The optical rogue wave(RW),known as a short-lived extraordinarily high amplitude dynamics phenomenon with small appearing probabilities,plays an important role in revealing and understanding the fundamental physics of...The optical rogue wave(RW),known as a short-lived extraordinarily high amplitude dynamics phenomenon with small appearing probabilities,plays an important role in revealing and understanding the fundamental physics of nonlinear wave propagations in optical systems.The random fiber laser(RFL),featured with cavity-free and“modeless”structure,has opened up new avenues for fundamental physics research and potential practical applications combining nonlinear optics and laser physics.Here,the extreme event of optical RW induced by noise-driven modulation instability that interacts with the cascaded stimulated Brillouin scattering,the quasi-phase-matched four-wave mixing as well as the random mode resonance process is observed in a Brillouin random fiber laser comb(BRFLC).Temporal and statistical characteristics of the RWs concerning their emergence and evolution are experimentally explored and analyzed.Specifically,temporally localized structures with high intensities including chair-like pulses with a sharp leading edge followed by a trailing plateau appear frequently in the BRFLC output,which can evolve to chair-like RW pulses with adjustable pulse duration and amplitude under controlled conditions.This investigation provides a deep insight into the extreme event of RWs and paves the way for RW manipulation for its generation and elimination in RFLs through adapted laser configuration.展开更多
The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense against mucosal microbial pathogens and it plays a crucial r...The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense against mucosal microbial pathogens and it plays a crucial role in maintaining mucosal homeostasis. Membranous or microfold cells, commonly referred to as microfold cells, are specialized epithelial cells of the gut-associated lymphoid tissues (GALT) and they play a sentinel role for the intestinal immune system by delivering luminal antigens through the follicle-associated epithelium to the underlying immune cells. M cells sample and uptake antigens at their apical membrane, encase them in vesicles to transport them to the basolateral membrane of M cells, and from there deliver antigens to the nearby lymphocytes. On the flip side, some intestinal pathogens exploit M cells as their portal of entry to invade the host and cause infections. In this article, we briefly review our current knowledge on the morphology, development, and function of M cells, with an emphasis on their dual role in the pathogenesis of gut infection and in the development of host mucosal immunity.展开更多
The human gastrointestinal （GI） tract is colonized by non-pathogenic commensal microflora and frequently exposed to many pathogenic organisms. For the maintenance of GI homeostasis, the host must discriminate betwee...The human gastrointestinal （GI） tract is colonized by non-pathogenic commensal microflora and frequently exposed to many pathogenic organisms. For the maintenance of GI homeostasis, the host must discriminate between pathogenic and non-pathogenic organisms and initiate effective and appropriate immune and inflammatory responses. Mammalian tolllike receptors （TLRs） are members of the patternrecognition receptor （PRR） family that plays a central role in the initiation of innate cellular immune responses and the subsequent adaptive immune responses to microbial pathogens. Recent studies have shown that gastrointestinal epithelial cells express almost all TLR subtypes characterized to date and that the expression and activation of TLRs in the GI tract are tightly and coordinately regulated. This review summarizes the current understanding of the crucial dual roles of TLRs in the development of host innate and adaptive immune responses to GI infections and the maintenance of the immune tolerance to commensal bacteria through downregulation of surface expression of TLRs in intestinal epithelial cells.展开更多
Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it re...Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer＇s disease patients. We performed a 30-month longitudi- nal cohort study to investigate the relationship between Alzheimer＇s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer＇s disease were recruit- ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa- tients＇ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE 4 carriers compared with non-carriers. In addition, the APOE 4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive im- pairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ~4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer＇s disease.展开更多
This study was conducted to compare lipid and fatty acid composition of cod,haddock and halibut.Three groups of cod（276 g±61 g）,haddock（538 g±83 g）and halibut（3704 g±221 g）were maintained with com...This study was conducted to compare lipid and fatty acid composition of cod,haddock and halibut.Three groups of cod（276 g±61 g）,haddock（538 g±83 g）and halibut（3704 g±221 g）were maintained with commercial feeds mainly based on fish meal and marine fish oil for 12 weeks prior to sampling.The fatty acid compositions of muscle and liver were determined by GC/FID after derivatization of extracted lipids into fatty acid methyl esters（FAME）.Lipids were also fractionated into neutral and polar lipids using Waters silica Sep-Pak（R）.The phospholipid fraction was further separated by high-performance thin-layer chromatography（HPTLC）and the FAME profile was obtained.Results of the present study showed that cod and haddock were lean fish and their total muscle lipid contents were 0.8% and 0.7%,respectively,with phospholipid constituting 83.6% and 87.5% of the total muscle lipid,respectively.Halibut was a medium-fat fish and its muscle lipid content was 8%,with 84% of the total muscle lipid being neutral lipid.Total liver lipid contents of cod,haddock and halibut were 36.9%,67.2% and 30.7%,respectively,of which the neutral lipids accounted for the major fraction（88.1%-97.1%）.Polyunsaturated fatty acids were the most abundant in cod and haddock muscle neutral lipid.Monounsaturated fatty acid level was the highest in halibut muscle neutral lipid.Fatty acid compositions of phospholipid were relatively constant.In summary,the liver of cod and haddock as lean fish was the main lipid reserve organ,and structural phospholipid is the major lipid form in flesh.However,as a medium-fat fish,halibut stored lipid in both their liver and muscle.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.62105180)the Natural Science Foundation of Shandong Province (Grant Nos.ZR2020MF110 and ZR2020MF118)+2 种基金the Taishan Scholar Foundation of Shandong Province (Grant No.tsqn202211027)the Qilu Young Scholar Program of Shandong Universitythe National Grant Program for High-level Returning Oversea Talents (2023).
文摘The optical rogue wave(RW),known as a short-lived extraordinarily high amplitude dynamics phenomenon with small appearing probabilities,plays an important role in revealing and understanding the fundamental physics of nonlinear wave propagations in optical systems.The random fiber laser(RFL),featured with cavity-free and“modeless”structure,has opened up new avenues for fundamental physics research and potential practical applications combining nonlinear optics and laser physics.Here,the extreme event of optical RW induced by noise-driven modulation instability that interacts with the cascaded stimulated Brillouin scattering,the quasi-phase-matched four-wave mixing as well as the random mode resonance process is observed in a Brillouin random fiber laser comb(BRFLC).Temporal and statistical characteristics of the RWs concerning their emergence and evolution are experimentally explored and analyzed.Specifically,temporally localized structures with high intensities including chair-like pulses with a sharp leading edge followed by a trailing plateau appear frequently in the BRFLC output,which can evolve to chair-like RW pulses with adjustable pulse duration and amplitude under controlled conditions.This investigation provides a deep insight into the extreme event of RWs and paves the way for RW manipulation for its generation and elimination in RFLs through adapted laser configuration.
基金Supported by the National Institutes of Health,USA,R21AI59064,National Research Council Canada (A-base) and Dow AgroScience
文摘The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense against mucosal microbial pathogens and it plays a crucial role in maintaining mucosal homeostasis. Membranous or microfold cells, commonly referred to as microfold cells, are specialized epithelial cells of the gut-associated lymphoid tissues (GALT) and they play a sentinel role for the intestinal immune system by delivering luminal antigens through the follicle-associated epithelium to the underlying immune cells. M cells sample and uptake antigens at their apical membrane, encase them in vesicles to transport them to the basolateral membrane of M cells, and from there deliver antigens to the nearby lymphocytes. On the flip side, some intestinal pathogens exploit M cells as their portal of entry to invade the host and cause infections. In this article, we briefly review our current knowledge on the morphology, development, and function of M cells, with an emphasis on their dual role in the pathogenesis of gut infection and in the development of host mucosal immunity.
基金Supported by the National Research Council Canada and the National Institutes of Health, United States
文摘The human gastrointestinal （GI） tract is colonized by non-pathogenic commensal microflora and frequently exposed to many pathogenic organisms. For the maintenance of GI homeostasis, the host must discriminate between pathogenic and non-pathogenic organisms and initiate effective and appropriate immune and inflammatory responses. Mammalian tolllike receptors （TLRs） are members of the patternrecognition receptor （PRR） family that plays a central role in the initiation of innate cellular immune responses and the subsequent adaptive immune responses to microbial pathogens. Recent studies have shown that gastrointestinal epithelial cells express almost all TLR subtypes characterized to date and that the expression and activation of TLRs in the GI tract are tightly and coordinately regulated. This review summarizes the current understanding of the crucial dual roles of TLRs in the development of host innate and adaptive immune responses to GI infections and the maintenance of the immune tolerance to commensal bacteria through downregulation of surface expression of TLRs in intestinal epithelial cells.
基金supported by the National Natural Science Foundation of China,No.81370445,81061120527,81241082Major Funding from Beijing Hospital,No.BJ-2010-30+4 种基金Key Project of Clinical Disciplines at the Subordinate Hospital,Ministry of Health,No.10120101National Department Public Benefit Research Foundation by the Ministry of Health,No.20130200812th 5-year National Program from Ministry of Scientific Technology,No.2012BAI10B01Science and Technology Development Foundation of Guangxi Zhuang Autonomous Region,No.1355005-62Canadian Institute of Health Research(CIHR),No.109606
文摘Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer＇s disease patients. We performed a 30-month longitudi- nal cohort study to investigate the relationship between Alzheimer＇s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer＇s disease were recruit- ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa- tients＇ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE 4 carriers compared with non-carriers. In addition, the APOE 4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive im- pairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ~4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer＇s disease.
文摘This study was conducted to compare lipid and fatty acid composition of cod,haddock and halibut.Three groups of cod（276 g±61 g）,haddock（538 g±83 g）and halibut（3704 g±221 g）were maintained with commercial feeds mainly based on fish meal and marine fish oil for 12 weeks prior to sampling.The fatty acid compositions of muscle and liver were determined by GC/FID after derivatization of extracted lipids into fatty acid methyl esters（FAME）.Lipids were also fractionated into neutral and polar lipids using Waters silica Sep-Pak（R）.The phospholipid fraction was further separated by high-performance thin-layer chromatography（HPTLC）and the FAME profile was obtained.Results of the present study showed that cod and haddock were lean fish and their total muscle lipid contents were 0.8% and 0.7%,respectively,with phospholipid constituting 83.6% and 87.5% of the total muscle lipid,respectively.Halibut was a medium-fat fish and its muscle lipid content was 8%,with 84% of the total muscle lipid being neutral lipid.Total liver lipid contents of cod,haddock and halibut were 36.9%,67.2% and 30.7%,respectively,of which the neutral lipids accounted for the major fraction（88.1%-97.1%）.Polyunsaturated fatty acids were the most abundant in cod and haddock muscle neutral lipid.Monounsaturated fatty acid level was the highest in halibut muscle neutral lipid.Fatty acid compositions of phospholipid were relatively constant.In summary,the liver of cod and haddock as lean fish was the main lipid reserve organ,and structural phospholipid is the major lipid form in flesh.However,as a medium-fat fish,halibut stored lipid in both their liver and muscle.
