Research on Operation Optimization of Heating System Based on Electric Storage Coupled Solar Energy and Air Source Heat Pump

For heating systems based on electricity storage coupled with solar energy and an air source heat pump(ECSA),choosing the appropriate combination of heat sources according to local conditions is the key to improving economic efficiency.In this paper,four cities in three climatic regions in China were selected,namely Nanjing in the hot summer and cold winter region,Tianjin in the cold region,Shenyang and Harbin in the severe cold winter region.The levelized cost of heat(LCOH)was used as the economic evaluation index,and the energy consumption and emissions of different pollutants were analyzed.TRNSYS software was used to simulate and analyze the system performance.The Hooke-Jeeves optimization algorithm and GenOpt software were used to optimize the system parameters.The results showed that ECSA systemhad an excellent operation effect in cold region and hot summer and cold winter region.Compared with ECS system,the systemenergy consumption,and the emission of different pollutants of ECSA system can be reduced by a maximum of 1.37 times.In cold region,the initial investment in an air source heat pump is higher due to the lower ambient temperature,resulting in an increase in the LOCH value of ECSA system.After the LOCH value of ECSA system in each region was optimized,the heating cost of the system was reduced,but also resulted in an increase in energy consumption and the emission of different pollutant gases.

Research progress on the source,function and application of AMPs

Antibacterial peptide,also known as a host defense peptide,is a small molecular peptide that exhibits antibacterial activity.It disrupts the cell membrane structure of bacteria,leading to the release of internal contents and subsequent cell death,all without promoting the development of drug resistance in bacteria.It serves as a crucial component of the body’s innate immunity,forming the initial defense against the invasion of pathogenic microorganisms.However,the functionality of this small molecule peptide extends beyond this role.It also demonstrates positive effects in promoting organism growth,maintaining the balance of beneficial bacteria within organisms,combating cancer,enhancing immune function,and combating viruses,among other benefits.Additionally,it finds applications in biomaterials,food preservation,animal husbandry,and aquaculture.In summary,this small molecular peptide plays a significant role in various domains.

The nutritional value of Spirulina and utilization research

With the development of modern society,the demand for nutrition,health,and food safety among people is also increasing.More and more consumers are connecting their diet to a healthy lifestyle in order to reduce the occurrence of chronic diseases.Spirulina,known as green ginseng,is one of the most productive microalgae with high output value.It is considered as one of the most ideal dietary supplements due to its unique nutritional and health benefits.The main components of spirulina include protein,fat,vitamins,chlorophyll,and minerals.The protein content is particularly high,ranging from 60-70%.Spirulina can be used as a natural nutritional supplement,providing various essential nutrients needed by the body.Apart from being a nutritional supplement,spirulina is also widely utilized in the food,medicine,and cosmetics industries.Spirulina powder can be added to various foods such as bread,cakes,and biscuits to enhance their nutritional value.Spirulina extract can also be used in the production of healthcare and beauty products.Furthermore,the antioxidant and immune-boosting effects of spirulina make it a promising natural medicine for research in the treatment of cancer and liver disease.This paper aims to provide comprehensive information on the nutritional composition,secondary metabolites,and biological activities of spirulina,thereby contributing to the spirulina industry.

Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

Diagnostic value associated with the combination of saliva pepsin and microorganisms in functional heartburn and gastroesophageal reflux disease

Heartburn is a common symptom shared by both gastroesophageal reflux disease(GERD)and functional heartburn(FHB),which can make it challenging to differentiate between the two conditions.However,examining oral manifestations of GERD can be a cost-effective and readily available method to aid in this differentiation process.It may serve as a valuable tool in distinguishing GERD from FHB.

Refinement modeling and verification of secure operating systems for communication in digital twins

In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the digital twin communication system implementation is completely correct.Formal verification is currently recognized as a method to ensure the correctness of software system for communication in digital twins because it uses rigorous mathematical methods to verify the correctness of systems for communication in digital twins and can effectively help system designers determine whether the system is designed and implemented correctly.In this paper,we use the interactive theorem proving tool Isabelle/HOL to construct the formal model of the X86 architecture,and to model the related assembly instructions.The verification result shows that the system states obtained after the operations of relevant assembly instructions is consistent with the expected states,indicating that the system meets the design expectations.

Movement analysis in the diagnosis and management of Parkinson’s disease

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall phenotype.Clinically,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses inexorably.New biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

An Insight Survey on Sensor Errors and Fault Detection Techniques in Smart Spaces

The widespread adoption of the Internet of Things (IoT) has transformed various sectors globally, making themmore intelligent and connected. However, this advancement comes with challenges related to the effectiveness ofIoT devices. These devices, present in offices, homes, industries, and more, need constant monitoring to ensuretheir proper functionality. The success of smart systems relies on their seamless operation and ability to handlefaults. Sensors, crucial components of these systems, gather data and contribute to their functionality. Therefore,sensor faults can compromise the system’s reliability and undermine the trustworthiness of smart environments.To address these concerns, various techniques and algorithms can be employed to enhance the performance ofIoT devices through effective fault detection. This paper conducted a thorough review of the existing literature andconducted a detailed analysis.This analysis effectively links sensor errors with a prominent fault detection techniquecapable of addressing them. This study is innovative because it paves theway for future researchers to explore errorsthat have not yet been tackled by existing fault detection methods. Significant, the paper, also highlights essentialfactors for selecting and adopting fault detection techniques, as well as the characteristics of datasets and theircorresponding recommended techniques. Additionally, the paper presents amethodical overview of fault detectiontechniques employed in smart devices, including themetrics used for evaluation. Furthermore, the paper examinesthe body of academic work related to sensor faults and fault detection techniques within the domain. This reflectsthe growing inclination and scholarly attention of researchers and academicians toward strategies for fault detectionwithin the realm of the Internet of Things.

When cryptography stops data science: strategies for resolving the conflicts between data scientists and cryptographers

The advent of the digital era and computer-based remote communications has significantly enhanced the applicability of various sciences over the past two decades,notably data science(DS)and cryptography(CG).Data science involves clustering and categorizing unstructured data,while cryptography ensures security and privacy aspects.Despite certain CG laws and requirements mandating fully randomized or pseudonoise outputs from CG primitives and schemes,it appears that CG policies might impede data scientists from working on ciphers or analyzing information systems supporting security and privacy services.However,this study posits that CG does not entirely preclude data scientists from operating in the presence of ciphers,as there are several examples of successful collaborations,including homomorphic encryption schemes,searchable encryption algorithms,secret-sharing protocols,and protocols offering conditional privacy.These instances,along with others,indicate numerous potential solutions for fostering collaboration between DS and CG.Therefore,this study classifies the challenges faced by DS and CG into three distinct groups:challenging problems(which can be conditionally solved and are currently available to use;e.g.,using secret sharing protocols,zero-knowledge proofs,partial homomorphic encryption algorithms,etc.),open problems(where proofs to solve exist but remain unsolved and is now considered as open problems;e.g.,proposing efficient functional encryption algorithm,fully homomorphic encryption scheme,etc.),and hard problems(infeasible to solve with current knowledge and tools).Ultimately,the paper will address specific solutions and outline future directions to tackle the challenges arising at the intersection of DS and CG,such as providing specific access for DS experts in secret-sharing algorithms,assigning data index dimensions to DS experts in ultra-dimension encryption algorithms,defining some functional keys in functional encryption schemes for DS experts,and giving limited shares of data to them for analytics.

Viral vectors as a novel tool for clinical and neuropsychiatric research applications

Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely accepted.Aim This article will focus on the application of viral vectors in basic and clinical neuropsychiatric research.Methods By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of patients.Perspective Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.

Genome-wide analysis of cytochrome P450 genes in Citrus clementina and characterization of a CYP gene encoding f lavonoid 3′-hydroxylase

Cytochrome P450s(CYPs)are the largest family of enzymes in plant and play multifarious roles in development and defense but the available information about the CYP superfamily in citrus is very limited.Here we provide a comprehensive genome-wide analysis of the CYP superfamily in Citrus clementina genome,identifying 301 CYP genes grouped into ten clans and 49 families.The characteristics of both gene structures and motif compositions strongly supported the reliability of the phylogenetic relationship.Duplication analysis indicated that tandem duplication was the major driving force of expansion for this superfamily.Promoter analysis revealed numerous cis-acting elements related to various responsiveness.RNA-seq data elucidated their expression patterns in citrus fruit peel both during development and in response to UV-B.Furthermore,we characterize a UV-B-induced CYP gene(Ciclev10019637m,designated CitF3′H)as a f lavonoid 3-hydroxylase for the first time.CitF3 H catalyzed numerous f lavonoids and favored naringenin in yeast assays.Virusinduced silencing of CitF3′ H in citrus seedlings significantly reduced the levels of 3′-hydroxylated f lavonoids and their derivatives.These results together with the endoplasmic reticulum-localization of CitF3 H in plant suggest that this enzyme is responsible for the biosynthesis of 3-hydroxylated f lavonoids in citrus.Taken together,our findings provide extensive information about the CYP superfamily in citrus and contribute to further functional verification.

Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases

Since dental pulp stem cells(DPSCs)were first reported,six types of dental SCs(DSCs)have been isolated and identified.DSCs originating from the craniofacial neural crest exhibit dental-like tissue differentiation potential and neuroectodermal features.As a member of DSCs,dental follicle SCs(DFSCs)are the only cell type obtained at the early developing stage of the tooth prior to eruption.Dental follicle tissue has the distinct advantage of large tissue volume compared with other dental tissues,which is a prerequisite for obtaining a sufficient number of cells to meet the needs of clinical applications.Furthermore,DFSCs exhibit a significantly higher cell proliferation rate,higher colony-formation capacity,and more primitive and better anti-inflammatory effects than other DSCs.In this respect,DFSCs have the potential to be of great clinical significance and translational value in oral and neurological diseases,with natural advantages based on their origin.Lastly,cryopreservation preserves the biological properties of DFSCs and enables them to be used as off-shelf products for clinical applications.This review summarizes and comments on the properties,application potential,and clinical transformation value of DFSCs,thereby inspiring novel perspectives in the future treatment of oral and neurological diseases.

Evaporative Cooling Applied in Thermal Power Plants:A Review of the State-ofthe-Art and Typical Case Studies

A review is conducted about the application of the evaporative cooling technology in thermal power plants.Different case studies are considered,namely,evaporative air conditioners,evaporative cooling in direct air-cooled systems,gas turbine inlet cooling,wet cooling towers,and hybrid cooling towers with a crosswind effect.Some effort is provided to describe the advantages related to direct evaporative cooling when it is applied in thermal power plants and illustrate the research gaps,which have not been filled yet.In particular,typical case studies are intentionally used to compare the cooling performances when direct evaporative cooling is implemented in different types of cooling towers,including the natural draft wet cooling tower(NDWCT)and the pre-cooled natural draft dry cooling tower(NDDCT).It is shown that the NDWCT provides the best cooling performance in terms of power station cooling,followed by the pre-cooled NDDCT,and the NDDCT;moreover,the evaporative pre-cooling is able to enhance the cooling performance of NDDCT.Besides,on a yearly basis,better NDDCT cooling performances can be obtained by means of a spray-based pre-cooling approach with respect to wet media pre-cooling.Therefore,the use of nozzle spray is suggested for improvement in the performance of indirect/direct air-cooling systems with controlled water consumption.

CHDTEPDB:Transcriptome Expression Profile Database and Interactive Analysis Platform for Congenital Heart Disease

CHDTEPDB(URL:http://chdtepdb.com/)is a manually integrated database for congenital heart disease(CHD)that stores the expression profiling data of CHD derived from published papers,aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression.The develop-ment of human diseases involves important regulatory roles of RNAs,and expression profiling data can reflect the underlying etiology of inherited diseases.Hence,collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases.CHDTEPDB stores the expression profiles of over 200 sets of 7 types of CHD and provides users with more convenient basic analytical functions.Due to the differences in clinical indicators such as disease type and unavoidable detection errors among various datasets,users are able to customize their selection of corresponding data for personalized analysis.Moreover,we provide a submission page for researchers to submit their own data so that increasing expression profiles as well as some other histological data could be supplemented to the database.CHDTEPDB is a user-friendly interface that allows users to quickly browse,retrieve,download,and analyze their target samples.CHDTEPDB will significantly improve the current knowledge of expression profiling data in CHD and has the potential to be exploited as an important tool for future research on the disease.

Rapid commentary:Ethical implications for clinical trialists and patients associated with COVID-19 research

Pandemics disrupt clinical trials worldwide,with lasting effects on research.It can severely impact clinical trialists ability to conduct safe and ethically uncompromised trials.Hence,the mounting pressure results in ethically and morally distressing decisions faced by clinical trial professionals during pandemic situations.Whilst clinical trialists attempt to think about preparedness and responses during a pandemic,the need to have an ethical framework that has real-world applicability is imperative.Pandemics are a challenging time for all,however,the safety and access to support for clinical trialists and patients within clinical trials should be at the forefront for their organisations and the government.

Development of a Seismometer-Type Absolute Displacement Sensor Aimed at Detecting Earthquake Waves with a Large Magnitude and Long Period

This paper proposes a novel seismometer-type absolute displacement sensor aimed at detecting earthquake waves with a large magnitude and long period. However, since the measuring range of the displacement sensor is higher than its natural frequency, it is difficult to detect low frequency vibrations below 1 Hz using a conventional a seismic-type displacement sensor. In order to provide an absolute displacement detection which is capable of lowering the natural frequency and enlarging the detectable amplitude without causing structural defects, the relative signals of displacement, velocity, and acceleration between a detected object and the auxiliary mass of the sensor are fed back into the sensor. In addition, phase lag compensation is inserted to adjust phase angles, which are of a frequency of 1 Hz. According to simulation results, a detection range from 0.1 Hz to 50 Hz is expected. It has been demonstrated that the developed sensor with a small size and light weight has a detection range of from 0.5 Hz to 50 Hz for absolute displacement and velocity. As an additional advantage, the measurement displacement amplitude has been expanded to about 20 dB. This sensor is available to use for the active control method. of flexible structures like high rise buildings using the LQ control

Technical Requirements and Principles for the Standards Development of the Key Parts for Rotor Air-conditioning Compressors

Introduction Since 2000, air-conditioning sales continues to grow, and the development of air-conditioning market makes a booming market of compressor. At the present time, compressor production rising all the way, and the sales steps up the new steps constantly. Tendency chart is shown in figure 1. Rotor compressor with its simple structure,

Drift characteristics and the multi-field coupling stress mechanism of the pantograph-catenary arc under low air pressure

The fault caused by a pantograph-catenary arc is the main factor that threatens the stability of high-speed railway energy transmission.Pantograph-catenary arc vertical drift is more severe than the case under normal pressure,as it is easy to develop the rigid busbar,which may lead to the flashover occurring around the support insulators.We establish a pantograph-catenary arc experiment and diagnosis platform to simulate low pressure and strong airflow environment.Meanwhile,the variation law of arc drift height with time under different air pressures and airflow velocities is analyzed.Moreover,arc drift characteristics and influencing factors are explored.The physical process of the arc column drifting to the rigid busbar with the jumping mechanism of the arc root on the rigid busbar is summarized.In order to further explore the mechanism of the above physical process,a multi-field stress coupling model is built,as the multi-stress variation law of arc is quantitatively evaluated.The dynamic action mechanism of multi-field stress on arc drifting characteristics is explored,as the physical mechanism of arc drifting under low pressure is theoretically explained.The research results provide theoretical support for arc suppression in high-altitude areas.

Solriamfetol impurities:Synthesis,characterization,and analytical method(UPLC-UV)validation

Given that impurities may affect the quality and safety of drug products,impurity identification and profiling is an integral part of drug quality control and is particularly important for newly developed medications such as solriamfetol,which is used to treat excessive daytime sleepiness.Although the highperformance liquid chromatography analysis of commercial solriamfetol has revealed the presence of several impurities,their synthesis,structure elucidation,and chromatographic determination have not been reported yet.To bridge this gap,we herein identified,synthesized,and isolated eight processrelated solriamfetol impurities,characterized them using spectroscopic and chromatographic techniques,and proposed plausible mechanisms of their formation.Moreover,we developed and validated a prompt impurity analysis method based on ultrahigh-performance liquid chromatography with UV detection,revealing that its selectivity,linearity,accuracy,precision,and quantitation limit meet the acceptance criteria of method validation stipulated by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use.Thus,the developed method was concluded to be suitable for the routine analysis of solriamfetol substances.

Experimental and ab initio study of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F stability in the pressure range of 0–10 GPa

Both numerical and experimental studies of the stability and electronic properties of barium–sodium metaborate Ba_(2)Na_(3)(B_(3)O_(6))_(2)F(P63/m) at pressures up to 10 GPa have been carried out. Electronic-structure calculations with HSE06 hybrid functional showed that Ba_(2)Na_(3)(B_(3)O_(6))_(2)F has an indirect band gap of 6.289 eV. A numerical study revealed the decomposition of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F into the BaB_(2)O_(4),Na BO_(2), and NaF phases above 3.4 GPa at 300 K. Subsequent high-pressure high-temperature experiments performed using ‘Discoverer-1500’DIA-type apparatus at pressures of 3 and 6 GPa and temperature of 1173 K confirmed the stability of Ba_(2)Na_(3)(B_(3)O_(6))_(2)F at 3 GPa and its decomposition into BaB_(2)O_(4), NaBO_(2), and NaF at 6 GPa, which was verified by energy-dispersive X-ray analysis and Raman spectroscopy. The observed Raman bands of the Ba_(2)Na_(3)(B_(3)O_(6))_(2)F phase were assigned by comparing the experimental and calculated spectra. The experimental Raman spectra of decomposition reaction products obtained at 6 GPa suggest the origin of a new high-pressure modification of barium metaborate BaB_(2)O_(4).