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阿尔茨海默病居家筛查专家共识
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作者 徐群 JWesson Ashford +29 位作者 陈彪 陈树斌 Jeffrey Cummings 顾柏俊 郭起浩 韩璎 花迎雪 金华 Nagaendran Kandiah 李海雁 刘晓蕾 刘新 卢佩琳 裴中 施晓耕 孙凯 汤彬 Goerge Vradenburg 王惠芳 王军 王晓明 王艳蕊 王艳梅 王玉林 翁文锋 辛美哲 张玉兰 赵禾欣 周显波 王虹峥 《阿尔茨海默病及相关病杂志》 2024年第3期176-183,共8页
老年人痴呆或认知障碍多由一种以上年龄相关的常见脑部疾病所致。阿尔茨海默病(Alzheimer's disease,AD)是其中最常见的神经变性疾病,且是全球前10位死因中唯一无法治愈或缺乏长期对症疗效的疾病,给个人、家庭和全球经济都带来了巨... 老年人痴呆或认知障碍多由一种以上年龄相关的常见脑部疾病所致。阿尔茨海默病(Alzheimer's disease,AD)是其中最常见的神经变性疾病,且是全球前10位死因中唯一无法治愈或缺乏长期对症疗效的疾病,给个人、家庭和全球经济都带来了巨大的负担。早期及时发现和干预是对抗AD的最佳策略。在过去的30年中,许多研究都提出了降低痴呆风险的方法,2020年《柳叶刀》杂志的痴呆预防报告已阐明通过应对风险因素可以预防或延缓超过40%的痴呆。然而,目前全球医疗体系尚未具备早期或及时发现AD的足够能力。最近的一项研究发现,只有不到10%的轻度认知障碍(mild cognitive impairment,MCI)是在初级医疗机构中诊断出来的。近来,抗淀粉样蛋白β(Amyloid beta,Aβ)抗体药物lecanemab和donanemab被批准上市用于早期AD治疗,以及30年的随访研究证明改善风险因素显著减少AD痴呆的发病率并延长了寿命,使得人们对AD早期识别的关注迅速增加。阿尔茨海默病防治协会(China Association for Alzheimer's Disease,CAAD)认识到居家早期和及时发现AD的重要性,并成立了一个由协会成员、临床医生和研究人员组成的全球AD多领域专家团队,就以下目标达成共识:①为个人、家庭、社区、协会和组织提供专家指导意见;②介绍用于认知障碍和痴呆居家筛查的数字工具和可用资源,并为AD高危人群或疑似患者制定下一步应对策略;③讨论现有可用或将来可能的居家筛查适宜AD生物标志物;④为未来的改进和全球应用建立可行性框架。专家组对于当前可用的证据、工具和资源进行综述,并进一步考量其在AD居家筛查中的价值。 展开更多
关键词 认知评估 阿尔茨海默病 认知障碍 痴呆 居家 筛查
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Fiber optic monitoring of an anti-slide pile in a retrogressive landslide 被引量:3
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作者 Lei Zhang Honghu Zhu +1 位作者 Heming Han Bin Shi 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期333-343,共11页
Anti-slide piles are one of the most important reinforcement structures against landslides,and evalu-ating the working conditions is of great significance for landslide mitigation.The widely adopted analytical methods... Anti-slide piles are one of the most important reinforcement structures against landslides,and evalu-ating the working conditions is of great significance for landslide mitigation.The widely adopted analytical methods of pile internal forces include cantilever beam method and elastic foundation beam method.However,due to many assumptions involved in calculation,the analytical models cannot be fully applicable to complex site situations,e.g.landslides with multi-sliding surfaces and pile-soil interface separation as discussed herein.In view of this,the combination of distributed fiber optic sensing(DFOS)and strain-internal force conversion methods was proposed to evaluate the working conditions of an anti-sliding pile in a typical retrogressive landslide in the Three Gorges reservoir area,China.Brillouin optical time domain reflectometry(BOTDR)was utilized to monitor the strain distri-bution along the pile.Next,by analyzing the relative deformation between the pile and its adjacent inclinometer,the pile-soil interface separation was profiled.Finally,the internal forces of the anti-slide pile were derived based on the strain-internal force conversion method.According to the ratio of calculated internal forces to the design values,the working conditions of the anti-slide pile could be evaluated.The results demonstrated that the proposed method could reveal the deformation pattern of the anti-slide pile system,and can quantitatively evaluate its working conditions. 展开更多
关键词 Anti-slide pile Multi-sliding surface Pile-soil interface Brillouin optical time domain reflectometry (BOTDR) Geotechnical monitoring Reservoir landslide
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Clinical associations of corneal neuromas with ocular surface diseases 被引量:1
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作者 Charmaine Jan Li Toh Chang Liu +3 位作者 Isabelle Xin Yu Lee Molly Tzu Yu Lin Louis Tong Yu-Chi Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期140-147,共8页
Corneal neuromas,also termed microneuromas,refer to microscopic,irregula rly-shaped enlargements of terminal subbasal nerve endings at sites of nerve damage or injury.The formation of corneal neuromas results from dam... Corneal neuromas,also termed microneuromas,refer to microscopic,irregula rly-shaped enlargements of terminal subbasal nerve endings at sites of nerve damage or injury.The formation of corneal neuromas results from damage to corneal nerves,such as following corneal pathology or corneal or intraocular surge ries.Initially,denervated areas of sensory nerve fibers become invaded by sprouts of intact sensory nerve fibers,and later injured axons regenerate and new sprouts called neuromas develop.In recent years,analysis of corneal nerve abnormalities including corneal neuromas which can be identified using in vivo confocal microscopy,a non-invasive imaging technique with microscopic resolution,has been used to evaluate corneal neuropathy and ocular surface dysfunction.Corneal neuromas have been shown to be associated with clinical symptoms of discomfort and dryness of eyes,and are a promising surrogate biomarker for ocular surface diseases,such as neuropathic corneal pain,dry eye disease,diabetic corneal neuropathy,neurotrophic keratopathy,Sjogren's syndrome,bullous keratopathy,post-refra ctive surgery,and others.In this review,we have summarized the current literature on the association between these ocular surface diseases and the presentation of corneal microneuromas,as well as elaborated on their pathogenesis,visualization via in vivo confocal microscopy,and utility in monitoring treatment efficacy.As current quantitative analysis on neuromas mainly relies on manual annotation and quantification,which is user-dependent and labor-intensive,future direction includes the development of artificial intelligence software to identify and quantify these potential imaging biomarkers in a more automated and sensitive manner,allowing it to be applied in clinical settings more efficiently.Combining imaging and molecular biomarkers may also help elucidate the associations between corneal neuromas and ocular surface diseases. 展开更多
关键词 CORNEA corneal diseases corneal nerve corneal neuropathy in vivo confocal microscopy microneuroma NEUROMA ocular surface diseases
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Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease 被引量:1
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作者 Evridiki Asimakidou Richard Reynolds +1 位作者 Anna M.Barron Chih Hung Lo 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1869-1870,共2页
Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellu... Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal loss.Recent evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression. 展开更多
关键词 Alzheimer death tau
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Design of Protograph LDPC-Coded MIMO-VLC Systems with Generalized Spatial Modulation 被引量:1
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作者 Dai Lin Fang Yi +1 位作者 Guan Yongliang Mohsen Guizani 《China Communications》 SCIE CSCD 2024年第3期118-136,共19页
This paper investigates the bit-interleaved coded generalized spatial modulation(BICGSM) with iterative decoding(BICGSM-ID) for multiple-input multiple-output(MIMO) visible light communications(VLC). In the BICGSM-ID ... This paper investigates the bit-interleaved coded generalized spatial modulation(BICGSM) with iterative decoding(BICGSM-ID) for multiple-input multiple-output(MIMO) visible light communications(VLC). In the BICGSM-ID scheme, the information bits conveyed by the signal-domain(SiD) symbols and the spatial-domain(SpD) light emitting diode(LED)-index patterns are coded by a protograph low-density parity-check(P-LDPC) code. Specifically, we propose a signal-domain symbol expanding and re-allocating(SSER) method for constructing a type of novel generalized spatial modulation(GSM) constellations, referred to as SSERGSM constellations, so as to boost the performance of the BICGSM-ID MIMO-VLC systems.Moreover, by applying a modified PEXIT(MPEXIT) algorithm, we further design a family of rate-compatible P-LDPC codes, referred to as enhanced accumulate-repeat-accumulate(EARA) codes,which possess both excellent decoding thresholds and linear-minimum-distance-growth property. Both analysis and simulation results illustrate that the proposed SSERGSM constellations and P-LDPC codes can remarkably improve the convergence and decoding performance of MIMO-VLC systems. Therefore, the proposed P-LDPC-coded SSERGSM-mapped BICGSMID configuration is envisioned as a promising transmission solution to satisfy the high-throughput requirement of MIMO-VLC applications. 展开更多
关键词 bit-interleaved coded modulation generalized spatial modulation multiple-input multipleoutput protograph LDPC codes visible light communication
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Investigating the impact of dynamic structural changes of Au/rutile catalysts on the catalytic activity of CO oxidation 被引量:1
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作者 Xiaochun Hu Qianwenhao Fan +9 位作者 Mingwu Tan Yuqing Luo Xianyue Wu Manoel Y.Manuputty Jie Ding Tej S.Choksi Markus Kraft Rong Xu Zhiqiang Sun Wen Liu 《Carbon Energy》 SCIE EI CAS CSCD 2024年第4期222-232,共11页
The surface properties of oxidic supports and their interaction with the supported metals play critical roles in governing the catalytic activities of oxide‐supported metal catalysts.When metals are supported on redu... The surface properties of oxidic supports and their interaction with the supported metals play critical roles in governing the catalytic activities of oxide‐supported metal catalysts.When metals are supported on reducible oxides,dynamic surface reconstruction phenomena,including strong metal–support interaction(SMSI)and oxygen vacancy formation,complicate the determination of the structural–functional relationship at the active sites.Here,we performed a systematic investigation of the dynamic behavior of Au nanocatalysts supported on flame‐synthesized TiO_(2),which takes predominantly a rutile phase,using CO oxidation above room temperature as a probe reaction.Our analysis conclusively elucidated a negative correlation between the catalytic activity of Au/TiO_(2) and the oxygen vacancy at the Au/TiO_(2) interface.Although the reversible formation and retracting of SMSI overlayers have been ubiquitously observed on Au/TiO_(2) samples,the catalytic consequence of SMSI remains inconclusive.Density functional theory suggests that the electron transfer from TiO_(2) to Au is correlated to the presence of the interfacial oxygen vacancies,retarding the catalytic activation of CO oxidation. 展开更多
关键词 CO oxidation electronic metal-support interactions flame‐synthesis metal-support interactions oxygen vacancy strong metal-support interaction
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Preparation of MXene-based hybrids and their application in neuromorphic devices 被引量:1
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作者 Zhuohao Xiao Xiaodong Xiao +8 位作者 Ling Bing Kong Hongbo Dong Xiuying Li Bin He Shuangchen Ruan Jianpang Zhai Kun Zhou Qin Huang Liang Chu 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第2期164-188,共25页
The traditional von Neumann computing architecture has relatively-low information processing speed and high power consumption,making it difficult to meet the computing needs of artificial intelligence(AI).Neuromorphic... The traditional von Neumann computing architecture has relatively-low information processing speed and high power consumption,making it difficult to meet the computing needs of artificial intelligence(AI).Neuromorphic computing systems,with massively parallel computing capability and low power consumption,have been considered as an ideal option for data storage and AI computing in the future.Memristor,as the fourth basic electronic component besides resistance,capacitance and inductance,is one of the most competitive candidates for neuromorphic computing systems benefiting from the simple structure,continuously adjustable conductivity state,ultra-low power consumption,high switching speed and compatibility with existing CMOS technology.The memristors with applying MXene-based hybrids have attracted significant attention in recent years.Here,we introduce the latest progress in the synthesis of MXene-based hybrids and summarize their potential applications in memristor devices and neuromorphological intelligence.We explore the development trend of memristors constructed by combining MXenes with other functional materials and emphatically discuss the potential mechanism of MXenes-based memristor devices.Finally,the future prospects and directions of MXene-based memristors are briefly described. 展开更多
关键词 MXene ETCHING FABRICATION MEMRISTOR neuromorphic
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UAV-Assisted Dynamic Avatar Task Migration for Vehicular Metaverse Services: A Multi-Agent Deep Reinforcement Learning Approach 被引量:1
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作者 Jiawen Kang Junlong Chen +6 位作者 Minrui Xu Zehui Xiong Yutao Jiao Luchao Han Dusit Niyato Yongju Tong Shengli Xie 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第2期430-445,共16页
Avatars, as promising digital representations and service assistants of users in Metaverses, can enable drivers and passengers to immerse themselves in 3D virtual services and spaces of UAV-assisted vehicular Metavers... Avatars, as promising digital representations and service assistants of users in Metaverses, can enable drivers and passengers to immerse themselves in 3D virtual services and spaces of UAV-assisted vehicular Metaverses. However, avatar tasks include a multitude of human-to-avatar and avatar-to-avatar interactive applications, e.g., augmented reality navigation,which consumes intensive computing resources. It is inefficient and impractical for vehicles to process avatar tasks locally. Fortunately, migrating avatar tasks to the nearest roadside units(RSU)or unmanned aerial vehicles(UAV) for execution is a promising solution to decrease computation overhead and reduce task processing latency, while the high mobility of vehicles brings challenges for vehicles to independently perform avatar migration decisions depending on current and future vehicle status. To address these challenges, in this paper, we propose a novel avatar task migration system based on multi-agent deep reinforcement learning(MADRL) to execute immersive vehicular avatar tasks dynamically. Specifically, we first formulate the problem of avatar task migration from vehicles to RSUs/UAVs as a partially observable Markov decision process that can be solved by MADRL algorithms. We then design the multi-agent proximal policy optimization(MAPPO) approach as the MADRL algorithm for the avatar task migration problem. To overcome slow convergence resulting from the curse of dimensionality and non-stationary issues caused by shared parameters in MAPPO, we further propose a transformer-based MAPPO approach via sequential decision-making models for the efficient representation of relationships among agents. Finally, to motivate terrestrial or non-terrestrial edge servers(e.g., RSUs or UAVs) to share computation resources and ensure traceability of the sharing records, we apply smart contracts and blockchain technologies to achieve secure sharing management. Numerical results demonstrate that the proposed approach outperforms the MAPPO approach by around 2% and effectively reduces approximately 20% of the latency of avatar task execution in UAV-assisted vehicular Metaverses. 展开更多
关键词 AVATAR blockchain metaverses multi-agent deep reinforcement learning transformer UAVS
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Toward Trustworthy Decision-Making for Autonomous Vehicles:A Robust Reinforcement Learning Approach with Safety Guarantees
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作者 Xiangkun He Wenhui Huang Chen Lv 《Engineering》 SCIE EI CAS CSCD 2024年第2期77-89,共13页
While autonomous vehicles are vital components of intelligent transportation systems,ensuring the trustworthiness of decision-making remains a substantial challenge in realizing autonomous driving.Therefore,we present... While autonomous vehicles are vital components of intelligent transportation systems,ensuring the trustworthiness of decision-making remains a substantial challenge in realizing autonomous driving.Therefore,we present a novel robust reinforcement learning approach with safety guarantees to attain trustworthy decision-making for autonomous vehicles.The proposed technique ensures decision trustworthiness in terms of policy robustness and collision safety.Specifically,an adversary model is learned online to simulate the worst-case uncertainty by approximating the optimal adversarial perturbations on the observed states and environmental dynamics.In addition,an adversarial robust actor-critic algorithm is developed to enable the agent to learn robust policies against perturbations in observations and dynamics.Moreover,we devise a safety mask to guarantee the collision safety of the autonomous driving agent during both the training and testing processes using an interpretable knowledge model known as the Responsibility-Sensitive Safety Model.Finally,the proposed approach is evaluated through both simulations and experiments.These results indicate that the autonomous driving agent can make trustworthy decisions and drastically reduce the number of collisions through robust safety policies. 展开更多
关键词 Autonomous vehicle DECISION-MAKING Reinforcement learning Adversarial attack Safety guarantee
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Direct recycling of Li-ion batteries from cell to pack level:Challenges and prospects on technology,scalability,sustainability,and economics
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作者 Joseph Jegan Roy Do Minh Phuong +5 位作者 Vivek Verma Richa Chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi Srinivasan 《Carbon Energy》 SCIE EI CAS CSCD 2024年第6期1-39,共39页
Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent yea... Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent years.The primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical performance.This technology's advantages over traditional pyrometallurgy and hydrometallurgy are costeffectiveness,energy efficiency,and sustainability,and it preserves the material structure and morphology and can shorten the overall recycling path.This review extensively discusses the advancements in the direct recycling of LIBs,including battery sorting,pretreatment processes,separation of cathode and anode materials,and regeneration and quality enhancement of electrode materials.It encompasses various approaches to successfully regenerate high-value electrode materials and streamlining the recovery process without compromising their electrochemical properties.Furthermore,we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives:(1)battery design,(2)disassembling,(3)electrode delamination,and(4)commercialization and sustainability.Based on these challenges and changing market trends,a few strategies are discussed to aid direct recycling efforts,such as binders,electrolyte selection,and alternative battery designs;and recent transitions and technological advancements in the battery industry are presented. 展开更多
关键词 battery design cathode regeneration direct recycling graphite recycling lithium-ion battery scaling-up
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In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds
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作者 Yanhao Hou Weiguang Wang Paulo Bartolo 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第5期651-669,共19页
Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field.Due to the intrinsic limitations of PCL,carbon nanomateria... Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the field.Due to the intrinsic limitations of PCL,carbon nanomaterials are often investigated to reinforce the PCL scaffolds.Despite several studies that have been conducted on carbon nanomaterials,such as graphene(G)and graphene oxide(GO),certain challenges remain in terms of the precise design of the biological and nonbiological properties of the scaffolds.This paper addresses this limitation by investigating both the nonbiological(element composition,surface,degradation,and thermal and mechanical properties)and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering applications.Results showed that the incorporation of G and GO increased surface properties(reduced modulus and wettability),material crystallinity,crystallization temperature,and degradation rate.However,the variations in compressive modulus,strength,surface hardness,and cell metabolic activity strongly depended on the type of reinforcement.Finally,a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight,fiber diameter,porosity,and mechanical properties as functions of degradation time and carbon nanomaterial concentrations.The results presented in this paper enable the design of three-dimensional(3D)bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers. 展开更多
关键词 Additive manufacturing Bone tissue engineering Carbon nanomaterial GRAPHENE Graphene oxide SCAFFOLD
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Automation 5.0: The Key to Systems Intelligence and Industry 5.0 被引量:1
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作者 Ljubo Vlacic Hailong Huang +10 位作者 Mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第8期1723-1727,共5页
AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with machinery.The rise of steam engines and water wheels represented the f... AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with machinery.The rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:L.Vlacic,H.Huang,M.Dotoli,Y.Wang,P.Ioanno,L.Fan,X.Wang,R.Carli,C.Lv,L.Li,X.Na,Q.-L.Han,and F.-Y.Wang,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA J.Autom.Sinica,vol.11,no.8,pp.1723-1727,Aug.2024. 展开更多
关键词 AUTOMATION MACHINERY INTELLIGENCE
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Jetting-based bioprinting:process,dispense physics,and applications
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作者 Wei Long Ng Viktor Shkolnikov 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2024年第5期771-799,共29页
Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a hig... Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication approach.Due to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based bioprinting.This review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based bioprinting.We first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve bioprinting.Next,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet impact.Finally,we highlight recent accomplishments in jetting-based bioprinting.We present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting. 展开更多
关键词 3D bioprinting BIOFABRICATION Jetting-based Dispense physics Machine learning
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Process,Material,and Regulatory Considerations for 3D Printed Medical Devices and Tissue Constructs
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作者 Wei Long Ng Jia An Chee Kai Chua 《Engineering》 SCIE EI CAS CSCD 2024年第5期146-166,共21页
Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on demand.It is a highly promising techniqu... Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on demand.It is a highly promising technique for the fabrication of personalized medical devices or even patient-specific tissue constructs.Each type of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly dependent on its intended application.In this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mechanical properties)for 3D printing of personalized medical devices.The goal of this review paper is to provide the readers with a good understanding of the various key considerations(process,material,and regulatory)in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs. 展开更多
关键词 3D printing BIOPRINTING BIOFABRICATION Medical devices Tissue constructs
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In-situ AFM and quasi-in-situ studies for localized corrosion in Mg-9Al-1Fe-(Gd) alloys under 3.5 wt.% NaCl environment
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作者 Junping Shen Tao Lai +7 位作者 Zheng Yin Yang Chen Kun Wang Hong Yan Honggun Song Ruiliang Liu Chao Luo Zhi Hu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第3期1170-1185,共16页
Revealing the localized corrosion process of Mg alloy is considered as one of the most significant ways for improving its corrosion resistance.The reliable monitor should be high distinguishability and real-time in li... Revealing the localized corrosion process of Mg alloy is considered as one of the most significant ways for improving its corrosion resistance.The reliable monitor should be high distinguishability and real-time in liquid environment.Herein,Mg-9Al-1Fe and Mg-9Al-1Fe-1Gd alloys were designed to highlight the impact of intermetallic on the corrosion behaviour.In-situ AFM with a special electrolyte circulation system and quasi-in-situ SEM observation were used to monitor the corrosion process of the designed alloys.SEM-EDS and TEM-SAED were applied to identify the intermetallic in the designed alloys,and their volta potentials were measured by SKPFM.According to the real-time and real-space in-situ AFM monitor,the corrosion process consisted of dissolution of anodicα-Mg phase,accumulation of corrosion products around cathodic phase and shedding of some fine cathodic phase.Then,the localized corrosion process of Mg alloy was revealed combined with the results of the monitor of corrosion process and Volta potential difference. 展开更多
关键词 Magnesium Localized corrosion In-situ AFM SKPFM Corrosion behaviour.
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Automatic Miscalibration Detection and Correction of LiDAR and Camera Using Motion Cues
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作者 Pai Peng Dawei Pi +3 位作者 Guodong Yin Yan Wang Liwei Xu Jiwei Feng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第2期318-329,共12页
This paper aims to develop an automatic miscalibration detection and correction framework to maintain accurate calibration of LiDAR and camera for autonomous vehicle after the sensor drift.First,a monitoring algorithm... This paper aims to develop an automatic miscalibration detection and correction framework to maintain accurate calibration of LiDAR and camera for autonomous vehicle after the sensor drift.First,a monitoring algorithm that can continuously detect the miscalibration in each frame is designed,leveraging the rotational motion each individual sensor observes.Then,as sensor drift occurs,the projection constraints between visual feature points and LiDAR 3-D points are used to compute the scaled camera motion,which is further utilized to align the drifted LiDAR scan with the camera image.Finally,the proposed method is sufficiently compared with two representative approaches in the online experiments with varying levels of random drift,then the method is further extended to the offline calibration experiment and is demonstrated by a comparison with two existing benchmark methods. 展开更多
关键词 Autonomous vehicle LiDAR and camera Miscalibration detection and correction Sensor drift
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Exploring an eco-friendly approach to improve soil tensile behavior and cracking resistance
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作者 Lin Li Chao-Sheng Tang +5 位作者 Jin-Jian Xu Yao Wei Zhi-Hao Dong Bo Liu Xi-Ying Zhang Bin Shi 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第10期4272-4284,共13页
Soil tensile strength is a critical parameter governing the initiation and propagation of tensile cracking.This study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey so... Soil tensile strength is a critical parameter governing the initiation and propagation of tensile cracking.This study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey soils.To validate the feasibility and efficacy of the proposed approach,direct tensile tests were employed to determine the tensile strength of the compacted soil with different W-OH treatment concentrations and water contents.Desiccation tests were also performed to evaluate the effectiveness of W-OH treatment in enhancing soil tensile cracking resistance.During this period,the effects of W-OH treatment concentration and water content on tensile properties,soil suction and microstructure were investigated.The tensile tests reveal that W-OH treatment has a significant impact on the tensile strength and failure mode of the soil,which not only effectively enhances the tensile strength and failure displacement,but also changes the brittle failure behavior into a more ductile quasi-brittle failure behavior.The suction measurements and mercury intrusion porosimetry(MIP)tests show that W-OH treatment can slightly reduce soil suction by affecting skeleton structure and increasing macropores.Combined with the microstructural analysis,it becomes evident that the significant improvement in soil tensile behavior through W-OH treatment is mainly attributed to the W-OH gel's ability to provide additional binding force for bridging and encapsulating the soil particles.Moreover,desiccation tests demonstrate that W-OH treatment can significantly reduce or even inhibit the formation of soil tensile cracking.With the increase of W-OH treatment concentration,the surface crack ratio and total crack length are significantly reduced.This study enhances a fundamental understanding of eco-polymer impacts on soil mechanical properties and provides valuable insight into their potential application for improving soil crack resistance. 展开更多
关键词 Clayey soil Tensile strength Eco-friendly approach Direct tensile test Desiccation cracking Crack resistance
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Effect of process parameters on microstructure and mechanical properties of a nickel-aluminum-bronze alloy fabricated by laser powder bed fusion
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作者 HAN Chang-jun ZOU Yu-jin +7 位作者 HU Gao-ling DONG Zhi LI Kai HUANG Jin-miao LI Bo-yuan ZHOU Kun YANG Yong-qiang WANG Di 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2944-2960,共17页
This work investigated the effect of process parameters on densification,microstructure,and mechanical properties of a nickel-aluminum-bronze(NAB)alloy fabricated by laser powder bed fusion(LPBF)additive manufacturing... This work investigated the effect of process parameters on densification,microstructure,and mechanical properties of a nickel-aluminum-bronze(NAB)alloy fabricated by laser powder bed fusion(LPBF)additive manufacturing.The LPBF-printed NAB alloy samples with relative densities of over 98.5%were obtained under the volumetric energy density range of 200−250 J/mm^(3).The microstructure of the NAB alloy printed in both horizontal and vertical planes primarily consisted ofβ'martensitic phase and bandedαphase.In particular,a coarser-columnar grain structure and stronger crystallographic texture were achieved in the vertical plane,where the maximum texture intensity was 30.56 times greater than that of random textures at the(100)plane.Increasing the volumetric energy density resulted in a decrease in the columnar grain size,while increasing the amount ofαphase.Notably,β_(1)'martensitic structures with nanotwins and nanoscaleκ-phase precipitates were identified in the microstructure of LPBF-printed NAB samples with a volumetric energy density of 250 J/mm^(3).Furthermore,under optimal process parameters with a laser power of 350 W and scanning speed of 800 mm/s,significant improvements were observed in the microhardness(HV 386)and ultimate tensile strength(671 MPa),which was attributed to an increase in refined acicular martensite. 展开更多
关键词 copper alloy nickel-aluminum-bronze alloy laser powder bed fusion additive manufacturing
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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration
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作者 Evridiki Asimakidou Eka Norfaishanty Saipuljumri +1 位作者 Chih Hung Lo Jialiu Zeng 《Neural Regeneration Research》 SCIE CAS 2025年第4期1069-1076,共8页
The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 d... The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this relationship.Peripheral lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory regions.Ceramide and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting gliosis.Peripheral insulin resistance further exacerbates brain insulin resistance and neuroinflammation.Preclinical interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal models.However,translating these findings to clinical practice requires further investigation into human subjects.In conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and neurodegeneration.Understanding these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases. 展开更多
关键词 Alzheimer’s disease inflammatory cytokines insulin resistance LIPID
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Nonlinear Absorption and Low-threshold Two-photon Pumped Amplified Stimulated Emission from FAPbBr_(3) Nanocrystals
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作者 WANG Yajuan TAY Yong Kang Eugene +3 位作者 WANG Fang YU Sheng SUM Tze Chien LIU Wei 《发光学报》 EI CAS CSCD 北大核心 2024年第8期1281-1291,共11页
Formamidinium lead bromide(FAPbBr_(3))nanocrystals(NCs)have been considered to be a good optoelectronic material due to their pure green emission,excellent stability and superior carrier transport characteristics.Howe... Formamidinium lead bromide(FAPbBr_(3))nanocrystals(NCs)have been considered to be a good optoelectronic material due to their pure green emission,excellent stability and superior carrier transport characteristics.However,two-photon pumped amplified spontaneous emission(ASE)and the corresponding nonlinear optical properties of FAPbBr_(3) NCs are scarcely revealed.Herein,we synthesized colloidal FAPbBr_(3) NCs with different sizes by changing the molar ratio of FABr/PbBr_(2) in the precursor solution,using ligand assisted precipitation(LARP)technology at room temperature.Photoluminescence(PL)and time resolved photoluminescence(TRPL)spectroscopy were measured to characterize their ASE properties.And their nonlinear optical properties were studied through the Zscan technique and the two-photon excited fluorescence method.The stimulated emission properties including oneand two-photon pumped ASE have been realized from FAPbBr_(3) NCs.With large two-photon absorption coefficient(0.27 cm/GW)and high non-linear absorption cross-section(7.52×10^(5) GM),ASE with threshold as low as 9.8μJ/cm^(2) and 487μJ/cm^(2) have been obtained from colloidal FAPbBr_(3) NCs using one-and two-photon excitations.These results indicate that as a new possible green-emitting frequency-upconversion material with low thresholds,FAPbBr_(3) NCs hold great potential in the development of high-performance two-photon pump lasers. 展开更多
关键词 perovskites formamidinium lead bromide nanocrystals NONLINEAR optical gain amplified spontaneous emission
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