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Anti-inflammatory and Chemical Composition of Two Plants Family Asteraceae Growing in Saudi Arabia
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作者 Eman Elsharkawy Mona Alshathly Mohamed Helal 《Journal of Chemistry and Chemical Engineering》 2014年第2期157-162,共6页
The study was designed to investigate the anti-inflammatory and composition of essential oil of two plant family Asteraceae, Achillea fragrantissima and Lactuca serriola growing under dry desert condition. The anti-in... The study was designed to investigate the anti-inflammatory and composition of essential oil of two plant family Asteraceae, Achillea fragrantissima and Lactuca serriola growing under dry desert condition. The anti-inflammatory effect of volatile oil extracted by hydrodistillation of plants was studied using carrageenan induced paw edema. Essential oil (100 mg/kg) and (200 mg/kg) were tested the two plant show high inhibition after 4 h, concentration (200 mg/kg) show high inhibition than (100 mg/kg) after 4 h. Sesqui sabinene hydrate, Azuline and u-Bisabolol are the main constituents of the volatile oil were investigated by capillary GC (gas chromatography) and GC-MS (gas chromatography-mass spectrometry). The discussion shows the role of chemical compound azulene in inflammatory inhibition. 展开更多
关键词 Achillea fragrantissima Lactuca serriola ANTI-INFLAMMATORY azulene.
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Inhibition of Ehrlich Ascites Carcinoma by Lactuca serriola in Swiss Albino Mice
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作者 Mona Alshathly Eman Elsharkawy 《Journal of Chemistry and Chemical Engineering》 2014年第1期66-71,共6页
To evaluate the antitumor activity of Lactuca serriola against EAC (Ehrlich ascites carcinoma) in Swiss albino mice. The in vivo antitumor activity of the methanol extract of plant Lactuca serriola was evaluated at ... To evaluate the antitumor activity of Lactuca serriola against EAC (Ehrlich ascites carcinoma) in Swiss albino mice. The in vivo antitumor activity of the methanol extract of plant Lactuca serriola was evaluated at (100 mg/kg and 200 mg/kg of hole plant and 200 mg/kg, 400 mg/kg of fruit bw) against EAC using mean survival time. After administration of the extracts of Lactuca serriola, viable EAC cell count and body weight in the EAC tumor hosts were observed. The animal was also observed for improvement in the hematological parameters (e.g., hemoglobin content, red and white blood cells count and differential cell count) after treatment of plant extract. Intraperitoneal administration of plant extracts reduced viable EAC cells, increased the survival time and restored altered hematological parameters. Significant efficacy was observed for fruit extract at high concentration 400 mg/kg dose (P 〈 0.05). It can be concluded that the methyl extract ofLactuca serriola possesses significant antitumor activity. 展开更多
关键词 Antitumor activity Lactuca serriola EAC hematological parameter.
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