distance-based regression model has many applications in analysis of multivariate response regression in various ?elds, such as ecology, genomics, genetics, human microbiomics, and neuroimaging. It yields a pseudo F test statistic that assesses the relation between the distance(dissimilarity) of the subjects and the predictors of interest. Despite its popularity in recent decades, the statistical properties of the pseudo F test statistic have not been revealed to our knowledge. This study derives the asymptotic properties of the pseudo F test statistic using spectral decomposition under the matrix normal assumption, when the utilized dissimilarity measure is the Euclidean or Mahalanobis distance. The pseudo F test statistic with the Euclidean distance has the same distribution as the quotient of two Chi-squared-type mixtures. The denominator and numerator of the quotient are approximated using a random variable of the form ξχ_d^2+ η, and the approximate error bound is given. The pseudo F test statistic with the Mahalanobis distance follows an F distribution.In simulation studies, the approximated distribution well matched the "exact" distribution obtained by the permutation procedure. The obtained distribution was further validated on H1N1 in?uenza data, aging human brain data, and embryonic imprint data.展开更多
基金partially the National Key R&D Program of China(2022YFA1007300)the NSFC(11901386,12031013)+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA25010403)the NSFC(11801194,11971188)the Hubei Key Laboratory of Engineering Modeling and Scientific Computing。
文摘A global weak solution to the isentropic Navier-Stokes equation with initial data around a constant state in the L^(1)∩BV class was constructed in[1].In the current paper,we will continue to study the uniqueness and regularity of the constructed solution.The key ingredients are the Holder continuity estimates of the heat kernel in both spatial and time variables.With these finer estimates,we obtain higher order regularity of the constructed solution to Navier-Stokes equation,so that all of the derivatives in the equation of conservative form are in the strong sense.Moreover,this regularity also allows us to identify a function space such that the stability of the solutions can be established there,which eventually implies the uniqueness.
基金This work was supported by the National Natural Science Foundation of China (No. 6022130, 60334040, 60428304).
文摘This paper studies the reachability problem of the switched linear discrete singular (SLDS) systems. Under the condition that all subsystems are regular, the reachability of the SLDS systems is characterized based on a peculiar repeatedly introduced switching sequence. The necessary and sufficient conditions are obtained for the reachability of the SLDS systems.
基金Supported by the National Key R&D Program of China(Grant No.2019YFA0709503)the Shanghai Sailing Program+3 种基金the Natural Science Foundation of Shanghai(Grant No.20ZR1429000)the National Natural Science Foundation of China(Grant No.62002221)Shanghai Municipal of Science and Technology Project(Grant No.20JC1419500)the HPC of School of Mathematical Sciences at Shanghai Jiao Tong University。
文摘Why heavily parameterized neural networks(NNs) do not overfit the data is an important long standing open question. We propose a phenomenological model of the NN training to explain this non-overfitting puzzle. Our linear frequency principle(LFP) model accounts for a key dynamical feature of NNs: they learn low frequencies first, irrespective of microscopic details. Theory based on our LFP model shows that low frequency dominance of target functions is the key condition for the non-overfitting of NNs and is verified by experiments. Furthermore,through an ideal two-layer NN, we unravel how detailed microscopic NN training dynamics statistically gives rise to an LFP model with quantitative prediction power.
基金partially supported by National Natural Science Foundation of China(11631008)。
文摘In this paper we deal with a nonlinear interaction problem between an incompressible viscous fluid and a nonlinear thermoelastic plate.The nonlinearity in the plate equation corresponds to nonlinear elastic force in various physically relevant semilinear and quasilinear plate models.We prove the existence of a weak solution for this problem by constructing a hybrid approximation scheme that,via operator splitting,decouples the system into two sub-problems,one piece-wise stationary for the fluid and one time-continuous and in a finite basis for the structure.To prove the convergence of the approximate quasilinear elastic force,we develop a compensated compactness method that relies on the maximal monotonicity property of this nonlinear function.
基金supported by the National Natural Science Foundation of China(Nos.U19A20105,52003153,22005186,52103303 and 52207027)Program of Shanghai Academic Research Leader(No.21XD1401600).
文摘Supercapacitors(SCs)have become increasingly important in electrical energy storage and delivery owing to their high power densities and long lifetimes.Aqueous SCs are promising for large-scale engineering applications because of their low cost and safety.However,the low operating voltage and low energy density of aqueous SCs severely limit their practical applications.In this study,a nanoscale dielectric layer is grafted onto a graphene electrode to achieve both a high operating voltage and enhanced capacitance.Compared with an SC without dielectric grafting,a dielectric-enhanced SC(DESC)shows a higher capacitance by 2200%.The mechanism of the capacitance enhancement can be attributed to three factors:the dielectric polarization,the ions desolvation by the dielectric,and the enhanced quantum capacitance from charge transfer and ion adsorption in the polymer molecules.In addition,a 2.5 V pouch DESC with a 1 M KCl electrolyte is confirmed to cycle up to 50,000 times with a capacitance retention of 87.5%.The DESC presents the optimal electrochemical properties after it is grafted with a 5 nm dielectric layer.This study provides new insights into the design of high-voltage and high-energy-density aqueous SCs.
基金This research was supported by the National Natural Science Foundation of China under Grant Nos.62122083,61903085 and 62022013Guangdong Basic and Applied Basic Research Foundation under Grant No.201515111070+1 种基金Shenzhen Key Technology Project under Grant No.20191113140425399Research Fund for the Industry-specific Program of China Aerospace Science and Technology Corporation under Grant No.6230109004.
文摘The attitude control and momentum management(ACMM)problem is quite fundamental for many spacecrafts including space stations,sky laboratories and etc.Instead of single attitude control problem,ACMM problem has to take account of both disturbance rejection and energy optimization.This paper studies the ACMM problem for general spacecraft.A practical active disturbance rejection control architecture is proposed with hierarchical compensation to different kinds of uncertain dynamics or disturbances.In particular,by integrating RLS into ESO,the constant and sinusoidal disturbance terms to be compensated are reconstructed.Also,the LQR law is implemented to achieve the desired performance of control systems after disturbance compensation.Furthermore,quantitative performances of the generalized ESO,the RLS algorithm and the closed-loop tracking system are rigorously analyzed.Finally,the results under 9-DOF semi-physical test environment show the effectiveness of our control method.
基金partially supported by Beijing Natural Science Foundation under Grant No.Z180006.
文摘Distance-based regression model,as a nonparametric multivariate method,has been widely used to detect the association between variations in a distance or dissimilarity matrix for outcomes and predictor variables of interest in genetic association studies,genomic analyses,and many other research areas.Based on it,a pseudo-F statistic which partitions the variation in distance matrices is often constructed to achieve the aim.To the best of our knowledge,the statistical properties of the pseudo-F statistic has not yet been well established in the literature.To fill this gap,the authors study the asymptotic null distribution of the pseudo-F statistic and show that it is asymptotically equivalent to a mixture of chi-squared random variables.Given that the pseudo-F test statistic has unsatisfactory power when the correlations of the response variables are large,the authors propose a square-root F-type test statistic which replaces the similarity matrix with its square root.The asymptotic null distribution of the new test statistic and power of both tests are also investigated.Simulation studies are conducted to validate the asymptotic distributions of the tests and demonstrate that the proposed test has more robust power than the pseudo-F test.Both test statistics are exemplified with a gene expression dataset for a prostate cancer pathway.
基金This paper was in part supported by China Postdoctoral Science Foundation Funded Project under Grant No.2021M700433the National Natural Science Foundation of China under Grant Nos.12101047 and 12201432.
文摘Multiple response regression model is commonly employed to investigate the relationship between multiple outcomes and a set of potential predictors,where single-response analysis and multivariate analysis of variance(MANOVA)are two frequently used methods for association analysis.However,both methods have their own limitations.The basis of the former method is independence of multiple responses and the latter one assumes that multiple responses are normally distributed.In this work,the authors propose a test statistic for multiple response association analysis in high-dimensional situations based on F statistic.It is free of normal distribution assumption and the asymptotic normal distribution is obtained under some regular conditions.Extensive computer simulations and four real data applications show its superiority over single-response analysis and MANOVA methods.
基金supported by National Natural Science Foundation of China (Grant Nos.11801102,11861017)Beijing Natural Science Foundation (Z180006)the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.
文摘We investigated the false-negative,true-negative,false-positive,and true-positive predictive values from a general group testing procedure for a heterogeneous population.We show that its false(true)-negative predictive value of a specimen is larger(smaller),and the false(true)-positive predictive value is smaller(larger)than that from individual testing procedure,where the former is in aversion.Then we propose a nested group testing procedure,and show that it can keep the sterling characteristics and also improve the false-negative predictive values for a specimen,not larger than that from individual testing.These characteristics are studied from both theoretical and numerical points of view.The nested group testing procedure is better than individual testing on both false-positive and false-negative predictive values,while retains the efficiency as a basic characteristic of a group testing procedure.Applications to Dorfman’s,Halving and Sterrett procedures are discussed.Results from extensive simulation studies and an application to malaria infection in microscopy-negative Malawian women exemplify the findings.
文摘Retinoic acid inducible gene-I(RIG-I)is a caspase recruitment domain(CARD)containing protein that acts as an intracellular RNA receptor and senses virus infection.After binding to double stranded RNA(dsRNA)or 5′-triphosphate single stranded RNA(ssRNA),RIG-I transforms into an open conformation,translocates onto mitochondria,and interacts with the downstream adaptor mitochondrial antiviral signaling(MAVS)to induce the production of type Ⅰ interferon and inflammatory factors via IRF3/7 and NF-κB pathways,respectively.Recently,accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events,such as inflammation and inflammation related diseases,cell proliferation,apoptosis and even senescence.Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields.
基金supported by the National Key Research and Development Program of China(Grant No.2016YFB0800401)the National Natural Science Foundation of China(Grant Nos.61621003,61532020 and11472290)
文摘Node dynamics and network topologies play vital roles in determining the network features and network dynamical behaviors.Thus it is of great theoretical significance and practical value to recover the topology structures and system parameters of uncertain complex networks with available information. This paper presents an adaptive anticipatory synchronization-based approach to identify the unknown system parameters and network topological structures of uncertain time-varying delayed complex networks in the presence of noise. Moreover, during the identification process, our proposed scheme guarantees anticipatory synchronization between the uncertain drive and constructed auxiliary response network simultaneously. Particularly, our method can be extended to several special cases. Furthermore, numerical simulations are provided to verify the effectiveness and applicability of our method for reconstructing network topologies and node parameters. We hope our method can provide basic insight into future research on addressing reconstruction issues of uncertain realistic and large-scale complex networks.
基金supported by the National Natural Science Foundation of China under Grant No.11688101
文摘In this paper, PID(proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.
基金supported by National Natural Science Foundation of China (Grant No. 11722113)
文摘The distance-based regression model has many applications in analysis of multivariate response regression in various ?elds, such as ecology, genomics, genetics, human microbiomics, and neuroimaging. It yields a pseudo F test statistic that assesses the relation between the distance(dissimilarity) of the subjects and the predictors of interest. Despite its popularity in recent decades, the statistical properties of the pseudo F test statistic have not been revealed to our knowledge. This study derives the asymptotic properties of the pseudo F test statistic using spectral decomposition under the matrix normal assumption, when the utilized dissimilarity measure is the Euclidean or Mahalanobis distance. The pseudo F test statistic with the Euclidean distance has the same distribution as the quotient of two Chi-squared-type mixtures. The denominator and numerator of the quotient are approximated using a random variable of the form ξχ_d^2+ η, and the approximate error bound is given. The pseudo F test statistic with the Mahalanobis distance follows an F distribution.In simulation studies, the approximated distribution well matched the "exact" distribution obtained by the permutation procedure. The obtained distribution was further validated on H1N1 in?uenza data, aging human brain data, and embryonic imprint data.