The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provide...The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provides an overview of exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic effect is that the phospholipid-binding protein ANXA1 improves its anti-inflammatory properties. The review also analyzes the intricate processes of exosome production and composition ability to transport biomolecules such as proteins, microRNAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of targeted drug administration due to their innate specificity. Through genetic engineering and chemical modifications, exosomes can be tailored for specific purposes, demonstrating their versatility in targeted therapy. With ongoing research uncovering their therapeutic potential, exosomes present a promising frontier in novel medical treatments across various health conditions.展开更多
Objective:To investigate the protective effects of Mucuna(M.)pruriens against arsenic-induced testicular impairment in albino mice.Methods:Thirty-six male albino mice were divided into six groups,with 6 mice in each g...Objective:To investigate the protective effects of Mucuna(M.)pruriens against arsenic-induced testicular impairment in albino mice.Methods:Thirty-six male albino mice were divided into six groups,with 6 mice in each group.Group 1 received drinking water as the normal control.Groups 2 to 6 received sodium arsenite(40 mg/L)in drinking water.Group 3 received sodium arsenite(40 mg/L)and 300 mg/kg body weight(b.w.)of N-acetylcysteine.Group 4 received sodium arsenite(40 mg/L)and 500 mg/kg b.w.of M.pruriens.Group 5 received sodium arsenite(40 mg/L)and 1000 mg/kg b.w.of M.pruriens.Group 6 received sodium arsenite(40 mg/L)and 2000 mg/kg b.w.of M.pruriens.N-acetylcysteine and M.pruriens were administered orally once a day.Animals were subjected to the above treatments for 45 days.Animals were sacrificed with overdose of ketamine 24 h following drug administration.The testis was used for biochemical estimations(lipid peroxidation and glutathione),and the epididymis was used to determine the sperm count and morphology.Results:Sodium arsenite significantly decreased(P<0.01)the sperm count and glutathione levels of the testis.It significantly increased(P<0.01)the abnormal architecture of the spermatozoa and lipid peroxidation levels.Treatment with M.pruriens significantly increased the sperm count and the glutathione levels[500 mg/kg b.w.and 1000 mg/kg b.w.(P<0.01)].A significant decrease in sperm abnormality and lipid peroxidation levels[500 mg/kg b.w.and 1000 mg/kg b.w.(P<0.01)]was also observed.Conclusions:The perturbed sperm parameters and antioxidant levels of the arsenic insulted testis are attenuated by 500 mg/kg b.w.and 1000 mg/kg b.w.M.pruriens.展开更多
文摘The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provides an overview of exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic effect is that the phospholipid-binding protein ANXA1 improves its anti-inflammatory properties. The review also analyzes the intricate processes of exosome production and composition ability to transport biomolecules such as proteins, microRNAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of targeted drug administration due to their innate specificity. Through genetic engineering and chemical modifications, exosomes can be tailored for specific purposes, demonstrating their versatility in targeted therapy. With ongoing research uncovering their therapeutic potential, exosomes present a promising frontier in novel medical treatments across various health conditions.
文摘Objective:To investigate the protective effects of Mucuna(M.)pruriens against arsenic-induced testicular impairment in albino mice.Methods:Thirty-six male albino mice were divided into six groups,with 6 mice in each group.Group 1 received drinking water as the normal control.Groups 2 to 6 received sodium arsenite(40 mg/L)in drinking water.Group 3 received sodium arsenite(40 mg/L)and 300 mg/kg body weight(b.w.)of N-acetylcysteine.Group 4 received sodium arsenite(40 mg/L)and 500 mg/kg b.w.of M.pruriens.Group 5 received sodium arsenite(40 mg/L)and 1000 mg/kg b.w.of M.pruriens.Group 6 received sodium arsenite(40 mg/L)and 2000 mg/kg b.w.of M.pruriens.N-acetylcysteine and M.pruriens were administered orally once a day.Animals were subjected to the above treatments for 45 days.Animals were sacrificed with overdose of ketamine 24 h following drug administration.The testis was used for biochemical estimations(lipid peroxidation and glutathione),and the epididymis was used to determine the sperm count and morphology.Results:Sodium arsenite significantly decreased(P<0.01)the sperm count and glutathione levels of the testis.It significantly increased(P<0.01)the abnormal architecture of the spermatozoa and lipid peroxidation levels.Treatment with M.pruriens significantly increased the sperm count and the glutathione levels[500 mg/kg b.w.and 1000 mg/kg b.w.(P<0.01)].A significant decrease in sperm abnormality and lipid peroxidation levels[500 mg/kg b.w.and 1000 mg/kg b.w.(P<0.01)]was also observed.Conclusions:The perturbed sperm parameters and antioxidant levels of the arsenic insulted testis are attenuated by 500 mg/kg b.w.and 1000 mg/kg b.w.M.pruriens.
