Overview of novel nanobiosensors for electrochemical and optical diagnosis of leukemia:Challenge and opportunity

Leukemia is one of the ten types of cancer that causes the biggest death in the world.Compared to other types of cancer,leukemia has a low life expectancy,so an early diagnosis of the cancer is necessary.A new strategy has been developed to identify various leukemia biomarkers by making blood cancer biosensors,especially by developing nanomaterial applications so that they can improve the performance of the biosensor.Although many biosensors have been developed,the detection of leukemia by using nanomaterials with electrochemical and optical methods is still less carried out compare to other types of cancer biosensors.Even the acoustic and calorimetric testing methods for the detection of leukemia by utilizing nanomaterials have not yet been carried out.Most of the reviewed works reported the use of gold nanoparticles and electrochemical characterization methods for leukemia detection with the object of study being conventional cancer cells.In order to be used clinically by the community,future research must be carried out with a lot of patient blood objects,develop non-invasive leukemia detection,and be able to detect all types of blood cancer specifically with one biosensor.This can lead to a fast and accurate diagnosis thus allowing for early treatment and easy periodic condition monitoring for various types of leukemia based on its biomarker and future design controlable via internet of things(IoT)so that why would be monitoring real times.

Numerical modeling of blast-induced rock fragmentation in deep mining with 3D and 2D FEM method approaches

To optimize the excavation of rock using underground blasting techniques,a reliable and simplified approach for modeling rock fragmentation is desired.This paper presents a multistep experimentalnumerical methodology for simplifying the three-dimensional(3D)to two-dimensional(2D)quasiplane-strain problem and reducing computational costs by more than 100-fold.First,in situ tests were conducted involving single-hole and free-face blasting of a dolomite rock mass in a 1050-m-deep mine.The results were validated by laser scanning.The craters were then compared with four analytical models to calculate the radius of the crushing zone.Next,a full 3D model for single-hole blasting was prepared and validated by simulating the crack length and the radius of the crushing zone.Based on the stable crack propagation zones observed in the 3D model and experiments,a 2D model was prepared.The properties of the high explosive(HE)were slightly reduced to match the shape and number of radial cracks and crushing zone radius between the 3D and 2D models.The final methodology was used to reproduce various cut-hole blasting scenarios and observe the effects of residual cracks in the rock mass on further fragmentation.The presence of preexisting cracks was found to be crucial for fragmentation,particularly when the borehole was situated near a free rock face.Finally,an optimization study was performed to determine the possibility of losing rock continuity at different positions within the well in relation to the free rock face.

Effect of TiB2 and Al3Ti on the microstructure,mechanical properties and fracture behaviour of near eutectic Al−12.6Si alloy

A near eutectic Al−12.6Si alloy was developed with 0.0wt%,2.0wt%,4.0wt%,and 6.0wt%Al−5Ti−1B master alloy.The micro-structural morphology,hardness,tensile strength,elongation,and fracture behaviour of the alloys were studied.The unmodified Al−12.6Si al-loy has an irregular needle and plate-like eutectic silicon(ESi)and coarse polygonal primary silicon(PSi)particles in the matrix-likeα-Al phase.The P_(Si),E_(Si),andα-Al morphology and volume fraction were changed due to the addition of the Al−5Ti−1B master alloy.The hardness,UTS,and elongation improved due to the microstructural modification.Nano-sized in-situ Al3Ti particles and ex-situ TiB_(2)particles caused the mi-crostructural modification.The fracture images of the developed alloys exhibit a ductile and brittle mode of fracture at the same time.The Al−5Ti−1B modified alloys have a more ductile mode of fracture and more dimples compared to the unmodified alloy.

Optimization Design of Double-parameter Shift Schedule of Tracked Vehicle with Hydrodynamic-mechanical Transmission

A kind of automatic shift schedule optimization method is provided for a tracked vehicle with hydrodynamic-mechanical transmission in order to improve its dynamic performance. A dynamic model of integrated hydrodynamic-mechanical transmission is built in MATLAB/Simdriveline environment, and an optimum shift schedule is derived by using iSight software to call the dynamic model above, then the shift schedule is achieved after optimization. The simulation results show that the method is significant to improve the dynamic performance and gear-shifting smoothness theoretically and practically.

Detection of mechanical stress in the steel structure of a bridge crane

A significant negative aspect in the operation of bridge-type cranes are the technical problems associated with wear of the wheels and the crane track,which causes crane skewing.The main causes of crane skewing include unevenness of the crane track,unequal loading of the traction drives depending on the position of the crane trolley,slips and different sizes of travel wheels and combinations of these causes.Firstly,this paper presents a design solution that can be used to detect the magnitude of mechanical stress and deformation of the steel structure of the crane,caused by the effects of skewing.The mechanical stress generated by the transverse forces of the deformed geometric shape of the crane bridge structure is recorded by mechanical stress detectors installed in the inner corners of the crane bridge.The resulting electrical signal from element mechanical voltage detectors,loaded by axial forces,can be used for feedback control of separate crane travel drives controlled by frequency converters.Secondly,this paper presents the calculation of the lateral transverse forces according to CSN 270103 and the determination of the values of mechanical stresses of the deformed steel structure of the crane bridge of a two-girder bridge crane using the finite element method in the program MSC.MARC 2019.Finally,this paper presents the structural and strength design of mechanical stress detectors and the conclusions of laboratory tests of axial force loading of mechanical stress detectors on the test equipment.At the same time,it presents records of the measured axial forces acting in the mechanical stress detectors,arising from the deformation and warping of the crane bridge by the known magnitude of the axial force acting on the crossbeam and from the deformation of the crane bridge caused by the crane operating modes.

Reliability-Based Topology Optimization of Fail-Safe Structures Using Moving Morphable Bars

This paper proposes an effective reliability design optimizationmethod for fail-safe topology optimization(FSTO)considering uncertainty based on the moving morphable bars method to establish the ideal balance between cost and robustness,reliability and structural safety.To this end,a performancemeasure approach(PMA)-based doubleloop optimization algorithmis developed tominimize the relative volume percentage while achieving the reliability criterion.To ensure the compliance value of the worst failure case can better approximate the quantified design requirement,a p-norm constraint approach with correction parameter is introduced.Finally,the significance of accounting for uncertainty in the fail-safe design is illustrated by contrasting the findings of the proposed reliabilitybased topology optimization(RBTO)method with those of the deterministic design method in three typical examples.Monte Carlo simulation shows that the relative error of the reliability index of the optimized structure does not exceed 3%.

A strategic way of high-performance energy storage device development with environmentally viable “Water-in-salt” electrolytes

Development of cost-effective and environmental friendly energy storage devices(ESDs) has attracted widespread attention in recent scenario of energy research.Recently,the environmentally viable "water-in-salt"(WiS) electrolytes has received significant interest for the development of advanced high performance ESDs.The WiS electrolyte exhibits wide electrochemical stability window(ESW),highsafety,non-flammability and superior electrochemical performance compared to the conventional "salt-in-water" electrolytes.This review aims to provide a comprehensive discussion on WiS electrolyte based on theoretical,electrochemical and physicochemical characteristics.A strategic way for the usage of WiS electrolyte in rechargeable metal-ion batteries and supercapacitors with potentially improved electrochemical performance has been reviewed systematically.This review also discussed the unique advantages of WiS electrolytes as well as the future scope and challenges.

当量比对斜爆轰波诱导区特性影响的数值模拟研究

为探索斜爆轰波诱导区特性变化的内在机制,利用带H2/O2详细化学反应模型的二维欧拉方程进行数值模拟,研究了当量比对诱导区特性的影响。结果表明,随着当量比增大,诱导区长度呈U型曲线变化,在此过程中温度起到了关键作用。通过研究诱导区末端的压力分布发现,诱导区末端的压缩波强度是影响诱导区过渡形式的决定性因素。当量比在0.6～2.5时,压缩波强度较强,过渡形式为突变型,超出该范围,压缩波强度较弱,过渡形式为平滑型。此外,结合定容燃烧(CVC)理论分析了不同来流压力下的诱导区长度随当量比的变化情况,得出诱导区内的化学动力学效应影响了诱导区长度,使其沿理论所预测的U型曲线变化;气动力学效应影响了诱导区长度的变化幅度和速率,避免其过度增大或减小。

Cold metal transfer(CMT) technology-An overview

Cold Metal Transfer technology has revolutionized the welding of dissimilar metals and thicker materials by producing improved weld bead aesthetics with controlled metal deposition and low heat-input. In this study, the process, weld combinations, laser-CMT hybrid welding and applications of CMT welding are critically reviewed. Microstructure and other weld characteristics have been discussed at length for various base metal combinations. Particularly, the welding of aluminium and steel with better results has been possible with CMT Welding. The results reviewed in this article indicate that the CMT-Laser hybrid welding is more preferable to Laser or Laser hybrid welding. CMT welding has found applications in automobile industries, defence sectors and power plants as a method of additive manufacturing.

FATIGUE LIFE PREDICTION OF CRANKSHAFT MADE OF MATERIAL 48MnV BASED ON FATIGUE TESTS,DYNAMIC SIMULATION AND FEA

S-N curve and fatigue parameters of 48MnV are obtained using small sample tests and staircase or up and down method, which paves the way for predicting fatigue life of crankshaft made of 48MnV. The fatigue life of the crankshaft of a six-cylinder engine is calculated using different damage models such as S-N method, normal strain approach, Smoth-Watson-Topper （SWT）Bannantine approach, shear strain approach, and Fatemi-Socie method based on dynamic simulation and finite element analysis （FEA） of crankshaft. The results indicate that the traditional calculation is conservative and the residual fatigue life of crankshaft is sufficient to maintain next life cycle if the crankshaft is remanufactured after its end of life.

Analysis of Efficiency of the Ship Propulsion System with Thermochemical Recuperation of Waste Heat

One of the basic ways to reduce polluting emissions of ship power plants is application of innovative devices for on-board energy generation by means of secondary energy resources.The combined gas turbine and diesel engine plant with thermochemical recuperation of the heat of secondary energy resources has been considered.It is suggested to conduct the study with the help of mathematical modeling methods.The model takes into account basic physical correlations,material and thermal balances,phase equilibrium,and heat and mass transfer processes.The paper provides the results of mathematical modeling of the processes in a gas turbine and diesel engine power plant with thermochemical recuperation of the gas turbine exhaust gas heat by converting a hydrocarbon fuel.In such a plant,it is possible to reduce the specific fuel consumption of the diesel engine by 20%.The waste heat potential in a gas turbine can provide efficient hydrocarbon fuel conversion at the ratio of powers of the diesel and gas turbine engines being up to 6.When the diesel engine and gas turbine operate simultaneously with the use of the LNG vapor conversion products,the efficiency coefficient of the plant increases by 4%–5%.

Physics-based Modeling and Simulation for Motional Cable Harness Design

The design work of motional cable in products is vital due to the difficulty in estimating the potential issues in current researches.In this paper,a physics-based modeling and simulation method for the motional cable harness design is presented.The model,based on continuum mechanics,is established by analyzing the force of microelement in equilibrium.During the analysis procedure,three coordinate systems：inertial,Frenet and main-axis coordinate systems are used.By variable substitution and dimensionless processing,the equation set is discretized by differential quadrature method and subsequently becomes an overdetermined nonlinear equation set with boundary conditions solved by Levenberg-Marquardt method.With the profile of motional cable harness obtained from the integral of arithmetic solution,a motion simulation system based on＂path＂and＂profile＂as well as the experimental equipments is built.Using the same parameters as input for the simulation and the real cable harness correspondingly,the issue in designing,such as collision,can be easily found by the simulation system.This research obtains a better result which has no potential collisions by redesign,and the proposed method can be used as an accurate and efficient way in motional cable harness design work.

Dolomite fracture modeling using the Johnson-Holmquist concrete material model:Parameter determination and validation

In this paper,the Johnson-Holmquist concrete(JHC)constitutive model is adopted for modeling and simulating the fracture of dolomite.A detailed step-by-step procedure for determining all required parameters,based on a series of experiments under quasi-static and dynamic regimes,is proposed.Strain rate coefficients,failure surfaces,equations of state and damage/failure constants are acquired based on the experimental data and finite element analyses.The JHC model with the obtained parameters for dolomite is subsequently validated using quasi-static uniaxial and triaxial compression tests as well as dynamic split Hopkinson pressure bar(SHPB)tests.The influence of mesh size is also analyzed.It shows that the simulated fracture behavior and waveform data are in good agreement with the experimental data for all tests under both quasi-static and dynamic loading conditions.Future studies will implement the validated JHC model in small-and large-scale blasting simulations.

Dynamic Feedforward Control of a Novel 3-PSP 3-DOF Parallel Manipulator

Parallel manipulators with less than six degrees of freedom （DOF） have been increasingly used in high-speed hybrid machine tools. The structural features of parallel manipulators are dynamic, a characteristic that is particularly significant when these manipulators are used in high-speed machine tools. However, normal kinematic control method cannot satisfy the requirements of the control system. Many researchers use model-based dynamic control methods, such as the dynamic feedforward control method. However, these methods are rarely used in hybrid machine tools because of the complex dynamic model of the parallel manipulator. In order to study the dynamic control method of parallel manipulators, the dynamic feedforward control method is used in the dynamic control system of a 3-PSP （prismatic-spherical-prismatic） 3-DOF spatial parallel manipulator used as a spindle head in a high-speed hybrid machine tool. Using kinematic analysis as basis and the Newton-Euler method, we derive the dynamic model of the parallel manipulator. Furthermore, a model-based dynamic feedforward control system consisting of both kinematic control and dynamic control subsystems is established. The dynamic control subsystem consists of two modules. One is used to eliminate the influence of the dynamic characteristics of high-speed movement, and the other is used to eliminate the dynamic disturbances in the milling process. Finally, the simulation model of the dynamic feedforward control system of the 3-PSP parallel manipulator is constructed in Matlab/Simulink. The simulations of the control system eliminating the influence of the dynamic characteristics and dynamic disturbances are conducted. A comparative study between the simulations and the normal kinematic control method is also presented.The simulations prove that the dynamic feedforward control method effectively eliminates the influence of the dynamic disturbances and dynamic characteristics of the parallel manipulator on high-speed machine tools, and significantly improves the trajectory accuracy. This is the first attempt to introduce the dynamic feedfordward control method into the 3-PSP spatial parallel manipulator whose dynamic model is complex and provides a study basis for the real-time dynamic control of the high-speed hybrid machine tools.

HIGH-ORDER SELF-EXCITED VIBRATION INDUCED BY DRY FRICTION BETWEEN TWO ELASTIC STRUCTURES——VIBRATION MECHANISM OF THE CHINESE CULTURE RELIC DRAGON WASHBASIN

Combining theoretical and experimental modal analyses on self-excited vibration induced by dry friction between two elastic structures, we can explain the high-order sell-excited vibration phenomenon in which water droplets spurt from fourteen or twelve areas of the Chinese culture relic dragon washbasin when it is rubbed with hands, and clarify the mechanism of the singular high-order self-excited vibration. The experimental modes and the practical measured results are presented for a special dragon washbasin. The theoretical results agree well with the experimental ones.

Microstructural evolution of a heat-treated H23 tool steel

The microstructure and the stability of carbides after heat treatments in an H23 tool steel were investigated. The heat treatments consisted of austenization at two different austenizing temperatures （1100℃ and 1250℃）, followed by water quenching and double-aging at 650℃, 750℃, and 800℃with air cooling between the first and second aging treatments. Martensite did not form in the as-quenched micro- structures, which consisted of a ferrite matrix, M6C, M7C3, and MC carbides. The double-aged microstructures consisted of a ferrite matrix and MC, M6C, M7C3, and M23C6 carbides. Secondary hardening as a consequence of secondary precipitation of fine M2C carbides did not occur. There was disagreement between the experimental microstructure and the results of thermodynamic calculations. The highest double-aged hardness of the H23 tool steel was 448 HV after austenization at 1250℃ and double-aging at 650℃, which suggested that this tool steel should be used at temperatures below 650℃.

Turbulent Heat Transfer and Pressure Drop in Tube Fitted with Square-cut Twisted Tape

Heat transfer,friction factor and thermal enhancement factor characteristics of a double pipe heat exchanger fitted with square-cut twisted tapes（STT） and plain twisted tapes（PTT） are investigated experimentally using the water as working fluid.The tapes（STT and PTT） have three twist ratios（y=2.0,4.4 and 6.0） and the Reynolds number ranges from 2000 to 12000.The experimental results reveal that heat transfer rate,friction factor and thermal enhancement factor in the tube equipped with STT are significantly higher than those fitted with PTT. The additional disturbance and secondary flow in the vicinity of the tube wall generated by STT are higher compared to that induced by the PTT is referred as the reason for better performance.Over the range considered,the Nusselt number,friction factor and thermal enhancement factor in a tube with STT are respectively,1.03 to 1.14,1.05 to 1.25 and 1.02 to 1.06 times of those in tube with PTT.An empirical correlation is also formulated to match with experimental data of Nusselt number and friction factor for STT and PTT.

Analysis of the Impact of Thermochemical Recuperation of Waste Heat on the Energy Efficiency of Gas Carriers

Enlarging the fleet of gas carriers would make it possible to respond to the growing demand for hydrocarbon gases,but it will increase carbon dioxide emissions.The International Maritime Organization(IMO)has developed the energy efficiency design index(EEDI)with the objective of carbon emission reduction for new ships.In this paper,thirty gas carriers transporting liquefied natural gas(LNG)and liquefied petroleum gas(LPG)and equipped with various types of main engines are considered.As shown by the calculation of the attained EEDI,2 of the 13 LPG carriers and 6 of the 17 LNG carriers under study do not comply with the EEDI requirements.To meet the stringent EEDI requirements,applying thermochemical regenerators(TCRs)fed by main engine exhaust gases is suggested.Mathematical modeling is applied to analyze the characteristics of the combined gas-turbine-electric and diesel-electric power plant with thermochemical recuperation of the exhaust gas heat.Utilizing TCR on gas carriers with engines fueled by syngas produced from boil-off gas(BOG)reduces the carbon content by 35%and provides the energy efficiency required by IMO without the use of other technologies.

Study on Tribological Properties of CVT Fluid Containing Inert and Active Functional Elements

The lubricating characteristics of CVTF(continuously variable transmission fluid) mixed with a multi-functional complex additive were studied. The said complex additive contained an organic borate ester and a new type of friction improver comprising phosphorus element and poly-methylmethacrylate(PMMA), and a viscosity index improver. The viscosity-pressure characteristics were evaluated by a high-pressure quartz viscometer, and the anti-wear property was investigated by a four-ball friction tester. The mechanism of lubrication by the CVTF was studied using X-ray photoelectron spectroscopy(XPS). The results showed that CVTF T10, which contained a multi-functional complex additive, exhibited excellent properties, featuring greater solidification pressure and pressure-viscosity coefficient, improved oil film strength, and low wear value. These attributes meet the special CVTF requirements for "high friction and low wear" that make it possible to provide both traction and lubrication. The lubricating mechanism was varied using different functional elements, such as inert and active elements. Sulfur and phosphorus are active extreme pressure elements that can react on the metal friction surface and produce an extreme pressure lubrication film. Boron is an inert functional element and does not react upon the metal surface; boron is only adsorbed onto the metal surface to act as a lubricant for adsorption film and fillers.

Cavity noise sensitivity analysis of tire contour design factors and application of contour optimization methodology

Cavity resonance noise of passenger car tires is generated by interacting excitation between a tire structure and the fill gas (air), and generally lies in a frequency range of 200?250 Hz. As such, this noise is strongly perceived and may be a serious source of driver annoyance. Thus, many studies regarding the cavity noise mechanism and its reduction have already been conducted. In this work, a vibro-acoustic coupled analysis was conducted between a tire structure and air cavity. Using this analysis, we can more accurately simulate the tire noise performance in the region of the cavity resonance frequency. An analysis of the effects of variation of tire contour design factors was conducted, using design-of-experiments methods. Finally, a multi-objective optimization was performed using in-house codes to reduce the cavity noise level while minimizing the loss of other performances, such as diminished ride comfort and handling caused by the variations of contour. As a result of this optimization, an optimized contour shape was derived, which satisfied the multi-objective performances.