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Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells 被引量:9
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作者 Rong, Q. F. Huang, J. Su, E. B. Li, J. Li, J. Y. Zhang, L. L. Cao, K. J. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第10期1091-1091,共1页
关键词 乙型肝炎病毒 祖细胞 肝细胞 肝组织 鉴别
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Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury 被引量:12
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作者 Fang, Fei Yang, Yuyu +4 位作者 Yuan, Zhibin Gao, Yuqi Zhou, Jiliang Chen, Qi Xu, Yong 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2011年第6期842-842,共1页
关键词 动脉粥样硬化 内皮损伤 低密度脂蛋白 细胞反应
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Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells 被引量:8
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作者 Zhong, X. S. Liu, L. Z. Skinner, H. D. Cao, Z. X. Ding, M. Jiang, B. H 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第10期1083-1083,共1页
关键词 卵巢癌 血管内皮生长因子 基因表达 受体 血管发生 发生机理
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Bone marrow-derived mesenchymal stem cells are capable of mediating hepatitis B virus infection in injured tissues 被引量:5
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作者 Rong, Q. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2008年第9期1141-1141,共1页
关键词 骨髓 间叶细胞 肝炎 治疗方法 临床分析
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Caveolae-dependent Endocytosis Is Required for Class A Macrophage Scavenger Receptor-mediated Apoptosis in Macrophages 被引量:2
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作者 Zhu, Xu-Dong Zhuang, Yan +6 位作者 Ben, Jing-Jing Qian, Ling-Ling Huang, Han-Peng Bai, Hui Sha, Jia-Hao He, Zhi-Gang Chen, Qi 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2011年第6期863-863,共1页
关键词 跨膜受体 脂蛋白 血管疾病 医学研究
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本校近期发表IF≥4.0的SCI论文摘要(英文)——RFXB and its splice variant RFXBSV mediate the antagonism between IFN gamma and TGF beta on COLIA2 transcription in vascular smooth muscle cells 被引量:1
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作者 Fang Mingming Kong Xiaocen +6 位作者 Li Ping Fang Fei Wu Xiaoyan Bai Hui Qi Xiaohong Chen Qi Xu Yong 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2009年第9期1284-1284,共1页
关键词 动脉平滑肌细胞 转录因子 异体结合 细胞活素
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Prevalence and characterization of class I integrons among Pseudomonas aeruginosa and Acinetobacter baumanhii isolates from patients in Nanjing, China 被引量:32
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作者 Gu,B. Tong, M. Q. Zhao, W. J. Liu, G. Y. Ning, M. Z. Pan, S. Y. Zhao, W. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第4期316-316,共1页
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Prevalence and characterization of class Ⅰ integrons among Pseudomonas aeruginosa and Acinetobacter baumanhii isolates from patients in Nanjing, China
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作者 Gu, B. Tong, M. Q. +4 位作者 Zhao, W. J. Liu, G. Y. Ning, M. Z. Pan, S. Y. Zhao, W. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第5期494-494,共1页
关键词 假单胞菌 抗药性 抗生素 病原菌 流行病学 生物学特性 分离 基因
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Glucose-regulated protein 78 inhibits scavenger receptor A-mediated internalization of acetylated low density lipoprotein
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作者 Ben, Jingjing Gao, Song +8 位作者 Zhu, Xudong Zheng, Yuan Zhuang, Yan Bai, Hui Xu, Yong Ji, Yong Sha, Jiahao He, Zhigang Chen, Qi 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第1期105-105,共1页
Class A scavenger receptor(SR-A) plays an important role in foam cell formation.However, the mechanism underlying the internalization of the receptor-ligand complexes remains unclear.The aim of the present study was t... Class A scavenger receptor(SR-A) plays an important role in foam cell formation.However, the mechanism underlying the internalization of the receptor-ligand complexes remains unclear.The aim of the present study was to investigate the molecular mechanism to regulate SR-A-mediated intracellular lipid accumulation in macrophages A pull-clown assay was performed and glucoseregulated protein 78(GRP78) was identified to bind with the cytoplasmic domain of SR-A(CSR-A).Immunoprecipitation and artificially expressed protein binding assay demonstrated the direct specific binding of GRP78 with SR-A in cells.Indirect immunofluorescence assay and western blot analysis showed their co-localization in membrane and cytoplasm.Over-expression of GRP78 specifically inhibited SR-A-mediated uptake of fluorescent acetylated low-density lipoprotein, a specific ligand for SR-A, without altering cellular SR-A expression and binding ability, and significantly inhibited cholesterol ester accumulation in cells, which can be partly attributed to the suppression of c-Jun-NH2-terminal kinase signaling pathway.These results suggest that GRP78 may act as an inhibitor of SR-A-mediated internalization of modified low-density lipoprotein into macrophages(C) 2009 Elsevier Inc.All rights reserved. 展开更多
关键词 受体 泡沫细胞 免疫沉淀 蛋白质
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Association between different obesity indicators and carotid intima-media thickness in patients with type 2 diabetes mellitus
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作者 崔茜 《China Medical Abstracts(Internal Medicine)》 2024年第1期27-28,共2页
Objective To explore the relationship between different obesity indicators and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 1 762 T2DM patients who visited ... Objective To explore the relationship between different obesity indicators and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 1 762 T2DM patients who visited the Endocrinology Department of Changzhou Second People’s Hospital Affiliated to Nanjing Medical University and the Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine from January2019 to February 2022 were enrolled in this study. 展开更多
关键词 OBESITY T2DM PATIENTS
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Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要) 被引量:141
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作者 Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第7期1030-1030,共1页
关键词 人类 RNA 疾病 医学研究 血清
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Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma 被引量:50
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作者 Lv, Jin Cao, Xiu-Feng +3 位作者 Zhu, Bin Ji, Lv Tao, Lei Wang, Dong-Dong 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第13期1649-1654,共6页
AIM: To investigate the role of perioperative chemoradiotherapy (CRT) in the treatment of locally advanced thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Using preoperative computed tomography (CT)-based... AIM: To investigate the role of perioperative chemoradiotherapy (CRT) in the treatment of locally advanced thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Using preoperative computed tomography (CT)-based staging criteria, 238 patients with ESCC (stage ⅡⅢ ) were enrolled in this prospective study between January 1997 and June 2004. With informed consent, patients were randomized into 3 groups: preoperative CRT (80 cases), postoperative CRT (78 cases) and surgery alone (S) (80 cases). The 1-, 3-, 5and 10-year survival were followed up. Progressionfree survival (PFS) was chosen as the primary endpoint by treatment arm measured from study entry until documented progression of disease or death from any cause. The secondary endpoint was overall survival (OS) determined as the time (in months) between the date of therapy and the date of death. Other objectives were surgical and adjuvant therapy complications.RESULTS: With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year OS (91.3%, 63.5%, 43.5%, 24.5% vs 91%, 62.8%, 42.3%, 24.4% vs 87.5%, 51.3%, 33.8%, 12.5%, P = 0.0176) and PFS (89.3%, 61.3%, 37.5%, 18.1% vs 89.1%, 61.1%, 37.2%, 17.8% vs 84.5%, 49.3%, 25.9%, 6.2%, P = 0.0151) were detected among the 3 arms. There were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm (P > 0.05). For the patients who had radical resection, significant differences in median PFS (48 mo vs 61 mo vs 39.5 mo, P = 0.0331) and median OS (56.5 mo vs 72 mo vs 41.5 mo, P = 0.0153) were detected among the 3 arms, but there were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm (P > 0.05). The local recurrence rates in the preoperative CRT, postoperative CRT group and S group were 11.3%, 14.1% and 35%, respectively (P < 0.05). No significant differences were detected among the 3 groups when comparing complications but tended to be in favor of the postoperative CRT and S groups (P > 0.05). Toxicities of CRT in the preoperative or postoperative CRT arms were mostly moderate, and could be quickly alleviated by adequate therapy. CONCLUSION: Rational application of preoperative or postoperative CRT can provide a benefit in PFS and OS in patients with locally advanced ESCC. 展开更多
关键词 Esophageal cancer Surgery ESOPHAGECTOMY CHEMOTHERAPY Radiation therapy
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Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration 被引量:46
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作者 Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第10期1133-1133,共1页
关键词 间叶细胞 干细胞 肝细胞生长因子 肝移植 肝再生
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Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling 被引量:31
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作者 Zeng, Y. Zhang, X. H. +8 位作者 Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第5期514-514,共1页
关键词 免疫缺陷性病毒1 疱疹病毒 肉瘤 JAK/STAT信号 HIV-1 T细胞 转录因子 基因表达
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EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women 被引量:34
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作者 Wang, Y. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2008年第12期1655-1655,共1页
关键词 表皮生长因子 单核苷酸 多态性 血浆EGF 乳腺癌 治疗方法
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Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women 被引量:29
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作者 Hu, Z. B. Liang, J. +7 位作者 Wang, Z. W. Tian, T. Zhou, X. Y. Chen, J. P. Miao, R. F. Wang, Y. Wang, X. R. Shen, H. B. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2009年第4期463-463,共1页
关键词 致癌基因 肿瘤 MIRNAS 医学
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Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes 被引量:20
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作者 Zeng, X. N. Sun, X. L. Gao, L. Fan, Y. Ding, J. H. Hu, G. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第5期431-431,共1页
关键词 星形胶质细胞 GLT-1基因表达 血脑屏障 水分转运 水肿 基因表型 谷氨酸酯
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Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome 被引量:21
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作者 Ma,X Fan,L +5 位作者 Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第11期1216-1216,共1页
关键词 蛋白质 卵巢 多囊卵巢综合征 生长因子 分子伴侣
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Epidural Analgesia in the Latent Phase of Labor and the Risk of Cesarean Delivery A Five-year Randomized Controlled Trial 被引量:41
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作者 Wang, F. Z. Shen, X. F. +2 位作者 Guo, X. R. Peng, Y. Z. Gu, X.Q. 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2009年第11期1628-1628,共1页
关键词 硬脑膜痛觉缺失 未生育妇女 怀孕 催产素
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Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要) 被引量:26
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作者 Gao, Y Yao, A +7 位作者 Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2010年第8期1064-1064,共1页
关键词 癌症 基因 治疗方法 临床分析
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