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Renin-angiotensin system in the central nervous system:focus on Huntington’s disease
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作者 Aline Silva de Miranda Antonio Lucio Teixeira 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第10期2206-2207,共2页
The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal homeostasis.With the discovery of local RAS components in diverse organ... The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal homeostasis.With the discovery of local RAS components in diverse organs,including the brain,and related biologically active peptides. 展开更多
关键词 HUNTINGTON ORGANS ANGIOTENSIN
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Renin angiotensin system in liver diseases: Friend or foe? 被引量:16
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作者 Ana Cristina Simoes e Silva Aline S Miranda +1 位作者 Natália P Rocha Antonio L Teixeira 《World Journal of Gastroenterology》 SCIE CAS 2017年第19期3396-3406,共11页
In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternat... In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. 展开更多
关键词 Renin angiotensin system Angiotensin Angiotensin-(1-7) Hepatic cirrhosis Liver fibrosis Hepatorenal syndrome
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Promises and pitfalls of immune-based strategies for Huntington's disease 被引量:1
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作者 Gabriela Delevati Colpo Erin Furr Stimming +1 位作者 Natalia Pessoa Rocha Antonio Lucio Teixeira 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第9期1422-1425,共4页
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selec- tive loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline ... Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selec- tive loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD. 展开更多
关键词 Huntington's disease treatment disease modifying therapy INFLAMMATION
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