The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki...The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki67 heterogeneity and distribution patterns in breast carcinoma. Using Smart Pathology software, we digitized and analyzed 42 excised breast carcinoma Ki67 slides. Boxplots, histograms, and heat maps were generated to illustrate the KI distribution. We found that 30% of cases (13/42) exhibited discrepancies between global and hotspot KI when using a 14% KI threshold for classification. Patients with higher global or hotspot KI values displayed greater heterogenicity. Ki67 distribution patterns were categorized as randomly distributed (52%, 22/42), peripheral (43%, 18/42), and centered (5%, 2/42). Our sampling simulator indicated analyzing more than 10 high-power fields was typically required to accurately estimate global KI, with sampling size being correlated with heterogeneity. In conclusion, using digital image analysis in whole-slide images allows for comprehensive Ki67 profile assessment, shedding light on heterogeneity and distribution patterns. This spatial information can facilitate KI surveys of breast cancer and other malignancies.展开更多
Officially, the environmental protection from industrial insults began with Rachel Carson＇s book ＂The Silent Spring＂ in 1963. Protection priorities have since changed. They can be grouped into three successive phases.
Images are generally corrupted by impulse noise during acquisition and transmission.Noise deteriorates the quality of images.To remove corruption noise,we propose a hybrid approach to restoring a random noisecorrupted...Images are generally corrupted by impulse noise during acquisition and transmission.Noise deteriorates the quality of images.To remove corruption noise,we propose a hybrid approach to restoring a random noisecorrupted image,including a block matching 3D(BM3D)method,an adaptive non-local mean(ANLM)scheme,and the K-singular value decomposition(K-SVD)algorithm.In the proposed method,we employ the morphological component analysis(MCA)to decompose an image into the texture,structure,and edge parts.Then,the BM3D method,ANLM scheme,and K-SVD algorithm are utilized to eliminate noise in the texture,structure,and edge parts of the image,respectively.Experimental results show that the proposed approach can effectively remove interference random noise in different parts;meanwhile,the deteriorated image is able to be reconstructed well.展开更多
The challenges and the path towards a(more)electronic transmission and distribution(eT&D)is presented in this paper.The challenges are first identified together with key stakeholders in the drive for grid moderniz...The challenges and the path towards a(more)electronic transmission and distribution(eT&D)is presented in this paper.The challenges are first identified together with key stakeholders in the drive for grid modernization.A fundamental question is then asked about the investment priority.Six basic characteristics are reviewed,leading to the composition of structured microgrids as the basic functional cell of a modern grid.One example of fractal radial structure and one fractal meshed structure are presented.The likely evolution path is then proposed together with basic technology sets.Specific foundation technologies are discussed in detail,including adiabatic power conversion,3MC technology,medium voltage conversion,distribution-level electronic power transformer and FACTs hardware integration,and back-to-back converters as a universal interconnect element.The rapidly emerging on-wire sensing technology is also discussed.It is pointed out that the distribution-level large electronic power transformer will provide a key component to enable hybrid ac/dc grid flow control and ancillary support for a flexible electronic transmission and distribution(eT&D)systems.展开更多
Recently,we demonstrated the success of a time-synchronized state estimator using deep neural networks(DNNs)for real-time unobservable distribution systems.In this paper,we provide analytical bounds on the performance...Recently,we demonstrated the success of a time-synchronized state estimator using deep neural networks(DNNs)for real-time unobservable distribution systems.In this paper,we provide analytical bounds on the performance of the state estimator as a function of perturbations in the input measurements.It has already been shown that evaluating performance based only on the test dataset might not effectively indicate the ability of a trained DNN to handle input perturbations.As such,we analytically verify the robustness and trustworthiness of DNNs to input perturbations by treating them as mixed-integer linear programming(MILP)problems.The ability of batch normalization in addressing the scalability limitations of the MILP formulation is also highlighted.The framework is validated by performing time-synchronized distribution system state estimation for a modified IEEE 34-node system and a real-world large distribution system,both of which are incompletely observed by micro-phasor measurement units.展开更多
Lasers with high average and high peak power as well as ultrashort pulse width have been all along demanded by nonlinear optics studies,strong-field experiments,electron dynamics investigations,and ultrafast spectrosc...Lasers with high average and high peak power as well as ultrashort pulse width have been all along demanded by nonlinear optics studies,strong-field experiments,electron dynamics investigations,and ultrafast spectroscopy.While the routinely used titanium-doped sapphire(Ti:sapphire)laser faces a bottleneck in the average power upscaling,ytterbium(Yb)-doped lasers have remarkable advantages in achieving high average power.However,there is still a substantial gap of pulse width and peak power between the Ti:sapphire and Yb-doped lasers.Here we demonstrate a high-power Yb:CaAlGdO4(Yb:CALGO)regenerative amplifier system,delivering 1040 nm pulses with11 W average power,50 fs pulse width,and 3.7 GW peak power at a repetition rate of 43 k Hz,which to some extent bridges the gap between the Ti:sapphire and Yb lasers.An ultrabroadband Yb-doped fiber oscillator,specially designed spectral shapers,and Yb:CALGO gain medium with broad emission bandwidth,together with a double-end pumping scheme enable an amplified bandwidth of 19 nm and 95 fs output pulse width.To the best of our knowledge,this is the first demonstration of sub-100 fs regenerative amplifier based on Yb-doped bulk medium without nonlinear spectral broadening.The amplified pulse is further compressed to 50 fs via cascaded-quadratic compression with a simple setup,producing 3.7 GW peak power,which boosts the record of peak power from Yb:CALGO regenerative amplifiers by 1 order.As a proof of concept,pumped by the high-power,50 fs pulses,7.5–11.5μm midinfrared(MIR)generation via intrapulse difference-frequency generation is performed,without the necessity of nonlinear fiber compressors.It leads to a simple and robust apparatus,and it would find good usefulness in MIR spectroscopic applications.展开更多
Aspects of terrestrial microgrids and ship power systems are examined.The work exposes a variety of technical synergies from these two power systems to effectively advance their technologies.Understanding their overla...Aspects of terrestrial microgrids and ship power systems are examined.The work exposes a variety of technical synergies from these two power systems to effectively advance their technologies.Understanding their overlap allows congruent efforts to target both systems;understanding their differences hinders conflict and redundancy in early-stage design.The paper concludes by highlighting how an understanding of both systems can reduce the investment in research resources.展开更多
This work addresses the nonlinear dynamic behavior of different electrostaticmicro-tweezers,amicro electric actuator.This actuator,a cantilever beamelectrostatic micro-tweezers,has been extensively used in micro-elect...This work addresses the nonlinear dynamic behavior of different electrostaticmicro-tweezers,amicro electric actuator.This actuator,a cantilever beamelectrostatic micro-tweezers,has been extensively used in micro-electro-mechanical systems(MEMS).The importance of micro electric actuators manufactured is higher than the other part of MEMS since it is the power source of the entire micro-electro-mechanical systems.In actual operation,the instability and bad dynamic characteristics of the electric actuators will cause larger displacement mobility error,such as transport behavior and response procedures failure,etc.,and even damage the micro-electro-mechanical systems.To improve the actuator dynamic displacement accuracy,the dynamic behavior in the electric actuator system must be studied,especially for nonlinear dynamic behavior of system.In this work,the differential quadrature method(DQM)was employed to solve the problem of nonlinearity in the equation of motion.The results reveal that the proposed DQM model can be used to simulate the nonlinear behavior of the micro-tweezers efficiently Micro-tweezers of various shapes were studied to examine the feasibility of applying the DQMin analyzing their nonlinear responses.The simulated results agree very closely with the calculated and experimental data in the literature.展开更多
The multiple quantum process, in which n quanta of energy ω0/n are absorbed or emitted between a pair of adjacent levels spaced out by ω0, is called subharmonie resonance （SHR）. There is no real intermediate level...The multiple quantum process, in which n quanta of energy ω0/n are absorbed or emitted between a pair of adjacent levels spaced out by ω0, is called subharmonie resonance （SHR）. There is no real intermediate level between the level pair. The transition between the two levels is generally allowed and it is directly observable under the pulsed excitation. The excitation will be very inefficient since the irradiation frequency is far away from, the resonance, so to deal with it, a higher order perturbation is needed.展开更多
文摘The Ki67 index (KI) is a standard clinical marker for tumor proliferation;however, its application is hindered by intratumoral heterogeneity. In this study, we used digital image analysis to comprehensively analyze Ki67 heterogeneity and distribution patterns in breast carcinoma. Using Smart Pathology software, we digitized and analyzed 42 excised breast carcinoma Ki67 slides. Boxplots, histograms, and heat maps were generated to illustrate the KI distribution. We found that 30% of cases (13/42) exhibited discrepancies between global and hotspot KI when using a 14% KI threshold for classification. Patients with higher global or hotspot KI values displayed greater heterogenicity. Ki67 distribution patterns were categorized as randomly distributed (52%, 22/42), peripheral (43%, 18/42), and centered (5%, 2/42). Our sampling simulator indicated analyzing more than 10 high-power fields was typically required to accurately estimate global KI, with sampling size being correlated with heterogeneity. In conclusion, using digital image analysis in whole-slide images allows for comprehensive Ki67 profile assessment, shedding light on heterogeneity and distribution patterns. This spatial information can facilitate KI surveys of breast cancer and other malignancies.
文摘Officially, the environmental protection from industrial insults began with Rachel Carson＇s book ＂The Silent Spring＂ in 1963. Protection priorities have since changed. They can be grouped into three successive phases.
基金supported by MOST under Grant No.104-2221-E-468-007
文摘Images are generally corrupted by impulse noise during acquisition and transmission.Noise deteriorates the quality of images.To remove corruption noise,we propose a hybrid approach to restoring a random noisecorrupted image,including a block matching 3D(BM3D)method,an adaptive non-local mean(ANLM)scheme,and the K-singular value decomposition(K-SVD)algorithm.In the proposed method,we employ the morphological component analysis(MCA)to decompose an image into the texture,structure,and edge parts.Then,the BM3D method,ANLM scheme,and K-SVD algorithm are utilized to eliminate noise in the texture,structure,and edge parts of the image,respectively.Experimental results show that the proposed approach can effectively remove interference random noise in different parts;meanwhile,the deteriorated image is able to be reconstructed well.
文摘The challenges and the path towards a(more)electronic transmission and distribution(eT&D)is presented in this paper.The challenges are first identified together with key stakeholders in the drive for grid modernization.A fundamental question is then asked about the investment priority.Six basic characteristics are reviewed,leading to the composition of structured microgrids as the basic functional cell of a modern grid.One example of fractal radial structure and one fractal meshed structure are presented.The likely evolution path is then proposed together with basic technology sets.Specific foundation technologies are discussed in detail,including adiabatic power conversion,3MC technology,medium voltage conversion,distribution-level electronic power transformer and FACTs hardware integration,and back-to-back converters as a universal interconnect element.The rapidly emerging on-wire sensing technology is also discussed.It is pointed out that the distribution-level large electronic power transformer will provide a key component to enable hybrid ac/dc grid flow control and ancillary support for a flexible electronic transmission and distribution(eT&D)systems.
基金supported in part by the Department of Energy(No.DE-AR-0001001,No.DE-EE0009355)the National Science Foundation(NSF)(No.ECCS-2145063)。
文摘Recently,we demonstrated the success of a time-synchronized state estimator using deep neural networks(DNNs)for real-time unobservable distribution systems.In this paper,we provide analytical bounds on the performance of the state estimator as a function of perturbations in the input measurements.It has already been shown that evaluating performance based only on the test dataset might not effectively indicate the ability of a trained DNN to handle input perturbations.As such,we analytically verify the robustness and trustworthiness of DNNs to input perturbations by treating them as mixed-integer linear programming(MILP)problems.The ability of batch normalization in addressing the scalability limitations of the MILP formulation is also highlighted.The framework is validated by performing time-synchronized distribution system state estimation for a modified IEEE 34-node system and a real-world large distribution system,both of which are incompletely observed by micro-phasor measurement units.
基金National Natural Science Foundation of China(62075144)Engineering Featured Team Fund of Sichuan University(2020SCUNG105)。
文摘Lasers with high average and high peak power as well as ultrashort pulse width have been all along demanded by nonlinear optics studies,strong-field experiments,electron dynamics investigations,and ultrafast spectroscopy.While the routinely used titanium-doped sapphire(Ti:sapphire)laser faces a bottleneck in the average power upscaling,ytterbium(Yb)-doped lasers have remarkable advantages in achieving high average power.However,there is still a substantial gap of pulse width and peak power between the Ti:sapphire and Yb-doped lasers.Here we demonstrate a high-power Yb:CaAlGdO4(Yb:CALGO)regenerative amplifier system,delivering 1040 nm pulses with11 W average power,50 fs pulse width,and 3.7 GW peak power at a repetition rate of 43 k Hz,which to some extent bridges the gap between the Ti:sapphire and Yb lasers.An ultrabroadband Yb-doped fiber oscillator,specially designed spectral shapers,and Yb:CALGO gain medium with broad emission bandwidth,together with a double-end pumping scheme enable an amplified bandwidth of 19 nm and 95 fs output pulse width.To the best of our knowledge,this is the first demonstration of sub-100 fs regenerative amplifier based on Yb-doped bulk medium without nonlinear spectral broadening.The amplified pulse is further compressed to 50 fs via cascaded-quadratic compression with a simple setup,producing 3.7 GW peak power,which boosts the record of peak power from Yb:CALGO regenerative amplifiers by 1 order.As a proof of concept,pumped by the high-power,50 fs pulses,7.5–11.5μm midinfrared(MIR)generation via intrapulse difference-frequency generation is performed,without the necessity of nonlinear fiber compressors.It leads to a simple and robust apparatus,and it would find good usefulness in MIR spectroscopic applications.
基金supported by a Grant from the Office of Naval Research(ONR)
文摘Aspects of terrestrial microgrids and ship power systems are examined.The work exposes a variety of technical synergies from these two power systems to effectively advance their technologies.Understanding their overlap allows congruent efforts to target both systems;understanding their differences hinders conflict and redundancy in early-stage design.The paper concludes by highlighting how an understanding of both systems can reduce the investment in research resources.
基金The financial support by the Ministry of Science and Technology,TAIWAN,through Grant MOST 105-2221-E-230-004 of the Cheng Shiu University is gratefully acknowledged.
文摘This work addresses the nonlinear dynamic behavior of different electrostaticmicro-tweezers,amicro electric actuator.This actuator,a cantilever beamelectrostatic micro-tweezers,has been extensively used in micro-electro-mechanical systems(MEMS).The importance of micro electric actuators manufactured is higher than the other part of MEMS since it is the power source of the entire micro-electro-mechanical systems.In actual operation,the instability and bad dynamic characteristics of the electric actuators will cause larger displacement mobility error,such as transport behavior and response procedures failure,etc.,and even damage the micro-electro-mechanical systems.To improve the actuator dynamic displacement accuracy,the dynamic behavior in the electric actuator system must be studied,especially for nonlinear dynamic behavior of system.In this work,the differential quadrature method(DQM)was employed to solve the problem of nonlinearity in the equation of motion.The results reveal that the proposed DQM model can be used to simulate the nonlinear behavior of the micro-tweezers efficiently Micro-tweezers of various shapes were studied to examine the feasibility of applying the DQMin analyzing their nonlinear responses.The simulated results agree very closely with the calculated and experimental data in the literature.
文摘The multiple quantum process, in which n quanta of energy ω0/n are absorbed or emitted between a pair of adjacent levels spaced out by ω0, is called subharmonie resonance （SHR）. There is no real intermediate level between the level pair. The transition between the two levels is generally allowed and it is directly observable under the pulsed excitation. The excitation will be very inefficient since the irradiation frequency is far away from, the resonance, so to deal with it, a higher order perturbation is needed.
