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Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: An Italian position statement 被引量:5
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作者 Gianni Testino Patrizia Burra +21 位作者 Ferruccio Bonino Francesco Piani Alessandro Sumberaz Roberto Peressutti Andrea Giannelli Castiglione Valentino Patussi Tiziana Fanucchi Ornella Ancarani Giovanna De Cerce Anna Teresa Iannini Giovanni Greco Antonio Mosti Marilena Durante Paola Babocci Mariano Quartini Davide Mioni Sarino Aricò Aniello Baselice Silvia Leone Fabiola Lozer Emanuele Scafato Paolo Borro 《World Journal of Gastroenterology》 SCIE CAS 2014年第40期14642-14651,共10页
Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all deaths from cirrhosis are attrib... Alcoholic liver disease encompasses a broad spectrum of diseases ranging from steatosis steatohepatitis, fibrosis, and cirrhosis to hepatocellular carcinoma. Forty-four per cent of all deaths from cirrhosis are attributed to alcohol. Alcoholic liver disease is the second most common diagnosis among patients undergoing liver transplantation (LT). The vast majority of transplant programmes (85%) require 6 mo of abstinence prior to transplantation; commonly referred to as the &#x0201c;6-mo rule&#x0201d;. Both in the case of progressive end-stage liver disease (ESLD) and in the case of severe acute alcoholic hepatitis (AAH), not responding to medical therapy, there is a lack of evidence to support a 6-mo sobriety period. It is necessary to identify other risk factors that could be associated with the resumption of alcohol drinking. The &#x0201c;Group of Italian Regions&#x0201d; suggests that: in a case of ESLD with model for end-stage liver disease &#x0003c; 19 a 6-mo abstinence period is required; in a case of ESLD, a 3-mo sober period before LT may be more ideal than a 6-mo period, in selected patients; and in a case of severe AAH, not responding to medical therapies (up to 70% of patients die within 6 mo), LT is mandatory, even without achieving abstinence. The multidisciplinary transplant team must include an addiction specialist/hepato-alcohologist. Patients have to participate in self-help groups. 展开更多
关键词 ALCOHOL Alcoholic hepatitis CIRRHOSIS Hepatocellular carcinoma Liver transplantation
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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain
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作者 Antonio Ríos Ana Isabel López-Navas +21 位作者 Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla 《World Journal of Gastroenterology》 SCIE CAS 2016年第25期5800-5813,共14页
AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this attitude.METHODS: Study type: A sociological, interdisciplinary, mul... AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this attitude.METHODS: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student&#x000b4;s t test, &#x003c7;<sup>2</sup> test and logistic regression analysis.RESULTS: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P &#x0003c; 0.001); (3) academic year (P &#x0003c; 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P &#x0003c; 0.001); (6) attitude toward deceased donation (P &#x0003c; 0.001); (7) attitude toward living kidney donation (P &#x0003c; 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P &#x0003c; 0.001); (9) having discussed the subject with one’s family (P &#x0003c; 0.001) and friends (P &#x0003c; 0.001); (10) a partner’s opinion about the subject (P &#x0003c; 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P &#x0003c; 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD. 展开更多
关键词 Attitude Living liver donation Medical students TRANSPLANTATION Organ donation Psychosocial variables Spain
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