Massachusetts General Hospital and the Shanghai Mental Health Center:the past,present and future of a psychiatric research partnership

INTRODUCTION There are many obstacles to developing,maintaining and strengthening international research collaborations,whether they are posed by geography,culture or,most recently,global economics and politics.It is critically important to overcome these obstacles,especially when it comes to fostering the types of breakthrough biomedical science that benefit from diverse perspectives,methodologies and data sets.Moreover,the research underlying these breakthroughs unfolds over the course of years,and even decades.For these reasons,and more,the Department of Psychiatry at Massachusetts General Hospital(Mass General)and the Shanghai Mental Health Center(SMHC)are taking the long view:exploring and implementing numerous collaborative research and training projects that are leading to better care and treatments for patients,both in the USA and China,who suffer from a range of psychiatric disorders.

Transdiagnostic considerations of mental health for the post-COVID era:Lessons from the first surge of the pandemic

BACKGROUND The Coronavirus disease 19(COVID-19)-related psychiatric burden partly results from prolonged social stress world-wide.Studies have examined the psychiatric impact of COVID-19 on Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM 5)and International Classification of Diseases 11th Revision(ICD-11)categories,implicating multiple diagnoses,complicating clinical management.AIM To verify whether COVID-19-related psychopathology spans multiple DSM-5 and ICD-11 diagnoses,but not in a random pattern.Consequently,empirical analysis of the multiple associated symptoms will better describe COVID-19-related psychopathology.METHODS We conducted a bi-national study during the first surge of the pandemic:an Italian sample(n=21217,studied March-April 2020);and three representative longitudinal samples from Israel(n=1276,1189,and 1432 respectively,studied May-July 2020).Data in Italy were collected by a national internet-based survey with an initially approached sample of about one million persons and in Israel by the Israeli Central Bureau of Statistics using probability-based national representative sampling.Data analysis focused on the frequency and patterns of reported multiple mental health symptoms.RESULTS Combinations with all symptoms were more prevalent than combinations with fewer symptoms,with no majorities-minorities differences in both countries,demonstrating the generalizability of the transdiagnostic pattern of mental health issues in both nations.A history of previous mental disorder(Italian study)and an increase in symptom prevalence over time(Israel study)were associated with an increased number of symptoms.Conclusions:Based on finding correlated symptom diversity spanning conventional diagnostic categories,we suggest that the pattern of mental health issues associated with the COVID-19 pandemic is transdiagnostic.CONCLUSION The findings have implications for improving prevention and treatment of COVID-19 related psychopathology and for post-pandemic times in conditions resulting from multiplicity of stressors with mixed symptomatology in the clinical picture.

Linking Perceived Risk of Public Health Emergency to Psychological Distress among Chinese College Students: The Chain Mediation Role of Balanced Time Perspective and Negative Coping Styles

Background:With public health emergencies(PHE)worldwide increasing,the perceived risk of PHE has been one of the critical factors influencing college students’psychological distress.However,the mechanisms by which the perceived risk of PHE affects college students’psychological distress are not clear.The study’s purpose was to investigate the mediation roles of deviation from a balanced time perspective(DBTP)and negative coping styles between the perceived risk of PHE and psychological distress.Methods:A convenience sampling method was used to survey 1054 Chinese college students with self-reporting.Data was collected using the Public Risk Perception Scale(PRPS),the Zimbardo Time Perspective Inventory(ZTPI),the Simplified Coping Style Questionnaire(SCSQ),the PHE Anxiety Scale,and the Chinese version of the Patient Health Questionnaire(PHQ).The associations between the perceived risk of PHE,DBTP,negative coping styles,and psychological distress were clarified using the correlation analysis.Additionally,the mediating roles of DBTP and negative coping styles between the perceived risk of PHE and psychological distress were investigated using a structural equation model.Results:The findings revealed low to moderate correlations between the variables studied.Students’perceived risk of PHE was a positive predictor of their psychological distress(b=0.219,p<0.01).DBTP and negative coping styles played chain mediation roles between them with the effect being 0.009 and a 95%Boot CI of[0.003,0.023].This chain mediation model had an excellent fit index(χ^(2)/df=4.732,CFI=0.973,TLI=0.930,RMSEA=0.048,SRMR=0.047).Conclusion:These findings showed how the perceived risk of PHE affected college students’psychological distress.Specifically,these results suggested that improving students’mental ability to switch effectively among different time perspectives depending on task features and situational considerations and reducing their negative coping styles might be effective ways to promote their mental health.

Toward International Collaboration on ICD-11- WHO Mental Health Collaborating Center in China 2017

The Meeting of the Field Studies Coordination Group and International Advisory Group for the Revision of ICD-10 Mental and Behavioral Disorders was held in Shanghai. The Chinese version of the ICD-11 is expected to be released next year. Mental health experts from China have been crucially involved in the revision of the ICD-11.

Predictive value of machine learning models for lymph node metastasis in gastric cancer: A two-center study

BACKGROUND Gastric cancer is one of the most common malignant tumors in the digestive system,ranking sixth in incidence and fourth in mortality worldwide.Since 42.5%of metastatic lymph nodes in gastric cancer belong to nodule type and peripheral type,the application of imaging diagnosis is restricted.AIM To establish models for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning(ML)algorithms and to evaluate their pre-dictive performance in clinical practice.METHODS Data of a total of 369 patients who underwent radical gastrectomy at the Depart-ment of General Surgery of Affiliated Hospital of Xuzhou Medical University(Xuzhou,China)from March 2016 to November 2019 were collected and retro-spectively analyzed as the training group.In addition,data of 123 patients who underwent radical gastrectomy at the Department of General Surgery of Jining First People’s Hospital(Jining,China)were collected and analyzed as the verifi-cation group.Seven ML models,including decision tree,random forest,support vector machine(SVM),gradient boosting machine,naive Bayes,neural network,and logistic regression,were developed to evaluate the occurrence of lymph node metastasis in patients with gastric cancer.The ML models were established fo-llowing ten cross-validation iterations using the training dataset,and subsequently,each model was assessed using the test dataset.The models’performance was evaluated by comparing the area under the receiver operating characteristic curve of each model.RESULTS Among the seven ML models,except for SVM,the other ones exhibited higher accuracy and reliability,and the influences of various risk factors on the models are intuitive.CONCLUSION The ML models developed exhibit strong predictive capabilities for lymph node metastasis in gastric cancer,which can aid in personalized clinical diagnosis and treatment.

Deliberate self-harm among pediatric psychiatric inpatients in China:A single-center retrospective study

BACKGROUND For children and adolescents,deliberate self-harm(DSH)is becoming a mental health problem of concern.Despite several studies on the prevalence and factors of DSH in the world,there is little information on DSH among children and adolescents in China.This study explores the prevalence,types,associated risk factors and tendency of DSH in pediatric psychiatric inpatients in China.AIM To understand the situation of DSH among hospitalized children and adolescents and its related factors.METHODS In this study,we retrospectively studied 1414 hospitalized children and adolescents with mental illness at Xiamen Mental Health Center from 2014 to 2019,extracted the demographic and clinical data of all patients,and analyzed clinical risk factors of DSH.RESULTS A total of 239(16.90%)patients engaged in at least one type of DSH in our study.Cutting(n=115,48.12%)was the most common type of DSH.Females(n=171,71.55%)were more likely to engage in DSH than males(n=68,28.45%).DSH was positively associated with depressive disorders[OR=3.845(2.196-6.732);P<0.01],female[OR=2.536(1.815-3.542);P<0.01],parental marital status[OR=5.387(2.254-12.875);P<0.01]and negative family history of psychiatric illness[OR=7.767(2.952-20.433);P<0.01],but not with occupation,substance use and history of physical abuse.CONCLUSION Our findings suggest that for patients with depression,females,an abnormal marriage of parents,and no history of mental illness,attention should be paid to the occurrence of DSH.

1992-2017年中文论文中Mental Health的五个中文译词的CiteSpace可视化分析

目的:探讨Mental Health对应五个汉译术语的使用现状。方法:借助信息可视化软件CiteSpace 4.0,分别以mental health、心理健康、心理卫生、精神卫生、精神健康和身心健康为主题词检索CNKI数据库收录的1992年以来核心期刊论文进行可视化分析,绘制关键词共现知识图谱。结果:Mental health相关的3287篇引文以基础研究为主,应用研究较少;数量逐年波动增长。五个对应汉译词"心理健康、精神卫生、心理卫生、身心健康和精神健康"使用频率依次递减,研究者、研究机构侧重不同,并衍生出不同的研究领域。心理健康频度最高,使用者主要是心理学科研院所人员;后四种译法使用者主要为精神科从业人员;心理卫生中心性最高。这表明mental health是心理学与精神病学的交叉点,但对应汉译词使用者和机构学科间或学科内合作广度及深度有待加强。结论:译法取决于概念界定,使用者则属于不同学科。Mental health五种汉译使用频率不同,在心理学、精神病学二十五年发展中各有侧重。

Translated and annotated version of the 2015-2020 National Mental Health Work Plan of the People's Republic of China

The following document is a translation of the 2015-2020 National Mental Health Work Plan of the People's Republic of China which was issued by the General Office of China's State Council on June 4, 2015. The original Chinese version of the document is available at the official government website: http://www.gov.cn/zhengce/content/2015-06/18/content_9860.htm. The translators have added annotations at the end of the document that provide background information to help contextualize content that may be unclear to readers unfamiliar with China and explain their decisions when translating terms that can have multiple interpretations.

Psychiatric Epidemiology and Mental Health Service in the Tibet Autonomous Region of the People＇s Republic of China

概述:西藏自治区的精神疾病流行病学和精神卫生服务情况在国际上鲜有提及。本文综述了中国西藏自治区的精神疾病流行病学和精神卫生服务以及相关研究。目前在西藏,有很多人存在精神障碍和心理问题,但由于缺乏现代精神治疗机构和专家,仍有很多的治疗需求没有被满足。

Strategic mental health planning and its practice in China：retrospect and prospect

As a large country with a population of over 1.3 billion people,China has been widely recognized for its roles in economic development and for its participation in global governance.However,China’s efforts in domestic social governance receive both praise and blame.On one hand,the management of a large country that has 18%of the world population,is worth 15.5%of the world economic gross,and is made up of 56

Challenges and opportunities in mental health services during the COVID-19 pandemic

As of 12 March 2020,the WHO upgraded the status of COVID-19 from epidemic to pandemic.1 Globally,as of 20 July 2020,14707451 confirmed cases of COVID-19,including 609985 deaths,have been reported by an interactive web-based dashboard released by Johns Hopkins University.2 Strict provisions and strategies have been implemented to suppress or mitigate the spread of the COVID-19 pandemic,such as government-imposed contact tracing and quarantine,lockdown,social and physical distance measures,and closure of non-essential facilities and services.The global spread of the COVID-19 pandemic and rapid escalation response undoubtedly put enormous stress on patients with confirmed or suspected COVID-19,medical personnel and even the public,increasing the risk of mental health problems.

Mental health status of students’parents during COVID-19 pandemic and its influence factors

Background During the outbreak of COVID-19,the national policy of home quarantine may affect the mental health of parents.However,few studies have investigated the mental health of parents during the COVID-19 pandemic.Aims To investigate the depression,anxiety and stress of the students'parents during the COVID-19 pandemic,and to explore the influence factors,especially the influence of social support and family-related factors.Methods The Generalised Anxiety Disorder-7,Patient Health Questionnaire-9,Perceived Stress Scale-10 and Social Support Rating Scale were applied to 1163 parents to measure the parents'depression,anxiety,stress and social support.Results(1)The detection rates of depression and anxiety in parents were 6.1%and 4.0%.The depression,anxiety and perceived stress of parents in central China were significantly higher than those in non-central China.The anxiety of college students'parents was lower than that of parents of the primary,middle and high school students.The depression,anxiety and perceived stress of parents with conflicts in the family were significantly higher than those with a harmonious family.Other factors that influence parents’depression,anxiety and perceived stress include marital satisfaction,social support,parents*history of mental illness and parenting style,etc.(2)The regression analysis results showed that perceived stress,social support,marital satisfaction,family conflicts,child's learning stage as well as parents'history of mental illness had significant effects on parents'anxiety and depression.Conclusion During the COVID-19 pandemic,the mental health of parents was affected by a variety of factors.Good marital relationships,good social support,family harmony and parents without a history of mental illness may be protective factors for parents*mental health,while perceived stress and child in middle or high school are risk factors for parents’mental health.

New journey,new mission: bolstering international communication about mental health

In the wake of the rapid economy and society development, phenomena such as industri-alisation, urbanisation, marketisation and the ageing of the population have shown an accelerating trend. As a result, mental health issues due to these phenomena are increasingly serious, making mental health both concerning public health and societal issues that have a great impact on economic and social development.^1 In 2014, there were 16 million persons with severe mental disor-ders in China.

Isolation and mental health:challenges and experiences from China

Isolation is a common phenomenon during the COVID-19 global pandemic,impacting people’s physical and mental health worldwide.12 Based on a rapid systematic review,Loades et al3 concluded that people were more likely to suffer from depression or anxiety during and after enforced isolation.

Mental health in the post-COVID-19 era:challenges and the way forward

The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management.

Practical Answers are Needed to Respond to the Myth of Mental Health Services in Tibet

The article by Liang Xie et al.examines the current situation of mental disorders and mental health services in the Tibet Autonomous Region(TAR)of China,the part of China where mental health resources are the most scarce.[5]For quite a long time,the most frequently asked questions by people who were concerned about the phenomenon of this impoverished

COVID-19 mental health care toolkit:an international collaborative effort by Early Career Psychiatrists section

The collaborative effort of an international research team from the Early Career Psychiatrists section of the World Psychiatry Association has brought about an easy-to-use,quick and stepwise mental health care toolkit for the identification and appropriate referral of those in need of mental health care during the pandemic.This simple guide can be applied in the general outpatient setting and is catered for all healthcare professionals,regardless of their expertise within the mental health field with minimal training.It is our hope that by incorporating this toolkit into our daily clinical care during the pandemic for high-risk patients and patients with non-specific complaints,we will be able to bridge the mental health gap present in our society.

Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation

Increasing observational and experimental trial data have shownthat mental stress can lead toan increase in adverse clinical cardiovascular events.Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction(MI)or direct myocardial injury.Mental stress leads to systemic inflammation.Inflammation is known to cause rapid atheromatous plaque progression,instability and thrombosis—the classic type 1 MI.Inflammation can also lead to type 2 MI or myocarditis and injury.The published data linking systemic inflammation,mental stress and cardiovascular disease will be reviewed to establish the linkage between mind and heart,thereby highlighting the importance of holistically managing the patient,not only addressing separate organ systems.Finally,recent trial evidence showing the value of anti-inflammatory drugs in cardiovascular and mental conditions will be briefly considered.